Genetic regulation of aflatoxin, ochratoxin A, trichothecene, and fumonisin biosynthesis: A review
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Aerts D, Hauer EE, Ohm RA, Arentshort M, Teertstra WR, Phippen C, Ram AFJ, Frisvad JC, Wösten HAB (2018) The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production. Antonie Van Leeuwenhoek 111:311–322. https://doi.org/10.1007/s10482-017-0952-1
Alexander NJ, McCormick SP, Larson TM, Jurgenson JE (2004) Expression of Tri15 in Fusarium sporotrichioides. Curr Genet 45:157–162. https://doi.org/10.1007/s00294-003-0467-3
Alexander NJ, Proctor RH, McCormick SP (2009) Genes, gene clusters and biosynthesis of trichothecenes and fumonisins in Fusarium. Toxin Rev 28:198–215. https://doi.org/10.1080/15569540903092142
Aoki T, O’Donnell K, Geiser DM (2014) Systematics of key phytopathogenic Fusarium species: current status and future challenges. J Gen Plant Pathol 80:189–201. https://doi.org/10.1007/s10327-014-0509-3
Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 13:1504–1506. https://doi.org/10.1126/science.1155888
Bhatnagar D, Rajasekaran K, Gilbert M, Cary JW, Magan N (2018) Advances in molecular genomic research to safeguard food and feed supply from aflatoxin contamination. World Mycotoxin J 11:47–72. https://doi.org/10.3920/WMJ2017.2283
Brown DW, Butchko RAE, Busman M, Proctor RH (2007) The Fusarium verticillioides FUM gene cluster encodes a Zn(II)2Cys6 protein that affects FUM gene expression and fumonisin production. Eukaryot Cell 6:1210–1218. https://doi.org/10.1128/EC.00400-06
Butchko RAE, Brown DW, Busman M, Tudzynski B, Wiemann P (2012) Lae1 regulates expression of multiple metabolite gene clusters in Fusarium verticillioides. Fungal Genet Biol 49:602–612. https://doi.org/10.1016/j.fgb.2012.06.003
Calvo AM, Bok J, Brooks W, Keller NP (2004) veA is required for toxin and sclerotial production in Aspergillus parasiticus. Appl Environ Microbiol 70:4733-4739. https://doi.org/10.1128/AEM.70.8.4733-4739.2004
Cary JW, Calvo AM (2008) Regulation of Aspergillus mycotoxin biosynthesis. Toxin Rev 27:347–370. https://doi.org/10.1080/15569540802373999
Chang PK (2003) The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR. Mol Genet Genomics 268:711-719. https://doi.org/10.1007/s00438-003-0809-3
Cheong K, Strub C, Montet D, Durand N, Alter P, Meile JC, Schorr S, Fontana A (2016) Effect of different light wavelengths on the growth and ochratoxin a production in Aspergillus carbonarius and Aspergillus westerdijkiae. Fungal Biol 120:745–751. https://doi.org/10.1016/j.funbio.2016.02.005
Crespo-Sempere A, Marín S, Sanchis V, Ramos AJ (2013) VeA and LaeA transcriptional factors regulate ochratoxin a biosynthesis in Aspergillus carbonarius. Int J Food Microbiol 166:479–486. https://doi.org/10.1016/j.ijfoodmicro.2013.07.027
Desjardins AE, Proctor RH (2007) Molecular biology of Fusarium mycotoxins. Int J Food Microbiol 119:47–50. https://doi.org/10.1016/j.ijfoodmicro.2007.07.024
Duran RM, Cary JW, Calvo AM (2007) Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation. Appl Microbiol Biotechnol 73:1158–1168. https://doi.org/10.1007/s00253-006-0581-5
Duran RM, Cary JW, Calvo AM (2010) Role of the osmotic stress regulatory pathway in morphogenesis and secondary metabolism in filamentous fungi. Toxins 2:367–381. https://doi.org/10.3390/toxins2040367
Fanelli F, Schmidt-Heydt M, Haidukowski M, Geisen R, Logrieco AF, Mulè G (2012a) Influence of light on growth, fumonisin biosynthesis and FUM1 gene expression by Fusarium proliferatum. Int J Food Microbiol 153:148–153. https://doi.org/10.1016/j.ijfoodmicro.2011.10.031
