Genetic Factors in Cardiovascular Disease

Allayee, 2003, Using mice to dissect genetic factors in atherosclerosis, Arterioscler Thromb Vasc Biol, 23, 1501, 10.1161/01.ATV.0000090886.40027.DC Altshuler, 2000, The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes, Nat Genet, 26, 76, 10.1038/79216 Barker, 1989, Weight in infancy and death from ischaemic heart disease, Lancet, 2, 577, 10.1016/S0140-6736(89)90710-1 Berg, 1989, Impact of medical genetics on research and practices in the area of cardiovascular disease, Clin Genet, 36, 299 Broeckel, 2002, A comprehensive linkage analysis for myocardial infarction and its related risk factors, Nat Genet, 30, 210, 10.1038/ng827 Cox, 2001, Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes, Hum Mol Genet, 10, 2301, 10.1093/hmg/10.20.2301 DeMeester, 1995, Genetic variation in lipoprotein(a) in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein(a) gene locus, Am J Hum Genet, 57, 286 Drazen, 1999, Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment, Nat Genet, 22, 168, 10.1038/9680 Dueland, 1993, Regulation of cholesterol-7α-hydroxylase and hepatic LDL receptors in inbred mice showing resistance and susceptibility to atherosclerosis, J Lipid Res, 34, 923, 10.1016/S0022-2275(20)39679-6 Eriksson, 2003, Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome, Nature, 423, 293, 10.1038/nature01629 Farooqi, 2000, Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency, J Clin Invest, 106, 271, 10.1172/JCI9397 Feldman, 1972, Lipid and cholesterol metabolism in Alaskan arctic eskimos, Arch Pathol, 94, 42 Han, 2003, Two Hsp70 family members expressed in atherosclerotic lesions, Proc Natl Acad Sci USA, 100, 1256, 10.1073/pnas.252764399 Ho, 1971, The Masai of East Africa, Arch Pathol, 91, 387 Jee, 2002, Major gene evidence after MTHFR-segregation analysis undergoing coronary arteriography, Hum Genet, 111, 128, 10.1007/s00439-002-0757-8 Kagan, 1974, Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California, J Chron Dis, 27, 345, 10.1016/0021-9681(74)90014-9 Keys, 1986, The diet and 15-year death rate in the Seven Countries Study, Am J Epidem, 124, 903, 10.1093/oxfordjournals.aje.a114480 2002 Lusis, 2000, Atherosclerosis, Nature, 407, 233, 10.1038/35025203 Lusis, 1998, Genetics of Atherosclerosis Lusis, 2002, Lipoprotein and lipid metabolism Ma, 1996, Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians, Circulation, 94, 2410, 10.1161/01.CIR.94.10.2410 Mackness MI, Durrington PN, Ayub A, Mackness B: 1999. Low serum paraoxonase: a risk factor for atherosclerotic disease? Chem Biol Interact 119–120:389–397. Mehrabian, 2002, Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice, Circ Res, 91, 120, 10.1161/01.RES.0000028008.99774.7F Merkel, 2002, Lipoprotein lipase, J Lipid Res, 43, 1997, 10.1194/jlr.R200015-JLR200 Nabel, 2003, Cardiovascular disease, N Engl J Med, 349, 60, 10.1056/NEJMra035098 Nichaman, 1975, Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California, Am J Epidemiol, 102, 491, 10.1093/oxfordjournals.aje.a112187 Ozaki, 2002, Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction, Nat Genet, 32, 650, 10.1038/ng1047 Paigen, 2003, One hundred years of mouse genetics, The molecular revolution (, 1981–2002)., 1227 Pajukanta, 1998, Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23, Nat Genet, 18, 369, 10.1038/ng0498-369 Palinski, 2002, The fetal origins of atherosclerosis, FASEB J, 16, 1348, 10.1096/fj.02-0226rev Reich, 2001, On the allelic spectrum of human disease, Trends Genet, 17, 502, 10.1016/S0168-9525(01)02410-6 Schadt, 2003, Genetics of gene expression surveyed in maize, mouse and man, Nature, 422, 297, 10.1038/nature01434 Schreyer, 2002, Loss of lymphotoxin-alpha but not tumor necrosis factor-alpha reduces atherosclerosis in mice, J Biol Chem, 277, 12,364, 10.1074/jbc.M111727200 Schwartz, 1998, Proliferation and the monoclonal origins of atherosclerotic lesions, Annu Rev Med, 49, 437, 10.1146/annurev.med.49.1.437 Sheth, 2002, Understanding atherosclerosis through mouse genetics, Curr Opin Lipidol, 13, 181, 10.1097/00041433-200204000-00010 Shi, 2000, Determinants of atherosclerosis susceptibility in C3H and C57BL/6 mouse model, Circ Res, 86, 1078, 10.1161/01.RES.86.10.1078 Shi, 2002, Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrow, Arterioscler Thromb Vasc Biol, 22, 650, 10.1161/01.ATV.0000013388.03553.31 Shih, 1998, Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis, Nature, 394, 284, 10.1038/28406 Sing CF, Stengard JH, Kardia SL: 2003. Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol e-publication ahead of print. Slack, 1966, The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease, J Med Genet, 2, 239, 10.1136/jmg.3.4.239 Smith, 2002, The allelic structure of common disease, Hum Mol Genet, 11, 2455, 10.1093/hmg/11.20.2455 Sugiyama, 2001, Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci, Genomics, 71, 70, 10.1006/geno.2000.6401 Talmud, 2002, Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides, Hum Mol Genet, 11, 3039, 10.1093/hmg/11.24.3039 Thomas, 1995, The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers, J Med Genet, 32, 585, 10.1136/jmg.32.8.585 Todd, 1999, From genome to aetiology in a multifactorial disease, type 1 diabetes, Bioessays, 21, 164, 10.1002/(SICI)1521-1878(199902)21:2<164::AID-BIES10>3.0.CO;2-4 Tward, 2002, Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice, Circulation, 106, 484, 10.1161/01.CIR.0000023623.87083.4F Ueda, 2003, Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease, Nature, 423, 506, 10.1038/nature01621 Vockley, 2000, Synergistic heterozygosity, Mol Genet Metab, 71, 10, 10.1006/mgme.2000.3066 Wang, 2002, Quantitative trait loci and candidate genes regulating HDL cholesterol, Arterioscler Thromb Vasc Biol, 22, 1390, 10.1161/01.ATV.0000030201.29121.A3