Genetic Variations and Association

Adham, 1992, The rat 5-hydroxytryptamine I B receptor is the species homologue of the human 5-hydroxytryptamine 1D9 receptor, Mol. Pharmacol., 41, 17 Alvarez-Alvarez, 2003, 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer’s disease in the Basque Country, Neurosci. Lett., 339, 85, 10.1016/S0304-3940(02)01425-8 Andreadis, 1987, Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications, Annu Rev. Cell. Biol., 31987, 207, 10.1146/annurev.cb.03.110187.001231 Bandiera, 2010, MicroRNAs in diseases: from candidate to modifier genes, Clin. Genet., 77, 306, 10.1111/j.1399-0004.2010.01370.x Chatzikyriakidou, 2010, The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility, Scand. J. Immunol., 71, 382, 10.1111/j.1365-3083.2010.02381.x Cheng, 2006, Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder, Mol. Psychiatry, 11, 252, 10.1038/sj.mp.4001778 Chiu, 2001, Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function, Neuropsychobiology, 43, 113, 10.1159/000054876 DeMichele-Sweet, 2010, Genetics of psychosis in Alzheimer’s disease: a review, J. Alzheimers Dis., 19, 761, 10.3233/JAD-2010-1274 Fukuo, 2010, Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis, Neurosci. Res., 67, 250, 10.1016/j.neures.2010.04.003 Garcia-Alloza, 2004, Differential involvement of 5-HT (1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer’s disease, Neuropsychopharmacology, 29, 410, 10.1038/sj.npp.1300330 Geldenhuys, 2009, The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease, Expert Rev. Neurother., 9, 1073, 10.1586/ern.09.51 Gerard, 1997, Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system, Brain Res., 746, 207, 10.1016/S0006-8993(96)01224-3 Harmer, 2008, Serotonin and emotional processing: does it help explain antidepressant drug action?, Neuropharmacology, 55, 1023, 10.1016/j.neuropharm.2008.06.036 Hirst, 2003, Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling, Mol. Pharmacol., 64, 1295, 10.1124/mol.64.6.1295 Hong, 1999, Association analysis of the 5-HT(6) receptor polymorphism (C267T) in mood disorders, Am. J. Med. Genet., 88, 601, 10.1002/(SICI)1096-8628(19991215)88:6<601::AID-AJMG4>3.0.CO;2-1 Hoyer, 1994, VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin), Pharmacol. Rev., 46, 157 Humphrey, 1993, A proposed new nomenclature for 5-HT receptors, Trends Pharmacol. Sci., 14, 233, 10.1016/0165-6147(93)90016-D Ikeda, 2008, Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia, Pharmacogenomics, 9, 1437, 10.2217/14622416.9.10.1437 Illi, 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression, Neuroreport, 20, 1125, 10.1097/WNR.0b013e32832eb708 Kan, 2004, Association of the HTR6 polymorphism C267T with late-onset Alzheimer’s disease in Chinese, Neurosci. Lett., 372, 27, 10.1016/j.neulet.2004.09.007 Kato, 2007, Molecular genetics of bipolar disorder and depression, Psychiatry Clin. Neurosci., 61, 3, 10.1111/j.1440-1819.2007.01604.x Kohen, 1996, Cloning, characterization and chromosomal localization of a human 5-HT6 serotonin receptor, J. Neurochem., 66, 47, 10.1046/j.1471-4159.1996.66010047.x Kulkarni, 2009, Current investigational drugs for major depression, Expert Opin. Investig. Drugs, 18, 767, 10.1517/13543780902880850 Lane, 2004, Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders, Schizophr. Res., 67, 63, 10.1016/j.schres.2003.08.006 Le Francois, 2008, Transcriptional regulation at a HTR1A polymorphism associated with mental illness, Neuropharmacology, 55, 977, 10.1016/j.neuropharm.2008.06.046 Lee, 2005, Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder, Psychiatry Clin. Neurosci., 59, 140, 10.1111/j.1440-1819.2005.01348.x Levinson, 2006, The genetics of depression: a