Gamma Band Neural Stimulation in Humans and the Promise of a New Modality to Prevent and Treat Alzheimer’s Disease

Reitz, 2011, Epidemiology of Alzheimer disease, Nat Rev Neurol, 7, 137, 10.1038/nrneurol.2011.2

Scheltens, 2016, Alzheimer’s disease, Lancet, 388, 505, 10.1016/S0140-6736(15)01124-1

Kumar, 2015, A review on Alzheimer’s disease pathophysiology and its management: An update, Pharmacol Rep, 67, 195, 10.1016/j.pharep.2014.09.004

National Institute for Health and Care Excellence. Dementia assessment and diagnosis, https://pathways.nice.org.uk/pathways/dementia/dementia-assessment-and-diagnosis. Accessed on February 28, 2018.

McKhann, 1984, Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease, Neurology, 34, 939, 10.1212/WNL.34.7.939

McKhann, 2011, The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease, Alzheimers Dement, 7, 263, 10.1016/j.jalz.2011.03.005

Johnson, 2012, Brain imaging in Alzheimer disease, Cold Spring Harb Perspect Med, 2, a006213, 10.1101/cshperspect.a006213

Iverson, 2010, Practice Parameter update: Evaluation and management of driving risk in dementia: Report of the Quality Standards Subcommittee of the American Academy of Neurology, Neurology, 74, 1316, 10.1212/WNL.0b013e3181da3b0f

Rayment, 2016, Neuroimaging in dementia: An update for the general clinician: Neuroimaging in dementia, Prog Neurol Psychiatry, 20, 16, 10.1002/pnp.420

Kepp, 2016, Alzheimer’s disease due to loss of function: A new synthesis of the available data, Prog Neurobiol, 143, 36, 10.1016/j.pneurobio.2016.06.004

Coppola, 2015, Optical coherence tomography in Alzheimer’s disease: A meta-analysis, PLoS One, 10, e0134750, 10.1371/journal.pone.0134750

Shah, 2017, Beta-amyloid sequelae in the eye: A critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease, Mol Psychiatry, 22, 353, 10.1038/mp.2016.251

Ovod, 2017, Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimers Dement, 13, 841, 10.1016/j.jalz.2017.06.2266

Nakamura, 2018, High performance plasma amyloid-β biomarkers for Alzheimer’s disease, Nature, 554, 249, 10.1038/nature25456

National Institute for Health and Care Excellence, Dementia overview, 2018

de Bruijn, 2015, The potential for prevention of dementia across two decades: The prospective, population-based Rotterdam Study, BMC Med, 13, 132, 10.1186/s12916-015-0377-5

Kurz, 2011, Novel insights for the treatment of Alzheimer’s disease, Prog Neuropsychopharmacol Biol Psychiatry, 35, 373, 10.1016/j.pnpbp.2010.07.018

Fitzgibbon, 2004, Cognitive tasks augment gamma EEG power, Clin Neurophysiol, 115, 1802, 10.1016/j.clinph.2004.03.009

Iaccarino, 2016, Gamma frequency entrainment attenuates amyloid load and modifies microglia, Nature, 540, 230, 10.1038/nature20587

Hardy, 2002, The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994

Hardy, 2009, The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal: Amyloid hypothesis for Alzheimer’s disease, J Neurochem, 110, 1129, 10.1111/j.1471-4159.2009.06181.x

Huang, 2011, Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer’s disease: Lessons from ApoE mouse models, Biochem Soc Trans, 39, 924, 10.1042/BST0390924

Maccioni, 2010, The revitalized tau hypothesis on Alzheimer’s disease, Arch Med Res, 41, 226, 10.1016/j.arcmed.2010.03.007

Kametani, 2018, Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer’s disease, Front Neurosci, 12, 25, 10.3389/fnins.2018.00025

Lambracht-Washington, 2013, Advances in the development of vaccines for Alzheimer’s disease, Discov Med, 15, 319

Mo, 2017, Efficacy and safety of anti-amyloid- β immunotherapy for Alzheimer’s disease: A systematic review and network meta-analysis, Ann Clin Transl Neurol, 4, 931, 10.1002/acn3.469

