Genetics of fibromyalgia

Wolfe F, Smythe HA, Yunus MB, et al.: The American College of Rheumatology criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33:160–172. Neumann L, Buskila D: Epidemiology of fibromyalgia. Curr Pain Headache Rep 2003, 7:362–368. Buskila D: Fibromyalgia: a bio-psychosocial syndrome. Isr Med Assoc J 2003, 5:887–888. Buskila D, Neumann L, Press J: Genetic factors in neuromuscular pain. CNS Spectr 2005, 10:281–284. A useful review describing familial and genetic aspects of FM and related syndromes. Clauw DJ, Crofford LJ: Chronic widespread pain and fibromyalgia: what we know and what we need to know. Best Pract Res Clin Rheumatol 2003, 17:685–701. Roizenblatt S, Tufik S, Goldenberg J, et al.: Juvenile fibromyalgia: clinical and polysomnographic aspects. J Rheumatol 1997, 24:579–585. Buskila D, Neumann L, Hazanov I, Carmi R: Familial aggregation in the fibromyalgia syndrome. Semin Arthritis Rheum 1996, 26:1–8. Buskila D, Neumann L: Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol 1997, 24:941–944. Neumann L, Buskila D: Quality of life and physical functioning of relatives of fibromyalgic patients. Semin Arthritis Rheum 1997, 26:834–839. Arnold LM, Hudson JI, Hess EV, et al.: Family study of fibromyalgia. Arthritis Rheum 2004, 50:944–952. The largest controlled study reporting that FM and reduced pressure pain thresholds aggregate in families and FM coaggregates with major mood disorder in families. Barsky AJ, Borus JF: Functional somatic disorders. Ann Intern Med 1999, 130:910–921. Hudson JI, Mangweth B, Pope HG Jr, et al.: Family study of affective spectrum disorder. Arch Gen Psychiatry 2003, 60:170–177. Hudson JI, Arnold LM, Keck PE Jr, et al.: Family study of fibromyalgia and affective spectrum disorder. Biol Psychiatry 2004, 56:884–891. Walsh CM, Zainal NZ, Middleton SJ, Paykel FS: A family history study of chronic fatigue syndrome. Psychiatr Genet 2001, 11:123–128. Kalantar JS, Locke GR, Zinsmeister AR, et al.: Familial aggregation of irritable bowel syndrome: a prospective study. Gut 2003, 52:1703–1707. A prospective study reporting on familial aggregation of IBS. Amir M, Kaplan Z, Neumann L, et al.: Post-traumatic stress disorder, tenderness, and fibromyalgia. J Psychosom Res 1997, 42:607–613. Cohen H, Neumann L, Haiman Y, et al.: Prevalence of posttraumatic stress disorder in fibromyalgia patients: overlapping syndromes or post-traumatic fibromyalgia syndrome? Semin Arthritis Rheum 2002, 32:38–50. Stein MB, Jang KL, Taylor S, et al.: Genetic and environment influences on trauma exposure and post-traumatic stress disorder symptoms: a twin study. Am J Psychiatry 2002, 159:1675–1681. Segman RH, Shalev AY: Genetics of post-traumatic stress disorder. CNS Spectr 2003, 8:693–698. Offenbaecher M, Bondy B, de Jonge S, et al.: Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999, 42:2482–2488. Bondy B, Spaeth M, Offenbaecher M, et al.: The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis 1999, 6:433–439. Cohen H, Buskila D, Neumann L, Ebstein RP: Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum 2002, 46:845–847. Gursoy S, Erdal E, Herken H, et al.: Significance of catechol-Omethyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int 2003, 23:104–107. Buskila D, Cohen H, Neumann L, Ebstein RP: An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry 2004, 9:730–731. This article reports on an association between FM and polymorphism in the dopaminergic system. Narita M, Nishigami N, Narita N, et al.: Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun 2003, 311:264–266. Camilleri M, Atanasova E, Carlson PJ, et al.: Serotonin transporter polymorphism pharmacogenetics in diarrheapredominant irritable bowel syndrome. Gastroenterology 2002, 123:425–432. Segman RH, Cooper-Kazaz R, Macciardi F, et al.: Association between the dopamine transporter gene and post-traumatic stress disorder. Mol Psychiatry 2002, 7:903–907. Lawford BR, McDyoung R, Noble EP, et al.: D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder. Eur Neuropsychoparmacol 2003, 13:313–320. Juhasz C, Zsombok T, Laszik A, et al.: Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102 T/C polymorphism and migraine. J Neurgenet 2003, 17:231–240.