Further Dissociating the Processes Involved in Recognition Memory: An fMRI Study

Journal of Cognitive Neuroscience - Tập 17 Số 7 - Trang 1058-1073 - 2005
Richard N. Henson1,2, Michael Hornberger1, Michael D. Rugg3
1MRC Cognition and Brain Sciences Unit, Cambridge, UK
2University College London
3University of California, Irvine

Tóm tắt

Abstract Based on an event-related potential study by Rugg et al. [Dissociation of the neural correlates of implicit and explicit memory. Nature, 392, 595-598, 1998], we attempted to isolate the hemodynamic correlates of recollection, familiarity, and implicit memory within a single verbal recognition memory task using event-related fMRI. Words were randomly cued for either deep or shallow processing, and then intermixed with new words for yes/no recognition. The number of studied words was such that, whereas most were recognized (“hits”), an appreciable number of shallow-studied words were not (“misses”). Comparison of deep hits versus shallow hits at test revealed activations in regions including the left inferior parietal gyrus. Comparison of shallow hits versus shallow misses revealed activations in regions including the bilateral intraparietal sulci, the left posterior middle frontal gyrus, and the left frontopolar cortex. Comparison of hits versus correct rejections revealed a relative deactivation in an anterior left medial-temporal region (most likely the perirhinal cortex). Comparison of shallow misses versus correct rejections did not reveal response decreases in any regions expected on the basis of previous imaging studies of priming. Given these and previous data, we associate the left inferior parietal activation with recollection, the left anterior medial-temporal deactivation with familiarity, and the intraparietal and prefrontal responses with target detection. The absence of differences between shallow misses and correct rejections means that the hemodynamic correlates of implicit memory remain unclear.

Từ khóa


Tài liệu tham khảo

10.1006/nimg.2001.0746

10.1002/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G

10.1097/00001756-200105080-00039

10.1038/35090048

10.1093/cercor/12.10.1048

10.1016/S0022-5371(72)80001-X

10.1162/089892901753294356

10.1073/pnas.0337195100

10.1016/S0028-3932(02)00164-1

10.1038/80671

10.1093/brain/124.5.849

10.1016/S0010-9452(08)70875-X

10.1006/nimg.1997.0306

10.1006/nimg.2002.1091

10.1037/0278-7393.29.6.1210

10.1016/S0301-0082(03)00086-8

10.1093/brain/122.7.1367

10.1093/cercor/12.2.178

10.1002/hipo.10117

10.1162/08989290051137468

10.1523/JNEUROSCI.19-10-03962.1999

10.1016/j.neuroimage.2003.09.039

10.1037/0096-3445.110.3.306

10.1098/rstb.1999.0475

10.1523/JNEUROSCI.23-06-02407.2003

10.1037/0033-295X.110.4.728

10.1073/pnas.97.1.506

10.1126/science.282.5397.2151a

10.1037/0033-295X.87.3.252

10.1016/S0149-7634(01)00034-3

10.1162/08989290051137503

10.1093/brain/awg020

10.1017/S1355617799533018

10.1093/brain/124.2.399

10.1093/cercor/11.12.1150

10.1016/S0960-9822(01)00454-7

10.1016/S1364-6613(00)01845-3

10.1016/j.neuropsychologia.2003.07.006

10.1016/S0028-3932(02)00129-X

10.1038/33396

10.1098/rstb.2002.1102

Schacter D. L., 1987, Journal of Experimental Psychology, 13, 501

10.1016/S0896-6273(00)80448-1

10.1073/pnas.0409070102

10.1037/0735-7044.114.3.459

10.1523/JNEUROSCI.22-02-00523.2002

10.1093/cercor/10.12.1176

10.1016/S0896-6273(01)00359-2

Wagner A. D., 1998, Science, 21, 188

10.1016/S0010-9452(08)70510-0

10.1093/cercor/bhg125

10.1523/JNEUROSCI.23-09-03869.2003

10.1016/j.neuroimage.2003.11.001

10.1037/0278-7393.26.3.547

10.3758/CABN.4.1.58

10.1006/jmla.2002.2864

10.1038/nn961

10.1523/JNEUROSCI.5295-04.2005

Thông tin
Thông tin xuất bản

Journal of Cognitive Neuroscience

Tập 17 Số 7

1058-1073

Thông tin tác giả