Genetic Determinants of Virulence in Pathogenic Lineage 2 West Nile Virus Strains

Petersen, 2001, West Nile virus: a reemerging global pathogen., Emerg Infect Dis, 7, 611, 10.3201/eid0704.017401

Beasley, 2002, Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype., Virology, 296, 17, 10.1006/viro.2002.1372

Burt, 2002, Phylogenetic relationships of southern African West Nile virus isolates., Emerg Infect Dis, 8, 820, 10.3201/eid0808.020027

Venter, 2005, Gene expression in mice infected with West Nile virus strains of different neurovirulence., Virology, 342, 119, 10.1016/j.virol.2005.07.013

Bakonyi, 2006, Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe., Emerg Infect Dis, 12, 618, 10.3201/eid1204.051379

Beasley, 2005, Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains., J Virol, 79, 8339, 10.1128/JVI.79.13.8339-8347.2005

Yamshchikov, 2004, An attenuated West Nile prototype virus is highly immunogenic and protects against the deadly NY99 strain: a candidate for live WNV vaccine development., Virology, 330, 304, 10.1016/j.virol.2004.09.014

Wicker, 2006, A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice., Virology, 349, 245, 10.1016/j.virol.2006.03.007

Puig-Basagoiti, 2007, A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis., Virology, 361, 229, 10.1016/j.virol.2006.11.012

Kinney, 2006, Avian virulence and thermostable replication of the North American strain of West Nile virus., J Gen Virol, 87, 3611, 10.1099/vir.0.82299-0

Thompson, 1994, CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice., Nucleic Acids Res, 22, 4673, 10.1093/nar/22.22.4673

Nicholas KB, Nicholas HB Jr. GeneDoc: a tool for editing and annotating multiple sequence alignments; 1997 [available from author].

Kumar, 2004, MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment., Brief Bioinform, 5, 150, 10.1093/bib/5.2.150

Von Heijne, 1986, A new method for predicting signal sequence cleavage sites., Nucleic Acids Res, 14, 4683, 10.1093/nar/14.11.4683

Castle, 1985, Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and the genome sequence of these proteins., Virology, 145, 227, 10.1016/0042-6822(85)90156-4

Keller, 2006, Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence., J Virol, 80, 9424, 10.1128/JVI.00768-06

Borisevich, 2006, Biological properties of chimeric West Nile viruses., Virology, 349, 371, 10.1016/j.virol.2006.02.013

Ding, 2005, Nucleotide and amino acid changes in West Nile virus strains exhibiting renal tropism in hamsters., Am J Trop Med Hyg, 73, 803, 10.4269/ajtmh.2005.73.803

Beasley, 2004, Genome sequence and attenuating mutations in West Nile virus isolate from Mexico., Emerg Infect Dis, 10, 2221, 10.3201/eid1012.040647

Coia, 1988, Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified protein., J Gen Virol, 69, 1, 10.1099/0022-1317-69-1-1

Lanciotti, 1999, Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States., Science, 286, 2333, 10.1126/science.286.5448.2333

Smithburn, 1940, A neurotropic virus isolated from the blood of a native Ugandan., Am J Trop Med Hyg, 20, 471, 10.4269/ajtmh.1940.s1-20.471

Bondre, 2007, West Nile virus isolates from India: evidence for a distinct genetic lineage., J Gen Virol, 88, 875, 10.1099/vir.0.82403-0

Campbell, 2002, West Nile virus., Lancet Infect Dis, 2, 519, 10.1016/S1473-3099(02)00368-7

Lindenbach, 2003, Molecular biology of flaviviruses., Adv Virus Res, 59, 23, 10.1016/S0065-3527(03)59002-9

Li, 2001, The 3′ stem loop of the West Nile virus genomic RNA can suppress translation of chimeric mRNAs., Virology, 287, 49, 10.1006/viro.2001.1015

Shurtleff, 2001, Genetic variation in the 3′ non-coding region of dengue viruses., Virology, 281, 75, 10.1006/viro.2000.0748

Hurrelbrink, 2003, Molecular determinants of virulence: the structural and functional basis for flavivirus attenuation., Adv Virus Res, 60, 1, 10.1016/S0065-3527(03)60001-1

Beasley, 2005, Recent advances in the molecular biology of West Nile virus., Curr Mol Med, 5, 835, 10.2174/156652405774962272

Davis, 2004, Emergence of attenuated West Nile virus variants in Texas, 2003., Virology, 330, 342, 10.1016/j.virol.2004.09.016

Lee, 2000, Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage in vitro is lethal for virus production., J Virol, 74, 24, 10.1128/JVI.74.1.24-32.2000

Stocks, 1998, Signal peptidase cleavage at the flavivirus C-prM junction: dependence on the viral NS2B–3 protease for efficient processing requires determinants in C, the signal peptide, and prM., J Virol, 72, 2141, 10.1128/JVI.72.3.2141-2149.1998