GRP78 at the Centre of the Stage in Cancer and Neuroprotection
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Abdel Malek, 2015, Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma, Oncotarget, 6, 3098, 10.18632/oncotarget.3075
Alder, 2005, The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum, J. Cell Biol., 168, 389, 10.1083/jcb.200409174
Alexandre, 1991, A binding site for the cyclic adenosine 3′,5′-monophosphate-response element-binding protein as a regulatory element in the grp78 promoter, Mol. Endocrinol., 5, 1862, 10.1210/mend-5-12-1862
Area-gomez, 2016, Science direct mitochondria-associated ER membranes and Alzheimer disease, Curr. Opin. Genet. Dev., 38, 90, 10.1016/j.gde.2016.04.006
Axe, 2008, Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum, J. Cell Biol., 182, 685, 10.1083/jcb.200803137
Barnham, 2004, Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid, FASEB J., 18, 1427, 10.1096/fj.04-1890fje
Bellucci, 2011, Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease, J. Neurochem., 116, 588, 10.1111/j.1471-4159.2010.07143.x
Bertolotti, 2000, Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response, Nat. Cell Biol., 2, 326, 10.1038/35014014
Birukova, 2014, GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids, Mol. Biol. Cell, 25, 2006, 10.1091/mbc.E13-12-0743
Blond-Elguindi, 1993, Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP, Cell, 75, 717, 10.1016/0092-8674(93)90492-9
Bosco, 2010, Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS, Nat. Neurosci., 13, 1396, 10.1038/nn.2660
Brown, 2012, The endoplasmic reticulum stress response in aging and age-related diseases, Front. Physiol., 3, 263, 10.3389/fphys.2012.00263
Buchkovich, 2010, Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site, J. Virol., 84, 11479, 10.1128/JVI.01330-10
Cadenas, 2000, Mitochondrial free radical generation, oxidative stress, and aging, Free Radic. Biol. Med., 29, 222, 10.1016/S0891-5849(00)00317-8
Cha-Molstad, 2015, Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding, Nat. Cell Biol., 17, 917, 10.1038/ncb3177
Cha-Molstad, 2016, Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP, Autophagy, 12, 426, 10.1080/15548627.2015.1126047
Chattopadhyay, 2008, Initiation and elongation in fibrillation of ALS-linked superoxide dismutase, Proc. Natl. Acad. Sci. U.S.A., 105, 18663, 10.1073/pnas.0807058105
Chen, 1997, Rapid induction of the Grp78 gene by cooperative actions of okadaic acid and heat-shock in 9L rat brain tumor cells–involvement of a cAMP responsive element-like promoter sequence and a protein kinase A signaling pathway, Eur. J. Biochem., 248, 120, 10.1111/j.1432-1033.1997.t01-1-00120.x
Cho, 2007, BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1, Mol. Cell. Biol., 27, 368, 10.1128/MCB.00814-06
Colla, 2012, Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo, J. Neurosci., 32, 3306, 10.1523/JNEUROSCI.5367-11.2012
Cook, 2012, Heat shock 70 kDa protein 5/glucose-regulated protein 78 “AMP”ing up autophagy, Autophagy, 8, 1827, 10.4161/auto.21765
Cook, 2016, Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer, Cancer Res., 76, 5657, 10.1158/0008-5472.CAN-15-2616
Corrigall, 2004, Inhibition of antigen-presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein bip. Relevance to the treatment of inflammatory arthritis, Arthritis Rheum., 50, 1164, 10.1002/art.20134
Dai, 2010, PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells, Folia Biol. (Praha)., 56, 37
Delpino, 2002, The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation, Biosci. Rep., 22, 407, 10.1023/A:1020966008615
Di Paolo, 2011, Linking lipids to Alzheimer's disease: cholesterol and beyond, Nat. Rev. Neurosci., 12, 284, 10.1038/nrn3012
Drake, 2015, Unfolding the promise of translational targeting in neurodegenerative disease, Neuromolecular Med., 17, 147, 10.1007/s12017-015-8346-x
