Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Tập 1874 Số 1 - Trang 188381 - 2020
Elham Hatami1, Meena Jaggi2,1,3, Subhash C. Chauhan2,1,3, Murali M. Yallapu2,1,3
1Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA
2Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA
3South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA

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Siegel, 2020, Cancer statistics, 2020, CA Cancer J Clin, 70, 7, 10.3322/caac.21590

Dias, 2012, A historical overview of natural products in drug discovery, Metabolites, 2, 303, 10.3390/metabo2020303

Nobili, 2009, Natural compounds for cancer treatment and prevention, Pharmacol Res, 59, 365, 10.1016/j.phrs.2009.01.017

Liesenklas, 1966, The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin, Arch Pharm Ber Dtsch Pharm Ges, 299, 797, 10.1002/ardp.19662990911

Han, 2005, Stability and cytotoxicity of gambogic acid and its derivative, gambogoic acid, Biol Pharm Bull, 28, 2335, 10.1248/bpb.28.2335

Lu, 1984, Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi), Yao Xue Xue Bao, 19, 636

Tisdale, 2004, Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement, Proc Natl Acad Sci U S A, 101, 12030, 10.1073/pnas.0401932101

Wang, 2012, Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis, Anticancer Agents Med Chem, 12, 994, 10.2174/187152012802650066

Zhang, 2004, Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay, Bioorg Med Chem, 12, 309, 10.1016/j.bmc.2003.11.013

Kashyap, 2016, Molecular targets of gambogic acid in cancer: recent trends and advancements, Tumour Biol, 37, 12915, 10.1007/s13277-016-5194-8

Luo, 2019, Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine, Chin Med, 14, 10.1186/s13020-019-0270-9

Chi, 2013, An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors, Chin Med J (Engl), 126, 1642, 10.3760/cma.j.issn.0366-6999.20122582

Zhao, 2010, General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent, Drug Chem Toxicol, 33, 88, 10.3109/01480540903173534

Zhou, 2007, Phase I human tolerability trial of gambogic acid, Chin J New Drugs, 16, 79

Banik, 2018, Therapeutic potential of gambogic acid, a caged xanthone, to target cancer, Cancer Lett, 416, 75, 10.1016/j.canlet.2017.12.014

Davenport, 2011, Gambogic acid, a natural product inhibitor of Hsp90, J Nat Prod, 74, 1085, 10.1021/np200029q

Duan, 2014, Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase, Free Radic Biol Med, 69, 15, 10.1016/j.freeradbiomed.2013.12.027

Xia, 2017, Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2), J Exp Clin Cancer Res, 36, 10.1186/s13046-017-0579-0

Wang, 2015, Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression, Chem Biol Interact, 235, 76, 10.1016/j.cbi.2015.03.017

Salmon, 1991, Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer, Blood, 78, 44, 10.1182/blood.V78.1.44.44

Chen, 2015, Anticancer effect and apoptosis induction of gambogic acid in human leukemia cell line K562 in vitro, Med Sci Monit, 21, 1604, 10.12659/MSM.893004

Hua, 2015, Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS/MS, Biomed Chromatogr, 29, 545, 10.1002/bmc.3311

He, 2012, Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agents, Bioorg Med Chem Lett, 22, 289, 10.1016/j.bmcl.2011.11.016

Pandey, 2016, Gambogic acid and its role in chronic diseases, Adv Exp Med Biol, 928, 375, 10.1007/978-3-319-41334-1_15

Yang, 2013, New targets for the antitumor activity of gambogic acid in hematologic malignancies, Acta Pharmacol Sin, 34, 191, 10.1038/aps.2012.163

Xu, 2015, Natural products against hematological malignancies and identification of their targets, Sci China Life Sci, 58, 1191, 10.1007/s11427-015-4922-4

Wang, 2014, Progress in research of the structural optimization of natural product-like Garcinia caged xanthones, Yao Xue Xue Bao, 49, 293

Wang, 2012, Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy, J Ethnopharmacol, 140, 33, 10.1016/j.jep.2011.12.041

Anantachoke, 2012, Prenylated caged xanthones: chemistry and biology, Pharm Biol, 50, 78, 10.3109/13880209.2011.636176

