Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Nature Genetics - Tập 51 Số 8 - Trang 1207-1214 - 2019
Hunna J. Watson1, Zeynep Yılmaz1, Laura M. Thornton1, Christopher Hübel2, Jonathan R. I. Coleman2, Héléna A. Gaspar2, Julien Bryois3, Anke Hinney4, Virpi Leppä3, Manuel Mattheisen5, Sarah E. Medland6, Stephan Ripke7, Shuyang Yao3, Paola Giusti‐Rodríguez8, Ken B. Hanscombe9, Kirstin L. Purves2, Roger A.H. Adan10, Lars Alfredsson11, Tetsuya Ando12, Ole A. Andreassen13, Jessica H. Baker1, Wade H. Berrettini14, Ilka Boehm15, Claudette Boni16, Vesna Boraska Perica17, Katharina Buehren18, Roland Burghardt19, Matteo Cassina20, Sven Cichon21, Maurizio Clementi20, Roger D. Cone22, Philippe Courtet23, Scott J. Crow24, James J. Crowley25, Unna N. Danner26, Oliver S. P. Davis27, Martina de Zwaan28, George Dedoussis29, Daniela Degortes30, Janiece E. DeSocio31, Danielle M. Dick32, Dimitris Dikeos33, Christian Dina34, Monika Dmitrzak‐Węglarz35, Elisa Docampo36, Laramie E. Duncan37, Karin Egberts38, Stefan Ehrlich15, Geòrgia Escaramís36, Tõnu Esko39, Xavier Estivill36, Anne Farmer2, Angela Favaro30, Fernando Fernández‐Aranda40, Manfred M. Fichter41, Krista Fischer39, Manuel Föcker4, Lenka Foretová42, Andreas J. Forstner21, Monica Forzan20, Christopher S. Franklin17, Steven Gallinger43, Ina Giegling44, Johanna Giuranna4, Fragiskos Gonidakis45, Philip Gorwood16, Monica Gratacos Mayora36, Sébastien Guillaume23, Yiran Guo46, Håkon Håkonarson46, Konstantinos Hatzikotoulas17, Joanna Hauser47, Johannes Hebebrand4, Sietske G. Helder2, Stefan Herms21, Beate Herpertz‐Dahlmann18, Wolfgang Herzog48, Laura M. Huckins17, James I. Hudson49, Hartmut Imgart50, Hidetoshi Inoko51, Vladimí­r Janout52, Susana Jiménez‐Múrcia40, Antonio Julià53, Gursharan Kalsi2, Deborah Kaminská54, Jaakko Kaprio55, Leila Karhunen56, Andreas Karwautz57, Martien J. Kas10, James L. Kennedy58, Anna Keski‐Rahkonen55, Kirsty Kiezebrink59, Youl‐Ri Kim60, Lars Klareskog61, Kelly L. Klump62, Gun Peggy Knudsen63, Maria C. La Via1, Stéphanie Le Hellard64, Robert D. Levitan58, Dong Li46, Lisa Lilenfeld65, Bochao Lin10, Jolanta Lissowska66, Jurjen J. Luykx10, Pierre J. Magistretti67, Mario Maj68, Katrin Männik39, Sara Marsal53, Christian R. Marshall69, Morten Mattingsdal13, Sara McDevitt70, Peter McGuffin2, Andres Metspalu39, Ingrid Meulenbelt71, Nadia Micali72, Karen S. Mitchell73, Alessio Maria Monteleone68, Palmiero Monteleone74, Melissa A. Munn‐Chernoff1, Benedetta Nacmias75, Marie Navratilova42, Ιωάννα Ντάλλα29, Julie K. O’Toole76, Roel A. Ophoff10, Leonid Padyukov61, Aarno Palotie77, Jacques Pantel16, Hana Papežová54, Dalila Pinto78, Raquel Rabionet79, Anu Raevuori55, Nicolás Ramoz16, Ted Reichborn‐Kjennerud63, Valdo Ricca75, Samuli Ripatti77, Franziska Ritschel15, Marion Roberts80, Alessandro Rotondo81, Dan Rujescu41, Filip Rybakowski82, Paolo Santonastaso83, André Scherag84, Stephen W. Scherer85, Ulrike Schmidt86, Nicholas J. Schork87, Alexandra Schosser88, Jochen Seitz18, Lenka Šlachtová89, P. Eline Slagboom71, M Landt90, Agnieszka Slopien91, Sandro Sorbi75, Beata Świątkowska92, Jin P. Szatkiewicz8, Ioanna Tachmazidou17, Elena Tenconi30, Alfonso Tortorella93, Federica Tozzi94, Janet Treasure95, Άρτεμις Τσίτσικα96, Marta Tyszkiewicz‐Nwafor91, Konstantinos Tziouvas97, Annemarie Elburg26, Eric F. van Furth90, Gudrun Wagner57, Esther Walton15, Elisabeth Widén98, Eleftheria Zeggini99, Stephanie Zerwas1, Stephan Zipfel100, Andrew W. Bergen101, Joseph M. Boden102, Harry Brandt103, Steven Crawford103, Katherine A. Halmi104, L. John Horwood102, Craig Johnson105, Allan S. Kaplan58, Walter H. Kaye106, James E. Mitchell107, Catherine M. Olsen6, John F. Pearson108, Nancy L. Pedersen3, Michael Strober109, Thomas Werge110, David C. Whiteman6, D. Blake Woodside111, Garret D. Stuber112, Scott D. Gordon6, Jakob Grove113, Anjali K. Henders114, Anders Juréus3, Katherine M. Kirk6, Janne Tidselbak Larsen113, Richard Parker6, Liselotte Petersen113, Jennifer Jordan80, Martin A. Kennedy115, Grant W. Montgomery114, Tracey Wade116, Andreas Birgegård117, Paul Lichtenstein3, Claes Norring117, Mikael Landén118, Nicholas G. Martin6, Preben Bo Mortensen113, Patrick F. Sullivan3, Gerome Breen86, Cynthia M. Bulik119
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
2Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
4Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
5Department of Biomedicine, Aarhus University, Aarhus, Denmark
6QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
7Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
8Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;
9Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital, London, UK
10Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
11Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
12Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
13NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway
14Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
15Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
16INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France
17Wellcome Sanger Institute, Hinxton, UK
18Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany
19Department of Child and Adolescent Psychiatry, Klinikum Frankfurt/Oder, Frankfurt, Germany
20Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy
21Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
22Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
23Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France
24Department of Psychiatry, University of Minnesota, Minneapolis, MN USA
25Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
26Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands
27MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
28Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany
29Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
