Phân bố địa lý của bệnh tăng uric huyết ở Trung Quốc đại lục: một nghiên cứu tổng hợp hệ thống và phân tích meta
Tóm tắt
Fructose đóng vai trò quan trọng trong quá trình chuyển hóa phức tạp của axit uric trong cơ thể con người. Tuy nhiên, nồng độ axit uric trong máu cao, được gọi là tăng uric huyết, là yếu tố nguy cơ chính cho sự phát triển của gout. Do đó, chúng tôi đã thực hiện một phân tích meta cập nhật về tỷ lệ và phân bố địa lý của tăng uric huyết trong dân số chung tại Trung Quốc đại lục bằng cách tìm kiếm tài liệu hệ thống.
Năm cơ sở dữ liệu điện tử đã được sử dụng để tìm kiếm các bài viết liên quan được xuất bản cho đến năm 2019. Tất cả các tính toán được thực hiện bằng phần mềm Comprehensive Meta-Analysis (CMA). Chúng tôi đã bao gồm 108 bài viết đủ tiêu chuẩn (172 nghiên cứu theo giới tính, 95 nghiên cứu theo vùng và 107 nghiên cứu theo loại hình nghiên cứu) với tổng kích thước mẫu là > 808,505 người tham gia.
Tỷ lệ chung của tăng uric huyết trong dân số chung tại Trung Quốc đại lục là 17.4% (95% CI: 15.8–19.1%). Phân tích phân nhóm của chúng tôi chỉ ra rằng tỷ lệ chung theo vùng dao động từ 15.5 đến 24.6%. Những người sống ở vùng Đông Bắc và là nam giới có tỷ lệ mắc bệnh cao nhất (
Tỷ lệ tăng uric huyết đang gia tăng ở Trung Quốc, và các nghiên cứu trong tương lai nên điều tra mối liên hệ giữa tỷ lệ tăng uric huyết và các yếu tố nguy cơ của nó để giải quyết vấn đề, đặc biệt là trong các nhóm dễ tổn thương. Ngoài ra, nghiên cứu của chúng tôi là nghiên cứu toàn diện đầu tiên điều tra tỷ lệ chung của tăng uric huyết tại Trung Quốc đại lục, bao gồm sáu vùng khác nhau.
Từ khóa
Tài liệu tham khảo
Puig JG, Martinez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol. 2008;20:187–91.
Huang J, Ma ZF, Tian Y, Lee YY. Epidemiology and prevalence of gout in mainland China: an updated systematic review and meta-analysis. SN Compr Clin Med. 2020. https://doi.org/10.1007/s42399-020-00416-8.
Ichida K, Matsuo H, Takada T, et al. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun. 2012;3:764.
Zhou H, Ma ZF, Lu Y, et al. Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China. J Pediatr Endocrinol Metab. 2020;33:487–93.
Degli Esposti L, Desideri G, Saragoni S, Buda S, Pontremoli R, Borghi C. Hyperuricemia is associated with increased hospitalization risk and healthcare costs: evidence from an administrative database in Italy. Nutr Metab Cardiovasc Dis. 2016;26:951–61.
Trinchieri A, Montanari E. Biochemical and dietary factors of uric acid stone formation. Urolithiasis. 2018;46:167–72.
Smith E, March L. Global prevalence of hyperuricemia: a systematic review of population-based epidemiological studies (abstract). Arthritis Rheumatol. 2015;67:10.
Li Y, Zeng P, Zhu M, Liu X, Li D. The clinical characteristics of gout attack and its complications of lower extremity deep vein thrombosis in elderly patietns during hospitalisation. Chin J Clin Healthc. 2018;21:398–401.
Liu B, Wang T, Zhao H, et al. The prevalence of hyperuricemia in China: a meta-analysis. BMC Public Health. 2011;11:832.
Liu R, Han C, Wu D, et al. Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: a systematic review and meta-analysis. Biomed Res Int. 2015;2015:762820.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Open Med. 2009;3:e123–30.
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.
Ma W, Chen W, Li X. Investigation and analysis of hyperuricemia in elderly population in Guangzhou. Guangzhou Med J. 1999;30:65–6.
Shao J, Mo B, Yu R, Li Z, Liu H, Xu Y. Epidemiological study on hyperuricemia and gout in community of Nanjing. Chin J Dis Control Prev. 2003;7:305–8.