Klein-Junior, 2020, Xanthones and cancer: from natural sources to mechanisms of action, Chem Biodivers, 17, 10.1002/cbdv.201900499

Avila-Carrasco, 2019, Natural plants compounds as modulators of epithelial-to-mesenchymal transition, Front Pharmacol, 10, 715, 10.3389/fphar.2019.00715

Mishra, 2019, Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases, Cell Mol Life Sci, 76, 1947, 10.1007/s00018-019-03053-0

Aksorn, 2019, Integrin as a molecular target for anti-cancer approaches in lung cancer, Anticancer Res, 39, 541, 10.21873/anticanres.13146

Sun, 2018, Anticancer activity and underlying mechanism of neogambogic acid, Chin J Nat Med, 16, 641

Rajagopal, 2018, Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy, Pharmacol Res, 130, 273, 10.1016/j.phrs.2017.12.034

Shahabipour, 2017, Naturally occurring anti-cancer agents targeting EZH2, Cancer Lett, 400, 325, 10.1016/j.canlet.2017.03.020

Hientz, 2017, The role of p53 in cancer drug resistance and targeted chemotherapy, Oncotarget, 8, 8921, 10.18632/oncotarget.13475

Sung, 2012, Cancer cell signaling pathways targeted by spice-derived nutraceuticals, Nutr Cancer, 64, 173, 10.1080/01635581.2012.630551

Pandey, 2018, Dietary nutraceuticals as backbone for bone health, Biotechnol Adv, 36, 1633, 10.1016/j.biotechadv.2018.03.014

Ruan, 2017, Chemical and biological research on herbal medicines rich in xanthones, Molecules, 22, 10.3390/molecules22101698

Han, 2009, Caged Garcinia xanthones: development since 1937, Curr Med Chem, 16, 3775, 10.2174/092986709789104993

DeSantis, 2019, Breast cancer statistics, 2019, CA, 69, 438

Gu, 2009, Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells, J Cancer Res Clin Oncol, 135, 1777, 10.1007/s00432-009-0624-2

Chen, 2008, Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells, Life Sci, 83, 103, 10.1016/j.lfs.2008.05.003

Zhen, 2015, Gambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species, Evid Based Complement Alternat Med, 2015, 10.1155/2015/842091

Qi, 2008, Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells, Biochem Cell Biol, 86, 386, 10.1139/O08-104

Kasibhatla, 2005, A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid, Proc Natl Acad Sci U S A, 102, 12095, 10.1073/pnas.0406731102

Jian, 2011, Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival, J Biol Chem, 286, 35708, 10.1074/jbc.M111.271585

Li, 2015, Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells, Chin J Nat Med, 13, 41

Theodoraki, 2015, Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening, Oncotarget, 6, 21255, 10.18632/oncotarget.4013

Chantarasriwong, 2019, Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer, Eur J Med Chem, 168, 405, 10.1016/j.ejmech.2019.02.047

Chantarasriwong, 2019, Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes, Bioorg Chem, 93, 10.1016/j.bioorg.2019.103303

Pandey, 2007, Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway, Blood, 110, 3517, 10.1182/blood-2007-03-079616

Zhu, 2009, Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors, J Chemother, 21, 666, 10.1179/joc.2009.21.6.666

Qi, 2015, Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells, Mol Carcinog, 54, E13, 10.1002/mc.22138

Ye, 2018, Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway, J Cancer Res Ther, 14, S942

Zhu, 2019, Gambogic acid shows anti-proliferative effects on non-small cell lung cancer (NSCLC) cells by activating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress-mediated apoptosis, Med Sci Monit, 25, 3983, 10.12659/MSM.916835

Zhao, 2017, Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway, Kaohsiung J Med Sci, 33, 543, 10.1016/j.kjms.2017.06.013

Li, 2019, Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid, Biochem Pharmacol, 169, 10.1016/j.bcp.2019.113635

Yang, 2007, Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes, Cancer Lett, 256, 259, 10.1016/j.canlet.2007.06.014

Lee, 2013, Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells, Oncol Rep, 29, 1744, 10.3892/or.2013.2291

Park, 2015, Antimetastatic effects of gambogic acid are mediated via the actin cytoskeleton and NF-kappaB pathways in SK-HEP1 cells, Drug Dev Res, 76, 132, 10.1002/ddr.21249

