Kim vi điểm chức năng cho hệ thống giám sát glucose liên tục

Nano Convergence - Tập 5 - Trang 1-10 - 2018
Kai Takeuchi1, Beomjoon Kim1
1Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Tóm tắt

Kim vi điểm (MNs) đã được xác lập như là những thiết bị y tế đầy hứa hẹn do tính xâm lấn tối thiểu, gây đau ít hơn và khả năng tự sử dụng thuốc bởi bệnh nhân. Có sự phát triển nhanh chóng trong các kim vi điểm cho hệ thống theo dõi và chẩn đoán qua da, theo sau là nghiên cứu tích cực về các phương pháp chế tạo và ứng dụng cho việc phát thuốc. Trong bài viết này, các nghiên cứu gần đây về cảm biến sinh học sử dụng MNs được xem xét từ góc độ khả năng áp dụng cho hệ thống giám sát glucose liên tục (CGMS), một trong những trọng tâm nghiên cứu chính của công nghệ kỹ thuật y sinh. Xu hướng của các kim vi điểm chức năng có thể được phân loại như sau: (i) như một đầu dò cảm biến, và (ii) như một bộ thu thập dịch sinh học. Các MNs như cảm biến trong cơ thể chủ yếu được tích hợp hoặc phủ bằng các vật liệu dẫn điện để có chức năng như điện cực. Các MNs như bộ thu thập dịch được thiết kế với hình dáng nhất định, chẳng hạn như cấu trúc rỗng và xốp được hỗ trợ bởi tác động mao dẫn hoặc áp suất âm, để trích xuất các dịch ngoại bào hoặc máu cho phân tích ex vivo. Để hiện thực hóa CGMS với MNs, cần phải nghiên cứu việc đo lường chính xác dài hạn bằng đầu dò cảm biến dựa trên MN hoặc kết nối dịch giữa bộ thu thập dịch dựa trên MN và các hệ thống đo vi lưu hiện có.

Từ khóa

#kim vi điểm #giám sát glucose liên tục #cảm biến sinh học #hệ thống vi lưu #thiết bị y tế