Chen M, Yang M, Wang C, et al. Relationship study of uric acid concentration of first-degree relatives of individuals with type 2 diabetes with metabolic syndrome. J Clin Intern Med. 2004;21:806–8.
Wu Z, Chen L, Zhao C, Peng C, Xiong Q. Serum uric acid level in middle-aged and elderly residents from the conjoining area between city and countryside in Guangzhou and association with risk factors of other cardiovascular diseases. Chin J Clin Rehabil. 2005;9:150–2.
Yang Y, Liu X, Xie H, et al. Association between prevalence rate of hyperuricemia and risk factors of cardiovascular disease in the population of Qingdao port. Chin J Clin Rehabil. 2005;9:1–3.
Wang Y, Zhao S, Chen X, et al. Influencing factors of serum uric acid and the critical concentration of serum uric acid to prevent and treat metabolic syndrome in female inhabitants from coastal area of Shandong province. Chin J Clin Rehabil. 2006;20:147–51.
Li Y, Zhao D, Liu J, Li ZA, Yong Q, Wang W. The association between hyperuricemia and prevalence of carotid plaque. Zhonghua Nei Ke Za Zhi. 2008;47:906–9.
Lu S, Pang W, Gao S, Lu H, Peng S, Jiang Y. The nutrition survey and energy expenditure in workers on offshore oil recovery platforms. Acta Nutr Sin. 2010;32:141–4.
Yu J, Yang T, Diao W, et al. Epidemiological study on hyperuricemia and gout in Foshan areas, Guangdong province. Chin J Epidemiol. 2010;31:860–2.
Yuan J, Shen Y, Hu Y, Cha Y. Epidemiological investigation of chronic kidney disease in the elderly in Guiyang City. Chin J Gerontol. 2011;31:1408–10.
Zhang Q, Zhang L. Research on noninfectious chronic disease of teachers from colleges and universities in China. Health Med Res Pract. 2011;08:4–7.
Guo W, Xioa C, Shen X, Liu G, Zhang H. Prevalence of hyperuricemia and its relationship to hypertension, hyperglycemia and hyperlipidemia in community residents in Taiyuan city. Chin Gen Pract. 2012;15:3045–7.
Wang L, Yuan N, Li X, Zhang K, Ma B. Analysis of health examination diseases of professional population in Yinchuan city from 2008 to 2010. J Ningxia Med Univ. 2012;34:627–9.
Chen Y, Luo Z, Deng Z, et al. 2012 health monitoring report of residents in Binyang County, Guangxi. J Applied Prev Med. 2013;19:300–2.
Duan W, Zhang J, Ma Y, Cheng J. Prevalence and influencing factors of hyperuricemia among residents in Korla region of Xinjiang. Chin Gen Pract. 2013;16:916–8.
Li L, Huang H, Liang B, Chen X, Cai H, Li X. Prevalence survey of hyperuricemia and its association with hypertriglyceridemia and hypertension in elderly people in Quanzhou of Fujian Province. Chin J Geriatri. 2013;32:338–40.
Li H, Cao X. Analysis on the prevalence rate and influencing factors of hyperuricemia in a company in Karamay city. Med Inf. 2013;32:220–1.
Lv C, Mou S, Ju J, He Z, Yi Y. Hypertension characteristics and renal damage of farmers in Yantai development zone. Chin J Integr Trad West Nephrol. 2013;14:881–3.
Su L, Xie B, Fan Y, Cha H. Analysis on the prevalence of hyperuricemia and related diseases among middle-aged and elderly cadres in the South China Sea. Chin J Clin Res. 2013;26:309–12.
Wang J, Gu H, Lu S, Xing Y, Qin L. Epidemiological survey of prevalence of hyperuricemia and its risk factors in adult population of Chongming District, Shanghai. J Chin Physician. 2013;15:1616–8.
Zhang C, Wu H, Lv C. Analysis of hyperuricemia and its risk factors in physical examination group. Chin J Gerontol. 2013;33:4048–9.
Zhou Q, He Z. Association analysis between serum uric acid levels and cerebral infarction, as well as serum glucose, blood pressure, blood lipids and c-reactive protein. Med Philos. 2013;34:29–32.
Chen S, Dai H, Lin A. Relationship between hyperuricemia and cardiovascular risk factors among middle-aged and elderly persons. Chin J Public Health. 2014;30:144–8.