Wang, 2011, Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity, Eur J Med Chem, 46, 1280, 10.1016/j.ejmech.2011.01.051

Mu, 2010, An oxidative analogue of gambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro, Eur J Cancer Prev, 19, 61, 10.1097/CEJ.0b013e328333fb22

Nie, 2009, Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells, Toxicology, 260, 60, 10.1016/j.tox.2009.03.010

Guo, 2006, Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells, Life Sci, 78, 1238, 10.1016/j.lfs.2005.06.046

Wu, 2016, UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3beta/beta-catenin pathway in hepatocellular carcinoma cells, Anticancer Drugs, 27, 988, 10.1097/CAD.0000000000000416

Wang, 2009, Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma, Proteomics, 9, 242, 10.1002/pmic.200800155

Hsieh, 2010, Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma, Mol Carcinog, 49, 476, 10.1002/mc.20627

Imura, 2017, miR-223 and Stathmin-1 expression in non-tumor liver tissue of patients with hepatocellular carcinoma, Anticancer Res, 37, 5877

Li, 2005, Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers, Proteomics, 5, 1125, 10.1002/pmic.200401141

Zhang, 2020, STMN1 upregulation mediates hepatocellular carcinoma and hepatic stellate cell crosstalk to aggravate cancer by triggering the MET pathway, Cancer Sci, 111, 406, 10.1111/cas.14262

Zhou, 2019, Gambogic acid suppresses colon cancer cell activity in vitro, Exp Ther Med, 18, 2917

Wei, 2017, Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis, Exp Ther Med, 13, 662, 10.3892/etm.2017.4021

Huang, 2015, Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways, World J Gastroenterol, 21, 6194, 10.3748/wjg.v21.i20.6194

Zhang, 2014, ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid, PLoS One, 9

Gao, 2018, Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog, Exp Ther Med, 16, 1758

Wei, 2018, Gambogic acid efficiently kills stem-like colorectal cancer cells by upregulating ZFP36 expression, Cell Physiol Biochem, 46, 829, 10.1159/000488740

Wen, 2015, Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells, Int J Oncol, 47, 1663, 10.3892/ijo.2015.3166

Youns, 2018, The growth inhibitory effect of gambogic acid on pancreatic cancer cells, Naunyn Schmiedebergs Arch Pharmacol, 391, 551, 10.1007/s00210-018-1485-5

Yi, 2008, Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling, Cancer Res, 68, 1843, 10.1158/0008-5472.CAN-07-5944

Lu, 2012, Gambogic acid inhibits TNF-alpha-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-kappaB signaling pathways, Acta Pharmacol Sin, 33, 531, 10.1038/aps.2011.180

Pan, 2017, Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer, Oncotarget, 8, 77181, 10.18632/oncotarget.20424

Pan, 2018, Gambogic acid induces cell apoptosis and inhibits MAPK pathway in PTEN(-/-)/p53(-/-) prostate cancer cells in vitro and ex vivo, Chin J Integr Med, 24, 109, 10.1007/s11655-017-2410-3

Liang, 2016, Gambogic acid inhibits malignant melanoma cell proliferation through mitochondrial p66shc/ROS-p53/Bax-mediated apoptosis, Cell Physiol Biochem, 38, 1618, 10.1159/000443102

Liang, 2018, Gambogic acid inhibits melanoma through regulation of miR-199a-3p/ZEB1 signalling, Basic Clin Pharmacol Toxicol, 123, 692, 10.1111/bcpt.13090

Li, 2019, Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways, Eur J Pharmacol, 864, 10.1016/j.ejphar.2019.172719

Qiang, 2008, Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study, Biochem Pharmacol, 75, 1083, 10.1016/j.bcp.2007.10.033

Thida, 2016, Gambogic acid induces apoptotic cell death in T98G glioma cells, Bioorg Med Chem Lett, 26, 1097, 10.1016/j.bmcl.2015.11.043

Fu, 2018, Gambogic acid inhibits spinal cord injury and inflammation through suppressing the p38 and Akt signaling pathways, Mol Med Rep, 17, 2026

Luo, 2012, Autophagy inhibition promotes gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells, Asian Pac J Cancer Prev, 13, 6211, 10.7314/APJCP.2012.13.12.6211