Duriez, 2008, The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway, J. Biol. Chem., 283, 32352, 10.1074/jbc.M807178200
Erickson, 2006, The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age, J. Gerontol. A. Biol. Sci. Med. Sci., 61, 435, 10.1093/gerona/61.5.435
Ezzi, 2007, Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation, J. Neurochem., 102, 170, 10.1111/j.1471-4159.2007.04531.x
Frazier, 2017, Calcium's role as nuanced modulator of cellular physiology in the brain, Biochem. Biophys. Res. Commun, 483, 981, 10.1016/j.bbrc.2016.08.105
Fu, 2008, Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium, Proc. Natl. Acad. Sci. U.S.A., 105, 19444, 10.1073/pnas.0807691105
Galán, 2014, Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction, Biochim. Biophys. Acta Mol. Cell Res., 1843, 1063, 10.1016/j.bbamcr.2014.02.009
Gardner, 2011, Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response, Science, 333, 1891, 10.1126/science.1209126
Gardner, 2013, Endoplasmic reticulum stress sensing in the unfolded protein response, Cold Spring Harb. Perspect. Biol., 5, a013169, 10.1101/cshperspect.a013169
Ghribi, 2003, MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways, J. Neuropathol. Exp. Neurol., 62, 1144, 10.1093/jnen/62.11.1144
Gonzalez-Gronow, 2006, Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum, Cancer Res., 66, 11424, 10.1158/0008-5472.CAN-06-1721
Gorbatyuk, 2012, Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease, Mol. Ther., 20, 1327, 10.1038/mt.2012.28
Gray, 2012, Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis, FEBS Lett., 586, 1836, 10.1016/j.febslet.2012.01.051
Greilberger, 2008, Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease, Free Radic. Res., 42, 633, 10.1080/10715760802255764
Gu, 2015, GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma, Oncotarget, 6, 33658, 10.18632/oncotarget.5603
Guzmán-Lenis, 2009, Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons, Neuroscience, 162, 31, 10.1016/j.neuroscience.2009.03.067
Haigh, 2002, A new role for BiP: closing the aqueous translocon pore during protein integration into the ER membrane, J. Cell Biol., 156, 261, 10.1083/jcb.200110074
Hamasaki, 2013, Up-to-date membrane biogenesis in the autophagosome formation, Curr. Opin. Cell Biol., 25, 455, 10.1016/j.ceb.2013.03.004
Hamman, 1998, BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation, Cell, 92, 747, 10.1016/S0092-8674(00)81403-8
Hara, 2006, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, 441, 885, 10.1038/nature04724
Hayashi, 2007, Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival, Cell, 131, 596, 10.1016/j.cell.2007.08.036
Hayashi-Nishino, 2009, A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation, Nat. Cell Biol., 11, 1433, 10.1038/ncb1991
Hetz, 2003, Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein, EMBO J., 22, 5435, 10.1093/emboj/cdg537
Hetz, 2005, The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity, J. Neurosci., 25, 2793, 10.1523/JNEUROSCI.4090-04.2005
Hoozemans, 2005, The unfolded protein response is activated in Alzheimer's disease, Acta Neuropathol., 110, 165, 10.1007/s00401-005-1038-0
Itakura, 2010, Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins, Autophagy, 6, 764, 10.4161/auto.6.6.12709
Itkin, 2011, Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease, PLoS ONE, 6, e18250, 10.1371/journal.pone.0018250
Iwamune, 2014, MicroRNA-376a regulates 78-kilodalton glucose-regulated protein expression in rat granulosa cells, PLoS ONE, 9, e108997, 10.1371/journal.pone.0108997
Jeon, 2016, GRP78 is required for cell proliferation and protection from apoptosis in chicken embryo fibroblast cells, Poult. Sci., 95, 1129, 10.3382/ps/pew016
