Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)
Tài liệu tham khảo
Honkakoski, 1996, Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes, J Biol Chem, 271, 9746, 10.1074/jbc.271.16.9746
Wei, 2000, The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism, Nature, 407, 920, 10.1038/35038112
Honkakoski, 1998, The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene, Mol Cell Biol, 18, 5652, 10.1128/MCB.18.10.5652
Lahtela, 1985, Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects, Diabetes, 34, 911, 10.2337/diab.34.9.911
Miao, 2006, Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha, J Biol Chem, 281, 14537, 10.1074/jbc.M510713200
Lynch, 2014, Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes, Toxicol Appl Pharmacol, 279, 33, 10.1016/j.taap.2014.05.009
Gao, 2015, CAR suppresses hepatic gluconeogenesis by facilitating the ubiquitination and degradation of PGC1alpha, Mol Endocrinol, 29, 1558, 10.1210/me.2015-1145
Yu, 2016, Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor, Biochim Biophys Acta, 1859, 1100, 10.1016/j.bbagrm.2015.10.001
Dong, 2009, Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease, Proc Natl Acad Sci U S A, 106, 18831, 10.1073/pnas.0909731106
Gao, 2009, The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity, J Biol Chem, 284, 25984, 10.1074/jbc.M109.016808
Yamamoto, 2010, Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B, PLoS One, 5, 10.1371/journal.pone.0010121
Tian, 2011, Gadd45beta is an inducible coactivator of transcription that facilitates rapid liver growth in mice, J Clin Invest, 121, 4491, 10.1172/JCI38760
Columbano, 2005, Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia, Hepatology, 42, 1118, 10.1002/hep.20883
Lu, 2004, Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells, Nat Immunol, 5, 38, 10.1038/ni1020
Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5
Galarraga, 2012, Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections, J Lipid Res, 53, 2791, 10.1194/jlr.D023788
Facchini, 2001, Insulin resistance as a predictor of age-related diseases, J Clin Endocrinol Metab, 86, 3574, 10.1210/jcem.86.8.7763
Ferrannini, 1997, Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR), J Clin Invest, 100, 1166, 10.1172/JCI119628
Janssen, 2002, Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women, Diabetes Care, 25, 431, 10.2337/diacare.25.3.431
Assali, 2001, Insulin resistance in obesity: body-weight or energy balance?, J Endocrinol, 171, 293, 10.1677/joe.0.1710293
Toledo, 2008, Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content, Diabetes, 57, 987, 10.2337/db07-1429
Baskin-Bey, 2007, Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse, World J Gastroenterol, 13, 5635, 10.3748/wjg.v13.i42.5635
Kawano, 2013, Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease, J Gastroenterol, 48, 434, 10.1007/s00535-013-0758-5
Narce, 2012, Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases, Curr Drug Metabol, 13, 1454, 10.2174/138920012803762693
Greenberg, 2006, Obesity and the role of adipose tissue in inflammation and metabolism, Am J Clin Nutr, 83, 10.1093/ajcn/83.2.461S
Shoelson, 2006, Inflammation and insulin resistance, J Clin Invest, 116, 1793, 10.1172/JCI29069
Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246
Apovian, 2008, Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects, Arterioscl Throm Vas, 28, 1654, 10.1161/ATVBAHA.108.170316
Alisi, 2017, The role of tissue macrophage-mediated inflammation on NAFLD pathogenesis and its clinical implications, Mediators inflamm, 2017, 8162421, 10.1155/2017/8162421
Cinti, 1997, Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue, Endocrinology, 138, 797, 10.1210/endo.138.2.4908
Sheikh, 2000, Role of Gadd45 in apoptosis, Biochem Pharmacol, 59, 43, 10.1016/S0006-2952(99)00291-9
Yamamoto, 2004, The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice, Canc Res, 64, 7197, 10.1158/0008-5472.CAN-04-1459
Huang, 2005, Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor, Mol Endocrinol, 19, 1646, 10.1210/me.2004-0520
Mattu, 2018, High frequency of beta-catenin mutations in mouse hepatocellular carcinomas induced by a nongenotoxic constitutive androstane receptor agonist, Am J Pathol, 188, 2497, 10.1016/j.ajpath.2018.07.022
Yamada, 2014, Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver, Toxicol Sci, 142, 137, 10.1093/toxsci/kfu173
Lake, 2018, Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators, Toxicol Res (Camb), 7, 697, 10.1039/C8TX00008E
Braeuning, 2014, Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?, Arch Toxicol, 88, 1771, 10.1007/s00204-014-1331-6
Braeuning, 2016, Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice, Arch Toxicol, 90, 1481, 10.1007/s00204-016-1667-1
Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131
Kodama, 2004, Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes, Mol Cell Biol, 24, 7931, 10.1128/MCB.24.18.7931-7940.2004
Tilg, 2011, Gut microbiome, obesity, and metabolic dysfunction, J Clin Invest, 121, 2126, 10.1172/JCI58109
Dussault, 2002, A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity, Mol Cell Biol, 22, 5270, 10.1128/MCB.22.15.5270-5280.2002
Shiraki, 2003, Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state, J Biol Chem, 278, 11344, 10.1074/jbc.M212859200
Lu, 2019, Constitutive activation of the human aryl hydrocarbon receptor in mice promotes hepatocarcinogenesis independent of its coactivator Gadd45b, Toxicol Sci, 167, 581, 10.1093/toxsci/kfy263