Krajarng, 2015, Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid, BMC Complement Altern Med, 15, 10.1186/s12906-015-0544-4

Yue, 2016, Proteomic analysis revealed the important role of vimentin in human cervical carcinoma HeLa cells treated with gambogic acid, Mol Cell Proteomics, 15, 26, 10.1074/mcp.M115.053272

Wang, 2013, Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis, Cell Biochem Biophys, 67, 199, 10.1007/s12013-013-9534-7

Tang, 2017, Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity, Oncol Lett, 13, 384, 10.3892/ol.2016.5433

Wang, 2018, Bromodomaincontaining protein 4 is critical for the antiproliferative and proapoptotic effects of gambogic acid in anaplastic thyroid cancer, Int J Mol Med, 42, 161

Wang, 2018, Gambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels, Oncol Lett, 16, 2366

Kang, 2018, Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA, Acta Biomater, 68, 137, 10.1016/j.actbio.2017.12.028

Wang, 2008, Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells, Cancer Lett, 262, 214, 10.1016/j.canlet.2007.12.004

Zou, 2012, Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines, BMC Complement Altern Med, 12, 58, 10.1186/1472-6882-12-58

Wang, 2019, Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species, Cancer Cell Int, 19

Tian, 2018, A targeted nanoplatform co-delivering chemotherapeutic and antiangiogenic drugs as a tool to reverse multidrug resistance in breast cancer, Acta Biomater, 75, 398, 10.1016/j.actbio.2018.05.050

Wang, 2014, Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-kappaB and MAPK/HO-1 signalling, Br J Cancer, 110, 341, 10.1038/bjc.2013.752

Liu, 2016, Nanomedicine-based combination of gambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma, Biomed Pharmacother, 83, 79, 10.1016/j.biopha.2016.06.001

Na, 2020, A solvent-assisted active loading technology to prepare gambogic acid and all-trans retinoic acid co-encapsulated liposomes for synergistic anticancer therapy, Drug Deliv Transl Res, 10, 146, 10.1007/s13346-019-00669-4

Bishayee, 2019, Targeting the difficult-to-drug CD71 and MYCN with gambogic acid and vorinostat in a class of neuroblastomas, Cell Physiol Biochem, 53, 258, 10.33594/000000134

Shi, 2014, Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation, Clin Cancer Res, 20, 151, 10.1158/1078-0432.CCR-13-1063

Ning, 2016, Gambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2, Xenobiotica, 46, 816, 10.3109/00498254.2015.1125560

Wang, 2015, Combined therapy with EGFR TKI and gambogic acid for overcoming resistance in EGFR-T790M mutant lung cancer, Oncol Lett, 10, 2063, 10.3892/ol.2015.3599

Pfister, 2012, Vascular endothelial growth factor signals through platelet-derived growth factor receptor beta in meningiomas in vitro, Br J Cancer, 107, 1702, 10.1038/bjc.2012.459

Wang, 2014, Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101, Br J Pharmacol, 171, 618, 10.1111/bph.12501

Liu, 2014, Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation, Toxicol In Vitro, 28, 419, 10.1016/j.tiv.2013.12.008

He, 2009, The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma, BMC Cancer, 9, 10.1186/1471-2407-9-343

Jiang, 2012, Targeting renal cell carcinoma with gambogic acid in combination with sunitinib in vitro and in vivo, Asian Pac J Cancer Prev, 13, 6463, 10.7314/APJCP.2012.13.12.6463

Zhang, 2016, Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression, Onco Targets Ther, 9, 3359, 10.2147/OTT.S100936

Ye, 2015, Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid, Yao Xue Xue Bao, 50, 1252

Wang, 2019, Gambogic acid increases the sensitivity to paclitaxel in drugresistant triplenegative breast cancer via the SHH signaling pathway, Mol Med Rep, 20, 4515

Hatami, 2020, 50

Deschatrette, 2013, Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells, Anticancer Res, 33, 133

Yang, 2016, The natural compound gambogic acid radiosensitizes nasopharyngeal carcinoma cells under hypoxic conditions, Tumori, 102, 135, 10.5301/tj.5000411

Yang, 2016, Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway, Tumour Biol, 37, 1853, 10.1007/s13277-015-3974-1

