Genetic evaluation of the serotonergic system in chronic fatigue syndrome

Abdolmaleky, 2004, Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia, Schizophr. Res., 67, 53, 10.1016/S0920-9964(03)00183-X Abecasis, 2000, GOLD—graphical overview of linkage disequilibrium, Bioinformatics, 16, 182, 10.1093/bioinformatics/16.2.182 Akazawa, 1995, A mammalian helix–loop–helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system, J. Biol. Chem., 270, 8730, 10.1074/jbc.270.15.8730 Arango, 2003, Genetics of the serotonergic system in suicidal behavior, J. Psychiatr. Res., 37, 375, 10.1016/S0022-3956(03)00048-7 Blomstrand, 1999, Effect of muscle glycogen on glucose, lactate and amino acid metabolism during exercise and recovery in human subjects, J. Physiol., 514, 293, 10.1111/j.1469-7793.1999.293af.x Bonnier, 2002, Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk, Biol. Psychiatry, 51, 762, 10.1016/S0006-3223(01)01228-8 Bray, 2004, The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain, Mol. Psychiatry, 9, 109, 10.1038/sj.mp.4001366 Buchwald, 2001, A twin study of chronic fatigue, Psychosom. Med., 63, 936, 10.1097/00006842-200111000-00012 Bunzel, 1998, Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain, Brain Res. Mol. Brain Res., 59, 90, 10.1016/S0169-328X(98)00146-6 Carlo-Stella, 2006, A first study of cytokine genomic polymorphisms in CFS: positive association of TNF-857 and IFNgamma 874 rare alleles, Clin. Exp. Rheumatol., 24, 179 Cartharius, 2005, MatInspector and beyond: promoter analysis based on transcription factor binding sites, Bioinformatics, 21, 2933, 10.1093/bioinformatics/bti473 Caudy, 1988, The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila, Genes Dev., 2, 843, 10.1101/gad.2.7.843 Chaudhuri, 2004, Fatigue in neurological disorders, Lancet, 363, 978, 10.1016/S0140-6736(04)15794-2 Chee, 2001, 5-HT2A receptor gene promoter polymorphism −1438A/G and bipolar disorder, Psychiatr. Genet., 11, 111, 10.1097/00041444-200109000-00001 Cleare, 1998, A research portfolio on chronic fatigue syndrome, 38 Cleare, 1995, Contrasting neuroendocrine responses in depression and chronic fatigue syndrome, J. Affect. Disord., 34, 283, 10.1016/0165-0327(95)00026-J Cleare, 2005, Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635, Biol. Psychiatry, 57, 239, 10.1016/j.biopsych.2004.10.031 Collier, 1997, Association between 5-HT2A gene promoter polymorphism and anorexia nervosa, Lancet, 350, 412, 10.1016/S0140-6736(05)64135-9 De La Vega, 2005, Power and sample size calculations for genetic case/control studies using gene-centric SNP maps: application to human chromosomes 6, 21, and 22 in three populations, Hum. Hered., 60, 43, 10.1159/000087918 De La Vega, 2005, The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern, Genome Res., 15, 454, 10.1101/gr.3241705 Demitrack, 1992, Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings, Biol. Psychiatry, 32, 1065, 10.1016/0006-3223(92)90187-5 Dinan, 1996, Serotonin and the regulation of hypothalamic–pituitary–adrenal axis function, Life Sci., 58, 1683, 10.1016/0024-3205(96)00066-5 Dinan, 1997, Blunted serotonin-mediated activation of the hypothalamic–pituitary–adrenal axis in chronic fatigue syndrome, Psychoneuroendocrinology, 22, 261, 10.1016/S0306-4530(97)00002-4 Enoch, 2001, Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder, Biol. Psychiatry, 49, 385, 10.1016/S0006-3223(00)01040-4 Farmer, 1999, Is disabling fatigue in childhood influenced by genes?, Psychol. Med., 29, 279, 10.1017/S0033291798008095 Fukuda, 2006, Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes, Biol. Psychiatry, 