Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

Tumor Biology - Tập 37 - Trang 4777-4784 - 2015
Fangyuan Shen1, Jiejun Chen2, Shicheng Guo3, Yinghui Zhou1, Yabiao Zheng1, Yajun Yang3, Junjie Zhang1, Xiaofeng Wang3, Chenji Wang1, Dunmei Zhao1, Mengyun Wang4,5, Meiling Zhu4,5, Lixia Fan1, Jiaqing Xiang5,6, Yong Xia7, Qingyi Wei4,8, Li Jin3, Jiucun Wang3, Minghua Wang1
1Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, China
2China National Center for Biotechnology Development, Beijing, China
3MOE Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
4Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China
5Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
6Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
7College of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China
8Duke Cancer Institute, Duke University Medical Center, Durham, USA

Tóm tắt

Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in the East Asian population. MicroRNAs (miRNAs) have been studied to play important roles in tumorigenesis. Single nucleotide polymorphisms (SNPs) in miRNA lead to the aberrant expression and structural alteration of miRNA and are hypothesized to be involved in tumorigenesis and cancer development. We conducted a population-based case-control study to evaluate the association between SNPs in miRNAs and ESCC risk in 1400 ESCC cases and 2185 matched controls. Four SNPs including miR-196a2 rs11614913, miR-146a rs2910164, miR-499 rs3746444, and miR-423 rs6505162 were selected with comprehensive collection strategy and genotyped using the SNaPshot Multiplex System. Odds ratio (OR) and 95 % confidence interval (95 % CI) were used to assess the strength of association. The CC genotype of miR-196a2 rs11614913 was significantly associated with an increased ESCC risk compared with the TT genotype (OR 1.11, 95 % CI 1.01–1.22, P 0.049) and the TT/TC genotypes (OR 1.09, 95 % CI 1.01–1.19, P 0.043). The association was more pronounced in non-drinkers in the recessive model (OR 1.13, 95 % CI 1.01–1.27, P 0.029). A significantly increased risk of ESCC associated with miR-499 rs3746444 polymorphism was evident among patients who never smoking and drinking. This study suggests that miR-196a2 rs11614913 and miR-499 rs3746444 are associated with an increased ESCC risk in a Chinese population.

Tài liệu tham khảo

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Tumor Biology

Tập 37

4777-4784

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