Genotoxicity of tobacco smoke and tobacco smoke condensate: a review

Mutation Research/Reviews in Mutation Research - Tập 567 Số 2-3 - Trang 447-474 - 2004
David M. DeMarini1
1Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. [email protected]

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World Health Organization, The World Health Report 2002, Reducing Risks, Promoting Healthy Life, World Health Organization, Geneva, 2002.

Peto, 1996, Mortality from smoking worldwide, Br. Med. Bull., 52

Burns, 2003, Epidemiology of smoking-induced cardiovascular disease, Prog. Cardiovasc. Dis., 46

International Agency for Research on Cancer, Tobacco smoking and tobacco smoke, IARC Monographs on the Evaluation of the Carcinogenic Risks of Chemicals to Humans, vol. 83, International Agency for Research on Cancer, Lyon, France, 2004.

Doll, 1998, Epidemiological evidence of the effects of behaviour and the environment on the risk of human cancer, Recent Results Cancer Res., 154, 3, 10.1007/978-3-642-46870-4_1

DeMarini, 1983, Genotoxicity of tobacco smoke and tobacco smoke condensate, Mutat. Res., 114, 59, 10.1016/0165-1110(83)90019-2

1984

International Agency for Research on Cancer, Tobacco smoking, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, vol. 38, Lyon, France, 1986.

Phillips, 2002, Smoking-related DNA and protein adducts in human tissues, Carcinogenesis, 23, 1979, 10.1093/carcin/23.12.1979

Hecht, 2003, Tobacco carcinogens, their biomarkers and tobacco-induced cancer, Nat. Rev., 3, 733, 10.1038/nrc1190

Steele, 1995, A comparison of the mutagenicity of the mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (K1R4F), Mutat. Res., 342, 179, 10.1016/0165-1218(95)90027-6

Chepiga, 2000, A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F), Food Chem. Toxicol., 38, 949, 10.1016/S0278-6915(00)00086-7

Chen, 1996, Genotoxicity and DNA adduct formation of incense smoke condensates: comparison with environmental tobacco smoke condensates, Mutat. Res., 367, 105, 10.1016/0165-1218(95)00067-4

Morin, 1987, The effect of solvent and extraction methods on the bacterial mutagenicity of sidestream cigarette smoke, Toxicol. Lett., 38, 279, 10.1016/0378-4274(87)90010-5

Ong, 1987, Application of SOS umu-test for the detection of genotoxic volatile chemicalsand air pollutants, Environ. Mutagen., 9, 171, 10.1002/em.2860090207

Doolittle, 1990, Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco, Environ. Mol. Mutagen., 15, 93, 10.1002/em.2850150206

Ji, 1996, Vica faba root tip micronucleus test on the mutagenicity of water-soluble contents of cigarette smoke, Mutat. Res., 359, 1, 10.1016/S0165-1161(96)90003-5

Clive, 1997, Validation and characterization of the L5178Y/Tk+/− mouse lymphoma mutagen assay system, Mutat. Res., 59, 61, 10.1016/0027-5107(79)90195-7

Mitchell, 1981, Mutagenic and carcinogenic potency of extracts of diesel and related environmental emissions: in vitro mutagenesis and DNA damage, Environ. Int., 5, 393, 10.1016/0160-4120(81)90089-1

Cobb, 1989, Preliminary molecular analysis of the TK locus in L5178Y large- and small-colony mouse lymphoma cell mutants, Mutat. Res., 226, 253, 10.1016/0165-7992(89)90078-X

Jongen, 1985, Genotoxicity testing of cigarette-smoke condensate in the SCE and HGPRT assays with V79 Chinese hamster cells, Food Chem. Toxicol., 23, 603, 10.1016/0278-6915(85)90186-3

Jongen, 1986, Inhibitory effects of the phorbolseter TPA and cigarette smoke condensate on the mutagneicity of benzo[a]pyrene in a co-cultivation system, Mutat. Res., 159, 133, 10.1016/0027-5107(86)90122-3

Krause, 1999, Spontaneous and chemically induced point mutations in HPRT cDNA of the metabolically competent human lymphoblastoid cell line, MCL-5, Mutat. Res., 431, 417, 10.1016/S0027-5107(99)00183-9

Yang, 1997, Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells, J. Cell. Biochem., 66, 309, 10.1002/(SICI)1097-4644(19970901)66:3<309::AID-JCB4>3.0.CO;2-T

Zhang, 1994, Studies on intrachromosomal recombination in SP5/V79 Chinese hamster cells upon exposure to different agents related to carcinogenesis, Carcinogenesis, 15, 2303, 10.1093/carcin/15.10.2303

Putnam, 1999, Comparison of the cytotoxic and mutagenic potential of liquid smoke food flavourings, cigarette smoke condensate and wood smoke condensate, Food Chem. Toxicol., 37, 1113, 10.1016/S0278-6915(99)00104-0

Fitzgerald, 2001, Cigarette smoke comparative toxicology, Food Chem. Toxicol., 39, 175, 10.1016/S0278-6915(00)00128-9

Smith, 2001, Response to cigarette smoke comparative toxicology, Food Chem. Toxicol., 39, 177, 10.1016/S0278-6915(00)00129-0

Williams, 1985, Metabolic activation of organic extracts from diesel, coke oven, roofing tar, and cigarette smoke emissions in the Ames assay, Environ. Mutagen., 7, 489, 10.1002/em.2860070408

Curvall, 1985, In vitro studies of biological effects of cigarette smoke condensate. I. genotoxic and cytotoxic effects of neutral, semivolatile constituents, Mutat. Res., 157, 169, 10.1016/0165-1218(85)90113-2

Salomaa, 1988, Genotoxicity and PAC analysis of particulate and vapour phases of environmental tobacco smoke, Mutat. Res., 204, 173, 10.1016/0165-1218(88)90087-0

Matsukura, 1991, Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells, Carcinogenesis, 12, 685, 10.1093/carcin/12.4.685

Asita, 1991, Mutagenicity of wood smoke condensates in the Salmonella/microsome assay, Mutat. Res., 264, 7, 10.1016/0165-7992(91)90039-7

Doolittle, 1995, The genotoxic potential of nicotine and its major metabolites, Mutat. Res., 344, 95, 10.1016/0165-1218(95)00037-2

Doolittle, 1991, The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine, Mutat. Res., 260, 9, 10.1016/0165-1218(91)90075-W

Smith, 2000, The relative toxicity of compounds in mainstream cigarette smoke condensate, Food Chem. Toxicol., 38, 637, 10.1016/S0278-6915(00)00051-X

Carmines, 2002, Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results, Food Chem. Toxicol., 40, 77, 10.1016/S0278-6915(01)00084-9

Roemer, 2002, Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxicity, Food Chem. Toxicol., 40, 105, 10.1016/S0278-6915(01)00086-2

Austin, 1985, Mutagenicity of the fractionated organic emissions from diesel, cigarette smoke condensate, coke oven, and roofing tar in the Ames assay, Environ. Mutagen., 7, 471, 10.1002/em.2860070407

Clapp, 1999, Reduction in Ames Salmonella mutagenicity of mainstream cigarette smoke condensate by tobacco protein removal, Mutat. Res., 446, 167, 10.1016/S1383-5718(99)00178-3

White, 2001, Effect of pyrolysis temperature on the mutagenicity of tobacco smoke condensate, Food Chem. Toxicol., 39, 499, 10.1016/S0278-6915(00)00155-1

Mori, 1995, Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster, Mutat. Res., 346, 1, 10.1016/0165-7992(95)90061-6

DeMarini, 1995, Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors, Carcinogenesis, 16, 2535, 10.1093/carcin/16.10.2535

Rutten, 1986, Effect of cigarette-smoke condensate and norharman on the induction of SCEs by direct and indirect mutagens in CHO cells, Mutat. Res., 172, 61, 10.1016/0165-1218(86)90107-2

Lafi, 1988, Cytogenetic activities of tobacco particulate matter (TPM) derived from a low to middle tar British cigarette, Mutat. Res., 201, 365, 10.1016/0027-5107(88)90024-3

