Genetic and pathogenic basis of autoimmune diabetes in NOD mice

Keller, 1989, Immunopathogenesis of type 1 diabetes mellitus, 1

Roep, 1990, T-cell clones from a type 1 diabetes patient respond to insulin secretory granule proteins, Nature, 345, 632, 10.1038/345632a0

Kikutani, 1992, The murine autoimmune diab́etes model: NOD and related strains, Adv Immunol, 51, 285, 10.1016/S0065-2776(08)60490-3

Leiter, 1992, Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice, Regional Immunol, 4, 263

Terada, 1988, The effect of H-2 compatibility on pancreatic beta cell survival in the non-obese diabetic mouse, Transplantation, 45, 622, 10.1097/00007890-198803000-00024

Wang, 1991, The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice, 88, 527

Serreze, 1993, Autoimmune diabetes results from genetic defects manifest by antigen presenting cells, FASEB J, 7, 1092, 10.1096/fasebj.7.11.8370480

Wicker, 1992, Autoimmune syndromes in major histocompatibility complex WHO con genic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes, J Exp Med, 176, 67, 10.1084/jem.176.1.67

Prochazka, 1989, Genetic control of diabetogenesis in NOD/Lt mice: development and analysis of congenic stocks, Diabetes, 38, 1446, 10.2337/diabetes.38.11.1446

Podolin, 1993, I-E+ nonobese diabetic mice develop insulitis and diabetes, J Exp Med, 178, 793, 10.1084/jem.178.3.793

Serreze, 1988, Defective activation of T suppressor cell function in non-obese diabetic mice. Potential relation to cytokine deficiencies, J Immunol, 140, 3801, 10.4049/jimmunol.140.11.3801

Reich, 1989, Prevention of diabetes in NOD mice by injection of autoreactive T lymphocytes, Diabetes, 38, 1647, 10.2337/diabetes.38.12.1647

Choisch, 1993, Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD-4+ T-cell line, Diabetologia, 36, 716, 10.1007/BF00401141

Serreze, 1991, Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hematopoietic origin, but not on thymic epithelium, J Immunol, 147, 1222, 10.4049/jimmunol.147.4.1222

Acha-Orbea, 1987, The first external domain of the nonobese diabetic mouse class II I-Aβ chain is unique, 84, 2435

Todd, 1988, A molecular basis for MHC class II-associated autoimmunity, Science, 240, 1003, 10.1126/science.3368786

Reich, 1994, Self peptides isolated from MHC glycoproteins of non-obese diabetic mice, J Immunol, 152, 2279, 10.4049/jimmunol.152.5.2279

Ikegami, 1990, Major histocompatibility complex-linked diabetogenic gene of the nonobese diabetic mouse. Analysis of genomic DNA amplified by the polymerase chain reaction, J Clin Invest, 85, 18, 10.1172/JCI114410

Lund, 1990, Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain, Nature, 345, 727, 10.1038/345727a0

Slattery, 1990, Prevention of diabetes in non-obese diabetic I-Ale transgenic mice, Nature, 345, 724, 10.1038/345724a0

Singer, 1993, An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells, 90, 9566

Parish, 1993, The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes, Eur J Immunol, 23, 2667, 10.1002/eji.1830231042

Slattery, 1993, Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes, 90, 10808

Faustman, 1991, Linkage of faulty major histocompatibility complex class I to autoimmune diabetes, Science, 254, 1756, 10.1126/science.1763324

Faustman, 1993, Mechanisms of autoimmunity in type 1 diabetes, J Clin Immunol, 13, 1, 10.1007/BF00920630

Gaskins, 1992, Expression of intra-MHC transporter (Ham) genes in diabetes-susceptible NOD mice, Science, 256, 1826, 10.1126/science.1352067

Pearce, 1993, Polymorphism in mouse Tapl gene, J Immunol, 151, 5338, 10.4049/jimmunol.151.10.5338

Schumacher, 1994, Transporters from H-26, H-2d H-25, H-2k, and H287 (NOD/Lt) haplotype translocate similar sets of peptides

Wicker, 1992, Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes susceptible NOD mice, Science, 256, 1828, 10.1126/science.1319611

Serreze, 1993, Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice, J Immunol, 150, 2534, 10.4049/jimmunol.150.6.2534

Serreze, 1994, MHC class I deficient NOD-B2mnull mice are diabetes and insulitis resistant, Diabetes, 43, 505, 10.2337/diabetes.43.3.505

