Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach

Aghajanian, 1982, Intracellular recording in vivo from serotonergic neurons in the rat dorsal raphe nucleus: methodological considerations, J. Histochem Cytochem., 30, 813, 10.1177/30.8.6749973 Aman, 2007, D2-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance, J. Pharmacol. Exp. Ther., 320, 376, 10.1124/jpet.106.111690 Banasr, 2004, Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone, Neuropsychopharmacology, 29, 450, 10.1038/sj.npp.1300320 Bill, 1991, Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia, Br. J. Pharmacol., 103, 1857, 10.1111/j.1476-5381.1991.tb12342.x Blier, 2003, The pharmacology of putative early-onset antidepressant strategies, Eur. Neuropsychopharmacol., 13, 57, 10.1016/S0924-977X(02)00173-6 Blier, 2005, Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety, J. Clin. Psychiatry, 66, 30 Boothman, 2003, Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat, Br. J. Pharmacol., 139, 998, 10.1038/sj.bjp.0705328 Boothman, 2005, A role for midbrain raphe gamma aminobutyric acid neurons in 5-hydroxytryptamine feedback control, Neuroreport, 16, 891, 10.1097/00001756-200506210-00004 Bortolozzi, 2003, In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs, Eur. J. Neurosci., 18, 1235, 10.1046/j.1460-9568.2003.02829.x Bortolozzi, 2005, The activation of 5-HT receptors in prefrontal cortex enhances dopaminergic activity, J. Neurochem., 95, 1597, 10.1111/j.1471-4159.2005.03485.x Choi, 2005, Serotonin receptor 2A gene polymorphism (-1438A/G) and short-term treatment response to citalopram, Neuropsychobiology, 52, 155, 10.1159/000087847 Corruble, 2015, Treating major depressive episodes with antidepressants can induce or worsen metabolic syndrome: results of the METADAP cohort, World Psychiatry, 14, 366, 10.1002/wps.20260 David, 2009, Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression, Neuron, 62, 479, 10.1016/j.neuron.2009.04.017 Dean, 2014, Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine, Int. J. Neuropsychopharmacol., 17, 895, 10.1017/S1461145713001648 Fabbri, 2014, PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway, Pharmacogenomics J., 14, 463, 10.1038/tpj.2014.15 Fernandes, 1997, Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety, Psychoneuroendocrinology, 22, 477, 10.1016/S0306-4530(97)00052-8 Fernandez, 2015, Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain, Brain Struct. Funct. Gardier, 1996, Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies, Fundam. Clin. Pharmacol., 10, 16, 10.1111/j.1472-8206.1996.tb00145.x Greenberg, 1999, Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets, Am. J. Med. Genet., 88, 83, 10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 Guiard, 2012, Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study, Int. J. Neuropsychopharmacol., 15, 349, 10.1017/S1461145711000484 Haj-Dahmane, 2001, D2-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro, Eur. J. Neurosci., 14, 125, 10.1046/j.0953-816x.2001.01616.x Hasegawa, 2012, 5-HT2A receptor antagonist M100907 reduces serotonin synthesis: an autoradiographic study, Brain Res. Bull., 87, 44, 10.1016/j.brainresbull.2011.10.009 Huang, 2005, The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids, Neuroscience, 135, 803, 10.1016/j.neuroscience.2005.05.056 Huang, 2006, Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone, Biol. Psychiatry, 59, 619, 10.1016/j.biopsych.2005.09.016 Horstmann, 2010, Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment, Neuropsychopharmacology, 35, 727, 10.1038/npp.2009.180 Jha, 2008, 5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus, Neurosci. Lett., 441, 210, 10.1016/j.neulet.2008.06.028 Kato, 2010, Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder, Mol. Psychiatry, 15, 473, 10.1038/mp.2008.116 Kato, 2009, 5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients, Psychiatry Res., 167, 97, 10.1016/j.psychres.2007.12.012 Kishi, 2010, HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort, Neuromol. Med., 12, 237, 10.1007/s12017-009-8105-y Kiyasova, 2011, Development of raphe serotonin neurons from specification to guidance, Eur. J. Neurosci., 34, 1553, 10.1111/j.1460-9568.2011.07910.x Klengel, 2013, Gene-environment interactions in major depressive disorder, Can. J. Psychiatry, 58, 76, 10.1177/070674371305800203 Laje, 2010, Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB, Int. J. Neuropsychopharmacol., 13, 715, 10.1017/S1461145709991027 Le Dantec, 2014, NREM sleep hypersomnia and reduced sleep/wake continuity in a neuroendocrine mouse model of anxiety/depression based on chronic corticosterone administration, Neuroscience, 274, 357, 10.1016/j.neuroscience.2014.05.050 Lechin, 2006, Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy, Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, 565, 10.1016/j.pnpbp.2005.11.025 Lemonde, 2004, Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response, Int. J. Neuropsychopharmacol., 7, 501, 10.1017/S1461145704004699 Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 Lin, 2014, Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: a meta-analysis, J. Affect Disord., 168, 430, 10.1016/j.jad.2014.06.012 Lucae, 2010, HTR2A gene variation is involved in antidepressant treatment response, Eur. Neuropsychopharmacol., 20, 65, 10.1016/j.euroneuro.2009.08.006 Lucki, 1997, The forced swimming test as a model for core and component behavioral effects of antidepressant drugs, Behav. Pharmacol., 8, 523, 10.1097/00008877-199711000-00010 Maejima, 2013, Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels, Front. Integr. Neurosci., 7, 40, 10.3389/fnint.2013.00040 Marek, 