Jones, 1991, 32P-postlabelling analysis and micronuclei induction in primary Chinese hamster lung cells exposed to tobacco particulate matter, Carcinogenesis, 12, 1507, 10.1093/carcin/12.8.1507

Jansson, 1986, In vitro studies of biological effects of cigarette smoke condensate. II. Induction of sister-chromatid exchanges in human lymphocytes by weakly acidic, semivolatile constituents, Mutat. Res., 169, 129, 10.1016/0165-1218(86)90092-3

Jansson, 1988, In vitro studies of the biological effects of cigarette smoke condensate. III. Induction of SCE by some phenolic and related constituents derived from cigarette smoke. A study of structure-activity relationships, Mutat. Res., 206, 17, 10.1016/0165-1218(88)90136-X

Massey, 1998, Micronucleus induction in V79 cells after direct exposure to whole cigarette smoke, Mutagenesis, 13, 145, 10.1093/mutage/13.2.145

Veltel, 1996, Characterization of cigarette smoke-induced micronuclei in vitro, Exp. Toxicol. Pathol., 48, 548, 10.1016/S0940-2993(96)80080-7

Lee, 1993, Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics, Fundam. Appl. Toxicol., 20, 393, 10.1006/faat.1993.1051

Lee, 1992, Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette, Fundam. Appl. Toxicol., 19, 141, 10.1016/0272-0590(92)90038-J

Rithidech, 1989, Cytogenetic effects of cigarette smoke on pulmonary alveolar macrophages of the rat, Environ. Mol. Mutagen., 14, 27, 10.1002/em.2850140106

Balansky, 1987, Investigation of the mutagenic activity of tobacco smoke, Mutat. Res., 188, 13, 10.1016/0165-1218(87)90109-1

Balansky, 1988, The mutagenic and clastogenic activity of tobacco smoke, Mutat. Res., 208, 237, 10.1016/0165-7992(88)90067-X

Balansky, 1999, Induction, persistence and modulation of cytogenetic alterations in cells of smoke-exposed mice, Carcinogenesis, 20, 1491, 10.1093/carcin/20.8.1491

Mohtashamipur, 1987, Clastogenic effect of passive smoking on bone marrow polychromatic erythrocytes of NMRI mice, Toxicol. Lett., 35, 153, 10.1016/0378-4274(87)90101-9

Mohtashamipur, 1988, Comparative bone marrow clastogenicity of cigarette sidestream, mainstream and recombined smoke condensates in mice, Mutagenesis, 3, 419, 10.1093/mutage/3.5.419

Stoichev, 1993, Dominant-lethal mutations and micronucleus inductionin male BALB/c, BDF1 and H mice by tobacco smoke, Mutat. Res., 319, 285, 10.1016/0165-1218(93)90017-8

Nersessian, 1994, The comparative clastogenic activity of mainstream tobacco smoke from cigarettes widely consumed in Armenia, Mutat. Res., 321, 89, 10.1016/0165-1218(94)90124-4

Nakayama, 1985, Cigarette smoke induces DNA single-strand breaks in human cells, Nature, 314, 462, 10.1038/314462a0

Fielding, 1989, Studies on the ability of smoke from different types of cigarettes to induce single-strand breaks in cultured human cells, Mutat. Res., 214, 147, 10.1016/0027-5107(89)90208-X

Leanderson, 1990, Cigarette smoke-induced DNA-damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine, Chem. Biol. Interact., 75, 71, 10.1016/0009-2797(90)90023-G

Leanderson, 1992, Cigarette smoke-induced DNA damage in cultured human cells: role of hydroxyl radicals and endonuclease activation, Chem. Biol. Interact., 81, 197, 10.1016/0009-2797(92)90034-I

Leanderson, 1994, Cigarette tar promotes neutrophil-induced DNA damage in cultured lung cells, Environ. Res., 64, 103, 10.1006/enrs.1994.1009

Bermudez, 1994, Environmental tobacco smoke is just as damaging to DNA as mainstream smoke, Environ. Health Perspect., 102, 870, 10.1289/ehp.94102870

Willey, 1987, Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro, Cancer Res., 47, 2045

Spencer, 1995, DNA damage in human respiratory tract epithelial cells: damage by gas phase cigarette smoke apparently involves attack by reactive nitrogen species in addition to oxygen radicals, FEBS Lett., 375, 179, 10.1016/0014-5793(95)01199-O

Seree, 1996, High inducibility of mouse renal CYP2E1 gene by tobacco smoke and its possible effect on DNA single strand breaks, Biochem. Biophys. Res. Commun., 219, 234, 10.1006/bbrc.1996.0250

Yoshie, 1997, Synergistic induction of DNA strand breakage by cigarette tar and nitric oxide, Carcinogenesis, 18, 1359, 10.1093/carcin/18.7.1359

Liu, 1999, Synergistic induction of hydroxyl radical-induced DNA single-strand breaks by chromium (VI) compound and cigarette smoke solution, Mutat. Res., 440, 109, 10.1016/S1383-5718(99)00015-7

Yang, 1999, Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji, Carcinogenesis, 20, 1769, 10.1093/carcin/20.9.1769

Zhang, 2001, Study on the effects of DNA damage induced by cigarette smoke in male mice testicular cells using comet assay, Wei. Sheng. Yan. Jiu., 30, 28

Hess, 1996, DNA damage by filtered, tar-and aerosol-free cigarette smoke in rodent cells: a novel evaluation, Toxicol. Lett., 88, 9, 10.1016/0378-4274(96)03711-3

Carnevali, 2003, Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts, Am. J. Physiol. Lung Cell Mol. Physiol., 284, L955, 10.1152/ajplung.00466.2001

Borgerding, 1998, Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 1. Chemical composition of mainstream smoke, Food Chem. Toxicol., 36, 169, 10.1016/S0278-6915(97)00108-7

Doolittle, 1989, Human urine mutagenicity study comparing cigarettes which burn or only heat tobacco, Mutat. Res., 223, 221, 10.1016/0165-1218(89)90050-5

deBethizy, 1990, Chemical and biological studies of a cigarette that heats rather than burns tobacco, J. Clin. Phamacol., 30, 755

Bombick, 1997, Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstream smoke condensate, Food Chem. Toxicol., 36, 183, 10.1016/S0278-6915(97)00107-5

Lee, 1990, Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco, Mutat. Res., 240, 251, 10.1016/0165-7992(90)90137-9

Lee, 1990, Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco, Mutat. Res., 242, 37, 10.1016/0165-1218(90)90097-L

Bombick, 1998, Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco, Environ. Mol. Mutagen., 31, 169, 10.1002/(SICI)1098-2280(1998)31:2<169::AID-EM9>3.0.CO;2-H

Bombick, 1998, Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 3. In vitro toxicity of whole smoke, Food Chem. Toxicol., 36, 191, 10.1016/S0278-6915(97)00155-5

Doolittle, 1990, Comparative studies of the mutagenicity of urine from smokers and non-smokers on a controlled non-mutagenic diet, Food Chem. Toxicol., 28, 639, 10.1016/0278-6915(90)90172-J

Smith, 1996, Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco, Mutat. Res., 361, 1, 10.1016/S0165-1161(96)90222-8

Bowman, 2002, Relationship between FTC “tar” and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes, Mutat. Res., 521, 137, 10.1016/S1383-5718(02)00219-X

Tewes, 2003, Toxicological evaluation of an electrically heated cigarette. Part 3: genotoxicity and cytotoxicity of mainstream smoke, J. Appl. Toxicol., 23, 341, 10.1002/jat.925

Patskan, 2003, Toxicological evaluation of an electrically heated cigarette. Part I: overview of technical concepts and summary of findings, J. Appl. Toxicol., 23, 323, 10.1002/jat.923

Brunnemann, 1994, Low ignition propensity cigarettes: smoke analysis for carcinogens and testing for mutagenic activity of the smoke particulate matter, Food Chem. Toxicol., 32, 917, 10.1016/0278-6915(94)90090-6

Bombick, 1997, Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter, Fundam. Appl. Toxicol., 39, 11, 10.1006/faat.1997.2334

Theophilus, 2003, Toxicological evaluation of dry ice expanded tobacco, Toxicol. Lett., 145, 107, 10.1016/S0378-4274(03)00235-2