Francis, 1999, The cholinergic hypothesis of Alzheimer’s disease: A review of progress, J Neurol Neurosurg Psychiatry, 67, 558, 10.1136/jnnp.67.4.558

McGeer, 2013, The amyloid cascade-inflammatory hypothesis of Alzheimer disease: Implications for therapy, Acta Neuropathol (Berl), 126, 479, 10.1007/s00401-013-1177-7

Sampson, 2014, Metal protein attenuating compounds for the treatment of Alzheimer’s dementia, Cochrane Database Syst Rev, CD005380

Pisa, 2015, Different brain regions are infected with fungi in Alzheimer’s disease, Sci Rep, 5, 15015, 10.1038/srep15015

de la Monte, 2008, Alzheimer’s disease is type 3 diabetes— evidence reviewed, J Diabetes Sci Technol, 2, 1101, 10.1177/193229680800200619

de la Monte, 2017, Insulin resistance and neurodegeneration: Progress towards the development of new therapeutics for Alzheimer’s disease, Drugs, 77, 47, 10.1007/s40265-016-0674-0

McShane, 2006, Memantine for dementia, Cochrane Database Syst Rev, CD003154

Bush, 2008, Therapeutics for Alzheimer’s disease based on the metal hypothesis, Neurotherapeutics, 5, 421, 10.1016/j.nurt.2008.05.001

Teplan, 2002, Fundamentals of EEG measurement, Meas Sci Rev, 2, 11

Palop, 2016, Network abnormalities and interneuron dysfunction in Alzheimer disease, Nat Rev Neurosci, 17, 777, 10.1038/nrn.2016.141

Herrmann, 2005, Human EEG gamma oscillations in neuropsychiatric disorders, Clin Neurophysiol, 116, 2719, 10.1016/j.clinph.2005.07.007

Kepecs, 2014, Interneuron cell types are fit to function, Nature, 505, 318, 10.1038/nature12983

Chen, 2012, A dynamic causal model for evoked and induced responses, Neuroimage, 59, 340, 10.1016/j.neuroimage.2011.07.066

Tallon-Baudry, 1999, Oscillatory gamma activity in humans and its role in object representation, Trends Cogn Sci, 3, 151, 10.1016/S1364-6613(99)01299-1

David, 2006, Mechanisms of evoked and induced responses in MEG/EEG, Neuroimage, 31, 1580, 10.1016/j.neuroimage.2006.02.034

Lopes, 2013, EEG and MEG: Relevance to neuroscience, Neuron, 80, 1112, 10.1016/j.neuron.2013.10.017

Galambos, 1981, A 40-Hz auditory potential recorded from the human scalp, Proc Natl Acad Sci U S A, 78, 2643, 10.1073/pnas.78.4.2643

Pantev, 1996, Tonotopic organization of the sources of human auditory steady-state responses, Hear Res, 101, 62, 10.1016/S0378-5955(96)00133-5

Plack, 2005, Pitch, 10.1007/0-387-28958-5

Ross, 2000, A high-precision magnetoencephalographic study of human auditory steady-state responses to amplitude-modulated tones, J Acoust Soc Am, 108, 679, 10.1121/1.429600

Pastor, 2002, Activation of human cerebral and cerebellar cortex by auditory stimulation at 40 Hz, J Neurosci, 22, 10501, 10.1523/JNEUROSCI.22-23-10501.2002

Herrmann, 2001, Human EEG responses to 1-100 Hz flicker: Resonance phenomena in visual cortex and their potential correlation to cognitive phenomena, Exp Brain Res, 137, 346, 10.1007/s002210100682

Artieda, 2004, Potentials evoked by chirp-modulated tones: A new technique to evaluate oscillatory activity in the auditory pathway, Clin Neurophysiol, 115, 699, 10.1016/j.clinph.2003.10.021

Becher, 2015, Intracranial electroencephalography power and phase synchronization changes during monaural and binaural beat stimulation, Eur J Neurosci, 41, 254, 10.1111/ejn.12760

Kuwada, 1979, Response of cat inferior colliculus neurons to binaural beat stimuli: Possible mechanisms for sound localization, Science, 206, 586, 10.1126/science.493964

