Genotoxicity testing of methyl tertiary-butyl ether (MTBE) in the Salmonella microsuspension assay and mouse bone marrow micronucleus test

Norman Y Kado1, Paul A Kuzmicky1, Guadalupe Loarca-Piña1,2, M Moiz Mumtaz3
1Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
2Departamento de Investigación y Posgrado, Facultad de Quı́mica, Universidad Autónoma de Querétaro, Querétaro, Qro 76010, México
3Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30333, USA

Tài liệu tham khảo

US EPA (1993) MTBE-Oxygenated Gasolines and Public Health Issues, 21 pp. Lioy, 1994, Micro-environmental and personal measurements of methyl-tertiary butyl ether (MTBE) associated with automobile use activities, J. Expos. Anal. Environ. Epidemiol., 4, 427 Newman, 1995, MTBE detected in survey of urban groundwater, Environ. Sci. Technol., 29, 305A Sugimura, 1992, Multiple genetic alterations in human carcinogenesis, Environ. Health Perspect., 98, 5, 10.1289/ehp.92985 Anderson, 1992, Role of protooncogene activation in carcinogenesis, Environ. Health Perspect., 98, 13, 10.1289/ehp.929813 J.S. Chun, H.D. Burleigh-Flayer, W.J. Kintish, Methyl-tertiary-butyl Ether: Vapor Inhalation Oncogenicity Study in Fisher-344 Rats, BRRC Report 91N0013B, Union Carbide, Bushy Run Research Center, Export, PA, 1992. H.D. Burleigh-Flayer, J.S. Chun, W.J. Kintish, Methyl-tertiary-butyl Ether: Vapor Inhalation Oncogenicity Study in CD-1 Mice, BRRC Report 91N0013A, Union Carbide, Bushy Run Research Center, Export, PA, 1992. Belpoggi, 1995, Methyl-tertiary-butyl-ether (MTBE) — a gasoline additive — causes testicular and lymphohaematopoietic cancers in rats, Toxicol. Environ. Health, 11, 119 Ames, 1975, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test, Mutation Res., 31, 347, 10.1016/0165-1161(75)90046-1 ARCO Chemical Company (1980) Methyl Tertiary Butyl Ether: Acute Toxicological Studies, 74 pp. Brusick, 1974, Comparison of the genetic activity of dimethyl-nitrosamine, ethylmethane sulfonate, 2-acetylaminofluorene and ICR-170 in Saccharomyces cerevisiae strains D3, D4, and D5 using in vitro assays with and without metabolic activation, Mutation Res., 26, 491, 10.1016/S0027-5107(74)80050-3 Clive, 1975, Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells, Mutation Res., 31, 17, 10.1016/0165-1161(75)90059-X Kado, 1983, A simple modification of the Salmonella liquid incubation assay. Increased sensitivity for detecting mutagens in human urine, Mutation Res., 121, 25, 10.1016/0165-7992(83)90082-9 Kado, 1992, Quantitative integration of the Salmonella microsuspension assay with supercritical fluid extraction of model airborne vapor-phase mutagens, Mutation Res., 271, 253, 10.1016/0165-1161(92)90020-M Kado, 1986, Mutagenicity of fine (<2.5 μm) airborne particles: diurnal variation in community air determined by a Salmonella micro preincubation (microsuspension) procedure, Environ. Mutagen., 8, 53, 10.1002/em.2860080106 Lowry, 1951, Protein measurement with folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 W. Schmid, The micronucleus test for cytogenetic analysis, in: A. Hollaender (Ed.), Chemical Mutagens: Principles and Methods for Their Detection, Plenum, New York, 1976, pp. 31–43. Marnett, 1985, Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104, Mutation Res., 148, 25, 10.1016/0027-5107(85)90204-0 Mackerer, 1996, Identification of formaldehyde as the metabolite responsible for the mutagenicity of methyl tertiary-butyl ether in the activated mouse lymphoma assay, Proc. Soc. Exp. Biol. Med., 212, 338, 10.3181/00379727-212-44023 Sofuni, 1996, Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study, Mutagenesis, 11, 349, 10.1093/mutage/11.4.349 Moser, 1996, Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice, Fundam. Appl. Toxicol., 31, 173, 10.1006/faat.1996.0089 McKee, 1997, Assessment of the in vivo mutagenic potential of methyl tertiary-butyl ether, J. Appl. Toxicol., 17, S31, 10.1002/(SICI)1099-1263(199705)17:1+<S31::AID-JAT408>3.3.CO;2-1