Trivedi, 1993, Genotoxic effects of tobacco extract on Chinese hamster ovary cells, Cancer Lett., 70, 107, 10.1016/0304-3835(93)90081-J

Kulhkarni, 1987, Mutagenicity of extracts of brown and black masheri, pyrolysed products of tobacco using short-term tests, Mutagenesis, 2, 263, 10.1093/mutage/2.4.263

Balansky, 1989, Tobacco smoke-induced clastogenicity in mouse fetuses and in newborn mice, Mutat. Res., 223, 1, 10.1016/0165-1218(89)90056-6

Karube, 1989, Analyses of transplacentally induced sister chromatid exchanges and micronuclei in mouse fetal liver cells following maternal exposure to cigarette smoke, Cancer Res., 49, 3550

Alaoui-Jamali, 1989, Transplacental genotoxicity of a tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in Syrian golden hamster, Mutat. Res., 223, 65, 10.1016/0165-1218(89)90063-3

Sipowicz, 1997, Oxidative DNA damage in tissues of pregnant female mice and fetuses caused by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), Cancer Lett., 117, 87, 10.1016/S0304-3835(97)00208-5

De Flora, 2003, Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis, Mutat. Res., 523-524, 237, 10.1016/S0027-5107(02)00340-8

Camoirano, 1994, Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke, Mutat. Res., 317, 89, 10.1016/0165-1110(94)90019-1

Romert, 1994, Screening for agents inhibiting the mutagenicity of extracts and constituents of tobacco products, Mutat. Res., 322, 97, 10.1016/0165-1218(94)00015-8

Tsuda, 2000, The influence of antioxidants on cigarette smoke-induced DNA single-strand breaks in mouse organs: a preliminary study with the alkaline single cell gel electrophoresis assay, Toxicol. Sci., 54, 104, 10.1093/toxsci/54.1.104

Balansky, 2003, Systemic genotoxic effects produced by light, and syngergism with cigarette smoke in the respiratory tract of hairless mice, Carcinogenesis, 24, 1525, 10.1093/carcin/bgg108

D’Agostini, 2001, Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats, Carcinogenesis, 22, 375, 10.1093/carcin/22.3.375

Izzotti, 2001, Moduation of biomarkers by chemopreventive agents in smoke-exposed rats, Cancer Res., 61, 2472

Dertinger, 2001, Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo, Carcinogenesis, 22, 171, 10.1093/carcin/22.1.171

De Flora, 2003, Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke, Cancer Res., 63, 793

Cole, 1994, Somatic mutation frequency, mutation rates and mutation spectra in the human population in vivo, Mutat. Res., 304, 33, 10.1016/0027-5107(94)90320-4

Curry, 1999, Influence of sex, smoking and age on human hprt mutation frequencies and spectra, Genetics, 152, 1065, 10.1093/genetics/152.3.1065

Robinson, 1994, An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four data sets, Mutat. Res., 313, 227, 10.1016/0165-1161(94)90053-1

Ammenheuser, 1997, Frequencies of hprt mutant lymphocytes in smokers, non-smokers, and former smokers, Environ. Mol. Mutagen., 30, 131, 10.1002/(SICI)1098-2280(1997)30:2<131::AID-EM5>3.0.CO;2-Q

Hou, 1999, Hprt mutant frequency and aromatic DNA adduct level in non-smoking and smoking lung cancer patients and population controls, Carcinogenesis, 20, 437, 10.1093/carcin/20.3.437

Burkhart-Schultz, 1996, Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (HPRT) gene of healthy people, Carcinogenesis, 17, 1871, 10.1093/carcin/17.9.1871

Podlutsky, 1998, Spectrum of point mutations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase gene in human T lymphocytes in vivo, Carcinogenesis, 19, 557, 10.1093/carcin/19.4.557

Podlutsky, 1999, Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults, Mutat. Res., 431, 325, 10.1016/S0027-5107(99)00176-1

Hackman, 2000, Mutational spectra at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of nonsmoking and smoking lung cancer patients, Mutat. Res., 468, 45, 10.1016/S1383-5718(00)00039-5

Yamasaki, 1977, Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine, Proc. Natl. Acad. Sci. USA, 74, 3555, 10.1073/pnas.74.8.3555

Jaffe, 1983, Urinary mutagen levels in smokers, Cancer Lett., 20

Kriebel, 1985, The mutagenicity of cigarette smokers’ urine, J. Environ. Pathol. Toxicol. Oncol., 6, 157

Putzrath, 1981, Analysis of mutagenic activity in cigarette smokers’ urine by high performance liquid chromatography, Mutat. Res., 85, 97, 10.1016/0165-1161(81)90025-X

Sasson, 1985, Mutagens in human urine: effects of cigarette smoking and diet, Mutat. Res., 158, 149, 10.1016/0165-1218(85)90078-3

Kuenemann-Migeot, 1996, Urinary promutagens of smokers: comparison of concentration methods and relation to cigarette consumption, Mutat. Res., 368, 141, 10.1016/0165-1218(96)00004-3

Williams, 1990, Stability of the mutagenicity in stored cigarette smokers’ urine and extract, Environ. Mol. Mutagen., 16, 246, 10.1002/em.2850160405

Kado, 1983, A simple modification of the Salmonella, liquid incubation assay, Mutat. Res., 121, 25, 10.1016/0165-7992(83)90082-9

Nylander, 1991, Mutagenicity study of urine from smoking and non-smoking road tanker drivers, Int. Arch. Occup. Environ. Health, 63, 229, 10.1007/BF00386370

Kado, 1985, The kinetics of mutagen excretion in the urine of cigarette smokers, Mutat. Res., 157, 227, 10.1016/0165-1218(85)90120-X

De Méo, 1988, Applicability of the SOS Chromotest to detect urinary mutagenicity caused by smoking, Mutagenesis, 3, 277, 10.1093/mutage/3.3.277

Trivedi, 1995, Urine of tobacco/areca nut chewers causes genomic damage in Chinese hamster ovary cells, Carcinogenesis, 16, 205, 10.1093/carcin/16.2.205

Curvall, 1987, Mutagen levels in urine from snuff users, cigarette smokers and non tobacco users—a comparison, Mutat. Res., 188, 105, 10.1016/0165-1218(87)90098-X

Bhisey, 1991, Biological monitoring of bidi rollers with respect to genotoxic hazards of occupational tobacco exposure, Mutat. Res., 261, 139, 10.1016/0165-1218(91)90060-Y

Tuomistoo, 1986, No difference between urinary mutagenicity in smokers of low-tar and medium-tar cigarettes: a double-blind cross-over study, Arch. Toxicol. Suppl., 9, 115, 10.1007/978-3-642-71248-7_13

Malaveille, 1989, Levels of mutagens in the urine of smokers of black and blond tobacco correlate with their risk of bladder cancer, Carcinogenesis, 10, 577, 10.1093/carcin/10.3.577

Pavanello, 2002, Tobacco-smoke exposure indicators and urinary mutagenicity, Mutat. Res., 521, 1, 10.1016/S1383-5718(02)00208-5

Kanaoka, 1990, Study on influence of cigarette smoking on the mutagenicity of urine. 1. Influence of cigarette smoking on the mutagenicity of urine in healthy smokers and bladder cancer patients, Acta Urol. Jpn., 36, 385

Peters, 2004, Urinary mutagenesis as an exposure biomarker to cooked-meat-associated mutagens: influence of cooking temperature, phenotype, and genotype in a controlled metabolic feeding study, Environ. Mol. Mutagen., 43, 53, 10.1002/em.10205

Bos, 1982, Mutagenicity of urine from nurses handling cytostatic drugs, influence of smoking, Int. Arch. Occup. Environ. Health, 50, 359, 10.1007/BF00377832

Dolara, 1981, Exposure to carcinogenic chemicals and smoking increases urinary excretion of mutagens in humans, J. Toxicol. Environ. Health, 8, 95, 10.1080/15287398109530053

Crebelli, 1985, Mutagenicity studies in a tyre plant: in vitro activity of workers’ urinary concentrates and raw materials, Br. J. Indust. Med., 42, 481

