Geraniol—a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa
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Abdallah DM, El-Abhar HS, Abdel-Aziz DH (2009) TEMPOL, a membrane permeable radical scavenger, attenuates gastric mucosal damage induced by ischemia–reperfusion: a key role for superoxide anion. Eur J Pharmacol 603:93–97
Allen A, Flemstrom G (2005) Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell 288:1–19
Anderson M (1985) Determination of glutathione disulfide in biological samples. Met Enzymol 113:548–555
Bakkali F, Averbeck S, Averbeck D, Idaomar M (2007) Biological effects of essential oils—a review. Food Chem Toxicol 46:446–475
Besouw M, Masereeuw R, Van Den Heuvel L, Levtchenko E (2013) Cysteamine: an old drug with new potential. Drug Discov Today 18(15-16):785–92. doi: 10.1016/j.drudis.2013.02.003
Cardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS (2011) Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 22:130–135
Carnesecchi S, Bras-Gonçalves R, Bradaia A, Zeisel M, Gossé F, Poupon MF, Raul F (2004) Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett 215:53–59
Garner A (1986) Future opportunities for drug therapy in peptic ulcer disease. Scand J Gastroenterol 125:203–210
Jeon JH, Lee CH, Lee HS (2009) Food protective effect of geraniol and its congeners against stored food mites. J Food Prot 72:1468–1471
Ji CX, Fan DS, Li W, Guo L, Xu ZL, Liang RM, Zhang JJ (2012) Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. Eur J Pharmacol 691:46–51
Khomenko T, Kolodney J, Pinto JT, McLaren GD, Deng X, Chen L, Tolstanova G, Paunovic B, Krasnikov BF, Hoa N, Cooper AJ, Szabo S (2012) New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine. Arch Biochem Biophys 525:60–70
Kim H, Kim KH (2001) Role of nitric oxide and mucus in ischemia/reperfusion-induced gastric mucosal injury in rats. Pharmacology 62:200–207
Krawisz JE, Sharon P, Stenson WF (1984) Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in the rat and hamster model. Gastroenterology 87:1344–1350
La Casa C, Villegas I, Alacrón de La Lastra C, Motilva V, Calero MJM (2000) Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 71:45–53
Laine L, Takeuchi K, Tarnawski A (2008) Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135:41–60
Li NS, Luo XJ, Dai Z, Liu B, Zhang YS, Yang ZC, Peng J (2012) Beneficial effects of capsiate on ethanol-induced mucosal injury in rats are related to stimulation of calcitonin gene-related peptide release. Planta Med 78:24–30
Luo XJ, Liu B, Dai Z, Yang ZC, Peng J (2013) Stimulation of calcitonin gene-related peptide release through targeting capsaicin receptor: a potential strategy for gastric mucosal protection. Dig Dis Sci 58:320–325
Madankumar A, Jayakumar S, Gokuladhas K, Rajan B, Raghunandhakumar S, Asokkumar S, Devaki T (2013) Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis. Eur J Pharmacol 705:148–155
Matsunaga T, Hasegawa C, Kawasuji T, Suzuki H, Saito H, Sagioka T, Takahashi R, Tsukamoto H, Morikawa T, Akiyama T (2000) Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica. Biol Pharm Bull 23:595–598
Muthuraman A, Ramesh M, Chauhan A (2011) Mitochondrial dependent apoptosis: ameliorative effect of flunarizine on ischemia–reperfusion of celiac artery-induced gastric lesions in the rat. Dig Dis Sci 56:2244–2251
Naito Y, Yoshikawa T, Matsuyama K, Yagi N, Arai M, Nakamura Y, Kaneko T, Yoshida N, Kondo M (1998) Neutrophils, lipid peroxidation, and nitric oxide in gastric reperfusion injury in rats. Free Radic Biol Med 24:494–502
Natale G, Lazzeri G, Lubrano V, Colucci R, Vassalle C, Fornai M, Blandizzi C, Del Tacca M (2004) Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds. Toxicol Appl Pharmacol 195:62–72
Olfert ED, Cross BM, McWilliam AA (1993) Guide to the care and use of experimental animals. Canadian Council on Animal Care, Ottawa, Ontario, pp 1–13
Oliveira IS, da Silva FV, Viana AF, dos Santos MR, Quintans-Júnior LJ, Martins MC, Nunes PH, Oliveira FA, Oliveira RC (2012) Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents. N Schmied Arch Pharmacol 385:899–908
Phillips L, Toledo AH, Lopez-Neblina F, Anaya-Prado R, Toledo-Pereyra LH (2009) Nitric oxide mechanism of protection in ischemia and reperfusion injury. J Invest Surg 22:46–55
Pongpiriyadacha Y, Matsuda H, Yoshikava M (2003) Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action. Biol Pharm Bull 26:651–657
Proença Cunha A (2005) Farmacognosia e Fitoquímica. Colouste F (ed) Gulbenkian Lisboa, Portugal
Rafatullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM (1990) Evaluation of tumeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol 29:25–34
Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433–440
Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43–61
Silva FV, Guimarães AG, Silva ER, Sousa-Neto BP, Machado FD, Quintans-Júnior LJ, Arcanjo DD, Oliveira FA, Oliveira RC (2012) Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. J Med Food 15:984–991
Silva MIG, Moura BA, Neto MRA, Tomé AR, Rocha NFM, Carvalho AMR, Macêdo DS, Vasconcelos SMM, Sousa DP, Viana GSB, Sousa CF (2009) Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. Naunyn Schmiedeberg’s Arch Pharmacol 380:233–245
Siqueira BPJ, Menezes CT, Silva JP, Sousa DP, Batista JS (2012) Antiulcer effects of epoxy-carvone. Rev Bras Farmacog 22:144–149
Souza R, Cardoso M, Menezes C, Silva J, De Sousa D, Batista J (2011) Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. Daru 19:277–281
Szabo S (1987) Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol 22:21–28
Szabo S, Nagy L, Plebani M (1992) Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin Chim Acta 206:95–105
Szallasi A (2006) Small molecule vanilloid TRPV1 receptor antagonist approaching drug status: can they live up to the expectations? Naunyn Schmiedeberg’s Arch Pharmacol 373:273–286
Takeuchi K, Kita K, Hayashi S, Aihara E (2011) Regulatory mechanism of duodenal bicarbonate secretion: roles of endogenous prostaglandins and nitric oxide. Pharmacol Ther 130:59–70
Tarnawski AS, Ahluwalia A, Jones MK (2012) The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem 19:4–15
Tiwari M, Kakkar P (2009) Plant derived antioxidants—geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol in Vitro 23:295–301
Tytgat GN (2011) Etiopathogenetic principles and peptic ulcer disease classification. Dig Dis 29:454–458
Ueda S, Yoshikawa T, Takahashi S, Ichikawa H, Yasuda M, Oyamada H, Tanigawa T, Sugino S, Kondo M (1989) Role of free radicals and lipid peroxidation in gastric mucosal injury induced by ischemia–reperfusion in rats. Scand J Gastroenterol 162:55–58
Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V (2012) Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Mol Cell Biochem 369:17–25