Patra, 2018, Nano based drug delivery systems: recent developments and future prospects, J Nanobiotechnology, 16, 10.1186/s12951-018-0392-8

Tran, 2017, Cancer nanomedicine: a review of recent success in drug delivery, Clin Transl Med, 6, 10.1186/s40169-017-0175-0

Bobo, 2016, Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date, Pharm Res, 33, 2373, 10.1007/s11095-016-1958-5

Ventola, 2017, Progress in nanomedicine: approved and investigational nanodrugs, P T, 42, 742

Yallapu, 2011, Design and engineering of nanogels for cancer treatment, Drug Discov Today, 16, 457, 10.1016/j.drudis.2011.03.004

Yallapu, 2012, Curcumin nanoformulations: a future nanomedicine for cancer, Drug Discov Today, 17, 71, 10.1016/j.drudis.2011.09.009

Yallapu, 2015, Therapeutic applications of curcumin nanoformulations, AAPS J, 17, 1341, 10.1208/s12248-015-9811-z

Chowdhury, 2017, Magnetic nanoformulations for prostate cancer, Drug Discov Today, 22, 1233, 10.1016/j.drudis.2017.04.018

Kumar, 2020, Advances in Nanotechnology based Strategies for Synthesis of Nanoparticles of Lignin, 203

Bor, 2019, Nanomedicines for cancer therapy: current status, challenges and future prospects, Ther Deliv, 10, 113, 10.4155/tde-2018-0062

Jin, 2019, Rational design of cancer nanomedicine for simultaneous stealth surface and enhanced cellular uptake, ACS Nano, 13, 954

Dai, 2018, Particle targeting in complex biological media, Adv Healthc Mater, 7

Haley, 2008, Nanoparticles for drug delivery in cancer treatment, Urol Oncol, 26, 57, 10.1016/j.urolonc.2007.03.015

Yamashita, 2013, Pharmacokinetic considerations for targeted drug delivery, Adv Drug Deliv Rev, 65, 139, 10.1016/j.addr.2012.11.006

Jain, 2010, Delivering nanomedicine to solid tumors, Nat Rev Clin Oncol, 7, 653, 10.1038/nrclinonc.2010.139

Wang, 2010, Nanoparticles for tumor targeted therapies and their pharmacokinetics, Curr Drug Metab, 11, 129, 10.2174/138920010791110827

Hare, 2017, Challenges and strategies in anti-cancer nanomedicine development: An industry perspective, Adv Drug Deliv Rev, 108, 25, 10.1016/j.addr.2016.04.025

Kumar, 2020, Preparation, characterization and in vitro cytotoxicity of Fenofibrate and Nabumetone loaded solid lipid nanoparticles, Mater Sci Eng C Mater Biol Appl, 106, 10.1016/j.msec.2019.110184

Kumar, 2019, Acoustic cavitation-assisted formulation of solid lipid nanoparticles using different stabilizers, ACS Omega, 4, 13360, 10.1021/acsomega.9b01532

Kumar, 2019, Acoustic cavitation assisted hot melt mixing technique for solid lipid nanoparticles formulation, characterization, and controlled delivery of poorly water soluble drugs, J Drug Deliver Sci Technol, 54, 10.1016/j.jddst.2019.101277

Doddapaneni, 2016, Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer, Drug Deliv, 23, 1232, 10.3109/10717544.2015.1124472

Yan, 2017, Gambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect, Int J Pharm, 522, 110, 10.1016/j.ijpharm.2017.02.051

Huang, 2018, Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment, Drug Deliv, 25, 757, 10.1080/10717544.2018.1446474

Kebebe, 2019, Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer, Int J Nanomedicine, 14, 6179, 10.2147/IJN.S202424

Wang, 2018, Gambogic acid-loaded polymeric micelles for improved therapeutic effect in breast cancer, J Biomed Nanotechnol, 14, 1695, 10.1166/jbn.2018.2626

Wang, 2015, Gambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance, Int J Pharm, 495, 840, 10.1016/j.ijpharm.2015.09.041

Yin, 2014, Gambogic acid-loaded electrosprayed particles for site-specific treatment of hepatocellular carcinoma, Mol Pharm, 11, 4107, 10.1021/mp500214a