Ferreira, 1994, Determinants of urinary thioethers, d-glucaric acid and mutagenicity after exposure to polycyclic aromatic hydrocarbons assessed by air monitoring and measurement of 1-hydroxypyrene in urine: a cross-sectional study in workers of coke and graphite-electrode-producing plants, Int. Arch. Occup. Environ. Health, 65, 329, 10.1007/BF00405698

De Méo, 1987, Urine mutagenicity of steel workers exposed to coke oven emissions, Carcinogenesis, 8, 363, 10.1093/carcin/8.3.363

DeMarini, 1987, Urinary mutagenicity as a biomarker in workers exposed to benzidine: correlation with urinary metabolites and urothelial DNA adducts, Carcinogenesis, 18, 981, 10.1093/carcin/18.5.981

Kato, 2004, Urinary biomarkers in charcoal workers exposed to wood smoke in Bahia State, Brazil, Cancer Epidemiol. Biomarkers Prevent., 13, 1005, 10.1158/1055-9965.1005.13.6

Einistö, 1990, Sensitivity of Salmonella typhimurium YG1024 to urine mutagenicity caused by cigarette smoking, Mutat. Res., 245, 87, 10.1016/0165-7992(90)90005-5

Camoirano, 2001, Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits, Cancer Epidemiol. Biomakers Prevent., 10, 775

Dunn, 1985, Clastogenic agents in the urine of coffee drinkers and cigarette smokers, Mutat. Res., 147, 179, 10.1016/0165-1161(85)90056-1

Talaska, 1991, Detection of carcinogen-DNA adducts in exfoliated urothelial cells of cigarette smokers: association with smoking, hemoglobin adducts, and urinary mutagenicity, Cancer Epidemiol. Biomarkers Prevent., 1, 61

Bartsch, 1990, Carcinogen hemoglobin adducts, urinary mutagenicity, and metabolic phenotype in active and passive cigarette smokers, J. Natl. Cancer Inst., 82, 1826, 10.1093/jnci/82.23.1826

Connor, 1983, The identification and characterization of a urinary mutagen resulting form cigarette smoke, Mutat. Res., 113, 161, 10.1016/0165-1161(83)90227-3

Mure, 1997, Heavy cigarette smokers show higher mutagenicity in urine, Mutat. Res., 373, 107, 10.1016/S0027-5107(96)00195-9

Granella, 1996, Excretion of mutagens, nicotine and its metabolites in urine of cigarette smokers, Mutagenesis, 11, 207, 10.1093/mutage/11.2.207

Rahn, 1991, Correlations between urinary nicotine or cotinine and urinary mutagenicity in smokers on controlled diets, Environ. Mol. Mutagen., 17, 244, 10.1002/em.2850170405

van Doorn, 1979, Thioether concentration and mutagenicity of urine from cigarette smokers, Int. Arch. Occup. Environ. Health, 43, 159, 10.1007/BF00381187

Møller, 1980, Mutagenicity studies with urine concentrates from coke plant workers, Scand. J. Work Environ. Health, 6, 216, 10.5271/sjweh.2611

De Flora, 1996, Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials, J. Cell Biochem. Suppl., 25, 92, 10.1002/(SICI)1097-4644(1996)25+<92::AID-JCB13>3.0.CO;2-P

Van Schooten, 2002, Effects of oral administration of N-acetyl-l-cysteine: a multi-biomarker study in smokers, Cancer Epidemiol. Biomarkers Prev., 11, 167

Schneider, 2001, Protective effects of vitamins C and E on the number of micronuclei in lymphocytes in smokers and their role in ascorbate free radical formation in plasma, Free Radic. Res., 34, 209, 10.1080/10715760100300201

Cheng, 1995, Glutathione S-transferase μ genotype, diet, and smoking as determinants of sister chromatid exchange frequency in lymphocytes, Cancer Epidemiol. Biomarkers Prevent., 4, 535

Hageman, 1998, Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers, Nutr. Cancer, 32, 113, 10.1080/01635589809514728

Hakim, 2003, Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study, J. Nutr., 133, 3303S, 10.1093/jn/133.10.3303S

Ammenheuser, 1994, Elevated frequencies of hprt mutant lymphocytes in cigarette-smoking mothers and their newborns, Mutat. Res., 304, 285, 10.1016/0027-5107(94)90221-6

Ammenheuser, 1998, Frequencies of hprt mutant lymphocytes in marijuana-smoking mothers and their newborns, Mutat. Res., 403, 55, 10.1016/S0027-5107(98)00027-X

Bigbee, 1999, Impact of maternal lifestyle factors on newborn HPRT mutant frequencies and molecular spectrum-Initial results from the Prenatal Exposures and Preeclampsia Prevention (PEPP) Study, Mutat. Res., 431, 279, 10.1016/S0027-5107(99)00172-4

Finette, 1997, The effects of maternal cigarette smoke exposure on somatic mutant frequencies at the hprt locus in healthy newborns, Mutat. Res., 377, 115, 10.1016/S0027-5107(97)00069-9

Finette, 1998, Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke, Nat. Med., 4, 1144, 10.1038/2640

Pluth, 2000, Role of maternal exposures and newborn genotypes on newborn chromosome aberration frequencies, Mutat. Res., 465, 101, 10.1016/S1383-5718(99)00217-X

Sardas, 1995, Assessment of smoking-induced DNA damage in lymphocytes of smoking mothers of newborn infants using the alkaline single-cell gel electrophoresis technique, Mutat. Res., 335, 213, 10.1016/0165-1161(95)00023-2

Harkonen, 1999, Aneuploidy in sperm and exposure to fungicides and lifestyle factors, ASCLEPOIS. A European concerted action on occupational hazards to male reproductive capability, Environ. Mol. Mutagen., 34, 39, 10.1002/(SICI)1098-2280(1999)34:1<39::AID-EM6>3.0.CO;2-F

Rubes, 1998, Smoking cigarettes is associated with increased sperm disomy in teenage men, Fertil. Steril., 70, 715, 10.1016/S0015-0282(98)00261-1

Shi, 2001, Cigarette smoking and aneuploidy in human sperm, Mol. Reprod. Dev., 59, 417, 10.1002/mrd.1048

Robbins, 1997, Use of fluoresence in situ hybridization (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men, Environ. Mol. Mutagen., 30, 175, 10.1002/(SICI)1098-2280(1997)30:2<175::AID-EM10>3.0.CO;2-A

Naccarati, 2003, Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styrene, Mutat. Res., 537, 131, 10.1016/S1383-5718(03)00081-0

Shen, 1997, Detection of oxidative DNA damage in human sperm and the association with cigarette smoking, Reprod. Toxicol., 11, 675, 10.1016/S0890-6238(97)00032-4

Saleh, 2002, Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study, Fertil. Steril., 78, 491, 10.1016/S0015-0282(02)03294-6

Potts, 1999, Sperm chromatin damage associated with male smoking, Mutat. Res., 423, 103, 10.1016/S0027-5107(98)00242-5

Horak, 2003, Bulky DNA adducts in human sperm: relationship with fertility semen quality, smoking, and environmental factors, Mutat. Res., 537, 53, 10.1016/S1383-5718(03)00051-2

Zitzmann, 2003, Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection, Fertil. Steril., 79, 1550, 10.1016/S0015-0282(03)00339-X

Perreault, 2000, Evaluation of aneuploidy and DNA damage in human spermatozoa: applications in field studies, Andrologia, 32, 247, 10.1046/j.1439-0272.2000.00392.x

Zenzes, 1995, Cigarette smoking may affect meiotic maturation of human oocytes, Hum. Reprod., 10, 3213, 10.1093/oxfordjournals.humrep.a135891

Matikainen, 2001, Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals, Nat. Genet., 28, 355, 10.1038/ng575

Holly, 1986, Mutagenic mucus in the cervix of smokers, J. Natl. Cancer Inst., 76, 983

Lähdetie, 1993, Maternal smoking induced cotinine levels and genotoxicity in second trimester amniotic fluid, Mutat. Res., 300, 37, 10.1016/0165-1218(93)90137-3

Cerqueira, 1998, Genetic damage in exfoliated cells of the uterine cervix, Acta Cytologia., 42, 639, 10.1159/000331820