Picton, 2003, Human auditory steady-state responses: Respuestas auditivas de estado estable en humanos, Int J Audiol, 42, 177, 10.3109/14992020309101316

Moore, 2013, Parvalbumin-expressing inhibitory interneurons in auditory cortex are well-tuned for frequency, J Neurosci, 33, 13713, 10.1523/JNEUROSCI.0663-13.2013

Fell, 2011, The role of phase synchronization in memory processes, Nat Rev Neurosci, 12, 105, 10.1038/nrn2979

Uhlhaas, 2006, Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology, Neuron, 52, 155, 10.1016/j.neuron.2006.09.020

Voicikas, 2016, Effect of attention on 40 Hz auditory steady-state response depends on the stimulation type: Flutter amplitude modulated tones versus clicks, Neurosci Lett, 629, 215, 10.1016/j.neulet.2016.07.019

Schulze, 1989, The perception of temporal deviations in isochronic patterns, Percept Psychophys, 45, 291, 10.3758/BF03204943

O’Donnell, 2013, The auditory steady-state response (ASSR): A translational biomarker for schizophrenia, Suppl Clin Neurophysiol, 62, 101, 10.1016/B978-0-7020-5307-8.00006-5

McFadden, 2014, Test-retest reliability of the 40 Hz EEG auditory steady-state response, PLoS One, 9, e85748, 10.1371/journal.pone.0085748

Light, 2006, Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients, Biol Psychiatry, 60, 1231, 10.1016/j.biopsych.2006.03.055

John, 2002, Auditory steady-state responses to exponential modulation envelopes, Ear Hear, 23, 106, 10.1097/00003446-200204000-00004

Rauschecker, 1998, Cortical processing of complex sounds, Curr Opin Neurobiol, 8, 516, 10.1016/S0959-4388(98)80040-8

Griskova-Bulanova, 2018, 40 Hz auditory steady-state response in schizophrenia: Sensitivity to stimulation type (clicks versus flutter amplitude-modulated tones), Neurosci Lett, 662, 152, 10.1016/j.neulet.2017.10.025

Miyazaki, 2013, Sound envelope encoding in the auditory cortex revealed by neuromagnetic responses in the theta to gamma frequency bands, Brain Res, 1506, 64, 10.1016/j.brainres.2013.01.047

Lutzenberger, 1995, Visual stimulation alters local 40-Hz responses in humans: An EEG-study, Neurosci Lett, 183, 39, 10.1016/0304-3940(94)11109-V

Lutzenberger, 1994, Words and pseudowords elicit distinct patterns of 30-Hz EEG responses in humans, Neurosci Lett, 176, 115, 10.1016/0304-3940(94)90884-2

Tallon-Baudry, 1996, Stimulus specificity of phase-locked and non-phase-locked 40 Hz visual responses in human, J Neurosci, 16, 4240, 10.1523/JNEUROSCI.16-13-04240.1996

Pokorny, 2014, A tactile stimulation device for EEG measurements in clinical use, IEEE Trans Biomed Circuits Syst, 8, 305, 10.1109/TBCAS.2013.2270176

Muller-Putz, 2006, Steady-state somatosensory evoked potentials: Suitable brain signals for brain– computer interfaces?, IEEE Trans Neural Syst Rehabil Eng, 14, 30, 10.1109/TNSRE.2005.863842

Kübler, 2009, A Brain-computer interface controlled auditory event-related potential (P300) spelling system for locked-in patients, Ann N Y Acad Sci, 1157, 90, 10.1111/j.1749-6632.2008.04122.x

Jamali, 2014, Sustained changes in somatosensory gamma responses after brief vibrotactile stimulation:, Neuroreport, 25, 537, 10.1097/WNR.0000000000000133

Giabbiconi, 2007, Sustained spatial attention to vibration is mediated in primary somatosensory cortex, Neuroimage, 35, 255, 10.1016/j.neuroimage.2006.11.022

Severens, 2010, Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition, Clin Neurophysiol, 121, 2090, 10.1016/j.clinph.2010.05.016

Kandel, 2013, Principles of neural science

Herrmann, 2013, Transcranial alternating current stimulation: A review of the underlying mechanisms and modulation of cognitive processes, Front Hum Neurosci, 7, 279, 10.3389/fnhum.2013.00279