Saini, 2016, The next generation non-competitive active polyester nanosystems for transferrin receptor-mediated peroral transport utilizing gambogic acid as a ligand, Sci Rep, 6, 10.1038/srep29501

Xu, 2016, Nanoparticles with optimal ratiometric co-delivery of docetaxel with gambogic acid for treatment of multidrug-resistant breast cancer, J Biomed Nanotechnol, 12, 1774, 10.1166/jbn.2016.2282

Han, 2019, A stage-specific cancer chemotherapy strategy through flexible combination of reduction-activated charge-conversional core-shell nanoparticles, Theranostics, 9, 6532, 10.7150/thno.35057

Ke, 2018, Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles, Int J Pharm, 545, 306, 10.1016/j.ijpharm.2018.04.016

Yu, 2014, N-octyl-N-arginine-chitosan (OACS) micelles for gambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion, Drug Dev Ind Pharm, 40, 774, 10.3109/03639045.2013.786723

Yu, 2018, N-octyl-N-arginine-chitosan micelles for gambogic acid intravenous delivery: characterization, cell uptake, pharmacokinetics, and biodistribution, Drug Dev Ind Pharm, 44, 615, 10.1080/03639045.2017.1405973

Ji, 2017, Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid, Acta Biomater, 62, 234, 10.1016/j.actbio.2017.08.036

Fang, 2017, Pluronic F68-linoleic acid nano-spheres mediated delivery of gambogic acid for cancer therapy, AAPS PharmSciTech, 18, 147, 10.1208/s12249-015-0473-z

Huang, 2015, Fine-tuning vitamin E-containing telodendrimers for efficient delivery of gambogic acid in colon cancer treatment, Mol Pharm, 12, 1216, 10.1021/acs.molpharmaceut.5b00051

Saxena, 2012, Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer, Int J Nanomed, 7, 713

Zhang, 2017, Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment, Int J Nanomed, 12, 1593, 10.2147/IJN.S127256

Zhang, 2018, Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment, Int J Nanomed, 13, 4961, 10.2147/IJN.S170148

Zhang, 2017, Development of a more efficient albumin-based delivery system for gambogic acid with low toxicity for lung cancer therapy, AAPS PharmSciTech, 18, 1987, 10.1208/s12249-016-0670-4

Chauhan, 2018, Dendrimers for drug delivery, Molecules, 23, 10.3390/molecules23040938

Madaan, 2014, Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues, J Pharm Bioallied Sci, 6, 139, 10.4103/0975-7406.130965

Fang, 2012, Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells, Int J Nanomedicine, 7, 4109

Wang, 2011, Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles, Int J Nanomedicine, 6, 1929

Wang, 2012, Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1, Int J Nanomed, 7, 781

Sang, 2018, A novel redox/pH dual-responsive and hyaluronic acid-decorated multifunctional magnetic complex micelle for targeted gambogic acid delivery for the treatment of triple negative breast cancer, Drug Deliv, 25, 1846, 10.1080/10717544.2018.1486472

Saeed, 2014, Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells, J Appl Toxicol, 34, 1188, 10.1002/jat.3018

Xu, 2013, Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition, Int J Nanomedicine, 8, 3729, 10.2147/IJN.S51622

Zhou, 2016, Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo, Int J Nanomed, 11, 5429, 10.2147/IJN.S115037

Habibi, 2020, Emerging methods in therapeutics using multifunctional nanoparticles, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 12, 10.1002/wnan.1625

Babu, 2014, Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer, AAPS PharmSciTech, 15, 709, 10.1208/s12249-014-0089-8

Srinivasan, 2015, Multifunctional nanomaterials and their applications in drug delivery and cancer therapy, Nanomaterials (Basel), 5, 1690, 10.3390/nano5041690

Shao, 2020, Multiboosting of cancer immunotherapy by a core-shell delivery system, Mol Pharm, 17, 338, 10.1021/acs.molpharmaceut.9b01113

Gao, 2019, Molecular targeting-mediated mild-temperature photothermal therapy with a smart albumin-based nano drug, Small, 15, 10.1002/smll.201900501

Liang, 2018, Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy, Theranostics, 8, 5059, 10.7150/thno.28344