Ji, 2017, PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a, Neuropharmacology, 113, 396, 10.1016/j.neuropharm.2016.10.022
Jin, 2014, Late-onset of spinal neurodegeneration in knock-in mice expressing a mutant BiP, PLoS ONE, 9, e112837, 10.1371/journal.pone.0112837
Jin, 2000, The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome, J. Biol. Chem., 275, 38699, 10.1074/jbc.M005543200
Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J., 19, 5720, 10.1093/emboj/19.21.5720
Kammoun, 2009, GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice, J. Clin. Invest., 119, 1201, 10.1172/JCI37007
Kelber, 2009, Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic cripto signaling via MAPK/PI3K and smad2/3 pathways, Oncogene, 28, 2324, 10.1038/onc.2009.97
Kikuchi, 2006, Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model, Proc. Natl. Acad. Sci. U.S.A., 103, 6025, 10.1073/pnas.0509227103
Kim, 2014, Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels, Exp. Cell Res, 327, 340, 10.1016/j.yexcr.2014.08.001
Kim, 2001, La autoantigen enhances translation of BiP mRNA, Nucleic Acids Res., 29, 5009, 10.1093/nar/29.24.5009
Klionsky, 2016, Guidelines for use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy, 12, 1, 10.1080/15548627.2015.1100356
Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723
Korennykh, 2009, The unfolded protein response signals through high-order assembly of Ire1, Nature, 457, 687, 10.1038/nature07661
Kroemer, 2010, Autophagy and the integrated stress response, Mol. Cell, 40, 280, 10.1016/j.molcel.2010.09.023
Kudo, 2006, Altered localization of amyloid precursor protein under endoplasmic reticulum stress, Biochem. Biophys. Res. Commun., 344, 525, 10.1016/j.bbrc.2006.03.173
Lagace, 2013, The role of phospholipids in the biological activity and structure of the endoplasmic reticulum, Biochim. Biophys. Acta Mol. Cell Res., 1833, 2499, 10.1016/j.bbamcr.2013.05.018
Laybutt, 2007, Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes, Diabetologia, 50, 752, 10.1007/s00125-006-0590-z
Lee, 1987, Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells, Trends Biochem. Sci., 12, 20, 10.1016/0968-0004(87)90011-9
Lee, 2010, Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice, Exp. Mol. Med., 42, 386, 10.3858/emm.2010.42.5.040
Li, 2012, Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol, Investig. Opthalmology Vis. Sci., 53, 3241, 10.1167/iovs.11-8406
Li, 2006, Stress induction of GRP78/BiP and its role in cancer, Curr. Mol. Med., 6, 45, 10.2174/156652406775574523
Li, 2009, The unfolded protein response regulator GRP78/Bip is required for ER integrity and stress-induced autophagy in mammalian cells, Cell Death Differ., 15, 1460, 10.1038/cdd.2008.81
Li, 1997, Induction of the mammalian GRP78/BiP gene by Ca2+ depletion and formation of aberrant proteins: activation of the conserved stress-inducible grp core promoter element by the human nuclear factor YY1, Mol. Cell. Biol., 17, 54, 10.1128/MCB.17.1.54
Li, 2015, GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ, Cell. Signal., 27, 1237, 10.1016/j.cellsig.2015.02.030
Li, 2013, Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion, Int. J. Biochem. Cell Biol, 45, 987, 10.1016/j.biocel.2013.02.002
Liu, 2016, Sil1 rescued Bip elevation-related tau hyperphosphorylation in ER stress, Mol. Neurobiol., 53, 983, 10.1007/s12035-014-9039-4
Luo, 2003, Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements, J. Biol. Chem., 278, 37375, 10.1074/jbc.M303619200
Määttänen, 2010, Protein quality control in the ER: the recognition of misfolded proteins, Semin. Cell Dev. Biol., 21, 500, 10.1016/j.semcdb.2010.03.006
Macejak, 1991, Internal initiation of translation mediated by the 5′ leader of a cellular mRNA, Nature, 353, 90, 10.1038/353090a0