Tài liệu tham khảo

L. Lin, A.P. Pisano, Silicon-processed microneedles. J. Microelectromech. Syst. 8(1), 78–84 (1999) P. Griss, G. Stemme, Novel, side opened out-of-plane microneedles for microfluidic transdermal interfacing, in Technical Digest MEMS 2002 IEEE international conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH66), pp. 467–470 (2002) P. Griss, G. Stemme, Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer. J. Microelectromech. Syst. 12(3), 296 (2003) K. Kabseog, S.P. Daniel, M.L. Hong, C. Wooseong, K. Kyunghwan, L. Jeong-Bong, H.A. Chong, A tapered hollow metallic microneedle array using backside exposure of su-8. J. Micromech. Microeng. 14(4), 597 (2004) A. Trautmann, P. Ruther, O. Paul, Microneedle arrays fabricated using suspended etch mask technology combined with fluidic through wafer vias, in IEEE the sixteenth annual international conference on micro electro mechanical systems. MEMS-03 Kyoto, pp. 682–685 (2003) A. Trautmann, F. Heuck, R. Denfeld, P. Ruther, O. Paul, Detachable silicon microneedle stamps for allergy skin prick testing, in 19th IEEE international conference on micro electro mechanical systems, pp. 434–437 (2006) Wei Chen, Rui Tian, Xu Can, Bryant C. Yung, Guohao Wang, Yijing Liu, Qianqian Ni, Fuwu Zhang, Zijian Zhou, Jingjing Wang, Gang Niu, Ying Ma, Fu Liwu, Xiaoyuan Chen, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy. Nat. Commun. 8(1), 1777 (2017) L. Luca, G.R. Bertrand, D. Floriant, M. Frank, M.T. Rex, H.G. Richard, I. Adelina, Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform. Nat. Nanotechnol. 13(6), 504–511 (2018) R.P. Mark, Microneedles for transdermal drug delivery. Adv. Drug Deliv. Rev. 56(5), 581–587 (2004) M. van der Koen, J. Wim, B. Joke, Microneedle technologies for (trans)dermal drug and vaccine delivery. J. Control. Release 161(2), 645–655 (2012) W. Sun, Z. Araci, M. Inayathullah, S. Manickam, X. Zhang, A. Marc, M. Bruce, P. Marinkovich, A.T. Lane, C. Milla, J. Rajadas, M.J. Butte, Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. Acta Biomater. 9(8), 7767 (2013) P. Van Damme, F. Oosterhuis-Kafeja, M. Van der Wielen, Y. Almagor, O. Sharon, Y. Levin, Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults. Vaccine 27(3), 454–459 (2009) M. Kim, H. Yang, H. Kim, H. Jung, H. Jung, Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles. Int. J. Cosmet. Sci. 36(3), 207–212 (2014) P. Yonghun, J. Park, G.S. Chu, K.S. Kim, J.H. Sung, B. Kim, Transdermal delivery of cosmetic ingredients using dissolving polymer microneedle arrays. Biotechnol. Bioprocess Eng. 20(3), 543–549 (2015) M. Karen, J.C. McElnay, F.D. Ryan, Children’s views on microneedle use as an alternative to blood sampling for patient monitoring. Int. J. Pharm. Pract. 22(5), 335 (2013) N. Fogh-Andersen, B.M. Altura, B.T. Altura, O. Siggaard-Andersen, Composition of interstitial fluid. Clin. Chem. 41(10), 1522–1525 (1995) J.P. Le Floch, B. Bauduceau, M. Lévy, H. Mosnier-Pudar, C. Sachon, B. Kakou, Self-monitoring of blood glucose, cutaneous finger injury, and sensory loss in diabetic patients. Diabetes Care 31(10), e73–e73 (2008) S. Vaddiraju, D.J. Burgess, I. Tomazos, F.C. Jain, F. Papadimitrakopoulos, Technologies for continuous glucose monitoring: current problems and future promises. J. Diab. Sci. Technol. 4(6), 1540–1562 (2010) V. Lodwig, B. Kulzer, O. Schnell, L. Heinemann, Current trends in continuous glucose monitoring. J. Diab. Sci. Technol. 8(2), 390 (2014) R. David, Continuous glucose monitoring: a review of successes, challenges, and opportunities. Diab. Technol. Ther. 18(S2), S2–S13 (2016) M.J. Fokkert, P.R. van Dijk, M.A. Edens, S. Abbes, D. de Jong, R.J. Slingerland, H.J.G. Bilo, Performance of the freestyle libre flash glucose monitoring system in patients with type 1 and 2 diabetes mellitus. BMJ Open 5(1), e000320 (2017) S.B. Michael, David, K. Joy, D.S. Christopher, Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor. Diabetes 52(ll), 2790–2794 (2003) J. Pickup, Developing glucose sensors for in vivo use. Trends Biotechnol. 11(7), 285–291 (1993) Y. Miyahara, T. Moriizumi, K. Ichimura, Integrated enzyme fets for simultaneous detections of urea and glucose. Sens. Actuat. 