Fanelli F, Schmidt-Heydt M, Haidukowski M, Susca A, Geisen R, Logrieco AF, Mulè G (2012b) Influence of light on growth, conidiation and fumonisin production by Fusarium verticillioides. Fungal Biol 116:241–248. https://doi.org/10.1016/j.funbio.2011.11.007
Fanelli F, Geisen R, Schmidt-Heydt M, Logrieco AF, Mulè G (2015) Light regulation of mycotoxin biosynthesis: new perspectives for food safety. World Mycotoxin J 9:129–146. https://doi.org/10.3920/WMJ2014.1860
Ferrara M, Perrone G, Gambacorta L, Epifani F, Solfrizzo M, Gallo A (2016) Identification of a halogenase involved in the biosynthesis of ochratoxin A in Aspergillus carbonarius. Appl Environ Microb 82:5631–5641. https://doi.org/10.1128/AEM.01209-16
Frisvad JC, Smedsgaard J, Samson RA, Larsen TO, Thrane U (2007) Fumonisin B2 production by Aspergillus niger. J Agr Food Chem 55:9727–9732. https://doi.org/10.1021/jf0718906
Gallo A, Ferrara M, Perrone G (2017) Recent advances on the molecular aspects of ochratoxin A biosynthesis. Curr Opin Food Sci 17:49-56. https://doi.org/10.1016/j.cofs.2017.09.011
Gil-Serna J, Vázquez C, González-Jaén MT, Patiño B (2014) Mycotoxins: toxicology. In: Batt C, Tortorello ML (eds) Encyclopedia of food microbiology, 2nd edn. Elsevier Ltd. Academic Press, Amsterdam, pp 1539–1547. https://doi.org/10.1016/B978-0-12-384730-0.00234-2
Gil-Serna J, García-Díaz M, González-Jaén MT, Vázquez C, Patiño B (2018) Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis. Int J Food Microbiol 268:35–43. https://doi.org/10.1016/j.ijfoodmicro.2017.12.028
Heusser AH, Bingle LEH (2015) Comparative ochratoxin toxicity: a review of the available data. Toxins 7:4253–4282. https://doi.org/10.3390/toxins7104253
Hohn TM, Krishna R, Proctor RH (1999) Characterization of a transcription factor activator controlling trichothecene toxin biosynthesis. Fungal Genet Biol 26:224–235. https://doi.org/10.1006/fgbi.1999.1122
Hong SY, Roze LV, Linz JE (2013) Oxidative stress-related transcription factors in the regulation of secondary metabolism. Toxins 5:683–702. https://doi.org/10.3390/toxins5040683
Huang JQ, Jiang HF, Zhou YQ, Lei Y, Wang SY, Liao BS (2009) Ethylene inhibited aflatoxin biosynthesis is due to oxidative stress alleviation and related to glutathione redox state changes in Aspergillus flavus. Int J Food Microbiol 130:17–21. https://doi.org/10.1016/j.ijfoodmicro.2008.12.027
Huff WE, Hamilton PB (1979) Mycotoxins- their biosynthesis in fungi: ochratoxins – metabolites of combined pathways. J Food Protect 42:815–820
Jayashree T, Subramanyam C (2000) Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus. Free Radical Bio Med 29:981–985
Jiang J, Yun Y, Fu J, Shim WB, Ma Z (2011) Involvement of a putative response regulator FgRrg-1 in osmotic stress response, fungicide resistance and virulence in Fusarium graminearum. Mol Plant Pathol 12:425–436. https://doi.org/10.1111/j.1364-3703.2010.00684.x
Khaldi N, Wolfe KH (2011) Evolutionary origins of the fumonisin secondary metabolite gene cluster in Fusarium verticillioides and Aspergillus niger. Int J Evol Biol 423821:1–7. https://doi.org/10.4061/2011/423821
Kimura M, Tokai T, Takahashi-Ando N, Ohsato S, Fujimura M (2007) Molecular and genetic studies of Fusarium trichothecene biosynthesis: pathways, genes, and evolution. Biosci Biotechnol Biochem 71:2105–2123
Kohut G, Adam AL, Fazekas B, Hornok L (2009) N-starvation stress induced FUM gene expression and fumonisin production is mediated via the HOG-type MAPK pathway in Fusarium proliferatum. Int J Food Microbiol 130:65–69. https://doi.org/10.1016/j.ijfoodmicro.2009.01.002
Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG (2017) Aflatoxins: a global concern for food safety, human health and their management. Front Microbiol 7:2170. https://doi.org/10.3389/fmicb.2016.02170
