Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype

PLoS ONE - Tập 3 Số 4 - Trang e2078
Charlotte Gustafsson1, Jenny Mjösberg1, Andreas Matussek2, Robert Geffers3, Leif Matthiesen4, Göran Berg4, Surendra Sharma5,6, Jan Buer7, Jan Ernerudh1
1Division of Clinical Immunology, Unit for Autoimmunity and Immune Regulation (AIR), Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University Hospital, Linköping, Sweden
2Department of Clinical Microbiology, County Hospital Ryhov, Jönköping, Sweden
3Mucosal Immunity, Helmholtz Centre for Infection Research (HCI), Braunschweig, Germany
4Division of Gynecology and Obstetrics, Faculty of Health Sciences, University Hospital, Linköping, Sweden
5Department of Pathology, Brown University and Women and Infants' Hospital of Rhode Island, Providence, Rhode Island, United States of America
6Department of Pediatrics, Brown University and Women and Infants' Hospital of Rhode Island, Providence, Rhode Island, United States of America
7Institute of Medical Microbiology, University Hospital Essen, Essen, Germany

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LA Koopman, 2003, Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential., J Exp Med, 198, 1201, 10.1084/jem.20030305

M Stein, 1992, Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation., J Exp Med, 176, 287, 10.1084/jem.176.1.287

S Gordon, 2003, Alternative activation of macrophages., Nat Rev Immunol, 3, 23, 10.1038/nri978

S Goerdt, 1999, Other functions, other genes: alternative activation of antigen-presenting cells., Immunity, 10, 137, 10.1016/S1074-7613(00)80014-X

A Mantovani, 2004, The chemokine system in diverse forms of macrophage activation and polarization., Trends Immunol, 25, 677, 10.1016/j.it.2004.09.015

G Mor, 2003, Potential role of macrophages as immunoregulators of pregnancy., Reprod Biol Endocrinol, 1, 119, 10.1186/1477-7827-1-119

G Chaouat, 1999, Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy., Am J Reprod Immunol, 42, 1, 10.1111/j.1600-0897.1999.tb00459.x

GP Sacks, 2001, Flow cytometric measurement of intracellular Th1 and Th2 cytokine production by human villous and extravillous cytotrophoblast., Placenta, 22, 550, 10.1053/plac.2001.0686

C Lidström, 2003, Cytokine secretion patterns of NK cells and macrophages in early human pregnancy decidua and blood: implications for suppressor macrophages in decidua., Am J Reprod Immunol, 50, 444, 10.1046/j.8755-8920.2003.00112.x

C Gustafsson, 2006, Cytokine secretion in decidual mononuclear cells from term human pregnancy with or without labour: ELISPOT detection of IFN-gamma, IL-4, IL-10, TGF-beta and TNF-alpha., J Reprod Immunol, 71, 41, 10.1016/j.jri.2005.12.009

GB Dealtry, 1998, Expression and localization of the Th2-type cytokine interleukin-13 and its receptor in the placenta during human pregnancy., Am J Reprod Immunol, 40, 283, 10.1111/j.1600-0897.1998.tb00419.x

L Rieger, 2002, Th1- and Th2-like cytokine production by first trimester decidual large granular lymphocytes is influenced by HLA-G and HLA-E., Mol Hum Reprod, 8, 255, 10.1093/molehr/8.3.255

M Brown, 2004, Correlation of human decidual and cord blood mononuclear cell cytokine production., Hum Immunol, 65, 1336, 10.1016/j.humimm.2004.08.176

I Roth, 1996, Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10., J Exp Med, 184, 539, 10.1084/jem.184.2.539

N Hanna, 2000, Gestational age-dependent expression of IL-10 and its receptor in human placental tissues and isolated cytotrophoblasts., J Immunol, 164, 5721, 10.4049/jimmunol.164.11.5721

B Mues, 1989, Phenotypic characterization of macrophages in human term placenta., Immunology, 67, 303

JS Hunt, 1992, Macrophages in the uterus and placenta., Curr Top Microbiol Immunol, 181, 39

K Cupurdija, 2004, Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation., Am J Reprod Immunol, 51, 117, 10.1046/j.8755-8920.2003.00128.x

J Heikkinen, 2003, Phenotypic characterization of human decidual macrophages., Clin Exp Immunol, 131, 498, 10.1046/j.1365-2249.2003.02092.x

RS Parhar, 1988, Suppression of lymphocyte alloreactivity by early gestational human decidua. I. Characterization of suppressor cells and suppressor molecules., Cell Immunol, 116, 392, 10.1016/0008-8749(88)90240-7

M Mizuno, 1994, Functions of macrophages in human decidual tissue in early pregnancy., Am J Reprod Immunol, 31, 180, 10.1111/j.1600-0897.1994.tb00865.x

FO Martinez, 2006, Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression., J Immunol, 177, 7303, 10.4049/jimmunol.177.10.7303

S Hashimoto, 2003, Lipopolysaccharide-inducible gene expression profile in human monocytes., Scand J Infect Dis, 35, 619, 10.1080/00365540310015926

E Volpe, 2006, Gene expression profiling of human macrophages at late time of infection with Mycobacterium tuberculosis., Immunology, 118, 449, 10.1111/j.1365-2567.2006.02378.x

V Kodelja, 1998, Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern., J Immunol, 160, 1411, 10.4049/jimmunol.160.3.1411

