Generation of Hematopoietic Stem Cells from Purified Embryonic Endothelial Cells by a Simple and Efficient Strategy

Bertrand, 2010, Haematopoietic stem cells derive directly from aortic endothelium during development, Nature, 464, 108, 10.1038/nature08738 Boisset, 2010, In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium, Nature, 464, 116, 10.1038/nature08764 Chen, 2009, Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter, Nature, 457, 887, 10.1038/nature07619 de Bruijn, 2002, Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta, Immunity, 16, 673, 10.1016/S1074-7613(02)00313-8 Dzierzak, 2008, Of lineage and legacy: the development of mammalian hematopoietic stem cells, Nat. Immunol., 9, 129, 10.1038/ni1560 Eilken, 2009, Continuous single-cell imaging of blood generation from haemogenic endothelium, Nature, 457, 896, 10.1038/nature07760 Gekas, 2005, The placenta is a niche for hematopoietic stem cells, Dev. Cell, 8, 365, 10.1016/j.devcel.2004.12.016 Kissa, 2010, Blood stem cells emerge from aortic endothelium by a novel type of cell transition, Nature, 464, 112, 10.1038/nature08761 Kumaravelu, 2002, Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta–gonad–mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver, Development, 129, 4891, 10.1242/dev.129.21.4891 Lan, 2007, Essential role of endothelial Smad4 in vascular remodeling and integrity, Mol. Cell. Biol., 27, 7683, 10.1128/MCB.00577-07 Li, 2012, Mouse embryonic head as a site for hematopoietic stem cell development, Cell Stem Cell, 11, 663, 10.1016/j.stem.2012.07.004 Matsubara, 2005, Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development, J. Exp. Med., 202, 1483, 10.1084/jem.20051325 Medvinsky, 1996, Definitive hematopoiesis is autonomously initiated by the AGM region, Cell, 86, 897, 10.1016/S0092-8674(00)80165-8 Medvinsky, 2011, Embryonic origin of the adult hematopoietic system: advances and questions, Development, 138, 1017, 10.1242/dev.040998 Muller, 1994, Development of hematopoietic stem cell activity in the mouse embryo, Immunity, 1, 291, 10.1016/1074-7613(94)90081-7 North, 1999, Cbfa2 is required for the formation of intra-aortic hematopoietic clusters, Development, 126, 2563, 10.1242/dev.126.11.2563 North, 2002, Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo, Immunity, 16, 661, 10.1016/S1074-7613(02)00296-0 Robin, 2006, An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells, Dev. Cell, 11, 171, 10.1016/j.devcel.2006.07.002 Rybtsov, 2011, Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region, J. Exp. Med., 208, 1305, 10.1084/jem.20102419 Taoudi, 2008, Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+ CD45+ pre-definitive HSCs, Cell Stem Cell, 3, 99, 10.1016/j.stem.2008.06.004 Tober, 2013, Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells, Development, 140, 3765, 10.1242/dev.094961 Yokomizo, 2010, Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos, Development, 137, 3651, 10.1242/dev.051094 Yoshimoto, 2011, Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential, Proc. Natl. Acad. Sci. USA, 108, 1468, 10.1073/pnas.1015841108 Yoshimoto, 2012, Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence, Blood, 119, 5706, 10.1182/blood-2011-12-397489 Zovein, 2008, Fate tracing reveals the endothelial origin of hematopoietic stem cells, Cell Stem Cell, 3, 625, 10.1016/j.stem.2008.09.018