Genotoxicity studies on the root extract of Polygala tenuifolia Willdenow

Ashby, 1985, Is there a continuing role for the intraperitoneal injection route of exposure in short-term rodent genotoxicity assays, Mutat. Res., 156, 239, 10.1016/0165-1218(85)90069-2 Chan, 2000, Examples of interactions between Chinese herbal medicinal products and orthodox drug, 57 Chau, 2006, The development of regulations of Chinese herbal medicines for both medicinal and food uses, Trends Food Sci. Technol., 17, 313, 10.1016/j.tifs.2005.12.005 Chen, 2010, Tenuigeninprotes cultured hippocampal neurons against methlglyoxal-induced neurotoxicity, Eur. J. Pharmacol., 645, 1, 10.1016/j.ejphar.2010.06.034 Chen, 2012, Tenuigenun promotes proliferation and differentiation of hippocampal neural stem cells, Neurochem. Res., 37, 771, 10.1007/s11064-011-0671-3 Dean, 1984, Assays for the detection of chemically-induced chromosome damage in cultured mammalian cells, 197 Dunnett, 1964, New tables for multiple comparisons with a control, Biometrics, 20, 482, 10.2307/2528490 Firenzuoli, 2007, Herbal medicine today: clinical and research issues, Evid. Based Compl. Altern. Med., 4, 37, 10.1093/ecam/nem096 Fisher, 1970 Heddle, 1984, The bone marrow micronucleus test, 441 Huang, 1993, 224 Ikeya, 2004, Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia, Biol. Pham. Bull., 27, 1081, 10.1248/bpb.27.1081 Ishidate, 1985, The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in culture, Program Mutat. Res., 5, 427 Ishidate, 1981, Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagens and/or carcinogens, GANN Monogr. Cancer Res., 27, 95 JEMS-MMS, 1988 Jin, 2012, The extracts of FructusAkebiae, a preparation containing 90% of the active ingredient hederagenin:serotomin, norepinephrine and dopamine reuptake inhibitor, Pharmacol. Biochem. Behav., 100, 431, 10.1016/j.pbb.2011.10.001 Jordan, 2010, Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment, Toxicol. Appl. Pharmacol., 243, 198, 10.1016/j.taap.2009.12.005 Klein, 2012, A pharmacognostic approach to the Polygala genus: phytochemical and pharmacological aspects, Chem. Biodivers., 9, 181, 10.1002/cbdv.201000319 Korea Food and Drug Administration (KFDA), 1999. The Standards of Toxicity Study for Medicinal Products, Notification No. 1999-61 (Dec 22, 1999). Kruskal, 1952, Use if ranks in one criterion variance analysis, J. Am. Stratist. Assoc., 47, 614 Lee, 2003, Four-week repeated-dose toxicity study on Pinellia extract, Korean J. Lab. Anim. Sci., 19, 127 Lee, 2009, Effects of BT-11 on memory in healthy humans, Neurosci. Lett., 454, 111, 10.1016/j.neulet.2009.03.024 Ling, 2013, J. Pharm. Biomed. Anal., 85, 1, 10.1016/j.jpba.2013.06.011 Liu, 2010, Potential antidepressant properties of radix polygalae (Yuan Zhi), Phytomedicine, 17, 794, 10.1016/j.phymed.2010.01.004 Lynch, 2007, Differences in perceived risks and benefits of herbal, over-the-counter conventional, and prescribed conventional, medicines, and the implications of this for the safe and effective use of herbal products, Compl. Ther. Med., 15, 84, 10.1016/j.ctim.2006.06.007 Manu, 2013, Evaluation of genotoxicity of Trois through Ames and in vitro chromosomal aberration tests, Asian. Pac J. Trop. Biomed., 3, 902, 10.1016/S2221-1691(13)60176-8 Maron, 1983, Revised methods for the Salmonella mutagenicity test, Mutat. Res., 113, 173, 10.1016/0165-1161(83)90010-9 Nagai, 2001, Onjisaponins, from the root of Polygala tenuifolia Wulldeow, as effective adjuvants for nasal influenza and diphtheria–pertussis–tetanus vaccines, Vaccine, 19, 4824, 10.1016/S0264-410X(01)00215-8 Organization for Economic Cooperation and Development (OECD) Guidelines for the Testing of Chemicals, 1997a. ‘Bacterial reverse mutation test’ (OECD TG #471). OECD Guidelines for the Testing pf Chemicals, 1997b. ‘Mammalian erythrocyte micronucleus test’ (OECD TG #474). OECD Guidelines for the Testing of Chemicals, 1997c. ‘In vitro mammalian chromosome aberration test’ (OECD TG #473). Pankaj, 2009, Laboratory evaluation of crude extracts of Cinnamomum tamala for potential antibacterial activity, Electr. J. Biol., 5, 75 Park, 2002, Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11, J. Neurosci. Res., 70, 484, 10.1002/jnr.10429 Richardson, 1989, Analysis of data from in vitro cytogenetics assays, 141 Rousseaux, 2003, Regulatory issues concerning the safety, efficacy and quality of herbal remedies, Birth Defects Res. B Dev. Reprod. Toxicol., 68, 505, 10.1002/bdrb.10053 Schmid, 1975, The micronucleus test, Mutat. Res., 31, 9, 10.1016/0165-1161(75)90058-8 Seeff, 2001, Complementary and alternative medicine in chronic liver disease, J. Hepatology., 34, 595, 10.1053/jhep.2001.27445 Shin, 2009, BT-11 improves stress-induced memory impairments through increment of glucose utilization and total neural cell adhesion molecule levels in rat brains, J. Neurosci. Res., 82, 260, 10.1002/jnr.21834 Shin, 2009, BT-11 is effective for enhancing cognitive functions in the elderly humans, Neurosci. Lett., 465, 157, 10.1016/j.neulet.2009.08.033 Shin, 2012, In vitro and in vivo evaluation of the genotoxicity Gumiganghwal-tang, a traditional herbal prescription, J. Ethnopharmacol., 141, 350, 10.1016/j.jep.2012.02.045 Shin, 2014, Preclinical safety of the root extract of Polygala tenuifolia Willdenow in sprague-dawley rats and beagle dogs, Evid.-Based Compl. Alt., 2014, 1 Spelman, 2006, Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators, Altern. Med. Rev., 11, 128 Wang, 2007, Brief review about compatibility and their pharmacological effects of Chinese material medica as tranquilizer, Zhongguo zhong Yao Za Zhi, 32, 2342 Wang, 2009, Quality and safety of Chinese herbal medicines guided by a systems biology perspective, J. Ethnopharmacol., 126, 31, 10.1016/j.jep.2009.07.040