Genetics of Anthracycline-Mediated Cardiotoxicity: Current Status and Challenges

Current Cardiovascular Risk Reports - Tập 14 - Trang 1-12 - 2020
Chris McDermott-Roe1,2, Bonnie Ky1,2,3,4,5
1Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
2Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, USA
3Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
4Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
5Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA

Tóm tắt

Anthracyclines are potent and widely used anti-cancer compounds which carry a significant risk of cardiotoxicity. Genetic background is a key determinant of risk susceptibility and identifying causal genes and polymorphisms is an area of intense and growing interest. In this review, we provide an overview of the strategies employed to identify causal alleles and key findings stemming from recent studies. We describe candidate gene association studies and genome-wide association studies of anthracycline cardiotoxicity and summarize key findings. The importance of data robustness is discussed, as well as the largely untapped potential of stem cell–based strategies for both validation and discovery purposes. Multi-disciplinary and coordinated efforts will be vital to fully understand the link between genetic background and anthracycline cardiotoxicity risk. Doing so will enhance understanding of pathological mechanisms and enable more personalized and nuanced treatment strategies for patients undergoing anthracycline chemotherapy.

Tài liệu tham khảo

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