Cui S, Wang X, Tian Z, Wei H, Tian X, Yi Y. Epidemiological study on hyperuricemia and gout in community of Yu County in Hebei Province. Chin J Traumatol. 2014;24:501–15.
Li S, Zhao Y, Gao X. Uric acid and associated factors of staff in Yunnan University. Chin J School Health. 2014;35:1199–203.
Lin X, Zou R, Li X, Zeng N. Prevalence survey and risk factors of hyperuricemia for rural elderly people of Licheng street in Zengcheng city. China Med Herald. 2014;11:101–4.
Liu J, Zhang X, Tan L, Song C, Zheng W. Investigation on the prevalence of hyperuricemia in physical examination population in Changchun and analysis of related risk factors. Chin J Clin Res. 2014;27:763–5.
Pan Y, Qiang D, Ding J, Shen Y. Analysis of the prevalence and influencing factors of hyperuricemia in Wujin district. Chin J Prev Control Chronic Dis. 2014;22:315–7.
Song W, Liu J, Chen Z, Huo Y, Lin A, Zhang Y. Hyperuricemia and gout: a prevalence survey among over-40-year-old community residents in Nanchang district. Chin Gen Pract. 2014;17:181–4.
Yong X, Ye Y. Analysis of uric acid test results in the blood of freshmen in a university. Chin J School Health. 2014;35:1430–1.
Zhu M, Wang M, Liu J. High uric acid hematic disease and renal damage epidemiological studies in Urumqi CHECK-UP CROWD. Chin J Integr Trad West Nephrol. 2014;15:125–8.
Cao X, Li X, Yi G. Correlation analysis of serum uric acid and blood lipid in 988 patients. Chin J Conv Med. 2015;8:851–2.
Li M, Liu J, Huang W, Zhang Q, et al. The relationship of hyperuricemia level with prediabetes and diabetes in Lanzhou. Chin J Diabetes. 2015a;23:11–4.
Li R, Li W, Wang Y, Jiang F, Chen H, Tu Q. Analysis on prevalence and influence factors of hyperuricemia among residents in Liuzhou. Chin J Health Lab Technol. 2015b;25:2807–9.
Li Y, Zhong G, Li Y, et al. Hyperuricemia prevalence analysis of township community residents in Dongguan. Chin Prim Health Care. 2015c;29:29–30,5.
Lu F. The correlative study on the relative risks of hyperuricemia of the elderly in community. Chin J Ethnomed Ethnopharm. 2015;2:76–7.
Zhao X. Analysis of hyperuricemia prevalence and related risk factors in cnooc employees. China: Tianjin Medial University; 2015. [Thesis].
Zhou A, Pan Q, Li A, et al. Predictive value of obesity and metabolism indexes for hyperuricemia among rural adult Yi residents in Liangshan region. Chin J Public Health. 2015a;31:1646–50.
Zhou M, Yang L, Kang L, Xu J, Xie L. Prevalence and influence factors of hyperuricemia among workers in Zhengzhou railway bureau. Chin J Health Lab Technol. 2015b;25:2599–601.
Guli A, He M, Zhang C. The incidence and related factors of fatty liver in minority population in Gansu province. Chin J Gerontol. 2016;36:3293–4.
Chen H, Xing Y. Correlation between hyperuricemia and hypertension of male faculty in a university. Chin J School Doct. 2016;30:344–5.
Chen N, Zhou J. Logistic regression analysis of risk factors of hyperuricemia in an elderly physical examination group in Shaoxing. Chin J Gerontol. 2016;36:4225–6.
Fan N, Zhang L, Xia Z, et al. Association between serum uric acid and nonalcoholic fatty liver disease. Chin J Diabetes. 2016;24:678–82.
Feng T, Tian F, Wu X, et al. Association analysis between serum uric acid and metabolic syndrome components. Chin J Diabetes. 2016;24:317–20.
Li Z. Cardiovascular health behavior and factors associated with hyperuricemia. China: Tianjin Medical University; 2016. [Thesis].
Li Q, Chen H, Lu A, et al. Investigation on the incidence of hyperuricemia in Qijiang district, Chongqing. China Health Care Nutr. 2016;26:305–6.
Liu X, Zhou Y, Ruan X, et al. Prevalence and risk factors of chronic kidney disease among residents from Pudong new area, Shanghai. Chin Gen Pract. 2016;19:3742–50.