Sastry, 1991, Placentla toxicology: tobacco smoke, abused drugs, multiple chemical interactions, and placental function, Reprod. Fertil. Dev., 3, 355, 10.1071/RD9910355

Zenzes, 2000, Smoking and reproduction: gene damage to human gametes and embryos, Hum. Reprod., 6, 122, 10.1093/humupd/6.2.122

Little, 1994, Mutagenic lifestyles? A review of evidence of associations between germ-cell mutations in humans and smoking, alcohol consumption and use of “recreational” drugs, Mutat. Res., 313, 131, 10.1016/0165-1161(94)90044-2

Ji, 1997, Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers, J. Natl. Cancer Inst., 89, 238, 10.1093/jnci/89.3.238

Lähdetie, 1987, Cigarette smoking: a possible genotoxic hazard to male germ cells?, Int. J. Androl., 10, 431, 10.1111/j.1365-2605.1987.tb00215.x

Bonassi, 2003, the HUMN collaborative group, effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus Project, Mutat. Res., 543, 155, 10.1016/S1383-5742(03)00013-9

Larramendy, 1991, Increased frequency of micronuclei in B and T8 lymphocytes from smokers, Mutat. Res., 259, 189, 10.1016/0165-1218(91)90052-N

Lippman, 1990, Broncial micronuclei as a marker of an early stage of carcinogenesis in the human tracheobronchial epithelium, Int. J. Cancer., 45, 811, 10.1002/ijc.2910450503

Livingston, 1990, Induction of nuclear aberrations by smokeless tobacco in epithelial cells of human oral mucosa, Environ. Mol. Mutagen., 15, 136, 10.1002/em.2850150304

Stich, 1992, Localized formation of micronuclei in the oral mucosa and tobacco-specific nitrosamines in the saliva of “reverse” smokers, khaini-tobacco chewers and gudakhu users, Int. J. Cancer., 50, 172, 10.1002/ijc.2910500203

Kayal, 1993, Incidence of micronuclei in oral mucosa of users of tobacco products singly or in various combinations, Mutagenesis, 8, 31, 10.1093/mutage/8.1.31

Bagwe, 1993, Occupational exposure to tobacco and resultant genotoxicity, Mutat. Res., 299, 103, 10.1016/0165-1218(93)90087-T

Sarto, 1985, Aging and smoking increase the frequency of sister-chromatid exchanges (SCE) in man, Mutat. Res., 144, 183, 10.1016/0165-7992(85)90137-X

Stenstrand, 1985, Effects of ionizing radiation on chromosome aberrations, sister chromatid exchanges and micronuclei in lymphocytes of smokers and nonsmokers, Hereditas, 102, 71, 10.1111/j.1601-5223.1985.tb00467.x

Nagaya, 1985, Effects of smoking on spontaneous and induced sister chromatid exchanges in lymphocytes, Toxicol. Lett., 25, 293, 10.1016/0378-4274(85)90210-3

Husgafvel-Pursiainen, 1987, Sister-chromatid exchange and cell proliferation in cultured lymphocytes of passively and actively smoking restaurant personnel, Mutat. Res., 190, 211, 10.1016/0165-7992(87)90031-5

Collman, 1986, Effects of α-naphthoflavone on levels of sister chromatid exchanges in lymphocytes from active and passive cigarette smokers: dose-response relationships, Cancer Res., 46, 6452

Wulf, 1986, Sister chromatid exchange (SCE) in Greenlandic Eskimos. Dose-response relationship between SCE and seal diet, smoking, and blood cadmium and mercury concentrations, Sci. Total Environ., 48, 81, 10.1016/0048-9697(86)90155-5

Perera, 1987, DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers, J. Natl. Cancer Inst., 79, 449

Bender, 1988, Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample, Mutat. Res., 204, 421, 10.1016/0165-1218(88)90038-9

Kelsey, 1988, Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters, Environ. Mol. Mutagen., 11, 389, 10.1002/em.2850110310

Reidy, 1988, Increased sister chromatid exchange associated with smoking and coffee consumption, Environ. Mol. Mutagen., 12, 311, 10.1002/em.2860120305

Thompson, 1989, Relationships among benzo(a)pyrene metabolism, benzo(a)pyrene-diol-epoxide:DNA adduct formation, and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers, Cancer Res., 49, 6503

Nordic Study Group on the Health Risk of Chromosome Damage, A Nordic Data Base on Somatic Chromosome Damage in Humans, Mutat. Res. 241 (1990) 325–337.

Brinkworth, 1992, A comparison of smokers and nonsmokers with respect to oncogene products and cytogenetic parameters, J. Occup. Med., 34, 1181

Gorecka, 1993, The influence of cigarette smoking on sister chromatid exchange frequencies in peripheral lymphocytes among nurses handling cytostatic drugs, Polish J. Occupat. Med. Environ. Health., 6, 143

Lazutka, 1994, Sister-chromatid exchanges and their distribution in human lymphocytes in relation to age, sex and smoking, Mutat. Res., 306, 173, 10.1016/0027-5107(94)90028-0

Rajah, 1995, In vivo genotoxic effects of smoking and occupational lead exposure in printing press workers, Toxicol. Lett., 76, 71, 10.1016/0378-4274(94)03200-9

Anderson, 1997, Factors affecting various biomarkers in untreated lung cancer patients and healthy donors, Environ. Mol. Mutagen., 30, 205, 10.1002/(SICI)1098-2280(1997)30:2<205::AID-EM13>3.0.CO;2-H

Lemasters, 1997, Genotoxic changes after low-level solvent and fuel exposure on aircraft maintenance personnel, Mutagenesis, 12, 237, 10.1093/mutage/12.4.237

Bukvic, 1998, Sister chromatid exchange (SCE) and micronucleus (MN) frequencies in lymphocytes of gasoline station attendants, Mutat. Res., 415, 25, 10.1016/S1383-5718(98)00045-X

Cebulska-Wasilewska, 1999, Cytogenetic damage and ras p21 oncoprotein levels from patients with chronic obstructive pulmonary disease (COPD), untreated lung cancer and healthy controls, Mutat. Res., 431, 123, 10.1016/S0027-5107(99)00192-X

Rowland, 1999, Increased sister chromatid exchange in the peripheral blood lymphocytes of young women who smoke cigarettes, Hereditas, 131, 143, 10.1111/j.1601-5223.1999.00143.x

Lee, 1989, Role of oxygen free radicals in the induction of sister chromatid exchanges by cigarette smoke, Environ. Mol. Mutagen., 13, 54, 10.1002/em.2850130107

Kao-Shan, 1987, Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers, Cancer Res., 47, 6278

Husum, 1986, Sister chromatid exchange frequency correlates with age and cigarette smoking in a 5-year material of 553 healthy adults, Hereditas, 105, 17, 10.1111/j.1601-5223.1986.tb00635.x

Sarto, 1987, Variations of SCE frequencies in peripheral lymphocytes of ex-smokers, Mutat. Res., 192, 157, 10.1016/0165-7992(87)90114-X

Ghosh, 1987, The effect of tobacco smoking on the frequency of sister chromatid exchanges in human lymphocyte chromosomes, Cancer Genet. Cytogenet., 27, 15, 10.1016/0165-4608(87)90254-8

Murthy, 1997, Sister chromatid exchange studies in oral cancer patients, Ind. J. Cancer., 34, 49

Yadav, 2000, Cytogenetic damage in bidi smokers, Nicotine Tob. Res., 2, 97, 10.1080/14622200050011367

Yadav, 2000, Genetic risk assessment in hookah smokers, Cytobios, 101, 101

Littlefield, 1986, Analysis of chromosome aberrations in lymphocytes of long-term heavy smokers, Mutat. Res., 170, 145, 10.1016/0165-1218(86)90028-5

Sinués, 1990, Chromosome aberrations and urinary thioethers in smokers, Mutat. Res., 240, 289, 10.1016/0165-1218(90)90079-H

