Genome Engineering Approaches to Improve Nosokomycin A Production by Streptomyces ghanaensis B38.3

Springer Science and Business Media LLC - Tập 59 - Trang 109-111 - 2018
Yuriy Kuzhyk1, Maria Lopatniuk2, Andriy Luzhetskyy2, Victor Fedorenko1, Bohdan Ostash1
1Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, Ukraine
2Actinobacteria Metabolic Engineering Group, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarland University, Saarbrücken, Germany

Tóm tắt

Here we describe our efforts to improve the levels of phosphoglycolipid antibiotic nosokomycin A production by Streptomyces ghanaensis ATCC14672 via genome engineering approaches. Introduction of two extra copies of leucyl tRNA (UUA) gene bldA and one copy of moenomycin biosynthesis gene cluster led, on average, to threefold increase in nosokomycin A titers (up to 1.5 mg/L). Our results validate genome engineering approach as a viable strategy to improve moenomycin production.

Tài liệu tham khảo

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