Liu Y, Zhou F, Yin X. Analysis of the rate of hyperuricemia in Zhaotong city level cadres. Chinese Comm Doct. 2016;32:139–41.
Lu Y. Analysis of the related factors of uric acid level and uric acid increase in elderly people. China Health Care Nutr. 2016;1:370–1.
Pu H, Bai Y, Zhao G, et al. Study on the prevalence and influencing factors of cholelithiasis in Jinchang cohort. Chin J Health Stat. 2016;33:94–6.
Wang Y. Relationship between high blood pressure and hyperuricemia in freshmen in a university. Chin J School Health. 2016;37:1588–9.
Xie Z, Jiang M, Tang J, Wei X, Wang T, Yao J. Correlation between hyperuricemia and cardiovascular risk factors in occupational population of a certain enterprise. China J Health Lab Technol. 2016;26:1980–2.
Yang X, Wang T, Wang Y. Prevalence and influencing factors of dyslipidemia among adult residents in Tianjin city: a cross-sectional study. Chin J Public Health. 2016;32:286–90.
Zhang C. Analysis of the prevalence of hyperuricemia and dietary factors among male freshmen in a university. In: Proceedings of the 2015 national sports health care and rehabilitation academic conference; 2016. p. 78–81.
Zhao X, Liu L, Wan Q, Min C, Gao J, Zhang Y. The prevalence rate of carotid atherosclerosis and related risk factors among middle-aged and elderly teachers of different ethnic groups in colleges and universities. Chin J Gerontol. 2016a;36:5142–4.
Zhao B, Nie Q, Qu F, Cui H, Liu J. The study on the correlation of asymptomatic hyperuricemia and blood lipid among young people. Chin Exp Diagn. 2016b;20:1486–9.
Zhao B, Qu F, Cui H, Yang L, Qu H, Liu X. Clinical research of relationship between blood uric acid level and biochemical indicators in faculty of Beijing university. Chin J Clin Healthc. 2016c;19:574–7.
Feng W, Li H, Tao L, et al. Relationship between metabolic syndrome and hyperuricemia in physical examination population in a hospital of Beijing. Chin J Cardiovasc Med. 2017;22:438–41.
Guo H, Fu J, Bao C, et al. Association of fasting plasma glucose and hyperuricemia among young and middle-aged occupational men, Harbin. Modern Prev Med. 2017;44:1941–58.
He Y. Analysis of hyperuricemia and its risk factors in Dalian university staff. Chin J School Health. 2017;38:1594–6.
Li Y, He P, Zhou J, Wang S, Hailati J, Yati M. Prevalence and risk factor of non-alcoholic fatty liver disease in Xinjiang Urumqi region. Chin J Clin Healthc. 2017;20:574–8.
Li W, Zhou Y, Pan C. Study on related indexes changes of non-alcoholic fatty liver disease and metabolic syndrome. China Pract Med. 2017;12:1–3.
Lin J, Liu J, Zhang S, Jiang A. Analysis of the prevalence situation and related diseases of hyperuricemia in physical examination population in Puer city. Chin Comm Doct. 2017;33:114–5.
Liu J, Shen P, Yu Z, et al. Prevalence and risk factors of hyperuricemia in a community population of Pudong District in Shanghai. Chin J Integr Trad West Nephrol. 2017a;18:401–4.
Liu X, Gu J, Ruan X, et al. Prevalence and risk factors of hyperuricemia in Pudong new district of Shanghai. Chin J Prev Control Chronic Dis. 2017b;25:165–70.
Liu P, Zhao Q, Chen H, Zhang G, Huang T, Xiao L. Study on body mass index and blood pressure, blood lipid, blood glucose and uric acid in Xiangtan city. China Health Care Nutr. 2017c;27:72–3.
Liu J, Yan W, Li Z. Study on body mass index and health status of 6045 employees in Shijiazhuang city. Chin J Prac Intern Med. 2017;37:437–9.
Liu Y, Yang L. Analysis of the prevalence of nonalcoholic fatty liver disease and its related diseases among faculties in a certain university in Beijing. China Med Herald. 2017;14:178–80.
Pan J, Jiang F. Serum uric acid level in elderly population from a city and its effect on renal function. Guide China Med. 2017;15:12–3.
Wang Y, Bai Y. Investigation on blood uric acid examination results of 1012 oil workers and analysis of related risk factors. Chinese Comm Doct. 2017;33:128,30.
