GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

Anthony, 2004, Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2, J. Biol. Chem., 279, 36553, 10.1074/jbc.M404559200

Beretta, 2004, Translational control in T lymphocytes, Int. Rev. Immunol., 23, 347, 10.1080/08830180490452549

Crosby, 2000, Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase, Blood, 96, 3241, 10.1182/blood.V96.9.3241

Dever, 2002, Gene-specific regulation by general translation factors, Cell, 108, 545, 10.1016/S0092-8674(02)00642-6

Dong, 2000, Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain, Mol. Cell, 6, 269, 10.1016/S1097-2765(00)00028-9

Fernandez, 2002, Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame, J. Biol. Chem., 277, 2050, 10.1074/jbc.M109199200

Fingar, 2004, Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression, Oncogene, 23, 3151, 10.1038/sj.onc.1207542

Forman, 2003, ‘Unfolding’ pathways in neurodegenerative disease, Trends Neurosci., 26, 407, 10.1016/S0166-2236(03)00197-8

Fox, 2005, The Pim kinases control rapamycin-resistant T cell survival and activation, J. Exp. Med., 201, 259, 10.1084/jem.20042020

Grohmann, 2003, Tolerance, DCs and tryptophan: much ado about IDO, Trends Immunol., 24, 242, 10.1016/S1471-4906(03)00072-3

Harding, 2000, Regulated translation initiation controls stress-induced gene expression in mammalian cells, Mol. Cell, 6, 1099, 10.1016/S1097-2765(00)00108-8

Harding, 2000, Perk is essential for translational regulation and cell survival during the unfolded protein response, Mol. Cell, 5, 897, 10.1016/S1097-2765(00)80330-5

Harding, 2003, An integrated stress response regulates amino acid metabolism and resistance to oxidative stress, Mol. Cell, 11, 619, 10.1016/S1097-2765(03)00105-9

Harrington, 2000, Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans, J. Exp. Med., 191, 1241, 10.1084/jem.191.7.1241

Hinnebusch, 1994, The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress, Semin. Cell Biol., 5, 417, 10.1006/scel.1994.1049

Hinnebusch, 2000, Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes

Hogquist, 1994, T cell receptor antagonist peptides induce positive selection, Cell, 76, 17, 10.1016/0092-8674(94)90169-4

Huang, 1994, Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens, Science, 264, 961, 10.1126/science.7513904

Jiang, 2003, Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses, Mol. Cell. Biol., 23, 5651, 10.1128/MCB.23.16.5651-5663.2003

Kurts, 1996, Constitutive class I-restricted exogenous presentation of self antigens in vivo, J. Exp. Med., 184, 923, 10.1084/jem.184.3.923

Li, 2004, Cell surface expression of MHC class I antigen is suppressed in indoleamine 2,3-dioxygenase genetically modified keratinocytes: implications in allogeneic skin substitute engraftment, Hum. Immunol., 65, 114, 10.1016/j.humimm.2003.11.004

Lu, 2004, Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response, J. Cell Biol., 167, 27, 10.1083/jcb.200408003

Marshall, 2001, Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme, BMC Biochem., 2, 5, 10.1186/1471-2091-2-5

Mellor, 2004, IDO expression by dendritic cells: Tolerance and tryptophan catabolism, Nat. Rev. Immunol., 4, 762, 10.1038/nri1457

Mellor, 2003, Cutting Edge: Induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion, J. Immunol., 171, 1652, 10.4049/jimmunol.171.4.1652

Munn, 2004, Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes, J. Clin. Invest., 114, 280, 10.1172/JCI21583

Munn, 2002, Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase, Science, 297, 1867, 10.1126/science.1073514

Munn, 2004, Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells, J. Immunol., 172, 4100, 10.4049/jimmunol.172.7.4100

Munn, 1998, Prevention of allogeneic fetal rejection by tryptophan catabolism, Science, 281, 1191, 10.1126/science.281.5380.1191

Natarajan, 2001, Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast, Mol. Cell. Biol., 21, 4347, 10.1128/MCB.21.13.4347-4368.2001

Niwa, 2000, Pausing to decide, Proc. Natl. Acad. Sci. USA, 97, 12396, 10.1073/pnas.250476097

Ozcan, 2004, Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes, Science, 306, 457, 10.1126/science.1103160

Rao, 2004, Coupling endoplasmic reticulum stress to the cell death program, Cell Death Differ., 11, 372, 10.1038/sj.cdd.4401378

Rutkowski, 2004, A trip to the ER: coping with stress, Trends Cell Biol., 14, 20, 10.1016/j.tcb.2003.11.001

Schwartz, 2003, T cell anergy, Annu. Rev. Immunol., 21, 305, 10.1146/annurev.immunol.21.120601.141110

Sood, 2000, A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha, Genetics, 154, 787, 10.1093/genetics/154.2.787

Tarazona, 1996, Effects of different antigenic microenvironments on the course of CD8+ T cell responses in vivo, Int. Immunol., 8, 351, 10.1093/intimm/8.3.351

van Wissen, 2002, IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase, J. Immunol., 169, 7039, 10.4049/jimmunol.169.12.7039

Vattem, 2004, Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells, Proc. Natl. Acad. Sci. USA, 101, 11269, 10.1073/pnas.0400541101

Zelenika, 1998, Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells, J. Immunol., 161, 1868, 10.4049/jimmunol.161.4.1868

Zhang, 2002, The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas, Mol. Cell. Biol., 22, 3864, 10.1128/MCB.22.11.3864-3874.2002

Zhang, 2002, The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice, Mol. Cell. Biol., 22, 6681, 10.1128/MCB.22.19.6681-6688.2002