Đặc điểm di truyền và sinh học của virus cúm gia cầm H5N1 được phân lập từ chim hoang dã và gia cầm ở Tây Siberia

Archives of Virology - Tập 155 - Trang 1145-1150 - 2010
Kirill Sharshov1, Alesia Romanovskaya1, Roman Uzhachenko1, Alexander Durymanov1, Anna Zaykovskaya1, Olga Kurskaya1, Philipp Ilinykh1, Nikita Silko1, Mikhail Kulak1, Alexander Alekseev1, Sergei Zolotykh1, Alexander Shestopalov1, Iliya Drozdov1
1FSRI SRC VB “Vector”, Novosibirsk, Russia

Tóm tắt

Ba loại virus trong nghiên cứu này được phân lập từ những con chim chết (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, và A/duck/Tuva/01/2006), trong khi virus A/common gull/Chany/P/2006 được phân lập từ một con nh gull dường như khỏe mạnh trong đợt bùng phát cúm gia cầm độc lực cao ở Nga vào năm 2006. Chỉ số độc lực tĩnh mạch (IVPI) của các virus A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, và A/duck/Tuva/01/2006 nằm trong khoảng từ 2.7 đến 3.0, trong khi virus A/common gull/Chany/P/2006 có IVPI thấp hơn rõ rệt là 1.7. Virus A/common gull/Chany/P/2006 có một mô hình đặc biệt với sáu sự thay thế axit amin trong các vùng của protein virus quan trọng cho virulence của virus H5N1. Chúng tôi giả thuyết rằng những thay thế này có thể ảnh hưởng đến tính gây bệnh của A/common gull/Chany/P/2006.

Từ khóa

#virus cúm gia cầm #H5N1 #di truyền #giới tính #độc lực #phân lập virus

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