Wang H, Bao X. Morbidity and risk factors of hyperuricemia in elderly people from a Shanghai community. Chin J Integr Trad West Nephrol. 2017;18:869–72.
Xie Y, Luo R, Song Y, He X. Prevalence and influence factors of hyperuricemia among residents in eastern mountain area of Guangdong province. Chin J Public Health. 2017;33:317–20.
Yu K, Jie X. Investigation and analysis on the prevalence of hyperuricemia in physical examination group. China Rural Health. 2017;18:28.
Zhang M. Analysis of health examination results of 500 cadres in a certain army. China Health Care Nutr. 2017a;27:289–90.
Zhang L. Epidemiological survey on hypertension among employees of Wuhu power generation co., LTD in 2015. Chin J Rural Med Pharm. 2017b;24:63–4.
Zhang L, Chen S, Liu X. Community prevalence of hyperuricemia and its comorbidities. J Inner Mongolia Med Univ. 2017;39:516–9.
Zheng X. The present status of hyperuricemia in civil aviation flying personnel. Chin J Aerosp Med. 2017;28:23–8.
Chen HG, Sheng LT, Wan ZZ, et al. The relationship between smoking and hyperuricemia in Chinese residents. Zhonghua Yu Fang Yi Xue Za Zhi. 2018;52:524–9.
Chen Y, Tang Z, Fang Z, et al. Analysis of biological indicators of long-lived elderly in five long-lived areas in Guangxi. Chin J Gerontol. 2018b;38:3259–62.
Chen S, Zhao N, Li H, Guang H, Wang H. Influence of shift work on common risk factors of cardiovascular disease in male workers in petrochemical enterprises. China Occup Med. 2018c;45:316–20.
Chen H, Qin C, He Z, Chen Y, Huang H, Feng M. Study on the correlation between body mass index, uric acid and dyslipidemia on the elderly of Yao nationality in Gongcheng, Guangxi. Chin J New Clin Med. 2018d;11:338–41.
Fan J, Mao Y, Chen X. Analysis of risk factors affecting thyroid nodules in middle-aged and el-derly people in Ningbo. China Mod Doct. 2018;56:81–7.
He S. Analysis of prevalence and influential factors of fatty liver in faculty staff in a university. Chin J Health Lab Technol. 2018;28:1016–22.
Hu M, Liu J, Zhou C, Li X. Analysis of risk factors of hyperuricemia based on classification regression tree model. Chin Gen Pract. 2018;21:283–8.
Huang H, Huang Q. Analysis of physical examination of retired army cadres and health care countermeasures. Chin J Conv Med. 2018;27:606–8.
Huang J, Li M, Yang Y, et al. Prevalence and influence factors of hyperuricemia among rural residents in Qiannan minority regions of Guizhou province. Chin J Public Health. 2018;34:29–33.
Li P, Wang X, Xu J. The prevalence of HUA and its influencing factors in community outpatients. China Health Stand Mgmt. 2018;9:11–3.
Lin S, Lai S, Huang Z, Yang L, Wu H. Dietary patterns and influencing factors of hyperuricemia among adult residents in Fujian province: a classification tree analysis. Chin J Public Health. 2018a;34:798–802.
Lin Q, Qiu C, Li Y, et al. Influencing factors on prevalence of chronic diseases in workers under high-temperature condition in a port of Guangzhou City. China Occup Med. 2018b;45:329–34.
Lu Z. Analysis of the prevalence and influencing factors of hyperuricemia in community residents. Chin J Rural Med Pharm. 2018a;25:52–3.
Lu H. Survey for four consecutive years uric acid levels and related factors in a company in the Ordos region population. Chin J Prim Med Pharm. 2018b;25:52–7.
Su Y, Ni J, Zheng J, Huang X, Wu W, Xu Z. Investigation on metabolic syndrome and related chronic diseases in residents of Ouhai district. Chin J Prev Control Chronic Dis. 2018;26:597–600.
Tuo Y, Ren X, Li G, et al. Prevalence and impact factors of hyperuricmeia among Han adults in Gansu province. Chin J Public Health. 2018;34:808–11.
Wang R, Tang Z, Sun F, Diao L. Prevalence of hyperuricemia in the elderly in 7 areas of China. Chin J Epidemiol. 2018a;39:286–8.