30Department of Neurosciences, University of Padova, Padova, Italy
31College of Nursing, Seattle University, Seattle, WA, USA
32Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
33Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece
34l'Institut du thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France
35Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
36Barcelona Institute of Science and Technology, Barcelona, Spain
37Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
38Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Centre for Mental Health, Würzburg, Germany
39Estonian Genome Center, University of Tartu, Tartu, Estonia
40Department of Psychiatry, University Hospital of Bellvitge –IDIBELL and CIBERobn, Barcelona, Spain
41Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany
42Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
43Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
44Department of Psychiatry, Psychotherapy, and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany
45First Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece
46Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
47Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
48Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany
49Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA
50Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany
51Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan
52Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic
53Rheumatology Research Group, Vall d’Hebron Research Institute, Barcelona, Spain
54Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic
55Department of Public Health, University of Helsinki, Helsinki, Finland
56Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
57Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria
58Centre for Addiction and Mental Health, Toronto, Ontario, Canada
59Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
60Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea
61Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
62Department of Psychology, Michigan State University, East Lansing, MI, USA
63Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway
64Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway
65American School of Professional Psychology, Argosy University, Northern Virginia, Arlington, VA, USA
66Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland
67BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
68Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy
69Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
70Department of Psychiatry, University College Cork, Cork, Ireland
71Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, The Netherlands
72Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland
73National Center for PTSD, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA
74Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy
75Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
76Kartini Clinic, Portland, OR, USA
77Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
78Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
79Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain
80Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
81Department of Psychiatry Neurobiology Pharmacology and Biotechnologies, University of Pisa, Pisa, Italy
82Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
83Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy
84Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany
85Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
86National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK
87J. Craig Venter Institute (JCVI), La Jolla, CA, USA
88Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
89Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic
90Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands
91Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
92Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
93Department of Psychiatry, University of Naples SUN, Naples, Italy
94Brain Sciences Department, Stremble Ventures, Limassol, Cyprus
95Institute of Psychiatry, Psychology and Neuroscience; Department of Psychological Medicine, King’s College London, London, UK
96Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece
97Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece
98Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
99Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany
100Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany
101BioRealm, LLC, Walnut, CA, USA
102Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand
103The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA
104Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA
105Eating Recovery Center, Denver, CO, USA
106Department of Psychiatry, University of California, San Diego, San Diego, CA, USA
107Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA
108Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand
109Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA
110Department of Clinical Medicine University of Copenhagen, Copenhagen, Denmark
111Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
112Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
113The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
114Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
115Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand
116School of Psychology, Flinders University, Adelaide, South Australia, Australia
117Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden
118Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
119Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC USA

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Nature Genetics

Tập 51 Số 8

1207-1214

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