Future and current surgical therapies in Parkinson's disease

Obeso, 2000, Pathophysiologic basis of surgery for Parkinsons disease., Neurology, 55, S7

2002, Surgical treatment for Parkinsons disease: deep brain surgery., Mov Disord, 17, S128

Benazzouz, 2000, Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat., Neuroscience, 99, 289, 10.1016/S0306-4522(00)00199-8

Su, 2001, Metabolic changes following subthalamotomy for advanced Parkinsons disease., Ann Neurol, 50, 514, 10.1002/ana.1232

Hutchison, 1998, Neurophysiological identification of the subthalamic nucleus in surgery for Parkinsons disease., Ann Neurol, 44, 622, 10.1002/ana.410440407

Fabbrini, 1987, Levodopa pharmacokinetic mechanisms and motor fluctuations in Parkinsons disease., Ann Neurol, 21, 370, 10.1002/ana.410210409

Ahlskog, 2001, Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature., Mov Disord, 16, 448, 10.1002/mds.1090

Lang, 1998, Parkinsons disease. First of two parts., N Engl J Med, 339, 1044, 10.1056/NEJM199810083391506

Lang, 1998, Parkinsons disease. Second of two parts., N Engl J Med, 339, 1130, 10.1056/NEJM199810153391607

Fung, 2002, Surgical treatment for Parkinsons disease., Med J Aust, 177, 125, 10.5694/j.1326-5377.2002.tb04694.x

Obwegeser, 2001, Quantitative and qualitative outcome measures after thalamic deep brain stimulation to treat disabling tremors., Neurosurgery, 48, 274

Schuurman, 2000, A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor., N Engl J Med, 342, 461, 10.1056/NEJM200002173420703

Koller, 2000, Deep brain stimulation of the Vim nucleus of the thalamus for the treatment of tremor., Neurology, 55, S29

Fox, 1991, Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinsons disease patients., J Neurosurg, 75, 723, 10.3171/jns.1991.75.5.0723

Jankovic, 1995, Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor., Neurosurgery, 37, 680, 10.1227/00006123-199510000-00011

de Bie, 1999, Unilateral pallidotomy in Parkinsons disease: a randomised, single-blind, multicentre trial., Lancet, 354, 1658, 10.1016/S0140-6736(99)03556-4

de Bie, 1999, Unilateral pallidotomy in advanced Parkinsons disease: a retrospective study of 26 patients., Mov Disord, 14, 951, 10.1002/1531-8257(199911)14:6<951::AID-MDS1007>3.0.CO;2-O

Parkin, 2002, Unilateral and bilateral pallidotomy for idiopathic Parkinsons disease: a case series of 115 patients., Mov Disord, 17, 682, 10.1002/mds.10186

De Bie, 2002, Bilateral pallidotomy in Parkinsons disease: a retrospective study., Mov Disord, 17, 533, 10.1002/mds.10090

Loher, 2002, Long-term pallidal deep brain stimulation in patients with advanced Parkinson disease: 1-year follow-up study., J Neurosurg, 96, 844, 10.3171/jns.2002.96.5.0844

Loher, 2002, Pallidal deep brain stimulation in a parkinsonian patient with late-life dementia: sustained benefit in motor symptoms but not in functional disability., Eur Neurol, 47, 122, 10.1159/000047964

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Ghika, 1998, Efficiency and safety of bilateral contemporaneous pallidal stimulation (deep brain stimulation) in levodoparesponsive patients with Parkinsons disease with severe motor fluctuations: a 2-year follow-up review., J Neurosurg, 89, 713, 10.3171/jns.1998.89.5.0713

Lozano, 2002, Physiologic studies in the human brain in movement disorders., Parkinsonism Relat Disord, 8, 455, 10.1016/S1353-8020(02)00027-5

Lozano, 2000, Neuronal recordings in Parkinsons disease patients with dyskinesias induced by apomorphine., Ann Neurol, 47, S141

Ostergaard, 2002, Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinsons disease and motor fluctuations., Mov Disord, 17, 693, 10.1002/mds.10188

Limousin, 1998, Electrical stimulation of the subthalamic nucleus in advanced Parkinsons disease., N Engl J Med, 339, 1105, 10.1056/NEJM199810153391603

Gray, 2002, Quality of life outcomes following surgical treatment of Parkinsons disease., Mov Disord, 17, 68, 10.1002/mds.1259

Pollak, 2002, Treatment results: Parkinsons disease., Mov Disord, 17, S75, 10.1002/mds.10146

Durif, 2002, Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinsons disease., Mov Disord, 17, 803, 10.1002/mds.10128

Su, 2002, Subthalamotomy for advanced Parkinson disease., J Neurosurg, 97, 598, 10.3171/jns.2002.97.3.0598

Keep, 2002, Gamma knife subthalamotomy for Parkinson disease: the subthalamic nucleus as a new radiosurgical target. Case report., J Neurosurg, 97, 592, 10.3171/jns.2002.97.supplement_5.0592

Kaplitt, 1994, Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain., Nat Genet, 8, 148, 10.1038/ng1094-148

Corti, 1999, Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinsons disease., Proc Natl Acad Sci USA, 96, 12120, 10.1073/pnas.96.21.12120

Ozawa, 2000, Gene therapy of Parkinsons disease using adeno-associated virus (AAV) vectors., J Neural Transm Suppl, 181

Kordower, 1999, Lentiviral gene transfer to the nonhuman primate brain., Exp Neurol, 160, 1, 10.1006/exnr.1999.7178

