GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease

Johnson, 2019, Triggers, facilitators, and aggravators: redefining Parkinson's disease pathogenesis, Trends Neurosci, 42, 4, 10.1016/j.tins.2018.09.007 Smeyne, 2021, Infection and risk of Parkinson's disease, J Parkinsons Dis, 11, 31, 10.3233/JPD-202279 Nielsen, 2012, Treatment for Helicobacter pylori infection and risk of Parkinson's disease in Denmark, Eur J Neurol, 19, 864, 10.1111/j.1468-1331.2011.03643.x Chiang, 2019, Altered gut microbiome and intestinal pathology in Parkinson's disease, J Mov Disord, 12, 67, 10.14802/jmd.18067 Dobbs, 2005, Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 1: eradication of Helicobacter in the cachexia of idiopathic parkinsonism, Helicobacter, 10, 267, 10.1111/j.1523-5378.2005.00331.x Kaur, 2016, Parkinson's disease and periodontitis—the missing link? A review, Gerodontology, 33, 434, 10.1111/ger.12188 Matheoud, 2019, Intestinal infection triggers Parkinson's disease-like symptoms in Pink1−/− mice, Nature, 571, 565, 10.1038/s41586-019-1405-y Muldoon, 2013, Immunologic privilege in the central nervous system and the blood–brain barrier, J Cerebr Blood Flow Metabol, 33, 13, 10.1038/jcbfm.2012.153 Daneman, 2015, The blood–brain barrier, Cold Spring Harbor Perspect Biol, 7, 10.1101/cshperspect.a020412 Quintin, 2014, Innate immune memory: towards a better understanding of host defense mechanisms, Curr Opin Immunol, 29, 1, 10.1016/j.coi.2014.02.006 Netea, 2016, Trained immunity: a program of innate immune memory in health and disease, Science, 352, 10.1126/science.aaf1098 Saeed, 2014, Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity, Science, 345, 10.1126/science.1251086 Biswas, 2009, Endotoxin tolerance: new mechanisms, molecules and clinical significance, Trends Immunol, 30, 475, 10.1016/j.it.2009.07.009 Kleinnijenhuis, 2012, Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes, Proc Natl Acad Sci U S A, 109, 17537, 10.1073/pnas.1202870109 Quintin, 2012, Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes, Cell Host Microbe, 12, 223, 10.1016/j.chom.2012.06.006 Christ, 2018, Western diet triggers NLRP3-dependent innate immune reprogramming, Cell, 172, 162, 10.1016/j.cell.2017.12.013 Gómez-Nicola, 2014, Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease, Glia, 62, 1041, 10.1002/glia.22660 Godbout, 2005, Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system, FASEB J, 19, 1329, 10.1096/fj.05-3776fje Ramaglia, 2012, C3-dependent mechanism of microglial priming relevant to multiple sclerosis, Proc Natl Acad Sci U S A, 109, 965, 10.1073/pnas.1111924109 Palin, 2008, Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration, Neurobiol Dis, 30, 19, 10.1016/j.nbd.2007.11.012 Wendeln, 2018, Innate immune memory in the brain shapes neurological disease hallmarks, Nature, 556, 332, 10.1038/s41586-018-0023-4 Paludan, 2021, Constitutive immune mechanisms: mediators of host defence and immune regulation, Nat Rev Immunol, 21, 137, 10.1038/s41577-020-0391-5 Lamkanfi, 2014, Mechanisms and functions of inflammasomes, Cell, 157, 1013, 10.1016/j.cell.2014.04.007 Heneka, 2018, Inflammasome signalling in brain function and neurodegenerative disease, Nat Rev Neurosci, 19, 610, 10.1038/s41583-018-0055-7 Shi, 2015, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death, Nature, 526, 660, 10.1038/nature15514 Liu, 2016, Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, 535, 153, 10.1038/nature18629 Storek, 2015, Bacterial recognition pathways that lead to inflammasome activation, Immunol Rev, 265, 112, 10.1111/imr.12289 Burdette, 2021, Gasdermin D in pyroptosis, Acta Pharm Sin B, 11, 2768, 10.1016/j.apsb.2021.02.006 Li, 2019, Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis, J Exp Med, 216, 2562, 10.1084/jem.20190377 Jackson-Lewis, 2007, Protocol for the MPTP mouse model of Parkinson's disease, Nat Protoc, 2, 141, 10.1038/nprot.2006.342 Shang, 2021, Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment, Acta Pharm Sin B, 11, 1213, 10.1016/j.apsb.2021.01.009 Lee, 2019, MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration, Cell Death Differ, 26, 213, 10.1038/s41418-018-0124-5 Liu, 2019, Nucleoporin Seh1 interacts with Olig2/Brd7 to promote oligodendrocyte differentiation and myelination, Neuron, 102, 587, 10.1016/j.neuron.2019.02.018 Sedelis, 2000, MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences, Behav Genet, 30, 171, 10.1023/A:1001958023096 Liu, 2022, Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease, Acta Pharm Sin B, 13, 662, 10.1016/j.apsb.2022.07.021 Chagniel, 2012, Partial dopamine depletion in MPTP-treated mice differentially altered motor skill learning and action control, Behav Brain Res, 228, 9, 10.1016/j.bbr.2011.11.019 Cheng, 2014, mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity, Science, 345, 10.1126/science.1250684 Evavold, 2018, The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages, Immunity, 48, 35, 10.1016/j.immuni.2017.11.013 Chang, 2013, MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling, Proc Natl Acad Sci U S A, 110, 2270, 10.1073/pnas.1206048110 Gulen, 2010, The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation, Immunity, 32, 54, 10.1016/j.immuni.2009.12.003 Hu, 2020, FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation, Nat Immunol, 21, 736, 10.1038/s41590-020-0669-6 Gordon, 2018, Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice, Sci Transl Med, 10, 10.1126/scitranslmed.aah4066 Huang, 2021, A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease, J Neuroimmunol, 354, 10.1016/j.jneuroim.2021.577543 Netea, 2015, Innate immune memory: a paradigm shift in understanding host defense, Nat Immunol, 16, 675, 10.1038/ni.3178 Deczkowska, 2018, Disease-associated microglia: a universal immune sensor of neurodegeneration, Cell, 173, 1073, 10.1016/j.cell.2018.05.003 Song, 2018, The identity and function of microglia in neurodegeneration, Nat Immunol, 19, 1048, 10.1038/s41590-018-0212-1 Krasemann, 2017, The TREM2–APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases, Immunity, 47, 566, 10.1016/j.immuni.2017.08.008 Ostuni, 2013, Latent enhancers activated by stimulation in differentiated cells, Cell, 152, 157, 10.1016/j.cell.2012.12.018 Kaikkonen, 2013, Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription, Mol Cell, 51, 310, 10.1016/j.molcel.2013.07.010 Sadowska, 2015, Interleukin-1β transfer across the blood–brain barrier in the ovine fetus, J Cerebr Blood Flow Metabol, 35, 1388, 10.1038/jcbfm.2015.134 Camacho-Soto, 2020, Herpesvirus infections and risk of Parkinson's disease, Neurodegener Dis, 20, 97, 10.1159/000512874 Wijarnpreecha, 2018, Hepatitis C virus infection and risk of Parkinson's disease: a systematic review and meta-analysis, Eur J Gastroenterol Hepatol, 30, 9, 10.1097/MEG.0000000000000991 Hsieh, 2002, Parkinson-like syndrome as the major presenting symptom of Epstein-Barr virus encephalitis, Arch Dis Child, 87, 358, 10.1136/adc.87.4.358