60, 1331, 10.1016/j.biopsych.2006.06.024 Georgiades, 2003, Chronic fatigue syndrome: new evidence for a central fatigue disorder, Clin. Sci., 105, 213, 10.1042/CS20020354 Goertzel, 2006, Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome, Pharmacogenomics, 7, 475, 10.2217/14622416.7.3.475 Hickie, 1999, Unique genetic and environmental determinants of prolonged fatigue: a twin study, Psychol. Med., 29, 259, 10.1017/S0033291798007934 Hollenberg, 1995, Identification of a new family of tissue-specific basic helix–loop–helix proteins with a two-hybrid system, Mol. Cell Biol., 15, 3813, 10.1128/MCB.15.7.3813 Hoyer, 2002, Molecular, pharmacological and functional diversity of 5-HT receptors, Pharmacol. Biochem. Behav., 71, 533, 10.1016/S0091-3057(01)00746-8 Keller, 1998, Use of structural equation modeling to test the construct validity of the SF-36 Health Survey in ten countries: results from the IQOLA Project. International Quality of Life Assessment, J. Clin. Epidemiol., 51, 1179, 10.1016/S0895-4356(98)00110-3 Kouzmenko, 1997, 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia, Lancet, 349, 1815, 10.1016/S0140-6736(05)61695-9 Kouzmenko, 1999, No correlation between A(−1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia, Hum. Hered., 49, 103, 10.1159/000022853 Lambert, 1998, A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease, Hum. Mol. Genet., 7, 533, 10.1093/hmg/7.3.533 Levitan, 2002, Polymorphism of the serotonin-2A receptor gene (HTR2A) associated with childhood attention deficit hyperactivity disorder (ADHD) in adult women with seasonal affective disorder, J. Affect. Disord., 71, 229, 10.1016/S0165-0327(01)00372-X Lohmueller, 2003, Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease, Nat. Genet., 33, 177, 10.1038/ng1071 Luciana, 2001, Effects of tryptophan loading on verbal, spatial and affective working memory functions in healthy adults, J. Psychopharmacol., 15, 219, 10.1177/026988110101500410 McAllister-Williams, 1998, Mood and neuropsychological function in depression: the role of corticosteroids and serotonin, Psychol. Med., 28, 573, 10.1017/S0033291798006680 Mikkelsen, 2004, Serotonergic stimulation of the rat hypothalamo–pituitary–adrenal axis: interaction between 5-HT1A and 5-HT2A receptors, Ann. N Y Acad. Sci., 1018, 65, 10.1196/annals.1296.007 Myers, 2007, Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression, Biol. Psychiatry, 61, 167, 10.1016/j.biopsych.2005.12.018 Narita, 2003, Association between serotonin transporter gene polymorphism and chronic fatigue syndrome, Biochem. Biophys. Res. Commun., 311, 264, 10.1016/j.bbrc.2003.09.207 Norton, 2005, HTR2A: association and expression studies in neuropsychiatric genetics, Ann. Med., 37, 121, 10.1080/07853890510037347 Parker, 2001, The neuroendocrinology of chronic fatigue syndrome and fibromyalgia, Psychol. Med., 31, 1331, 10.1017/S0033291701004664 Parsons, 2004, The −1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity, Biol. Psychiatry, 56, 406, 10.1016/j.biopsych.2004.06.020 Petronis, 2000, The genes for major psychosis: aberrant sequence or regulation?, Neuropsychopharmacology, 23, 1, 10.1016/S0893-133X(00)00127-5 Polesskaya, 2002, Differential expression of the “C” and “T” alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics, J. Neurosci. Res., 67, 812, 10.1002/jnr.10173 Rajeevan, 2005, Epidemiologic and viral factors associated with cervical neoplasia in HPV-16-positive women, Int. J. Cancer, 115, 114, 10.1002/ijc.20894 Rajeevan, 2007, Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome, Genes