Gas chromatographic/mass spectrometric determination of mono- and dioctyltinchloride in aqueous solutions and biological samples
Tóm tắt
A gas chromatographic/mass spectrometric method is described for the determination of mono- and dioctyltinchloride (MOTC and DOTC). Quantitative extraction from aqueous solutions was obtained with diethyl ether at pH=2. Several derivatization methods were tested. Grignard butylation in closed systems was most efficient. In the selected ion monitoring mode, the detection limits were 5 ng/ml for MOTC and 50 ng/ml for DOTC with a mean coefficient of variation of approximately 15%. Calibrations from different matrices were performed, e.g. from water, hepatocyte suspensions, urine and feces. The water solubility of DOTC was determined as 0.7 mg/l.
Tài liệu tham khảo
J.W. Burley, Appl. Organomet. Chem.1, 95–113 (1987).
H. A. Müller, Dtsch. Lebensm.-Rdsch.83, 382–385 (1987).
M. D. Müller, Anal. Chem.59, 617–623 (1987).
H. A. Meinema, T. Burger-Wiersma, G. Verslius-de Haan, E.C. Gevers, Environ. Sci. Techn.12, 288–293 (1978).
A. W. Varnes, V. Fran Gaylor, Anal. Chim. Acta101, 393–399 (1978).
G. Hennighausen, U. Karnstedt, P. Lange, Pharmazie (GDR36, 710–711 (1981).
G. Neubert, H. O. Wirth, Z. Anal. Chem.273, 19–23 (1975)
K. Figge, J. Koch, H. Lubba, J. Chromatogr.131, 317–327 (1977).
G. J. M. van der Kerk, J. G. A. Luijten, J. Appl. Chem.7, 369–374 (1957).
K. G. Steinhäuser, W. Amann, A. Späth, A. Polenz, Vor Wasser65, 203–214 (1985).
own unpublished results, 1988.
A. H. Penninks, L. Hilgers, W. Seinen, Toxicology44, 107–120 (1987).