Genetic toxicology at the crossroads — a personal view on the deployment of short-term tests for predicting carcinogenicity

Ashby, 1986, The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens, Mutagenesis, 1, 3, 10.1093/mutage/1.1.3 Bridges, 1973, Some general principles of mutagenicity screening and a possible framework for testing procedures, Environ. Hlth. Perspect., 6, 221, 10.1289/ehp.7306221 Bridges, 1976, Use of a three-tier protocol for evaluation of long-term toxic hazards particularly mutagenicity and carcinogenicity, 549 Bridges, 1981, Summary report on the performance of bacterial mutation assays Bridges, 1986, Recommendations for screening for potential human germ cell mutagens: an ICPEMC working paper, 51 Cole, 1986, The mutagenicity of sodium fluoride to L5178Y [wild-type and TK+/− (3.7.2.c)] mouse lymphoma cells, Mutagenesis, 1, 157, 10.1093/mutage/1.2.157 Friesen, 1985, Characterization and identification of six mutagens in opium pyrolysates implicated in oesophageal cancer in Iran, Mutation Res., 150, 177, 10.1016/0027-5107(85)90114-9 IARC, 1983, Approaches to classifying chemical carcinogens according to mechanism of action, IARC Internal Technical Report No. 83/001 ICPEMC Committee 2, 1982, Final Report, 99, 73 Jansen, 1980, Isoniazid — an attempt at retrospective prediction, Mutation Res., 76, 85, 10.1016/0165-1110(80)90004-4 Mendelsohn, 1986, Can chemical carcinogenicity be predicted by short-term tests? Mirsalis, 1980, Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents, Carcinogenesis, 1, 621, 10.1093/carcin/1.7.621 Nair, 1985, Tobacco-specific and betel nut-specific compounds: occurrence in saliva and urine of betel quid chewers and formation in vitro by nitrosation of betel quid, Carcinogenesis, 6, 295, 10.1093/carcin/6.2.295 Ramel, 1986, Deployment of short-term assays for the detection of carcinogens and the evaluation of carcinogenic activity of environmental chemicals, Mutation Res., 168, 327, 10.1016/0165-1110(86)90025-4 Upton, 1984, Report of ICPEMC Task Group 5 on the differentiation between genotoxic and non-genotoxic carcinogens, Mutation Res., 133, 1, 10.1016/0165-1110(84)90002-2 Zeiger, 1986, Mutagenesis, clastogenesis, carcinogenesis: expectations, correlations and relations, 75