Lindo L, McCormick SP, Cardoza RE, Brown DW, Kim HS, Alexander NJ, Proctor RH, Gutierrez S (2018) Effect of deletion of a trichothecene toxin regulatory gene on the secondary metabolism transcriptome of the saprophytic fungus Trichoderma arundinaceum. Fungal Genet Biol 119:29–46. https://doi.org/10.1016/j.fgb.2018.08.002
Lizarraga-Paulín EG, Moreno-Martínez E, Miranda-Castro P (2011) Aflatoxins and their impact on human and animal health: an emerging problem. In: Guevara-González RG (ed) Aflatoxins. Biochemistry and molecular biology. IntechOpen, London, pp 255–282. https://doi.org/10.5772/26196
Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J (2016) Ochratoxin A: 50 Years of Research. Toxins 8:191. https://doi.org/10.3390/toxins8070191
Matic S, Spadaro D, Prelle A, Gullino ML, Garibaldi A (2013) Light affects fumonisin production in strains of Fusarium fujikuroi, Fusarium proliferatum, and Fusarium verticillioides isolated from rice. Int J Food Microbiol 166:515–523. https://doi.org/10.1016/j.ijfoodmicro.2013.07.026
Merhej J, Richard-Forget F, Barreau C (2011) Regulation of trichothecene biosynthesis in Fusarium: recent advances and new insights. Appl Microbiol Biotechnol 91:519–528. https://doi.org/10.1007/s00253-011-3397-x
Merhej J, Urban M, Dufresne M, Hammond-Kosack KE, Richard-Forget F, Barreau C (2012) The velvet gene, FgVe1, affects fungal development and positively regulates trichothecene biosynthesis and pathogenicity in Fusarium graminearum. Mol Plant Pathol 13:363–374. https://doi.org/10.1111/j.1364-3703.2011.00755.x
Montiban M, Ducos C, Bonnin-Verdal MN, Ponts N, Richard-Forget F, Barreau C (2013) The bZIP transcription factor Fgap1 mediates oxidative stress response and trichothecene biosynthesis but not virulence in Fusarium graminearum. PLoS One 8:e83377. https://doi.org/10.1371/journal.pone.0083377
Moretti A, Susca A, Mulè G, Logrieco AF, Proctor RH (2013) Molecular diversity of mycotoxigenic fungi that threaten food safety. Int J Food Microbiol 167:57–66. https://doi.org/10.1016/j.ijfoodmicro.2013.06.033
Myung K, Li S, Butchko RAE, Busman M, Proctor RH, Abbas HK, Calvo AM (2009) FvVE1 regulates biosynthesis of fumonisins and fusarins in Fusarium verticillioides. J Agric Food Chem 57:5089–5094. https://doi.org/10.1021/jf900783u
Nasmith CG, Walkowiak S, Wang L, Leung WWY, Gong Y, Johnston A, Harris LJ, Guttman DS, Subramaniam R (2011) Tri6 is a global transcriptional regulator in the phytopathogen Fusarium graminearum. PLoS Pathog 7(9):e1002266. https://doi.org/10.1371/journal.ppat.1002266
Perrone G, Stea G, Epifani F, Varga J, Frisvad JC, Samson RA (2011) Aspergillus niger contains the cryptic phylogenetic species A. awamori. Fungal Biol 115:1138–1150. https://doi.org/10.1016/j.funbio.2011.07.008
Proctor RH, McCormick SP, Alexnader NJ, Desjardins AE (2009) Evidence that a secondary metabolic biosynthetic gene cluster has grown by gene relocation during evolution of the filamentous fungus Fusarium. Mol Microbiol 74:1128-1142. https://doi.org/10.1111/j.1365-2958.2009.06927.x
Proctor RH, Van Hove F, Susca A, Stea G, Busman M, Van der Lee T, Waalwijk C, Moretti A, Ward TJ (2013) Birth, death and horizontal transfer of the fumonisin biosynthetic gene cluster during the evolutionary diversification of Fusarium. Mol Microbiol 90:290–306. https://doi.org/10.1111/mmi.12362
Proctor RH, McCormick SP, Kim HS, Cardoza RE, Stanley AM, Lindo L, Kelly A, Brown DW, Lee T, Vaughan MM, Alexander NJ, Busman M, Gutierrez S (2018) Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi. PLoS Pathog 14:e1006946. https://doi.org/10.1371/journal.ppat.1006946
Reverberi M, Zjalic S, Ricelli A, Fabbri AA, Fanelli C (2006) Oxidant/antioxidant balance in Aspergillus parasiticus affects aflatoxin biosynthesis. Mycotoxin Res 22:39–47. https://doi.org/10.1007/BF02954556
