Generation and characterization of human-derived iPSC lines from two cousins with schizophrenia and bipolar disorder and their unaffected cousin

Stem Cell Research - Tập 63 - Trang 102832 - 2022
Peiyan Ni1, Chuqing Zhou1, Yajing Meng1, Rui Xue1, Xia Yang1, Lei Li1, Liansheng Zhao1, Jinxue Wei1, Rongjun Ni1, Yingcheng Wang1, Xiaohong Ma1, Wanjun Guo1, Qiang Wang1, Tao Li2,3
1The Psychiatric Laboratory and Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China
2Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang, China
3NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Tài liệu tham khảo

Kathuria, 2020, Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder, Genome Med., 12, 34, 10.1186/s13073-020-00733-6 Kloiber, 2020, Neurodevelopmental pathways in bipolar disorder, Neurosci. Biobehav. Rev., 112, 213, 10.1016/j.neubiorev.2020.02.005 Lewis, 2002, Schizophrenia as a disorder of neurodevelopment, Annu. Rev. Neurosci., 25, 409, 10.1146/annurev.neuro.25.112701.142754 Ni, 2020, iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function, Mol. Psychiatry, 25, 2873, 10.1038/s41380-019-0423-3 Yu, 2009, Human induced pluripotent stem cells free of vector and transgene sequences, Science (New York, NY), 324, 797, 10.1126/science.1172482