Tawn, 2001, Frequencies of chromosome aberrations in a control population determined by G banding, Mutat. Res., 490, 171, 10.1016/S1383-5718(00)00164-9

van Diemen, 1995, Influence of smoking habits on the frequencies of structural and numerical chromosomal aberrations in human peripheral blood lymphocytes using the fluoresence in situ hybridization (FISH) technique, Mutagenesis, 10, 487, 10.1093/mutage/10.6.487

Pressl, 1999, The influence of age, sex and smoking habits on the background level of fish-detected translocations, Mutat. Res., 442, 89, 10.1016/S1383-5718(99)00067-4

Ramsey, 1995, The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting, Mutat. Res., 338, 95, 10.1016/0921-8734(95)00015-X

Anwar, 1988, Cytogenetic effects in a group of traffic policemen in Cairo, Mutat. Res., 208, 225, 10.1016/0165-7992(88)90065-6

Mahimkar, 1995, Occupational exposure to bidi tobacco increases chromosomal aberrations in tobacco processors, Mutat. Res., 334, 139, 10.1016/0165-1161(95)90004-7

Garcia, 1999, Chromosome aberrations study in human lymphocytes from marijuana smokers, Bull. Environ. Contam. Toxicol., 62, 117, 10.1007/s001289900849

Chen, 1989, Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption, Environ. Mol. Mutagen., 13, 319, 10.1002/em.2850130407

Au, 1991, Factors contributing to chromosome damage in lymphocytes of cigarette smokers, Mutat. Res., 260, 137, 10.1016/0165-1218(91)90001-3

Ban, 1995, Effect of radiation and cigarette smoking on expression of FUdR-inducible common fragile sites in human peripheral lymphocytes, Mutat. Res., 334, 197, 10.1016/0165-1161(95)90011-X

Strom, 1995, Lung cancer, smoking patterns, and mutagen sensitivity in Mexican–Americans, J. Natl. Cancer Inst. Monogr., 18, 29

Wang, 2000, Gender difference in smoking effect on chromosome sensitivity to gamma radiation in a health population, Rad. Res., 154, 20, 10.1667/0033-7587(2000)154[0020:GDISEO]2.0.CO;2

Paz-y-Miño, 2001, Telomeric associations in cigarette smokers exposed to low levels of X-rays, Mutat. Res., 490, 77, 10.1016/S1383-5718(00)00156-X

Hall, 1993, Alkylation and oxidative-DNA damage repair activity in blood leukocytes of smokers and non-smokers, Int. J. Cancer., 54, 728, 10.1002/ijc.2910540504

Bonassi, 2000, Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens, Cancer Res., 60, 1619

Lechner, 1997, Molecular identification of individuals at high risk for lung cancer, Radiat. Oncol. Invest., 5, 103, 10.1002/(SICI)1520-6823(1997)5:3<103::AID-ROI3>3.0.CO;2-1

Mao, 1997, Clonal genetic alterations in the lungs of current and former smokers, J. Natl. Cancer Inst., 89, 834, 10.1093/jnci/89.12.857

Sanzchez-Cespedes, 2001, Chromosomal alterations in lung adenocracinoma from smokers and nonsmokers, Cancer Res., 61, 1309

Slattery, 2000, Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors, J. Natl. Cancer Inst., 92, 1831, 10.1093/jnci/92.22.1831

Zhang, 1997, Cigarette smoking and chromosome 9 alterations in bladder cancer, Cancer Epidemiol. Biomarkers Prevent., 6, 321

Wu, 2002, Chromosome instability in lymphocytes: a potential indicator of predisposition to oral premalignant lesions, Cancer Res., 62, 1818

Spitz, 1993, Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis, Cancer Epidemiol. Biomarkers Prevent., 2, 329

Sandler, 1993, Cigarette smoking and risk of acute leukemia: associations with morphology and cytogenetic abnormalities in bone marrow, J. Natl. Cancer Inst., 85, 1994, 10.1093/jnci/85.24.1994

Davico, 1998, Chromosome 8, occupational exposures, smoking, and acute nonlymphocytic leukemias: a population-based study, Cancer Epidemiol. Biomarkers Prevent., 7, 1123

Bjork, 2000, Smoking and myelodysplastic syndromes, Epidemiology, 11, 285, 10.1097/00001648-200005000-00010

Bjork, 2001, Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations, Leuk. Res., 25, 865, 10.1016/S0145-2126(01)00048-0

Moorman, 2002, Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups, Br. J. Cancer., 86, 60, 10.1038/sj.bjc.6600010

Pylkkanen, 1997, No evidence of microsatellite instability but frequent loss of heterozygosity in primary resected lung cancer, Environ. Mol. Mutagen., 30, 217, 10.1002/(SICI)1098-2280(1997)30:2<217::AID-EM14>3.0.CO;2-G

Einhaus, 1994, Determination of DNA single-strand breaks in lymphocytes of smokers and nonsmokers exposed to environmental tobacco smoke using the nick translation assay, Clin. Invest., 72, 930, 10.1007/BF00190755

Piperakis, 1998, Effects of smoking and aging on oxidative DNA damage of human lymphocytes, Carcinogenesis, 19, 695, 10.1093/carcin/19.4.695

Poli, 1999, DNA damage by tobacco smoke and some antiblastic drugs evaluated using the comet assay, Toxicol. Lett., 108, 267, 10.1016/S0378-4274(99)00098-3

Lam, 2002, Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China, Mutat. Res., 515, 147, 10.1016/S1383-5718(02)00010-4

Park, 2004, Smoking and high plasma triglyceride levels as risk factors for oxidative DNA damage in the Korean population, Ann. Nutr. Metab., 48, 36, 10.1159/000075083

Rojas, 1996, DNA damage in exfoliated buccal cells of smokers assessed by the single cell gel electrophoresis assay, Mutat. Res., 370, 115, 10.1016/0165-1218(96)00062-6

Gontijo, 2001, Single-cell gel (comet) assay detects primary DNA damage in nonneoplastic urothelial cells of smokers and ex-smokers, Cancer Epidemiol. Biomarkers Prevent., 10, 987

Zwingmann, 1998, Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation, Environ. Mol. Mutagen., 32, 121, 10.1002/(SICI)1098-2280(1998)32:2<121::AID-EM7>3.0.CO;2-4

van Zeeland, 1999, 8-Hydroxydeoxyguanosine in DNA from leukocytes of healthy adults: relationship with cigarette smoking, environmental tobacco smoke, alcohol and coffee consumption, Mutat. Res., 439, 249, 10.1016/S1383-5718(98)00192-2

Nia, 2001, A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms, Carcinogenesis, 21, 395, 10.1093/carcin/22.3.395

Kiyosawa, 1990, Cigarette smoking induces formation of 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes, Free Radic. Res. Commun., 11, 23, 10.3109/10715769009109664

Loft, 1992, Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index, Carcinogenesis, 13, 2241, 10.1093/carcin/13.12.2241

Asami, 1996, Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking, Cancer Res., 56, 2546

Asami, 1997, Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung, Carcinogenesis, 18, 1763, 10.1093/carcin/18.9.1763

Hernandez-Boussard, 1998, A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database, Environ. Health Perspect., 106, 385, 10.1289/ehp.98106385

Hainaut, 2001, Patterns of p53 G → T transversions in lung cancer reflect the primary mutagenic signature of DNA-damage by tobacco smoke, Carcinogenesis, 22, 367, 10.1093/carcin/22.3.367

Hussain, 2001, Tumor suppressor genes: at the crossroads of molecular carcniogenesis, molecular epidemiology and human risk assessment, Lung Cancer, 34, S7, 10.1016/S0169-5002(01)00339-7

Pfeifer, 2002, Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers, Oncogene, 21, 7435, 10.1038/sj.onc.1205803

DeMarini, 2001, Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich col combustion emissions, Cancer Res., 61, 6679

Smith, 2000, Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons, J. Natl. Cancer Inst., 92, 803, 10.1093/jnci/92.10.803

Denissenko, 1996, Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53, Science, 274, 430, 10.1126/science.274.5286.430

Tretyakova, 2002, Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach, Biochemistry, 41, 9535, 10.1021/bi025540i

Yoon, 2001, Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers, Cancer Res., 61, 7110

Rodin, 2000, Human lung cancer and p53: the interplay between mutagenesis and selection, Proc. Natl. Acad. Sci. USA, 97, 12244, 10.1073/pnas.180320897