Wicker, 1994, β2-microglobulin-deficient NOD mice do not develop insulitis or diabetes, Diabetes, 43, 500, 10.2337/diabetes.43.3.500

Ikegami, 1993, MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3′ boundary of the diabetogenic region, Biochem Biophys Res Commun, 192, 677, 10.1006/bbrc.1993.1468

Wicker, 1994, Genetic control of autoimmune diabetes in the NOD mouse, Annu Rev Immunol

Hattori, 1986, The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex, Science, 231, 733, 10.1126/science.3003909

Prochazka, 1987, Three recessive loci required for insulin-dependent diabetes in NOD mice, Science, 237, 286, 10.1126/science.2885918

Todd, 1991, Genetic analysis of autoimmune type 1 diabetes mellitus in mice, Nature, 351, 542, 10.1038/351542a0

Garchon, 1991, Identification and mapping of a susceptibility locus for periinsulitis in non-obese diabetic mice, Nature, 353, 260, 10.1038/353260a0

Cornall, 1991, Type 1 diabetes in mice is linked to the interleukin1 receptor and Lsh/Ity/Bcg genes on chromosome 1, Nature, 351, 262, 10.1038/353262a0

Ghosh, 1993, Polygenic control of autoimmune diabetes in nonobese diabetic mice, Nature Genet, 4, 404, 10.1038/ng0893-404

de Gouyon, 1993, Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus, 90, 1877

Risch, 1993, Statistical evaluation of multiple locus linkage data in experimental species and relevance to human studies: application to murine and human IDDM, Am J Hum Genet, 53, 702

Morahan, 1994, Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity, 91, 5898

Baxter, 1993, Complement lytic activity has no role in the pathogenesis of autoimmune diabetes in NOD mice, Diabetes, 42, 1574, 10.2337/diabetes.42.11.1574

Serreze, 1994, Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin dependent diabetes resistance gene, J Exp Med, 180, 1553, 10.1084/jem.180.4.1553

Miller, 1988, Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice, J Immunol, 140, 52, 10.4049/jimmunol.140.1.52

Bendelac, 1987, Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates: requirement for both L3T4+ and Lyt-2+ T cells, J Exp Med, 166, 823, 10.1084/jem.166.4.823

Reich, 1989, An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes, Nature, 341, 326, 10.1038/341326a0

Haskins, 1989, Pancreatic islet-specific T-cell clones from nonobese diabetic mice, 86, 8000

Bradley, 1990, In vivo activity of an islet-reactive T-cell clone, J Autoimmun, 3, 449, 10.1016/S0896-8411(05)80012-5

Bradley, 1992, CD8 T cells are not required for islet destruction induced by a CD4+ isletspecific T-cell clone, Diabetes, 41, 1603, 10.2337/diabetes.41.12.1603

Katz, 1993, Following a diabetogenic T cell from genesis through pathogenesis, Cell, 74, 1089, 10.1016/0092-8674(93)90730-E

Prochazka, 1992, The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency, 89, 3290

Christianson, 1993, Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: Relative contributions of CD4+ and CD8+ T lymphocytes from diabetic versus prediabetic NOD.NON-Thy 1a Donors, Diabetes, 42, 44, 10.2337/diabetes.42.1.44

Peterson, 1993, Transfer of diabetes to NOD F1 and NOD-scid mice by CD-4+ Islet-specific T cell clones, Autoimmunity, 15, 48

Maeda, 1991, T-lymphocyte-receptor repertoire of infiltrating T lymphocytes into NOD mouse pancreas, Diabetes, 40, 1580, 10.2337/diabetes.40.12.1580

Waters, 1992, Multiple TCR Vβ gene usage by infiltrates of young NOD mouse islets of Langerhans: a polymerase chain reaction analysis, Diabetes, 41, 308, 10.2337/diabetes.41.3.308

Kaufman, 1993, Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes, Nature, 366, 69, 10.1038/366069a0

Tisch, 1993, Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice, Nature, 366, 72, 10.1038/366072a0

Aguilar-Diosdado, 1994, Potential autoantigens in IDDM: expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the β-cell surface, Diabetes, 43, 418, 10.2337/diabetes.43.3.418

Gelber, 1994, Isolation of nonobese diabetic mouse T-lymphocytes that recognize novel autoanti gens involved in the early events of diabetes, Diabetes, 43, 33, 10.2337/diabetes.43.1.33

Baekkeskov, 1990, Identification of the 64k autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase, Nature, 347, 151, 10.1038/347151a0