Maharjan, 2016, ER strikes again: proteostasis dysfunction in ALS, EMBO J., 35, 798, 10.15252/embj.201694117
Mancuso, 2012, Sigma-1R agonist improves motor function and motoneuron survival in ALS mice, Neurotherapeutics, 9, 814, 10.1007/s13311-012-0140-y
Marín-Briggiler, 2010, Glucose-regulated protein 78 (Grp78/BiP) is secreted by human oviduct epithelial cells and the recombinant protein modulates sperm–zona pellucida binding, Fertil. Steril., 93, 1574, 10.1016/j.fertnstert.2008.12.132
Mark, 1997, A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide, J. Neurochem., 68, 255, 10.1046/j.1471-4159.1997.68010255.x
Martinez-Lopez, 2015, Autophagy and aging, Adv. Exp. Med. Biol., 847, 73, 10.1007/978-1-4939-2404-2_3
Matsunaga, 2010, Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L, J. Cell Biol., 190, 511, 10.1083/jcb.200911141
Mattson, 1994, Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise, Ann. N.Y. Acad. Sci., 747, 50, 10.1111/j.1749-6632.1994.tb44401.x
Misra, 2010a, Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells, Cancer Biol. Ther., 9, 142, 10.4161/cbt.9.2.10422
Misra, 2010b, Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78, Apoptosis, 15, 173, 10.1007/s10495-009-0430-y
Misra, 2005a, Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK, J. Biol. Chem., 280, 26278, 10.1074/jbc.M414467200
Misra, 2006, Activation and cross-talk between Akt, NF-κB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78, J. Biol. Chem., 281, 13694, 10.1074/jbc.M511694200
Misra, 2005b, The role of MTJ-1 in cell surface translocation of GRP78, a receptor for α2-macroglobulin-dependent signaling, J. Immunol., 174, 2092, 10.4049/jimmunol.174.4.2092
Misra, 2004, A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates α2-M*-induced signalling, Cell. Signal., 16, 929, 10.1016/j.cellsig.2004.01.003
Misra, 2009, Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis, Mol. Cancer Ther., 8, 1350, 10.1158/1535-7163.MCT-08-0990
Morris, 1997, Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins, J. Biol. Chem., 272, 4327, 10.1074/jbc.272.7.4327
Muñoz-Lobato, 2014, Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases, Antioxid. Redox Signal., 20, 217, 10.1089/ars.2012.5051
Nakatsuka, 2012, Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex, Diabetes, 61, 2823, 10.2337/db12-0232
Ni, 2011, Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signaling and therapeutic targeting, Biochem. J., 434, 181, 10.1042/BJ20101569
Ni, 2009, Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP, PLoS ONE, 4, e6868, 10.1371/journal.pone.0006868
Ntsapi, 2016, Caloric restriction and the precision-control of autophagy: a strategy for delaying neurodegenerative disease progression, Exp. Gerontol., 83, 97, 10.1016/j.exger.2016.07.014
Nuss, 2008, Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers, Biochem. Biophys. Res. Commun., 365, 355, 10.1016/j.bbrc.2007.10.194
Okamura, 2000, Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast, Biochem. Biophys. Res. Commun., 279, 445, 10.1006/bbrc.2000.3987
Otero, 2010, Life and death of a BiP substrate, Semin. Cell Dev. Biol., 21, 472, 10.1016/j.semcdb.2009.12.008
Ouyang, 2011, Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress, Mitochondrion, 11, 279, 10.1016/j.mito.2010.10.007
Ouyang, 2012, miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo, Neurobiol. Dis., 45, 555, 10.1016/j.nbd.2011.09.012
Oyadomari, 2004, Roles of CHOP/GADD153 in endoplasmic reticulum stress, Cell Death Differ., 11, 381, 10.1038/sj.cdd.4401373
Panayi, 2014, Immunoglobulin heavy-chain-binding protein (BiP): a stress protein that has the potential to be a novel therapy for rheumatoid arthritis, Biochem. Soc. Trans., 42, 1752, 10.1042/bst20140230
Parker, 2001, Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6, Mol. Cell. Biol., 21, 3220, 10.1128/MCB.21.9.3220-3233.2001
