Gender and oncology: Pathological observations

memo - Magazine of European Medical Oncology - Tập 4 - Trang 236-240 - 2012
W. Sterlacci1, R. Stockinger1, M. Fiegl2
1University Teaching Hospital Feldkirch, Institute for Pathology, Feldkirch, Austria
2Department of Internal Medicine, Hematology and Oncology, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria

Tóm tắt

Sex differences concerning incidence, risk factors, morphology and prognosis have been encountered in a variety of non-sex specific neoplasms. However, the reason for such disparities is usually not apparent. Therefore, gender aspects should be actively identified and analyzed in future studies to gain further insight and achieve potential practical benefits. This review briefly presents tumour entities commonly associated with apparent differences between women and men. Possible causes for this phenomenon are outlined and discussed.

Tài liệu tham khảo

Cheng YW, Hsieh LL, Lin PP, et al. Gender difference in DNA adduct levels among nonsmoking lung cancer patients. Environ Mol Mutagen, 37: 304–10, 2001 Kilfoy BA, Devesa SS, Ward MH, et al. Gender is an age-specific effect modifier for papillary cancers of the thyroid gland. Cancer Epidemiol Biomarkers Prev, 18: 1092–1100, 2009 Rahbari R, Zhang L, Kebebew E. Thyroid cancer gender disparity. Future Oncol, 6: 1771–9, 2010 Glinoer D. Maternal and neonatal thyroid function in mild iodine deficiency. In: Nauman J, Glinoer D, Braverman LE, Hostalek U, editors. The thyroid and iodine. Stuttgart: Schattauer 1996. pp. 129–43 Nadler NJ, Mandavia M, Goldberg M. The effect of hypophysectomy on the experimental production of rat thyroid neoplasms. Cancer Res, 30: 1909–11, 1970 Kumar H, Daykin J, Holder R, et al. Gender, clinical findings, and serum thyrotropin measurements in the prediction of thyroid neoplasia in 1005 patients presenting with thyroid enlargement and investigated by fine-needle aspiration cytology. Thyroid, 9: 1105–9, 1999 Moore R, Doherty D, Chamberlain R, et al. Sex differences in survival in non-small cell lung cancer patients 1974–1998. Acta Oncol, 43: 57–64, 2004 Kirsch MM, Tashian J, Sloan H. Carcinoma of the lung in women. Ann Thorac Surg, 34: 34–9, 1982 Hsu LH, Chu NM, Liu CC, et al. Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor? Lung Cancer, 66: 262–7, 2009 Paggi MG, Vona R, Abbruzzese C, et al. Gender-related disparities in non-small cell lung cancer. Cancer Lett, 298: 1–8, 2010 Kiyohara C, Ohno Y. Sex differences in lung cancer susceptibility: a review. Gend Med, 7: 381–401, 2010 Sterlacci W, Tzankov A, Veits L, et al. The prognostic impact of sex on surgically resected non-small cell lung cancer depends on clinicopathologic characteristics. Am J Clin Pathol, 135: 611–8, 2011 Fentiman IS, Fourquet A, Hortobagyi GN. Male breast cancer. Lancet, 367: 595–604, 2006 Giordano SH, Cohen DS, Buzdar AU, et al. Breast carcinoma in men: a population-based study. Cancer, 101: 51–7, 2004 Thomas DB, Jimenez LM, McTiernan A, et al. Breast cancer in men: risk factors with hormonal implications. Am J Epidemiol, 135: 734–48, 1992 Martin AM, Weber BL. Genetic and hormonal risk factors in breast cancer. J Natl Cancer Inst, 92: 1126–35, 2000 Muir D, Kanthan R, Kanthan SC. Male versus female breast cancers. A population-based comparative immunohistochemical analysis. Arch Pathol Lab Med, 127: 36–41, 2003 Borgen PI, Senie RT, McKinnon WM, et al. Carcinoma of the male breast: analysis of prognosis compared with matched female patients. Ann Surg Oncol, 4: 385–8, 1997 Anderson WF, Althuis MD, Brinton LA, et al. Is male breast cancer similar or different than female breast cancer? Breast Cancer Res Treat, 83: 77–86, 2004 Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol, 19: 3622–34, 2001 Lasithiotakis K, Leiter U, Meier F, et al. Age and gender are significant independent predictors of survival in primary cutaneous melanoma. Cancer, 112: 1795–804, 2008 Quaglia A, Capocaccia R, Micheli A, et al. A wide difference in cancer survival between middle aged and elderly patients in Europe. Int J Cancer, 120: 2196–201, 2007 Agarwala S, Ferri W, Gooding W, et al. A phase III randomized trial of dacarbazine and carboplatin with and without tamoxifen in the treatment of patients with metastatic melanoma. Cancer, 85: 1979–84, 1999 Diehl LF, Karnell LH, Menck HR. The American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia. Cancer, 86: 2684–92, 1999 Doubek M, Mayer J, Obrtlíková P, et al. Modern and conventional prognostic markers of chronic lymphocytic leukemia (CLL) in the everyday hematological practice. Eur J Haematol, 2011; in press Morton LM, Wang SS, Devesa SS, et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood, 107: 265–76, 2006 Mitterlechner T, Fiegl M, Mühlböck H, et al. Epidemiology of non-Hodgkin lymphomas in Tyrol/Austria from 1991 to 2000. J Clin Pathol, 59: 48–55, 2006 El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132: 2557–76, 2007 Shimizu I. Impact of oestrogens on the progression of liver disease. Liver Int, 23: 63–9, 2003 Nagasue N, Kohno H, Chang YC, et al. Androgen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in women. Cancer, 63: 112–6, 1989 De Maria N, Manno M, Villa E. Sex hormones and liver cancer. Mol Cell Endocrinol 193: 59–63, 2002 Shimizu I, Yasuda M, Mizobuchi Y, et al. Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats. Gut 42: 112–9, 1998 Bluteau O, Jeannot E, Bioulac-Sage P, et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet, 32: 312–5, 2002 Bioulac-Sage P, Balabaud C, Zucman-Rossi J. Subtype classification of hepatocellular adenoma. Dig Surg, 27: 39–45, 2010 Ries LA, Wingo PA, Miller DS, et al. The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer, 88: 2398–424, 2000 Murphy G, Devesa SS, Cross AJ, et al. Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer, 128: 1668–75, 2011 Grodstein F, Newcomb PA, Stampfer MJ. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am J Med, 106: 574–82, 1999 Franceschi S, Gallus S, Talamini R, et al. Menopause and colorectal cancer. Br J Cancer, 82: 1860–2, 2000 Murillo-Ortiz B, Perez-Luque E, Malacara JM, et al. Expression of Estrogen Receptor Alpha and Beta in Breast Cancers of Pre- and Postmenopausal Women. Pathol Oncol Res, 14: 435–42, 2008 Foley EF, Jazaeri AA, Shupnik MA, et al. Selective loss of estrogen receptor beta in malignant human colon. Cancer Res, 60: 245–8, 2000 Press OA, Zhang W, Gordon MA, et al. Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res, 68: 3037–42, 2008 Micheli A, Ciampichini R, Oberaigner W, et al. The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer, 45: 1017–27, 2009 Oertelt-Prigione S, Parol R, Krohn S, et al. Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines. BMC Med, 8: 70, 2010