Brain Behav., 6, 167, 10.1111/j.1601-183X.2006.00244.x Raymond, 2001, Multiplicity of mechanisms of serotonin receptor signal transduction, Pharmacol. Ther., 92, 179, 10.1016/S0163-7258(01)00169-3 Reeves, 2005, Chronic fatigue syndrome—a clinically empirical approach to its definition and study, BMC Med., 3, 19, 10.1186/1741-7015-3-19 Reynolds, 2004, The economic impact of chronic fatigue syndrome, Cost Eff. Resour. Alloc., 2, 4, 10.1186/1478-7547-2-4 Reynolds, 2006, Longitudinal change in memory performance associated with HTR2A polymorphism, Neurobiol. Aging, 27, 150, 10.1016/j.neurobiolaging.2004.12.009 Ross, 2003, Basic helix–loop–helix factors in cortical development, Neuron, 39, 13, 10.1016/S0896-6273(03)00365-9 Samochowiec, 1999, Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism, Psychiatry Res., 86, 67, 10.1016/S0165-1781(99)00020-7 Schaid, 2002, Score tests for association between traits and haplotypes when linkage phase is ambiguous, Am. J. Hum. Genet., 70, 425, 10.1086/338688 Schwartz, 2006, Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development, Proc. Natl. Acad. Sci. USA, 103, 9976, 10.1073/pnas.0603728103 Sharpe, 1996, Increased prolactin response to buspirone in chronic fatigue syndrome, J. Affect. Disord., 41, 71, 10.1016/0165-0327(96)00075-4 Smets, 1995, The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue, J. Psychosom. Res., 39, 315, 10.1016/0022-3999(94)00125-O Smith, 2006, Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue, Pharmacogenomics, 7, 387, 10.2217/14622416.7.3.387 Sorbi, 1998, 5-HT2A promoter polymorphism in anorexia nervosa, Lancet, 351, 1785, 10.1016/S0140-6736(05)78745-6 Spurlock, 1998, A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter, Mol. Psychiatry, 3, 42, 10.1038/sj.mp.4000342 Sullivan, 2005, Twin analyses of chronic fatigue in a Swedish national sample, Psychol. Med., 35, 1327, 10.1017/S0033291705005222 Swain, 2000, Fatigue in chronic disease, Clin. Sci. (Lond), 99, 1, 10.1042/CS19990372 Torpy, 2004, Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism, Endocr. Res., 30, 417, 10.1081/ERC-200035599 Turecki, 1999, Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide, Am. J. Psychiatry, 156, 1456, 10.1176/ajp.156.9.1456 van de Putte, 2006, Mirrored symptoms in mother and child with chronic fatigue syndrome, Pediatrics, 117, 2074, 10.1542/peds.2005-2307 Vernon, 2006, The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndrome, Pharmacogenomics, 7, 345, 10.2217/14622416.7.3.345 Vladutiu, 2004, Association of medically unexplained fatigue with ACE insertion/deletion polymorphism in Gulf War veterans, Muscle Nerve, 30, 38, 10.1002/mus.20055 Vollmer-Conna, 2006, An empirical delineation of the heterogeneity of chronic unexplained fatigue in women, Pharmacogenomics, 7, 355, 10.2217/14622416.7.3.355 Wagner, 2005, Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome, Popul. Health Metr., 3, 8, 10.1186/1478-7954-3-8 Walsh, 2001, A family history study of chronic fatigue syndrome, Psychiatr. Genet., 11, 123, 10.1097/00041444-200109000-00003 Ware, 1992, The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection, Med. Care, 30, 473, 10.1097/00005650-199206000-00002 Weaver, 2004, Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites, Ann. N Y Acad. Sci., 1024, 182, 10.1196/annals.1321.099 Williams, 1997, Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia, Lancet, 349, 1221, 10.1016/S0140-6736(05)62413-0 Yu, 2005, Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response, Neuropsychopharmacology, 30, 1719, 10.1038/sj.npp.1300785