Genetic influences on rheumatoid arthritis in african americans

Springer Science and Business Media LLC - Tập 26 - Trang 15-26 - 2002
Laura B. Hughes1, Larry W. Moreland1, S. Louis Bridges1
1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham

Tóm tắt

Rheumatoid arthritis is a common autoimmune disease characterized by inflammation of the synovial membrane of diarthrodial joints, which often leads to joint damage and disability. There are known associations between major histocompatibility complex class II alleles and susceptibility to rheumatoid arthritis and its severity in Caucasians. African Americans, an admixed population in the United States, has been underrepresented in genetic studies of the susceptibility and severity of rheumatoid arthritis. With the advent of biologic agents, which target specific molecules of the immune system (e.g., tumor necrosis factor, interleukin-1), biologic markers of treatment response in Caucasians and in African Americans would be clinically useful.

Tài liệu tham khảo

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