Genetics of ABO, H, Lewis, X and Related Antigens

Vox Sanguinis - Tập 51 Số 3 - Trang 161-171 - 1986
Rafaël Oriol1, Jacques Le Pendu1, Rosella Mollicone1
1Institut d'Immunobiologie, CNRS ER‐281, Hôpital Broussais, Paris, France

Tóm tắt

Abstract. The present knowledge on chemical, enzymatic, serologic and genetic aspects of ABH antigens is reviewed in an effort to produce a simple and coherent genetic model for the biosynthesis of these antigens and chemically related structures. The genetic control of type 1 (Lea, Leb, Lec and Led), type 2 (X, Y, I, and H), type 3 and type 4 ABH and related antigens in different animal and human tissues is analyzed, taking into account the properties of the glycosyltransferases which are involved in their synthesis and considering possible competition for common acceptor and donor substrates. The phylogeny of ABH determinants shows that they appeared as tissular antigens much earlier than as red cell antigens. The ontogeny of ABH antigens suggests that they behave as differentiation antigens, and an effort is made to correlate their tissular distribution in the adult with the embryological origin of each tissue.

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