Paschen, 2004, Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesis, Curr. Neurovasc. Res., 1, 173, 10.2174/1567202043480125
Paz Gavilán, 2006, Cellular environment facilitates protein accumulation in aged rat hippocampus, Neurobiol. Aging, 27, 973, 10.1016/j.neurobiolaging.2005.05.010
Penas, 2009, Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion, J. Neurotrauma, 26, 763, 10.1089/neu.2008.0661
Penas, 2011a, Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons, Cell Death Differ., 18, 1617, 10.1038/cdd.2011.24
Penas, 2011b, Sigma receptor agonist 2-(4-Morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury, J. Neurotrauma, 28, 831, 10.1089/neu.2010.1674
Peng, 2013, Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1, J. Neurosci. Res., 91, 1349, 10.1002/jnr.23255
Petrova, 2008, Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3, EMBO J., 27, 2862, 10.1038/emboj.2008.199
Pfaffenbach, 2011, The critical role of GRP78 in physiological and pathologic stress, Curr. Opin. Cell Biol., 23, 150, 10.1016/j.ceb.2010.09.007
Philippova, 2008, Identification of proteins associating with Glycosylphosphatidylinositol-anchored T-cadherin on the surface of vascular endothelial cells: the role for Grp78/BiP in T-cadherin-dependent cell survival, Mol. Cell. Biol., 28, 4004, 10.1128/MCB.00157-08
Pincus, 2010, BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response, PLoS Biol., 8, e1000415, 10.1371/journal.pbio.1000415
Printsev, 2016, Membrane protein quantity control at the endoplasmic reticulum, J. Membr. Biol, 10.1007/s00232-016-9931-0
Rabek, 2003, Carbonylation of ER chaperone proteins in aged mouse liver, Biochem. Biophys. Res. Commun., 305, 566, 10.1016/S0006-291X(03)00826-X
Rajawat, 2009, Aging: central role for autophagy and the lysosomal degradative system, Ageing Res. Rev., 8, 199, 10.1016/j.arr.2009.05.001
Ravikumar, 2004, Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease, Nat. Genet., 36, 585, 10.1038/ng1362
Resendez, 1985, Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes, Mol. Cell. Biol., 5, 1212, 10.1128/MCB.5.6.1212
Resendez, 1988, Identification of highly conserved regulatory domains and protein-binding sites in the promoters of the rat and human genes encoding the stress-inducible 78-kilodalton glucose-regulated protein, Mol. Cell. Biol., 8, 4579, 10.1128/MCB.8.10.4579
Roy, 1995, Transduction of calcium stress through interaction of the human transcription factor CBF with the proximal CCAAT regulatory element of the grp78/BiP promoter, Mol. Cell. Biol., 15, 2263, 10.1128/MCB.15.4.2263
Rozas, 2017, The ER proteostasis network in ALS: determining the differential motoneuron vulnerability. Neurosci, Lett., 636, 9, 10.1016/j.neulet.2016.04.066
Russell, 2013, ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase, Nat. Cell Biol., 15, 741, 10.1038/ncb2757
Rutkowski, 2007, The role of p58IPK in protecting the stressed endoplasmic reticulum, Mol. Biol. Cell, 18, 3681, 10.1091/mbc.E07-03-0272
Saffran, 2010, Evidence for translational regulation by the herpes simplex virus virion host shutoff protein, J. Virol., 84, 6041, 10.1128/JVI.01819-09
Salganik, 2015, The loss of glucose regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human α-synuclein (α-syn) toxicity to rat nigral neurons, Neurobiol. Aging, 36, 2213, 10.1016/j.neurobiolaging.2015.02.018
Sato, 2015, The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease, Front. Aging Neurosci., 7, 199, 10.3389/fnagi.2015.00199
Satoh, 2000, Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor, J. Neurochem., 75, 1092, 10.1046/j.1471-4159.2000.0751092.x
Sayre, 1997, 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease, J. Neurochem., 68, 2092, 10.1046/j.1471-4159.1997.68052092.x