Reverberi M, Zjalic S, Ricelli A, Punelli F, Camera E, Fabbri C, Picardo M, Fanelli C, Fabbri AA (2008) Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene. Eukaryot Cell 7(6):988–1000. https://doi.org/10.1128/EC.00228-07
Reverberi M, Ricelli A, Zjalic S, Fabbri AA, Fanelli C (2010) Natural functions of mycotoxins and control of their biosynthesis in fungi. Appl Environ Microbiol 87:899–911. https://doi.org/10.1007/s00253-010-2657-5
Reverberi M, Gazzetti K, Punelli F, Scarpari M, Zjalic S, Ricelli A, Fabbri AA, Fanelli C (2012) Aoyap1 regulates OTA synthesis by controlling cell redox balance in Aspergillus ochraceus. Appl Microbiol Biotechnol 95:1293–1304. https://doi.org/10.1007/s00253-012-3985-4
Rushing BR, Selim MI (2019) Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food Chem Toxicol 124:81–100. https://doi.org/10.1016/j.fct.2018.11.047
Schmidt-Heydt M, Rüfer C, Raupp F, Bruchmann A, Perrone G, Geisen R (2011) Influence of light on food relevant fungi with emphasis on ochratoxin producing species. Int J Food Microbiol 145:229–237. https://doi.org/10.1016/j.ijfoodmicro.2010.12.022
Seong KY, Pasquali M, Zhou X, Song J, Hilburn K, McCormick S, Dong Y, Xu JR, Kistler HC (2009) Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis. Mol Microbiol 72:354–367. https://doi.org/10.1111/j.1365-2958.2009.06649.x
Shwab EK, Keller NP (2008) Regulation of secondary metabolite production in filamentous ascomycetes. Mycol Res 112:225–230. https://doi.org/10.1016/j.mycres.2007.08.021
Stockmann-Juvala H, Savolainen K (2008) A review of the toxic effects and mechanisms of action of fumonisin B1. Hum Exp Toxicol 27:799–809. https://doi.org/10.1177/0960327108099525
Stoll D, Schmidt-Heydt M, Geisen R (2013) Differences in the regulation of ochratoxin a by the HOG pathway in Penicillium and Aspergillus in response to high osmolar environments. Toxins 5:1282–1298. https://doi.org/10.3390/toxins5071282
Susca A, Proctor RH, Morelli M, Haidukowski M, Gallo A, Logrieco AF, Moretti A (2016) Variation in fumonisin and ochratoxin production associated with differences in biosynthetic gene content in Aspergillus niger and A. welwitschiae isolates from multiple crop and geographic origin. Front Microbiol 7:1412. https://doi.org/10.3389/fmicb.2016.01412
Tag AG, Garifullina GF, Peplow AW, Ake C Jr, Phillips TD, Hohn TM, Beremand MN (2001) A novel regulatory gene, Tri10, controls trichothecene toxin production and gene expression. Appl Environ Microbiol 67:5294–5302. https://doi.org/10.1128/AEM.67.11.5294-5302.2001
Wang Y, Wang L, Liu F, Wang Q, Selvaraj J, Xing F, Zhao Y, Liu Y, (2016) Ochratoxin A Producing Fungi, Biosynthetic Pathway and Regulatory Mechanisms. Toxins 8 (3):83 https://doi.org/10.3390/toxins8030083
Woloshuk CP, Shim WB (2013) Aflatoxins, fumonisins, and trichothecenes: a convergence of knowledge. FEMS Microbiol Rev 37:94–109. https://doi.org/10.1111/1574-6976.12009
Wu Q, Wang X, Nepovimova E, Miron A, Liu Q, Wang Y, Su D, Yang H, Li L, Kuca K (2017) Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential. Arch Toxicol 91:3737–3785. https://doi.org/10.1007/s00204-017-2118-3
Yu J (2012) Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination. Toxins 4:1024–1057. https://doi.org/10.3390/toxins4111024
Yu J, Ehrlich KC (2011) Aflatoxin biosynthetic pathway and pathway genes. In: Guevara-González RG (ed) Aflatoxins. Biochemistry and Molecular Biology. IntechOpen, London, pp 41–65. https://doi.org/10.5772/23034
Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS (1993) Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl Environ Microbiol 59:3564–3571. https://doi.org/10113/38668