A Puig-Kröger, 2004, Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages., J Biol Chem, 279, 25680, 10.1074/jbc.M311516200

G Laskarin, 2005, The presence of functional mannose receptor on macrophages at the maternal-fetal interface., Hum Reprod, 20, 1057, 10.1093/humrep/deh740

MR Burk, 2001, Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae., Placenta, 22, 309, 10.1053/plac.2001.0624

EJ Soilleux, 2002, Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro., J Leukoc Biol, 71, 445, 10.1189/jlb.71.3.445

U Kämmerer, 2003, Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy., Am J Pathol, 162, 887, 10.1016/S0002-9440(10)63884-9

DA Clark, 2003, Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2)., Am J Reprod Immunol, 50, 187, 10.1034/j.1600-0897.2003.00086.x

D Bruder, 2004, Neuropilin-1: a surface marker of regulatory T cells., Eur J Immunol, 34, 623, 10.1002/eji.200324799

IR Turnbull, 2006, Cutting edge: TREM-2 attenuates macrophage activation., J Immunol, 177, 3520, 10.4049/jimmunol.177.6.3520

NA Begum, 2004, Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages., Infect Immun, 72, 937, 10.1128/IAI.72.2.937-948.2004

JA Hamerman, 2006, Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12., J Immunol, 177, 2051, 10.4049/jimmunol.177.4.2051

K Takahashi, 2005, Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2., J Exp Med, 201, 647, 10.1084/jem.20041611

AW van Lieshout, 2006, Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid., BMC Immunol, 7, 23, 10.1186/1471-2172-7-23

KW Marvin, 2002, Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm., Mol Hum Reprod, 8, 399, 10.1093/molehr/8.4.399

C Daly, 2003, Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies., Microcirculation, 10, 247, 10.1080/mic.10.3-4.247.257

WK Ip, 2006, Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways., Clin Exp Immunol, 145, 162, 10.1111/j.1365-2249.2006.03085.x

S Saito, 2002, Prostaglandin D2 and reproduction., Am J Reprod Immunol, 47, 295, 10.1034/j.1600-0897.2002.01113.x

DH Munn, 1998, Prevention of allogeneic fetal rejection by tryptophan catabolism., Science, 281, 1191, 10.1126/science.281.5380.1191

P Terness, 2007, Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells., Am J Reprod Immunol, 58, 238, 10.1111/j.1600-0897.2007.00510.x

C Tayade, 2005, Functions of alpha 2 macroglobulins in pregnancy., Mol Cell Endocrinol, 245, 60, 10.1016/j.mce.2005.10.004

SS Larin, 2002, Binding of alpha2-macroglobulin to collagen type I: modification of collagen matrix by alpha2-macroglobulin induces the enhancement of macrophage migration., Russ J Immunol, 7, 34

NR Nayak, 2003, Comparative biology of the IGF system in endometrium, decidua, and placenta, and clinical implications for foetal growth and implantation disorders., Placenta, 24, 281, 10.1053/plac.2002.0906

V Kodelja, 1997, Differences in angiogenic potential of classically vs alternatively activated macrophages., Immunobiology, 197, 478, 10.1016/S0171-2985(97)80080-0

U Kämmerer, 2005, Antigen-presenting cells in the decidua., Chem Immunol Allergy, 89, 96, 10.1159/000087951

DL Cheung, 1992, Regulation of human monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate., Blood, 79, 1972, 10.1182/blood.V79.8.1972.1972

RJ Bischof, 2000, Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation., Clin Exp Immunol, 119, 361, 10.1046/j.1365-2249.2000.01125.x

RD Stout, 2004, Functional plasticity of macrophages: reversible adaptation to changing microenvironments., J Leukoc Biol, 76, 509, 10.1189/jlb.0504272

K Takabayshi, 2006, Induction of a homeostatic circuit in lung tissue by microbial compounds., Immunity, 24, 475, 10.1016/j.immuni.2006.02.008

CE Lewis, 2006, Distinct role of macrophages in different tumor microenvironments., Cancer Res, 66, 605, 10.1158/0008-5472.CAN-05-4005

S Rutella, 2006, Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features., Blood, 108, 218, 10.1182/blood-2005-08-3141

S Aoki, 1998, Decreased maternal circulating hepatocyte growth factor (HGF) concentrations in pregnancies with small for gestational age infants., Hum Reprod, 13, 2950, 10.1093/humrep/13.10.2950

C Baykal, 2005, Expression of hepatocyte growth factor/scatter factor receptor in IUGR fetuses' placentas: an immunohistochemical analysis., Fetal Diagn Ther, 20, 249, 10.1159/000085079

K Furugori, 1997, Levels of hepatocyte growth factor and its messenger ribonucleic acid in uncomplicated pregnancies and those complicated by preeclampsia., J Clin Endocrinol Metab, 82, 2726

SK Watkins, 2007, IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo., J Immunol, 178, 1357, 10.4049/jimmunol.178.3.1357

T Gabinskaya, 1998, Gestational age-dependent extravillous cytotrophoblast osteopontin immunolocalization differentiates between normal and preeclamptic pregnancies., Am J Reprod Immunol, 40, 339, 10.1111/j.1600-0897.1998.tb00063.x

M Coolman, 2007, Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism Mitigates Preeclampsia., Placenta, 28, 709, 10.1016/j.placenta.2006.06.017