During, 1994, Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase., Science, 266, 1399, 10.1126/science.266.5189.1399

Azzouz, 2002, Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinsons disease., J Neurosci, 22, 10302, 10.1523/JNEUROSCI.22-23-10302.2002

Shen, 2000, Triple transduction with adenoassociated virus vectors expressing tyrosine hydroxylase, aromatic-L-aminoacid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinsons disease., Hum Gene Ther, 11, 1509, 10.1089/10430340050083243

Fan, 2001, Adeno-associated virus vector-mediated triple gene transfer of dopamine synthetic enzymes., Chin Med J (Engl), 114, 1276

Leff, 1999, Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adenoassociated viral vector gene transfer in a rodent model of Parkinsons disease., Neuroscience, 92, 185, 10.1016/S0306-4522(98)00741-6

Muramatsu, 2002, Behavioral recovery in a primate model of Parkinsons disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes., Hum Gene Ther, 13, 345, 10.1089/10430340252792486

During, 1998, In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector., Gene Ther, 5, 820, 10.1038/sj.gt.3300650

Muramatsu, 2002, Behavioral recovery in a primate model of Parkinsons disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes., Hum Gene Ther, 13, 345, 10.1089/10430340252792486

Lee, 1999, Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase enhance dopamine delivery after L-3,4-dihydroxyphenylalanine administration in Parkinsonian rats., J Neurosci, 19, 3266, 10.1523/JNEUROSCI.19-08-03266.1999

Sanchez-Pernaute, 2001, Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats., Mol Ther, 4, 324, 10.1006/mthe.2001.0466

Bankiewicz, 2000, Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach., Exp Neurol, 164, 2, 10.1006/exnr.2000.7408

Shingo, 2002, Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF-producing cells in a rat model of Parkinsons disease., J Neurosci Res, 69, 946, 10.1002/jnr.10375

McBride, 2002, Neuroprotection for Parkinsons disease using viral vector-mediated delivery of GDNF., Prog Brain Res, 138, 421, 10.1016/S0079-6123(02)38091-9

Gash, 1998, Neuroprotective and neurorestorative properties of GDNF., Ann Neurol, 44, S121, 10.1002/ana.410440718

Grondin, 1998, Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinsons disease., J Neurol, 245, 35, 10.1007/PL00007744

Kordower, 2000, Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinsons disease., Science, 290, 767, 10.1126/science.290.5492.767

Bjorklund, 2000, Towards a neuroprotective gene therapy for Parkinsons disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model., Brain Res, 886, 82, 10.1016/S0006-8993(00)02915-2

Gerin, 2002, Behavioral improvement and dopamine release in a Parkinsonian rat model., Neurosci Lett, 330, 5, 10.1016/S0304-3940(02)00672-9

Jin, 2002, Activation of cell-survival signal Akt by GDNF in normal rat brain., Brain Res, 958, 429, 10.1016/S0006-8993(02)03521-7

Trupp, 1999, Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells., J Biol Chem, 274, 20885, 10.1074/jbc.274.30.20885

Gill, 2003, Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease., Nat Med, 9, 589, 10.1038/nm850

During, 2001, Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation., Hum Gene Ther, 12, 1589

Luo, 2002, Subthalamic GAD gene therapy in a Parkinsons disease rat model., Science, 298, 425, 10.1126/science.1074549

Arenas, 2002, Stem cells in the treatment of Parkinsons disease., Brain Res Bull, 57, 795, 10.1016/S0361-9230(01)00772-9

Grondin, 2002, Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys., Brain, 125, 2191, 10.1093/brain/awf234

Nutt, 2003, Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD., Neurology, 60, 69, 10.1212/WNL.60.1.69

Baron, 2002, Effects of transient focal inactivation of the basal ganglia in parkinsonian primates., J Neurosci, 22, 592, 10.1523/JNEUROSCI.22-02-00592.2002

Levy, 2001, Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms., Brain, 124, 2105, 10.1093/brain/124.10.2105

Freed, 2001, Transplantation of embryonic dopamine neurons for severe Parkinsons disease., N Engl J Med, 344, 710, 10.1056/NEJM200103083441002

Hagell, 2002, Dyskinesias following neural transplantation in Parkinsons disease., Nat Neurosci, 5, 627, 10.1038/nn863

Ma, 2002, Dyskinesia after fetal cell transplantation for parkinsonism: a PET study., Ann Neurol, 52, 628, 10.1002/ana.10359

Mendez, 2002, Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases., J Neurosurg, 96, 589, 10.3171/jns.2002.96.3.0589

Kim, 2002, Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins., Neurosci Lett, 333, 74, 10.1016/S0304-3940(02)00981-3

Kim, 2002, Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinsons disease., Nature, 418, 50, 10.1038/nature00900

Yang, 2002, Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopaminelesioned rat., Exp Neurol, 177, 50, 10.1006/exnr.2002.7989

Bjorklund, 2002, Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model., Proc Natl Acad Sci USA, 99, 2344, 10.1073/pnas.022438099

Ostenfeld, 2002, Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons., J Neurosci Res, 69, 955, 10.1002/jnr.10396

Akerud, 2001, Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinsons disease., J Neurosci, 21, 8108, 10.1523/JNEUROSCI.21-20-08108.2001

Akerud, 2002, Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinsons disease., Mol Cell Neurosci, 21, 205, 10.1006/mcne.2002.1171