Rodin, 2002, On the origin of p53 G:C → T:A transversions in lung cancers, Mutat. Res., 508, 1, 10.1016/S0027-5107(02)00106-9

Hainaut, 2001, TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database, Mutagenesis, 16, 551, 10.1093/mutage/16.6.551

Cooper, 2002, Smoking, lung cancers and their TP53 mutations, Mutagenesis, 17, 279, 10.1093/mutage/17.4.279

Pfeifer, 2003, On the origin of G → T transversions in lung cancer, Mutat. Res., 526, 39, 10.1016/S0027-5107(03)00013-7

Slebos, 1991, Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung, J. Natl. Cancer Inst., 83, 1024, 10.1093/jnci/83.14.1024

Husgafvel-Pursiainen, 1993, K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos, Int. J. Cancer., 53, 250, 10.1002/ijc.2910530213

Westra, 1993, K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung, Cancer, 72, 432, 10.1002/1097-0142(19930715)72:2<432::AID-CNCR2820720219>3.0.CO;2-#

Gealy, 1999, Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women, Cancer Epidemiol. Biomarkers Prev., 8, 297

Marchetti, 1998, Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus, Br. J. Cancer., 78, 73, 10.1038/bjc.1998.445

Keohavong, 2001, Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung cancer patients, Br. J. Cancer., 85, 235, 10.1054/bjoc.2001.1913

Spuck, 1993, Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage, Cancer Res., 53, 1162

Schreiber, 1997, Smoking, gender, and survival association with allele loss for the LOH11B lung cancer region on chromosome 11, Cancer Epidemiol. Biomarkers Prev., 6, 15

Sozzi, 1997, Association between cigarette smoking and FHIT gene alterations in lung cancer, Cancer Res., 57, 2121

Baral, 1998, Co-overexpression of p53 and c-myc proteins linked with advanced stages of betel- and tobacco-related oral squamous cell carcinomas from eastern India, Eur. J. Oral Sci., 106, 907, 10.1046/j.0909-8836.1998.eos106502.x

Kaur, 1998, Prognostic significance of p53 protein overexpression in betel- and tobacco-related oral oncogenesis, Int. J. Cancer., 79, 370, 10.1002/(SICI)1097-0215(19980821)79:4<370::AID-IJC11>3.0.CO;2-9

Dosaka-Akita, 1999, Bcl-2 expression in non-small cell lung cancers: higher frequency of expression in squamous cell carcinomas with earlier pT status, Oncology, 56, 259, 10.1159/000011974

Tseng, 1999, Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smokers, Cancer Res., 59, 4798

LaRue, 2000, P53 point mutations in initial superficial bladder cancer occur only in tumors from current or recent cigarette smokers, Carcinogenesis, 21, 101, 10.1093/carcin/21.1.101

Ahrendt, 2001, Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung, Cancer, 92, 1525, 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO;2-H

Hirao, 2001, Tobacco smoke-induced DNA damage and an early age of smoking initation induce chromosome loss at 3p21 in lung cancer, Cancer Res., 61, 612

Conway, 2002, Prevalance and spectrum of p53 mutations associated with smoking in breast cancer, Cancer Res., 62, 1987

Pylkkanen, 2002, Reduced Fhit protein expression and loss of heterozygosity at the FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients, Int. J. Oncol., 20

Li, 2003, Molecular epidemiology of pancreatic cancer, Int. J. Gastrointest. Cancer., 33, 3, 10.1385/IJGC:33:1:3

Szyfter, 1999, Molecular and cellular alterations in tobacco smoke-associated larynx cancer, Mutat. Res., 445, 259, 10.1016/S1383-5718(99)00131-X

Montesano, 1996, Molecular etiopathogenesis of esophageal cancers, Ann. 1st Super Sanita, 32, 73

P. Vineis, N. Malats, M. Lang, A. d’Errico, N. Caparaso, J. Cuzick, P. Boffetta, Metabolic polymorphisms and susceptibility to cancer, IARC Sci. Publ. No. 148, International Agency for Research on Cancer, Lyon, France, 1999.

Bartsch, 1991, Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients, Mutat. Res., 250, 103, 10.1016/0027-5107(91)90167-M

London, 1997, Myeloperoxidase genetic polymorphism and lung cancer risk, Cancer Res., 57, 5001

Kantarci, 2002, Myeloperoxidase-463 (G → A) polymorphism associated with lower risk of lung cancer, Mayo Clin. Proc., 77, 17, 10.4065/77.1.17

Ishibe, 1998, Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer risk in the nurses’ health study, Cancer Res., 58, 667

Kawajiri, 1996, Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer, Cancer Res., 56, 72

Wu, 1997, Association between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer, Carcinogenesis, 18, 967, 10.1093/carcin/18.5.967

Abdel-Rahman, 2000, Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes, Pharmacogenetics, 10, 239, 10.1097/00008571-200004000-00005

Bartsch, 2000, Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers, Cancer Epidemiol. Biomarkers Prev., 9, 3

Tyndale, 1999, A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption, Nicotine Tob. Res., 1, S63, 10.1080/14622299050011831

d′Errico, 1996, Genetic metabolic polymorphisms and the risk of cancer: a review of the literature, Biomarkers, 1, 149, 10.3109/13547509609079352

Stucker, 1999, GSTM1, smoking and lung cancer: a case-control study, Int. J. Epidemiol., 28, 829, 10.1093/ije/28.5.829

Ford, 2000, Glutathione S-transferase M1 polymorphism and lung cancer risk in African–Americans, Carcinogenesis, 21, 1971, 10.1093/carcin/21.11.1971

Autrup, 2000, Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response, Mutat. Res., 464

Landi, 2000, Mammalian class theta GST and differential susceptibility to carcinogens: a review, Mutat. Res., 463, 247, 10.1016/S1383-5742(00)00050-8

Bouchardy, 2001, Metabolic genetic polymorphisms and susceptibility to lung cancer, Lung Cancer., 32, 109, 10.1016/S0169-5002(00)00215-4

Reszka, 2001, Significance of genetic polymorphisms in glutathione S-transferase multigene family and lung cancer risk, Int. J. Occup. Med. Environ. Health., 14, 99

Benhamou, 2002, Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk, Carcinogenesis, 23, 1343, 10.1093/carcin/23.8.1343

Matsuzoe, 2001, Glutathione S-transferase mu-1 null genotype is associated with K-ras gene mutation in lung adenocarcioma among smokers, Carcinogenesis, 22, 1327, 10.1093/carcin/22.8.1327

Hirvonen, 1994, Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers, Carcinogenesis, 15, 813, 10.1093/carcin/15.5.813

Pavanello, 2000, Exposure levels and cytochrome P4501A2 activity, but not N-acetyltransferase, glutathione S-transferase (GST) M1 and T1, influence urinary mutagen excretion in smokers, Cancer Epidemiol. Biomarkers Prevent., 11, 998

Li, 2000, Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease, Atherosclerosis, 149, 451, 10.1016/S0021-9150(99)00483-9

de Waart, 2001, Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers, Atherosclerosis, 158, 227, 10.1016/S0021-9150(01)00420-8

Duell, 2002, A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk, J. Natl. Cancer Inst., 94, 297, 10.1093/jnci/94.4.297

Kelada, 2000, The glutathione S-transferase-mu and -theta genotypes in the etiology of prostate cancer: genotype-environment interactions with smoking, Cancer Epidemiol. Biomarkers Prevent., 9, 1329

Mattey, 2002, Smoking and disease severity in rheumatoid arthritis: association with polymorphism at the glutathione S-transferase M1 locus, Arthritis. Rheum., 46, 640, 10.1002/art.10174

Gronau, 2003, Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer?, Otolaryngol. Head Neck Surg., 128, 674, 10.1016/S0194-5998(03)00176-1

Hong, 2000, Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers, Clin. Chem. Lab. Med., 38, 917, 10.1515/CCLM.2000.134

Jourenkova, 1998, Larynx cancer risk in relationship to glutathione S-transferase M1 and T1 genotypes and tobacco smoking, Cancer Epidemiol. Biomarkers Prevent., 7, 19