Schröder, 2005, ER stress and the unfolded protein response, Mutat. Res., 569, 29, 10.1016/j.mrfmmm.2004.06.056
Shamu, 1994, The unfolded-protein-response pathway in yeast, Trends Cell Biol., 4, 56, 10.1016/0962-8924(94)90011-6
Shani, 2008, GRP78 and cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth, Mol. Cell. Biol., 28, 666, 10.1128/MCB.01716-07
Shen, 2002, ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals, Dev. Cell, 3, 99, 10.1016/S1534-5807(02)00203-4
Shiu, 1977, Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts, Proc. Natl. Acad. Sci. U.S.A., 74, 3840, 10.1073/pnas.74.9.3840
Soejima, 2013, Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease, Curr. Alzheimer Res., 10, 11, 10.2174/1567205011310010003
Sokolowska, 2012, Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells, FEBS J., 279, 2579, 10.1111/j.1742-4658.2012.08641.x
Sörgjerd, 2006, Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis, J. Mol. Biol., 356, 469, 10.1016/j.jmb.2005.11.051
Sun, 2006, Localization of GRP78 to mitochondria under the unfolded protein response, Biochem. J., 396, 31, 10.1042/BJ20051916
Suzuki, 1991, Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP, J. Cell Biol., 114, 189, 10.1083/jcb.114.2.189
Szegezdi, 2006, Mediators of endoplasmic reticulum stress-induced apoptosis, EMBO Rep., 7, 880, 10.1038/sj.embor.7400779
Tang, 2010, Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy, PLoS ONE, 5, e14207, 10.1371/journal.pone.0014207
Tao, 2011, Structural insight into the protective role of P58(IPK) during unfolded protein response, Methods Enzymol., 490, 259, 10.1016/B978-0-12-385114-7.00015-5
Tsai, 2015, Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface, J. Biol. Chem, 290, 8049, 10.1074/jbc.M114.618736
Wadsworth, 2003, Molecular and clinical classification of human prion disease, Br. Med. Bull., 66, 241, 10.1093/bmb/66.1.241
Wang, 2016, Protein misfolding in the endoplasmic reticulum as a conduit to human disease, Nature, 529, 326, 10.1038/nature17041
Wang, 2010, Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis, Cell Death Differ., 17, 488, 10.1038/cdd.2009.144
Wang, 2015, Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke, J. Neurosci. Res., 93, 1756, 10.1002/jnr.23637
Wang, 1996, Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153), Mol. Cell. Biol., 16, 4273, 10.1128/MCB.16.8.4273
Wang, 2011, Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis, Cell Death Differ., 18, 38, 10.1038/cdd.2010.68
Wang, 2015, GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice, Metab. Clin. Exp., 64, 1435, 10.1016/j.metabol.2015.08.005
Wen, 2012, Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness, Cancer Res., 72, 3337, 10.1158/0008-5472.CAN-12-0269
Yang, 1997, Location of the internal ribosome entry site in the 5′ non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions, Nucleic Acids Res., 25, 2800, 10.1093/nar/25.14.2800
Yang, 1998, The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Aβ40 and Aβ42 secretion, J. Biol. Chem., 273, 25552, 10.1074/jbc.273.40.25552
Ye, 2010, Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance, Diabetes, 59, 6, 10.2337/db09-0755
Yerbury, 2010, Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Aβ(1-42) toxicity and uptake, Cell Stress Chaperones, 15, 115, 10.1007/s12192-009-0122-0
Yoshida, 2001a, XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor, Cell, 107, 881, 10.1016/S0092-8674(01)00611-0
Yoshida, 2001b, Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response, Mol. Cell. Biol., 21, 1239, 10.1128/MCB.21.4.1239-1248.2001
Yu, 1999, The Endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis, Exp. Neurol., 155, 302, 10.1006/exnr.1998.7002
Zhang, 2015, Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells, Mol. Brain, 8, 20, 10.1186/s13041-015-0112-3