review, Biol. Psychiatry., 60, 84, 10.1016/j.biopsych.2005.08.024 Liu, 2001, Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer’s disease, Psychiatry Clin. Neurosci., 55, 427, 10.1046/j.1440-1819.2001.00886.x Masellis, 2001, Lack of association between the T–>C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia, Schizophr. Res., 47, 49, 10.1016/S0920-9964(00)00016-5 Monsma, 1993, Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs, Mol. Pharmacol., 43, 320 Mount, 1982, A catalogue of splice junction sequences, Nucleic Acids Res., 10, 459, 10.1093/nar/10.2.459 Murray, 2010, An in silico analysis of microRNAs: mining the miRNAome, Mol. Biosyst., 10, 1853, 10.1039/c003961f Nash, 2004, Genomewide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships, Hum. Mol. Genet., 13, 2173, 10.1093/hmg/ddh239 Ohmori, 2001, Novel polymorphism in the 5′-upstream region of the human 5-HT6 receptor gene and schizophrenia, Neurosci. Lett., 310, 17, 10.1016/S0304-3940(01)02075-4 Olsen, 1999, Identification of a human 5-HT6 receptor variant produced by alternative splicing, Brain Res. Mol. Brain Res., 64, 255, 10.1016/S0169-328X(98)00338-6 Orlacchio, 2002, Association study of the 5-hydroxytryptamine (6) receptor gene in Alzheimer’s disease, Neurosci. Lett., 325, 13, 10.1016/S0304-3940(02)00221-5 Roth, 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors, J. Pharmacol. Exp. Ther., 268, 1403 Ryan, 2010, Genetic variation in microRNA networks: the implications for cancer research, Nat. Rev. Cancer., 10, 523, 10.1038/nrc2885 Schoeffter, 1994, 5-Hydroxytryptamine receptors with a 5-UT6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes, Arch. Pharmacol., 350, 356, 10.1007/BF00178951 Schumacher, 2005, Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24, Am. J. Hum. Genet., 77, 1102, 10.1086/498619 Shinkai, 1999, Association study of the 5-HT6 receptor gene in schizophrenia, Am. J. Hum. Genet., 88, 120, 10.1002/(SICI)1096-8628(19990416)88:2<120::AID-AJMG4>3.0.CO;2-Y Sleight, 1998, The putative 5-ht6 receptor: localization and function, Ann. N. Y. Acad. Sci., 861, 91, 10.1111/j.1749-6632.1998.tb10178.x Thome, 2001, Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer’s disease, J. Neural. Trans., 108, 1175, 10.1007/s007020170007 Tsai, 1999, Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior, Neurosci. Lett., 271, 135, 10.1016/S0304-3940(99)00542-X Tsai, 1999, Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer’s disease, Neurosci. Lett., 276, 138, 10.1016/S0304-3940(99)00802-2 Vazza, 2007, Genome-wide scan supports the existence of a susceptibility locus for schizophrenia and bipolar disorder on chromosome 15q26, Mol. Psychiatry, 12, 87, 10.1038/sj.mp.4001895 Vogt, 2000, Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia, Am. J. Med. Genet., 96, 217, 10.1002/(SICI)1096-8628(20000403)96:2<217::AID-AJMG17>3.0.CO;2-0 Wesolowska, 2007, Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression, Neuropharmacology, 52, 1274, 10.1016/j.neuropharm.2007.01.007 Wesolowska, 2007, Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats, Behav. Pharmacol., 18, 439, 10.1097/FBP.0b013e3282d28f9c Wilkie, 2009, Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy, J. Pharmacogenomics, 9, 61, 10.1038/sj.tpj.6500491 Wu, 2001, Association study of the 5-HT(6) receptor polymorphism (C267T) and symptomatology and antidepressant response in major depressive disorders, Neuropsychobiology, 44, 172, 10.1159/000054938 Xu, 2010, A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform, J. Affect. Disord., 10.1016/j.jad.2010.05.019 Yu, 1999, Serotonin-6 receptor variant (C267T) and clinical response to clozapine, Neuroreport, 10, 1231, 10.1097/00001756-199904260-00014