Toruner, 2001, Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1, and GSTT1) and bladder cancer susceptibility in the Turkish population, Arch. Toxicol., 75, 459, 10.1007/s002040100268

Curigliano, 2001, GSTM1, P53, and K-ras, molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis, Anticancer Res., 21, 3461

Wang, 2002, Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi’an, World J. Gastroenterol., 8, 49, 10.3748/wjg.v8.i1.49

Sato, 2000, Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes, Oral Oncol., 36, 267, 10.1016/S1368-8375(99)00090-1

Yamamura, 2000, Lung cancer risk and genetic polymorphism at the glutathione S-transferase P1 locus in male Japanese, Fukuoka Igaku. Zasshi., 91, 203

Pierce, 2000, Relationship of the TP53 codon 72 and HRAS1 polymorphisms with lung cancer risk in an ethnically diverse population, Cancer Epidemiol. Biomarkers Prevent., 9, 1199

Murata, 1996, Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history, Carcinogenesis, 17, 261, 10.1093/carcin/17.2.261

Wu, 2002, p53 Genotypes and haplotypes associated with lung cancer susceptibility and ethnicity, J. Natl. Cancer Inst., 94, 681, 10.1093/jnci/94.9.681

Gao, 2003, Association of the DNA repair gene XPD Asp312Asn polymorphism with P53 gene mutations in tobacco-related non-small cell lung cancer, Carcinogenesis, 24, 1671, 10.1093/carcin/bgg115

Le Marchand, 2002, Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk, Cancer Epidemiol. Biomarkers Prev., 11, 409

Park, 2002, Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer, Cancer Epidemiol. Biomarkers Prev., 11, 23

Zhou, 2002, Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer, Cancer Res., 62, 1377

Hou, 2003, Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors, Environ. Mol. Mutagen., 41, 37, 10.1002/em.10128

Wang, 2003, Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis, Lung Cancer., 35, 137, 10.1016/S0169-5002(01)00406-8

Zhao, 2002, Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites, Mol. Carcinogen., 33, 99, 10.1002/mc.10023

Wong, 1998, Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers, Mutat. Res., 420, 99, 10.1016/S1383-5718(98)00150-8

van Poppel, 1993, Markers for cytogenetic damage in smokers: associations with plasma antioxidants and glutathione S-transferase μ, Cancer Epidemiol. Biomarkers Prevent., 2, 441

van Poppel, 1992, Increased cytogenetic damage in smokers deficient in glutathione S-transferase isozyme μ, Carcinogenesis, 13, 303, 10.1093/carcin/13.2.303

Taioli, 2003, Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years, Int. J. Epidemiol., 32, 60, 10.1093/ije/dyg001

Abdel-Rahman, 1998, Association of the NAT*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers, Mutat. Res., 398, 43, 10.1016/S0027-5107(97)00238-8

Zhou, 2002, Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer, Cancer Epidemiol. Biomarkers Prev., 11, 15

Hou, 2001, Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls, Cancer Epidemiol. Biomarkers Prevent., 10, 133

Smith, 2003, IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values, Food Chem. Toxicol., 41, 807, 10.1016/S0278-6915(03)00021-8

Peto, 2000, Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies, Br. Med. J., 321, 323, 10.1136/bmj.321.7257.323

Rubin, 2001, Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates, Carcinogenesis, 22, 1903, 10.1093/carcin/22.12.1903

Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9

Wistuba, 2002, Smoking molecular damage in bronchial epithelium, Oncogene, 21, 7298, 10.1038/sj.onc.1205806

Rubin, 2002, Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis, Oncogene, 21, 7392, 10.1038/sj.onc.1205800

Osada, 2002, Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer, Oncogene, 21, 7421, 10.1038/sj.onc.1205802

Jarmalaite, 2003, Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer, Int. J. Cancer., 106, 913, 10.1002/ijc.11322

Powell, 2003, Patterns of allelic loss differ in lung adenocarcinomas of smoker and nonsmokers, Lung Cancer., 39, 23, 10.1016/S0169-5002(02)00384-7

Wiencke, 2002, Teen smoking, field cancerization, and a “critical period” hypothesis for lung cancer susceptibility, Environ. Health Perspect., 110, 555, 10.1289/ehp.02110555

Heusch, 1998, Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells, Carcinogenesis, 19, 551, 10.1093/carcin/19.4.551

Aoshiba, 2001, Acute cigarette smoke exposure induces apoptosis of alveolar macrophages, Am. J. Physiol. Lung Cell. Mol. Physiol., 281, 1401, 10.1152/ajplung.2001.281.6.L1392

Brandau, 2001, Bladder cancer. I. Molecular and genetic basis of carcinogenesis, Eur. Urol., 39, 491, 10.1159/000052494

Chang, 2001, Increased expression of iNOS and c-fos via regulation of protein tyrosine phosphorylation and MEK1/ERK2 proteins in terminal bronchiole lesions in the lungs of rats exposed to cigarette smoke, Arch. Toxicol., 75, 28, 10.1007/s002040000168

Forgacs, 2001, Molecular genetic abnormalities in the pathogenesis of human lung cancer, Pathol. Oncol. Res., 7, 6, 10.1007/BF03032598

Hittelman, 2001, Genetic instability in epithelial tissues at risk for cancer, Ann. N.Y. Acad. Sci., 952, 1, 10.1111/j.1749-6632.2001.tb02723.x

Jull, 2001, Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells, J. Cancer Res. Clin. Oncol., 127, 707, 10.1007/s004320100289

Kang, 2001, Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes, Crit. Rev. Oral Biol. Med., 12, 38, 10.1177/10454411010120010301

Kim, 2001, Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer, Oncogene, 20, 1765, 10.1038/sj.onc.1204302

Wistuba, 2001, Molecular genetics of small cell lung carcinoma, Semin. Oncol., 28, 3, 10.1016/S0093-7754(01)90072-7

Franklin, 1997, Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis, J. Clin. Invest., 100, 2133, 10.1172/JCI119748

Hellmann, 2001, Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells, Toxicol. Sci., 61, 154, 10.1093/toxsci/61.1.154

Chen, 1995, Cigarette smoke extract inhibits oxidative modification of low density lipoprotein, Atherosclerosis, 112, 177, 10.1016/0021-9150(94)05412-C

Albano, 2001, Cigarette smoking and rheumatoid arthritis, Semin. Arthritis. Rheum., 31, 146, 10.1053/sarh.2001.27719

Wang, 2001, Cigarette smoke activates caspase-3 to induce apoptosis of human umbilical venous endothelial cells, Mol. Genet. Metab., 72, 82, 10.1006/mgme.2000.3115

Wang, 2001, DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is over expressed in lung cancer, Cancer Res., 61, 5366

Doll, 1950, Smoking and carcinoma of the lung. Preliminary report, Br. Med. J., ii, 739, 10.1136/bmj.2.4682.739

Vineis, 2004, Tobacco cancer: recent epidemiological evidence, J. Natl. Cancer Inst., 96, 99, 10.1093/jnci/djh014

Husgafvel-Pursiainen, 2004, Genotoxicity of environmental tobacco smoke, Mutat. Res., 567, 427, 10.1016/j.mrrev.2004.06.004

Hecht, 2004, Effects of reduced cigarette smoking on the uptake of tobacco-specific lung carcinogen, J. Natl. Cancer Inst., 96, 107, 10.1093/jnci/djh016

Baker, 2004, The Effect of tobacco ingredients on smoke chemistry. Part 1: flavourings and additives, Food Chem. Toxicol., 42, S3, 10.1016/S0278-6915(03)00189-3

Baker, 2004, The effect of tobacco ingredients on smoke chemistry. Part II: Casing ingredients, Food Chem. Toxicol., 42, S39, 10.1016/j.fct.2003.08.009

Baker, 2004, An overview of the effects of tobacco ingredients on smoke chemistry and toxicity, Food Chem. Toxicol., 42, S53, 10.1016/j.fct.2004.01.001

Curtin, 2004, Short-term in vitro and in vivo analyses for assessing the tumor-promoting potentials of cigarette smoke condensates, Toxicol. Sci., 81, 14, 10.1093/toxsci/kfh172