Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling

Ramachandran, 2019, Acetaminophen hepatotoxicity: a mitochondrial perspective, Adv. Pharmacol., 85, 195, 10.1016/bs.apha.2019.01.007 Jaeschke, 2015, Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients, Dig. Dis., 33, 464, 10.1159/000374090 Ramachandran, 2019, Acetaminophen hepatotoxicity, Semin. Liver Dis., 39, 221, 10.1055/s-0039-1679919 Guarente, 2000, Sir2 links chromatin silencing, metabolism, and aging, Genes Dev., 14, 1021, 10.1101/gad.14.9.1021 Vaziri, 2001, hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase, Cell, 107, 149, 10.1016/S0092-8674(01)00527-X Prola, 2017, SIRT1 protects the heart from ER stress-induced cell death through eIF2alpha deacetylation, Cell Death Differ., 24, 343, 10.1038/cdd.2016.138 Han, 2017, O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress, Nat. Commun., 8, 1491, 10.1038/s41467-017-01654-6 Mitchell, 2014, The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet, Cell Rep., 6, 836, 10.1016/j.celrep.2014.01.031 Liu, 2015, Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression, Cell Death Dis., 6, 10.1038/cddis.2015.193 Nemoto, 2004, Nutrient availability regulates SIRT1 through a forkhead-dependent pathway, Science, 306, 2105, 10.1126/science.1101731 Huang, 2013, Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-beta1 by activating the Nrf2/ARE pathway in glomerular mesangial cells, Free Radic. Biol. Med., 65, 528, 10.1016/j.freeradbiomed.2013.07.029 Yang, 2018, Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats, Eur. J. Pharmacol., 836, 83, 10.1016/j.ejphar.2018.08.015 Yan, 2019, The beneficial roles of SIRT1 in drug-induced liver injury, Oxid. Med. Cell Longev., 8506195 Liu, 2019, Acetaminophen responsive miR-19b modulates SIRT1/Nrf2 signaling pathway in drug-induced hepatotoxicity, Toxicol. Sci., 170, 476, 10.1093/toxsci/kfz095 Bai, 2018, Small molecules as SIRT modulators, Mini Rev. Med. Chem., 18, 1151, 10.2174/1389557516666160620095103 Li, 2017, Genistein ameliorates ischemia/reperfusion-induced renal injury in a SIRT1-dependent manner, Nutrients, 403, 10.3390/nu9040403 Ganai, 2015, Bioactivity of genistein: a review of in vitro and in vivo studies, Biomed. Pharmacother., 76, 30, 10.1016/j.biopha.2015.10.026 Marcelo, 2018, The relationship between urinary genistein levels and serum alanine aminotransferase levels in adults in the USA: national Health and Nutrition Examination Survey 1999-2010, Eur. J. Gastroenterol. Hepatol., 30, 904, 10.1097/MEG.0000000000001121 Fan, 2013, Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes, Food Chem. Toxicol., l55, 172, 10.1016/j.fct.2013.01.003 Yuan-Jing, 2016, Genistein promotes the metabolic transformation of acetaminophen to glucuronic acid in human L-O2, HepG2 and Hep3b cells via the Nrf2/Keap1 pathway, Food Funct., 7, 4683, 10.1039/C6FO00889E Gao, 2012, Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-kappaB and MAPKs signaling pathways, Toxicol. In Vitro, 26, 1, 10.1016/j.tiv.2011.09.019 Pei, 2014, The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice, Environ. Toxicol. Pharmacol., 37, 423, 10.1016/j.etap.2013.12.005 Zhang, 2018, Darunavir alleviates irinotecan-induced intestinal toxicity in Vivo, Eur. J. Pharmacol., 834, 288, 10.1016/j.ejphar.2018.07.044 Xie, 2016, Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance, Chem. Biol. Interact., 246, 11, 10.1016/j.cbi.2016.01.004 Tsai, 2018, Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice, Toxicol. Lett., 290, 97, 10.1016/j.toxlet.2018.03.024 Yang, 2019, Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARalpha, Biochem. Biophys. Res. Commun., 512, 770, 10.1016/j.bbrc.2019.03.131 Arunkumar, 2013, Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat-high-fructose diet-fed mice, Pharm. Biol., 51, 815, 10.3109/13880209.2013.766896 Wan, 2017, Genistein improves schistosomiasis liver granuloma and fibrosis via dampening NF-kB signaling in mice, Parasitol. Res., 116, 1165, 10.1007/s00436-017-5392-3 Luo, 2018, Genistein and daidzein decrease food intake and body weight gain in mice, and alter LXR signaling in vivo and in vitro, Food Funct., 9, 6257, 10.1039/C8FO01718B Lee, 2019, Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation, BMC Canc., 19, 6, 10.1186/s12885-018-5222-8 Zhong, 2017, Genistein ameliorates fat accumulation through AMPK activation in fatty acid-induced BRL cells, J. Food. Sci, 82, 2719, 10.1111/1750-3841.13856 Canto, 2009, AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature, 458, 1056, 10.1038/nature07813 Elangovan, 2011, SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor alpha in breast cancer,Cancer, Res., 71, 6654 Kostrubsky, 2005, Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes, Toxicol. Sci., 87, 146, 10.1093/toxsci/kfi211 Meng, 2018, Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1, J. Anim. Sci. Biotechnol., 9, 34, 10.1186/s40104-018-0248-y