Wang Y, Tian F, Wen J, Guo X, Yang X. Effect of total energy and three major nutrients intake and their changes on serum uric acid level. Sichuan Med J. 2018b;39:383–9.
Wang J, Ma M. Physical health among male civil aviation aircrews in China. Chin J Public Health. 2018;34:1174–7.
Yang Y, Zhou W, Zhang D, Zhou R, Wang Y. Correlation between hyperuricemia and chronic kidney disease in different sexes. Chin J Arterioscl. 2018;26:825–30.
Yu R, Wu J, Yang X, Chen J, Wang S. Analysis of related factors of blood lipid levels and elevated triglycerides in hyperuricemia population in healthy subjects. Med Inf. 2018;31:62–4.
Zhang H, Zhao X, Meng L, Dong J, Liu L. Relationship between hyperuricemia and metabolic syndrome in healthy people in Ningxia. Chin J Prev Control Chronic Dis. 2018;26:660–3.
Zhou Y, Song Q, Li W, Li X, Wang S, Dai X. Analysis on health examination of senior technical personnel in Ningxia in 2015. J Ningxia Med Univ. 2018;40:137–41.
Hu Y, Zhao C, Shang J. Disease composition analysis of sanitariums in Tibetan areas in a sanitarium from 2015 to 2017. Chin J Conv Med. 2019;28:222–4.
Tian Q, Wang Y, Li Z, et al. Correlation between uric acid and risk factors of cardiovascular disease in people under physical examination. China Contin Med Educ. 2019;11:62–5.
Yang H. Analysis of physical examination results and suggestions on health management of staff in a university in Guilin. China Health Care Nutr. 2019;29:311.
Yu Z, Chen L, Xiao J, Wang L. Detection and risk factors of fatty liver in 20316 physical examinees in Jinqiu Hospital of Liaoning Province. Chin Pract Rural Doct. 2019;26:63–6.
Fan XH, Sun K, Wang YB, et al. Prevalence and associated risk factors of hyperuricemia in rural hypertensive patients. Natl Med J China. 2009;89:2667–70.
Fu J, Huang Y, Liu J. Effects of high-intensity interval training on serum uric acid and muscle content in sea crew with hyperuricemia. Zhonghua Hang Hai Yi Xue Za Zhi. 2017;24:407–8.
Liu X, Han Y, Jiang J. Investigation on the current situation of hyperuricemia associated with related diseases in a university staff in Guangdong province in 2013. Chin J School Doct. 2015;29:412–3.
Min L. Analysis of hyperuricemia prevalence and related risk factors in idiopathic membranous nephropathy patients. China: China Medical University; 2017. [Thesis].
Nagahama K, Iseki K, Inoue T, Touma T, Ikemiya Y, Takishita S. Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertens Res. 2004;27:227–33.
Wang D, Yi Y, Qiu L, et al. The serum uric acid is related to hypertension in Chinese population. Basic Clin Med. 2019;39:182–6.
Lohsoonthorn V, Dhanamun B, Williams MA. Prevalence of hyperuricemia and its relationship with metabolic syndrome in Thai adults receiving annual health exams. Arch Med Res. 2006;37:883–9.
Sari I, Akar S, Pakoz B, Sisman AR, Gurler O, Birlik M, et al. Hyperuricemia and its related factors in an urban population, Izmir, Turkey. Rheumatol Int. 2009;29:869–74.
Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the national health and nutrition examination survey 2007-2008. Arthritis Rheum. 2011;63:3136–41.
Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet. 2012;379:815–22.
Song P, Wang H, Xia W, Chang X, Wang M, An L. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci Rep. 2018;8:4314.
Ghei M, Mihailescu M, Levinson D. Pathogenesis of hyperuricemia: recent advances. Curr Rheumatol Rep. 2002;4:270–4.
Kumar S, Singh A, Takhelmayum R, Shrestha P, Sinha J. Prevalence of hyperuricemia in Chitwan District of Nepal. J Coll Med Sci Nepal. 2010;6:18–23.
Jularattanaporn V, Krittayaphong R, Boonyasirinant T, Udol K, Udompunurak S. Prevalence of hyperuricemia in Thai patients with acute coronary syndrome. Thai Heart J. 2008;21:86–92.
Conen D, Wietlisbach V, Bovet P, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health. 2004;4:9.
Klemp P, Stansfield SA, Castle B, Robertson MC. Gout is on the increase in New Zealand. Ann Rheum Dis. 1997;56:22–6.