Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
Tóm tắt
Từ khóa
Tài liệu tham khảo
Marshall, 2014, Why have clinical trials in sepsis failed?, Trends Mol Med, 20, 195, 10.1016/j.molmed.2014.01.007
Cohen, 2015, Sepsis: a roadmap for future research, Lancet Infect Dis, 15, 581, 10.1016/S1473-3099(15)70112-X
Hotchkiss, 2013, Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy, Nat Rev Immunol, 13, 862, 10.1038/nri3552
Chapman, 2012, Human genetic susceptibility to infectious disease, Nat Rev Genet, 13, 175, 10.1038/nrg3114
Rautanen, 2015, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, Lancet Respir Med, 3, 53, 10.1016/S2213-2600(14)70290-5
2015, The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans, Science, 348, 648, 10.1126/science.1262110
Fairfax, 2014, Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression, Science, 343, 1246949, 10.1126/science.1246949
Knaus, 1985, APACHE II: a severity of disease classification system, Crit Care Med, 13, 818, 10.1097/00003246-198510000-00009
Vincent, 1996, The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine, Intensive Care Med, 22, 707, 10.1007/BF01709751
Kiiveri, 2008, A general approach to simultaneous model fitting and variable elimination in response models for biological data with many more variables than observations, BMC Bioinformatics, 9, 195, 10.1186/1471-2105-9-195
Arlot, 2010, A survey of cross-validation procedures for model selection, Stat Surv, 4, 40, 10.1214/09-SS054
del Fresno, 2009, Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients, J Immunol, 182, 6494, 10.4049/jimmunol.0803350
Pena, 2011, Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells, J Immunol, 186, 7243, 10.4049/jimmunol.1001952
Wu, 2010, ROAST: rotation gene set tests for complex microarray experiments, Bioinformatics, 26, 2176, 10.1093/bioinformatics/btq401
Biswas, 2008, Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis, BMC Bioinformatics, 9, 244, 10.1186/1471-2105-9-244
Westra, 2013, Systematic identification of trans eQTLs as putative drivers of known disease associations, Nat Genet, 45, 1238, 10.1038/ng.2756
Saeed, 2014, Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity, Science, 345, 1251086, 10.1126/science.1251086
Fairfax, 2012, Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles, Nat Genet, 44, 502, 10.1038/ng.2205
Bryois, 2014, Cis and trans effects of human genomic variants on gene expression, PLoS Genet, 10, e1004461, 10.1371/journal.pgen.1004461
Dimas, 2009, Common regulatory variation impacts gene expression in a cell type-dependent manner, Science, 325, 1246, 10.1126/science.1174148
Hutchins, 2014, The new normal: immunomodulatory agents against sepsis immune suppression, Trends Mol Med, 20, 224, 10.1016/j.molmed.2014.01.002
Pachot, 2006, Systemic transcriptional analysis in survivor and non-survivor septic shock patients: a preliminary study, Immunol Lett, 106, 63, 10.1016/j.imlet.2006.04.010
Tang, 2010, Genome-wide transcription profiling of human sepsis: a systematic review, Crit Care, 14, R237, 10.1186/cc9392
Biswas, 2009, Endotoxin tolerance: new mechanisms, molecules and clinical significance, Trends Immunol, 30, 475, 10.1016/j.it.2009.07.009
Pena, 2014, An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation, EBioMedicine, 1, 64, 10.1016/j.ebiom.2014.10.003
Pachot, 2005, Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients, Crit Care Med, 33, 31, 10.1097/01.CCM.0000150958.20209.A3
Boomer, 2011, Immunosuppression in patients who die of sepsis and multiple organ failure, JAMA, 306, 2594, 10.1001/jama.2011.1829
Falasca, 2008, Transglutaminase type II is involved in the pathogenesis of endotoxic shock, J Immunol, 180, 2616, 10.4049/jimmunol.180.4.2616
Cai, 2006, SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes, Nat Genet, 38, 1278, 10.1038/ng1913
Caliskan, 2015, Host genetic variation influences gene expression response to rhinovirus infection, PLoS Genet, 11, e1005111, 10.1371/journal.pgen.1005111
Lill, 2013, Peripheral blood RNA gene expression profiling in patients with bacterial meningitis, Front Neurosci, 7, 33, 10.3389/fnins.2013.00033
Vanden Berghe, 2014, Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock, Am J Respir Crit Care Med, 189, 282, 10.1164/rccm.201308-1535OC
Kirino, 2013, Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1, Nat Genet, 45, 202, 10.1038/ng.2520
He, 2007, Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis, Am J Physiol Gastrointest Liver Physiol, 292, G1173, 10.1152/ajpgi.00420.2006
Venet, 2004, The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock, Clin Immunol, 113, 278, 10.1016/j.clim.2004.07.005
Arlt, 2011, Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis, Eur J Cell Biol, 90, 545, 10.1016/j.ejcb.2010.10.002
Pham, 1999, Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo, Proc Natl Acad Sci USA, 96, 8627, 10.1073/pnas.96.15.8627
Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385
Shalova, 2015, Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible Factor-1α, Immunity, 42, 484, 10.1016/j.immuni.2015.02.001
Cheng, 2014, mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity, Science, 345, 1250684, 10.1126/science.1250684
Bakker, 1996, Serial blood lactate levels can predict the development of multiple organ failure following septic shock, Am J Surg, 171, 221, 10.1016/S0002-9610(97)89552-9
Takaoka, 2014, Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice, Sci Rep, 4, 5204, 10.1038/srep05204
Liu, 2015, Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis, J Biol Chem, 290, 396, 10.1074/jbc.M114.566349
Villar, 1994, Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model, Crit Care Med, 22, 914, 10.1097/00003246-199406000-00007
Banton, 2014, Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression, Mol Cell Biol, 34, 1486, 10.1128/MCB.01331-13
Yang, 2013, Novel function of Trim44 promotes an antiviral response by stabilizing VISA, J Immunol, 190, 3613, 10.4049/jimmunol.1202507
Ma, 2013, DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling, PLoS Pathog, 9, e1003721, 10.1371/journal.ppat.1003721
Scicluna, 2015, A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission, Am J Respir Crit Care Med, 192, 826, 10.1164/rccm.201502-0355OC