2005, The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine, Neuropsychopharmacology, 30, 2205, 10.1038/sj.npp.1300762 Martin-Ruiz, 2001, Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism, J. Neurosci., 21, 9856, 10.1523/JNEUROSCI.21-24-09856.2001 Massou, 1997, Frontal 5-HT2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors, Psychopharmacol. (Berl), 133, 99, 10.1007/s002130050377 McMahon, 2006, Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment, Am. J. Hum. Genet., 78, 804, 10.1086/503820 Messa, 2003, 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study, Psychopharmacol. (Berl), 167, 72, 10.1007/s00213-002-1379-5 Montalbano, 2015, Cellular resilience: 5-HT neurons in Tph2(−/−) mice retain normal firing behavior despite the lack of brain 5-HT, Eur. Neuropsychopharmacol., 25, 2022, 10.1016/j.euroneuro.2015.08.021 Muguruza, 2014, Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment, Neuropharmacology, 86, 311, 10.1016/j.neuropharm.2014.08.009 Myers, 2007, Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression, Biol. Psychiatry, 61, 167, 10.1016/j.biopsych.2005.12.018 Niitsu, 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis, Prog. Neuropsychopharmacol. Biol. Psychiatry, 45, 183, 10.1016/j.pnpbp.2013.05.011 Noro, 2010, 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder, Int. Clin. Psychopharmacol., 25, 228, 10.1097/YIC.0b013e328338bcf4 Okaty, 2015, Multi-scale molecular deconstruction of the serotonin neuron system, Neuron, 88, 774, 10.1016/j.neuron.2015.10.007 Ozaki, 1997, A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization, J. Neurochem., 68, 2186, 10.1046/j.1471-4159.1997.68052186.x Pandey, 2010, A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants, Pharmacol. Biochem. Behav., 94, 363, 10.1016/j.pbb.2009.09.018 Paxinos, 2001 Petit, 2014, Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder, Prog. Neuropsychopharmacol. Biol. Psychiatry, 54, 76, 10.1016/j.pnpbp.2014.04.013 Polesskaya, 2006, Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1, J. Neurosci. Res., 83, 362, 10.1002/jnr.20732 Polesskaya, 2002, Differential expression of the “C” and “T” alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics, J. Neurosci. Res., 67, 812, 10.1002/jnr.10173 Quesseveur, 2013, 5-HT(2)A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system, Exp. Brain Res., 226, 285, 10.1007/s00221-013-3434-3 Radley, 2002, 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus, Brain Res., 955, 264, 10.1016/S0006-8993(02)03477-7 Rainer, 2012, Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration, Mol. Pharmacol., 81, 106, 10.1124/mol.111.075796 Rasul, 2013, Chronic mild stress modulates 5-HT1A and 5-HT2A receptor expression in the cerebellar cortex of NC/Nga atopic-like mice, Arch. Dermatol. Res., 305, 407, 10.1007/s00403-013-1325-x Reynolds, 2014, Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms, Br. J. Clin. Pharmacol., 77, 654, 10.1111/bcp.12312 Richardson-Jones, 2010, 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants, Neuron, 65, 40, 10.1016/j.neuron.2009.12.003 Sairanen, 2005, Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus, J. Neurosci., 25, 1089, 10.1523/JNEUROSCI.3741-04.2005 Samuels, 2015, 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response, Nat. Neurosci., 18, 1606, 10.1038/nn.4116 Santarelli, 2003, Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants, Science, 301, 805, 10.1126/science.1083328 Serretti, 2013, No effect of serotoninergic gene variants on response to interpersonal counseling and antidepressants in major depression, Psychiatry Investig., 10, 180, 10.4306/pi.2013.10.2.180 Soumier, 2010, Region- and phase-dependent effects of 5-HT(1A) and 5-HT(2C) receptor activation on adult neurogenesis, Eur. Neuropsychopharmacol., 20, 336, 10.1016/j.euroneuro.2009.11.007 Sotty, 2009, Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRIs effects, Neuropharmacology, 57, 18, 10.1016/j.neuropharm.2009.03.016 Spurlock, 1998, A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter, Mol. Psychiatry, 3, 42, 10.1038/sj.mp.4000342 Steru, 1985, The tail suspension test: a new method for screening antidepressants in mice, Psychopharmacol. (Berl), 85, 367, 10.1007/BF00428203 Surget, 2008, Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal, Biol. Psychiatry, 64, 293, 10.1016/j.biopsych.2008.02.022 Taliaz, 2010, Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis, Mol. Psychiatry, 15, 80, 10.1038/mp.2009.67 Vaidya, 1997, 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex, J. Neurosci., 17, 2785, 10.1523/JNEUROSCI.17-08-02785.1997 Vazquez-Borsetti, 2011, Simultaneous projections from prefrontal cortex to dopaminergic and serotonergic nuclei, Int. J. Neuropsychopharmacol., 14, 289, 10.1017/S1461145710000349 Viikki, 2011, Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD, Neurosci. Lett., 501, 20, 10.1016/j.neulet.2011.06.031 Wang, 2013, Quetiapine add-on therapy improves the depressive behaviors and hippocampal neurogenesis in fluoxetine treatment resistant depressive rats, Behav. Brain Res., 253, 206, 10.1016/j.bbr.2013.07.021 Warden, 2007, Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D report, Am. J. Psychiatry, 164, 1189, 10.1176/appi.ajp.2007.06071225 Wilkie, 2009, Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy, Pharmacogenomics J., 9, 61, 10.1038/sj.tpj.6500491 Xu, 2006, Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus, Hippocampus, 16, 551, 10.1002/hipo.20184 Zanardi, 2001, Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study, J. Clin. Psychopharmacol., 21, 53, 10.1097/00004714-200102000-00010 Zaniewska, 2010, Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal, Neuropharmacology, 58, 1140, 10.1016/j.neuropharm.2010.02.006