G-protein Coupled Receptors in Stem Cell Self-Renewal and Differentiation

Springer Science and Business Media LLC - Tập 6 - Trang 351-366 - 2010
Nao R. Kobayashi1,2, Susan M. Hawes3, Jeremy M. Crook1,2, Alice Pébay1,4
1Stem Cell Medicine, O’ Brien Institute, Melbourne, Australia
2Department of Surgery, The University of Melbourne, Melbourne, Australia
3Monash Immunology and Stem Cell Laboratories, Monash University, Melbourne, Australia
4Centre for Neuroscience & Department of Pharmacology, The University of Melbourne, Melbourne, Australia

Tóm tắt

Stem cells have great potential for understanding early development, treating human disease, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidence now exists demonstrating the potent effects of various G-protein coupled receptor (GPCR) ligands on the biology of stem cells. This review aims to give an overview of the current knowledge of the regulation of embryonic and somatic stem cell maintenance and differentiation by GPCR ligands.

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Springer Science and Business Media LLC

Tập 6

351-366

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