Genistein: a promising modulator of apoptosis and survival signaling in cancer

Hemant Joshi1, Dhruv Sanjay Gupta2, Nosheen Kamruddin Abjani2, Ginpreet Kaur2, Chakrabhavi Dhananjaya Mohan3, Jagjit Kaur4, Diwakar Aggarwal5, Isha Rani6, Seema Ramniwas7, Hadi Sajid Abdulabbas8, Madhu Gupta9, Hardeep Singh Tuli5
1School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
2Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V. L. Mehta Road, Mumbai, India
3Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore-570006, India
4Graduate School of Biomedical Engineering, Faculty of Engineering, The University of New South Wales, Sydney, Australia
5Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, India
6Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur, India
7University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, India
8Continuous Education Department, Faculty of Dentistry, University of Al-Ameed, Karbala, Iraq
9Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India

Tóm tắt

Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely evaluated for its anti-cancer potential. Several studies have established the potential for its usage in the management of breast, lung, and prostate cancers, and its usage has significantly evolved from early applications in traditional systems of medicine. This review offers an insight into its current status of usage, the chemistry, and pharmacokinetics of the molecule, an exploration of its apoptotic mechanisms in cancer management, and opportunities for synergism to improve therapeutic outcomes. In addition to this, the authors have presented an overview of recent clinical trials, to offer an understanding of contemporary studies and explore prospects for a greater number of focused trials, moving forward. Advancements in the application of nanotechnology as a strategy to improve safety and efficacy have also been highlighted, with a brief discussion of results from safety and toxicology studies.

Tài liệu tham khảo

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