Kanai, 2010, Transcranial alternating current stimulation (tACS) modulates cortical excitability as assessed by TMS-induced phosphene thresholds, Clin Neurophysiol, 121, 1551, 10.1016/j.clinph.2010.03.022

Laczó, 2012, Transcranial alternating stimulation in a high gamma frequency range applied over V1 improves contrast perception but does not modulate spatial attention, Brain Stimulat, 5, 484, 10.1016/j.brs.2011.08.008

Strüber, 2014, Antiphasic 40 Hz oscillatory current stimulation affects bistable motion perception, Brain Topogr, 27, 158, 10.1007/s10548-013-0294-x

Marshall, 2006, Boosting slow oscillations during sleep potentiates memory, Nature, 444, 610, 10.1038/nature05278

Kirov, 2009, Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding, Proc Natl Acad Sci U S A, 106, 15460, 10.1073/pnas.0904438106

Ross, 2005, Stimulus induced desynchronization of human auditory 40-Hz steady-state responses, J Neurophysiol, 94, 4082, 10.1152/jn.00469.2005

DeLosAngeles, 2010, Eletroencephalographic, Cognitive and Autonomic Correlates of States of Concentrative Meditation

Kösem, 2014, Encoding of event timing in the phase of neural oscillations, Neuroimage, 92, 274, 10.1016/j.neuroimage.2014.02.010

Fitzgibbon, 2016, Automatic determination of EMG-contaminated components and validation of independent component analysis using EEG during pharmacologic paralysis, Clin Neurophysiol, 127, 1781, 10.1016/j.clinph.2015.12.009

Bertrand, 2000, Oscillatory gamma activity in humans: A possible role for object representation, Int J Psychophysiol, 38, 211, 10.1016/S0167-8760(00)00166-5

Buzsáki, 2006, Rhythms of the brain, 10.1093/acprof:oso/9780195301069.001.0001

Goncharova, 2003, EMG contamination of EEG: Spectral and topographical characteristics, Clin Neurophysiol, 114, 1580, 10.1016/S1388-2457(03)00093-2

Mirzadeh, 2016, The rationale for deep brain stimulation in Alzheimer’s disease, J Neural Transm, 123, 775, 10.1007/s00702-015-1462-9

Fraser, 2002, Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury, Neuron, 34, 831, 10.1016/S0896-6273(02)00705-5

Silva, 2015, Stimulation by light and sound: Therapeutics effects in humans. Systematic Review, Clin Pract Epidemiol Ment Health, 11, 150, 10.2174/1745017901511010150

Vieira, 2008, Efeitos de urn programa conjugado da metodologia de luz e som e prdtica motriz complexa em funcoes de memoria em individuos portadores da doenca de Alzheimer: Relacdes com hemisfericidade

Clements-Cortes, 2016, Short-term effects of rhythmic sensory stimulation in Alzheimer’s disease: An exploratory pilot study, J Alzheimers Dis, 52, 651, 10.3233/JAD-160081

Ribary, 1991, Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans, Proc Natl Acad Sci U S A, 88, 11037, 10.1073/pnas.88.24.11037

Llinas, 1993, Coherent 40-Hz oscillation characterizes dream state in humans, Proc Natl Acad Sci U S A, 90, 2078, 10.1073/pnas.90.5.2078

Next Wave Headquarters, Next Wave Physioacoustic MX therapy chair. http://www.nextwaveworldwide.com/%20products/physioacoustic-mx-therapy-chair/ Accessed on March 24. 2018.

