Gene silencing, cell fate and nuclear organisation

Nutt, 1999, Commitment to the B-lymphoid lineage depends on the transcription factor Pax5, Nature, 401, 556, 10.1038/44076 Busslinger, 2000, Lineage commitment in lymphopoiesis, Curr Opin Immunol, 12, 151, 10.1016/S0952-7915(99)00065-5 Horcher, 2001, Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis, Immunity, 14, 779, 10.1016/S1074-7613(01)00153-4 Eberhard, 2000, Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family, EMBO J, 19, 2292, 10.1093/emboj/19.10.2292 Muhr, 2001, Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube, Cell, 104, 861, 10.1016/S0092-8674(01)00283-5 Vallstedt, 2001, Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification, Neuron, 31, 743, 10.1016/S0896-6273(01)00412-3 Marquardt, 2001, Cracking the transcriptional code for cell specification in the neural tube, Cell, 106, 651, 10.1016/S0092-8674(01)00499-8 Isshiki, 2001, Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny, Cell, 106, 511, 10.1016/S0092-8674(01)00465-2 Cremer, 2001, Chromosome territories, nuclear architecture and gene regulation in mammalian cells, Nat Rev Genet, 2, 292, 10.1038/35066075 Gasser, 2001, Positions of potential: nuclear organization and gene expression, Cell, 104, 639, 10.1016/S0092-8674(01)00259-8 Spector, 2001, Nuclear domains, J Cell Sci, 114, 2891, 10.1242/jcs.114.16.2891 Festenstein, 1999, Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner, Nat Genet, 23, 457, 10.1038/70579 Francastel, 1999, A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin, Cell, 99, 259, 10.1016/S0092-8674(00)81657-8 Schubeler, 2000, Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus, Genes Dev, 14, 940, 10.1101/gad.14.8.940 Lundgren, 2000, Transcription factor dosage affects changes in higher order chromatin structure associated with activation of a heterochromatic gene, Cell, 103, 733, 10.1016/S0092-8674(00)00177-X Dernburg, 1996, Perturbation of nuclear architecture by long-distance chromosome interactions, Cell, 85, 745, 10.1016/S0092-8674(00)81240-4 Csink, 1996, Genetic modification of heterochromatic association and nuclear organization in Drosophila, Nature, 381, 529, 10.1038/381529a0 Andrulis, 1998, Perinuclear localization of chromatin facilitates transcriptional silencing, Nature, 394, 592, 10.1038/29100 Galy, 2000, Nuclear pore complexes in the organization of silent telomeric chromatin, Nature, 403, 108, 10.1038/47528 Moazed, 2001, Common themes in mechanisms of gene silencing, Mol Cell, 8, 489, 10.1016/S1097-2765(01)00340-9 Cheng, 2000, Yeast heterochromatin is a dynamic structure that requires silencers continuously, Genes Dev, 14, 452, 10.1101/gad.14.4.452 Marshall, 1996, Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster, Mol Biol Cell, 7, 825, 10.1091/mbc.7.5.825 Wilkie, 1999, Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei, Curr Biol, 9, 1263, 10.1016/S0960-9822(99)80509-0 Boyle, 2001, The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells, Hum Mol Genet, 10, 211, 10.1093/hmg/10.3.211 Bridger, 2000, Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts, Curr Biol, 10, 149, 10.1016/S0960-9822(00)00312-2 Volpi, 2000, Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei, J Cell Sci, 113, 1565, 10.1242/jcs.113.9.1565 Francastel, 2001, Nuclear relocation of a transactivator subunit precedes target gene activation, Proc Natl Acad Sci USA, 98, 12120, 10.1073/pnas.211444898 Brown, 1997, Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin, Cell, 91, 845, 10.1016/S0092-8674(00)80472-9 Brown, 1999, Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division, Mol Cell, 3, 207, 10.1016/S1097-2765(00)80311-1 Brown, 2001, Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells, Nat Cell Biol, 3, 602, 10.1038/35078577 Skok, 2001, Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes, Nat Immunol, 2, 848, 10.1038/ni0901-848 Kosak ST, Skok JA, Medina KL, Riblet R, Le Beau MM, Fisher AG, Singh H: Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 2002, in press. Reiner, 1999, Dealing from the evolutionary pawnshop: how lymphocytes make decisions, Immunity, 11, 1, 10.1016/S1074-7613(00)80076-X Grogan, 2001, Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets, Immunity, 14, 205, 10.1016/S1074-7613(01)00103-0 Georgopoulos, 1994, The Ikaros gene is required for the development of all lymphoid lineages, Cell, 79, 143, 10.1016/0092-8674(94)90407-3 Georgopoulos, 1992, Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment, Science, 258, 808, 10.1126/science.1439790 Lo, 1991, LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes, Mol Cell Biol, 11, 5229, 10.1128/MCB.11.10.5229 Kim, 1999, Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes, Immunity, 10, 345, 10.1016/S1074-7613(00)80034-5 Koipally, 2000, Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity, J Biol Chem, 275, 19594, 10.1074/jbc.M000254200 Hahm, 1998, Helios, a T cell-restricted Ikaros family member that quatitatively associates with Ikaros at centromeric heterocromatin, Genes Dev, 12, 782, 10.1101/gad.12.6.782 Ernst, 1993, Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene, Mol Cell Biol, 13, 2982, 10.1128/MCB.13.5.2982 Cobb, 2000, Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding, Genes Dev, 14, 2146, 10.1101/gad.816400 Trinh, 2001, Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator, Genes Dev, 15, 1817, 10.1101/gad.905601 Sabbattini, 2001, Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation, EMBO J, 20, 2812, 10.1093/emboj/20.11.2812 Heun, 2001, Chromosome dynamics in the yeast interphase nucleus, Science, 294, 2181, 10.1126/science.1065366 Phair, 2000, High mobility of proteins in the mammalian cell nucleus, Nature, 404, 604, 10.1038/35007077 Wijgerde, 1995, Transcription complex stability and chromatin dynamics in vivo, Nature, 377, 209, 10.1038/377209a0 Tumbar, 2001, Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator, Nat Cell Biol, 3, 134, 10.1038/35055033 Tsukamoto, 2000, Visualization of gene activity in living cells, Nat Cell Biol, 2, 871, 10.1038/35046510 Mukhopadhyay, 2001, Translocation of sigma(70) with RNA polymerase during transcription: fluorescence resonance energy transfer assay for movement relative to DNA, Cell, 106, 453, 10.1016/S0092-8674(01)00464-0