GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)

Journal of Medicinal Chemistry - Tập 60 Số 22 - Trang 9162-9183 - 2017
F. Anthony Romero1, Jeremy Murray1, Kwong Wah Lai2, Vickie Tsui1, Brian K. Albrecht3, Le An1, Maureen H. Beresini1, Gladys de Leon Boenig1, Emily Chan1, Kevin X. Chen2, Zhongguo Chen2, Edna F. Choo1, Kyle Clagg1, Kevin Clark1, Terry D. Crawford1, Patrick Cyr1, Denise de Almeida Nagata1, Karen E. Gascoigne1, Jane L. Grogan1, Georgia Hatzivassiliou1, Wei Huang2, Thomas Hunsaker1, Susan Kaufman1, Stefan G. Koenig1, Ruina Li1, Yingjie Li2, Xiaorong Liang1, Jiangpeng Liao2, Wenfeng Liu2, Justin Q. Ly1, Jonathan Maher1, Colin Masui1, Mark Merchant1, Yingqing Ran1, Alexander M. Taylor3, John Wai2, Fei Wang2, Xiaocang Wei2, Dong Yu2, Bing‐Yan Zhu1, Xiaoyu Zhu2, Steven Magnuson1
1Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
2WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’s Republic of China
3Constellation Pharmaceuticals, Inc. 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States

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