Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)

Acta Pharmaceutica Sinica B - Tập 11 - Trang 434-441 - 2021
Xinran Cai1, Ye Feng1,2, Meishu Xu1, Chaohui Yu3, Wen Xie1,4
1Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
2Department of Endocrinology and Metabolic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
3Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
4Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA

Tài liệu tham khảo

Honkakoski, 1996, Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes, J Biol Chem, 271, 9746, 10.1074/jbc.271.16.9746 Wei, 2000, The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism, Nature, 407, 920, 10.1038/35038112 Honkakoski, 1998, The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene, Mol Cell Biol, 18, 5652, 10.1128/MCB.18.10.5652 Lahtela, 1985, Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects, Diabetes, 34, 911, 10.2337/diab.34.9.911 Miao, 2006, Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha, J Biol Chem, 281, 14537, 10.1074/jbc.M510713200 Lynch, 2014, Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes, Toxicol Appl Pharmacol, 279, 33, 10.1016/j.taap.2014.05.009 Gao, 2015, CAR suppresses hepatic gluconeogenesis by facilitating the ubiquitination and degradation of PGC1alpha, Mol Endocrinol, 29, 1558, 10.1210/me.2015-1145 Yu, 2016, Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor, Biochim Biophys Acta, 1859, 1100, 10.1016/j.bbagrm.2015.10.001 Dong, 2009, Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease, Proc Natl Acad Sci U S A, 106, 18831, 10.1073/pnas.0909731106 Gao, 2009, The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity, J Biol Chem, 284, 25984, 10.1074/jbc.M109.016808 Yamamoto, 2010, Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B, PLoS One, 5, 10.1371/journal.pone.0010121 Tian, 2011, Gadd45beta is an inducible coactivator of transcription that facilitates rapid liver growth in mice, J Clin Invest, 121, 4491, 10.1172/JCI38760 Columbano, 2005, Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia, Hepatology, 42, 1118, 10.1002/hep.20883 Lu, 2004, Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells, Nat Immunol, 5, 38, 10.1038/ni1020 Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5 Galarraga, 2012, Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections, J Lipid Res, 53, 2791, 10.1194/jlr.D023788 Facchini, 2001, Insulin resistance as a predictor of age-related diseases, J Clin Endocrinol Metab, 86, 3574, 10.1210/jcem.86.8.7763 Ferrannini, 1997, Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR), J Clin Invest, 100, 1166, 10.1172/JCI119628 Janssen, 2002, Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women, Diabetes Care, 25, 431, 10.2337/diacare.25.3.431 Assali, 2001, Insulin resistance in obesity: body-weight or energy balance?, J Endocrinol, 171, 293, 10.1677/joe.0.1710293 Toledo, 2008, Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content, Diabetes, 57, 987, 10.2337/db07-1429 Baskin-Bey, 2007, Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse, World J Gastroenterol, 13, 5635, 10.3748/wjg.v13.i42.5635 Kawano, 2013, Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease, J Gastroenterol, 48, 434, 10.1007/s00535-013-0758-5 Narce, 2012, Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases, Curr Drug Metabol, 13, 1454, 10.2174/138920012803762693 Greenberg, 2006, Obesity and the role of adipose tissue in inflammation and metabolism, Am J Clin Nutr, 83, 10.1093/ajcn/83.2.461S Shoelson, 2006, Inflammation and insulin resistance, J Clin Invest, 116, 1793, 10.1172/JCI29069 Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246 Apovian, 2008, Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects, Arterioscl Throm Vas, 28, 1654, 10.1161/ATVBAHA.108.170316 Alisi, 2017, The role of tissue macrophage-mediated inflammation on NAFLD pathogenesis and its clinical implications, Mediators inflamm, 2017, 8162421, 10.1155/2017/8162421 Cinti, 1997, Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue, Endocrinology, 138, 797, 10.1210/endo.138.2.4908 Sheikh, 2000, Role of Gadd45 in apoptosis, Biochem Pharmacol, 59, 43, 10.1016/S0006-2952(99)00291-9 Yamamoto, 2004, The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice, Canc Res, 64, 7197, 10.1158/0008-5472.CAN-04-1459 Huang, 2005, Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor, Mol Endocrinol, 19, 1646, 10.1210/me.2004-0520 Mattu, 2018, High frequency of beta-catenin mutations in mouse hepatocellular carcinomas induced by a nongenotoxic constitutive androstane receptor agonist, Am J Pathol, 188, 2497, 10.1016/j.ajpath.2018.07.022 Yamada, 2014, Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver, Toxicol Sci, 142, 137, 10.1093/toxsci/kfu173 Lake, 2018, Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators, Toxicol Res (Camb), 7, 697, 10.1039/C8TX00008E Braeuning, 2014, Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?, Arch Toxicol, 88, 1771, 10.1007/s00204-014-1331-6 Braeuning, 2016, Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice, Arch Toxicol, 90, 1481, 10.1007/s00204-016-1667-1 Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131 Kodama, 2004, Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes, Mol Cell Biol, 24, 7931, 10.1128/MCB.24.18.7931-7940.2004 Tilg, 2011, Gut microbiome, obesity, and metabolic dysfunction, J Clin Invest, 121, 2126, 10.1172/JCI58109 Dussault, 2002, A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity, Mol Cell Biol, 22, 5270, 10.1128/MCB.22.15.5270-5280.2002 Shiraki, 2003, Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state, J Biol Chem, 278, 11344, 10.1074/jbc.M212859200 Lu, 2019, Constitutive activation of the human aryl hydrocarbon receptor in mice promotes hepatocarcinogenesis independent of its coactivator Gadd45b, Toxicol Sci, 167, 581, 10.1093/toxsci/kfy263