Tariq, 2006, Comparison of the Saint Louis University Mental Status Examination and the Mini-Mental State Examination for detecting dementia and mild neurocognitive disorder— a pilot study, Am J Geriatr Psychiatry, 14, 900, 10.1097/01.JGP.0000221510.33817.86

Clements-Cortes, 2017, Can rhythmic sensory stimulation decrease cognitive decline in Alzheimer’s disease?: A clinical case study, Music Med, 9, 174, 10.47513/mmd.v9i3.565

Clements-Cortes, 2017, The potential of rhythmic sensory stimulation treatments for persons with Alzheimer’s disease, Music Med, 9, 167, 10.47513/mmd.v9i3.536

Punkanen, 2012, Contemporary vibroacoustic therapy: Perspectives on clinical practice, research, and training, Music Med, 4, 128, 10.1177/1943862112445324

Bartel, 2017, Vibroacoustic stimulation and brain oscillation: From basic research to clinical application, Music Med, 9, 153, 10.47513/mmd.v9i3.542

Naro, 2016, Promising role of neuromodulation in predicting the progression of mild cognitive impairment to dementia, J Alzheimers Dis, 53, 1375, 10.3233/JAD-160305

Hugo, 2014, Dementia and cognitive impairment, Clin Geriatr Med, 30, 421, 10.1016/j.cger.2014.04.001

Calomeni, 2017, Modulatory effect of association of brain stimulation by light and binaural beats in specific brain waves, Clin Pract Epidemiol Ment Health, 13, 134, 10.2174/1745017901713010134

Basar, 2017, Increased long distance event-related gamma band connectivity in Alzheimer’s disease, Neuroimage Clin, 14, 580, 10.1016/j.nicl.2017.02.021

Rossini, 2006, Conversion from mild cognitive impairment to Alzheimer’s disease is predicted by sources and coherence of brain electroencephalography rhythms, Neuroscience, 143, 793, 10.1016/j.neuroscience.2006.08.049

van Deursen, 2011, 40-Hz steady state response in Alzheimer’s disease and mild cognitive impairment, Neurobiol Aging, 32, 24, 10.1016/j.neurobiolaging.2009.01.002

Wilson, 2018, Brainwave therapy for Alzheimer’s. Can flickering lights, low hums and vibrating pads zap brain plaques, New Sci, 237, 6, 10.1016/S0262-4079(18)30543-8

CLS (Coalition for the Life Sciences), Shining a Light on the Treatment of Alzheimer's Disease. https://www.coalitionforlifesciences.org/shining-light-treatment-alzheimers-disease/. Accessed on June 5, 2018.

Neuroscience 2017, November 11-15, Washington, DC. Society for Neuroscience, Advancing the Understanding of the Brain and Nervous System, Last updated April 1. 2018. Accessed on April 1, 2018.

Cognito Therapeutics. https://www.cognitotx.com/. Accessed on April 1, 2018.

Freund, 2009, Cognitive functions in a patient with Parkinson-Dementia syndrome undergoing deep brain stimulation, Arch Neurol, 66, 781, 10.1001/archneurol.2009.102

Kuhn, 2015, Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia, Mol Psychiatry, 20, 353, 10.1038/mp.2014.32

Hamani, 2011, Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone, Exp Neurol, 232, 100, 10.1016/j.expneurol.2011.08.023

Laxton, 2010, A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease, Ann Neurol, 68, 521, 10.1002/ana.22089

Sankar, 2015, Deep brain stimulation influences brain structure in Alzheimer’s disease, Brain Stimulat, 8, 645, 10.1016/j.brs.2014.11.020

Solito, 2012, Microglia function in Alzheimer’s disease, Front Pharmacol, 3, 14, 10.3389/fphar.2012.00014

Striano, 2012, Reflex seizures and reflex epilepsies: Old models for understanding mechanisms of epileptogenesis, Epilepsy Res, 100, 1, 10.1016/j.eplepsyres.2012.01.013

Stam, 2002, Generalized synchronization of MEG recordings in Alzheimer’s disease: Evidence for involvement of the gamma band, J Clin Neurophysiol, 19, 562, 10.1097/00004691-200212000-00010

Koenig, 2005, Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment, Neurobiol Aging, 26, 165, 10.1016/j.neurobiolaging.2004.03.008

Stam, 2006, Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer’s disease, Neuroimage, 32, 1335, 10.1016/j.neuroimage.2006.05.033

Wang, 2017, Enhanced gamma activity and cross-frequency interaction of resting-state electroencephalographic oscillations in patients with Alzheimer’s disease, Front Aging Neurosci, 9, 243, 10.3389/fnagi.2017.00243

van Deursen, 2008, Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment, J Neural Transm, 115, 1301, 10.1007/s00702-008-0083-y