7(1), 1–10 (1985) H. Yoon, Sungrok Ko, J. Jang, Field-effect-transistor sensor based on enzyme-functionalized polypyrrole nanotubes for glucose detection. J. Phys. Chem. B 112(32), 9992–9997 (2008) J. Kimura, N. Ito, T. Kuriyama, M. Kikuchi, T. Arai, N. Negishi, Y. Tomita, A novel blood glucose monitoring method an isfet biosensor applied to transcutaneous effusion fluid. J. Electrochem. Soc. 136(6), 1744–1747 (1989) P. Keun-Yong, C. Sang-Bok, L. Minho, S. Byung-Ki, C. Sie-Young, Isfet glucose sensor system with fast recovery characteristics by employing electrolysis. Sens. Actuators 83(1), 90–97 (2002) M.R. Robinson, R.P. Eaton, D.M. Haaland, G.W. Koepp, E.V. Thomas, B.R. Stallard, P.L. Robinson, Noninvasive glucose monitoring in diabetic patients: a preliminary evaluation. Clin. Chem. 38(9), 1618–1622 (1992) T. Andrea, M. Alberto, P. Giovanni, Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diabetes Res. Clin. Pract. 77(1), 16–40 (2007) F.D. Ryan, M. Karen, E. Caffarel-Salvador, B.M. Torrisi, E. Eyman, J.C. McElnay, Microneedle-mediated minimally invasive patient monitoring. Ther. Drug Monit. 36(1), 10–17 (2014) P.R. Miller, R.J. Narayan, R. Polsky, Microneedle-based sensors for medical diagnosis. J. Mater. Chem. B 4, 1 (2016) V. Letizia, M.S. Lucanos, B. Giuseppe, Microneedles for transdermal biosensing: current picture and future direction. Adv. Healthcare Mater. 4(17), 2606–2640 (2015) S.J. Updike, M.C. Shults, B.J. Gilligan, R.K. Rhodes, A subcutaneous glucose sensor with improved longevity, dynamic range, and stability of calibration. Diabetes Care 23(2), 208–214 (2000) P. Jung-Hwan, M.G. Allen, M.R. Prausnitz, Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J. Control. Release 104(1), 51–66 (2005) J.Y. Lee, K. Dae-Hyun, K.J. Lee II, H. Seo, S.H. Park, E.H. Jang, Y. Park, Y.-N. Youn, W. Ryu, Transfer-molded wrappable microneedle meshes for perivascular drug delivery. J. Control. Release 268, 237–246 (2017) Y. Ito, K. Matsumoto, N. Osakama, R. Yoshioka, S. Kobuchi, T. Sakaeda, K. Takada, Dissolving microneedles as skin allergy test device. Biol. Pharm. Bull. 40(4), 531–534 (2017) K. Tsioris, W.K. Raja, E.M. Pritchard, B. Panilaitis, D.L. Kaplan, F.G. Omenetto, Fabrication of silk microneedles for controlled-release drug delivery. Adv. Funct. Mater. 22(2), 330 (2012) J.D. Kim, M. Kim, H. Yang, K. Lee, H. Jung, Droplet-born air blowing: novel dissolving microneedle fabrication. J. Control. Release 170(3), 430–436 (2013) K.J. Lee, S.H. Park, J.Y. Lee, H.C. Joo, E.H. Jang, Y.N. Youn, W. Ryu, Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury. J. Control. Release 192(Supplement C), 174–181 (2014) S.J. Lee, H.S. Yoon, X. Xuan, J.Y. Park, S.J. Paik, M.G. Allen, A patch type non-enzymatic biosensor based on 3d sus micro-needle electrode array for minimally invasive continuous glucose monitoring. Sens. Actuat. B 222, 1144–1151 (2016) Y. Sun, L. Ren, L. Jiang, Y. Tang, B. Liu, Fabrication of composite microneedle array electrode for temperature and bio-signal monitoring. Sensors 18(4), 1193 (2018) S.A. Skoog, P.R. Miller, R.D. Boehm, A.V. Sumant, R. Polsky, R.J. Narayan, Nitrogen-incorporated ultrananocrystalline diamond microneedle arrays for electrochemical biosensing. Diamond Related Mater. 54, 39–46 (2015) L. Tang, Y. Li, H. Xie, Q. Shu, F. Yang, Y. Liu, F. Liang, H. Wang, Weihua Huang, G. Zhang, A sensitive acupuncture needle microsensor for real-time monitoring of nitric oxide in acupoints of rats. Sci. Rep. 7(1), 6446 (2017) D. Chen, C. Wang, W. Chen, Y. Chen, X.J. John, Pvdf-nafion nanomembranes coated microneedles for in vivo transcutaneous implantable glucose sensing. Biosens. Bioelectron. 74, 1047–1052 (2015) Z. Jin-Xiu, T. Li-Na, Y. Fan, L. Feng-Xia, W. Hua, L. Yu-Tao, Z. Guo-Jun, Mos2/pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells. Analyst 142, 4 (2017) S.R. Chinnadayyala, I. Park, S. Cho, Nonenzymatic determination of glucose at near neutral ph values based on the use of nafion and platinum black coated microneedle electrode array. Microchimica Acta 185(5), 250 (2018) L. Ren, Q. Jiang, Z. Chen, K. Chen, X. Shujia, J. Gao, L. Jiang, Flexible microneedle array electrode using magnetorheological drawing lithography for bio-signal monitoring. Sens. Actuators A 268, 38–45 (2017) C. O’Mahony, K. Grygoryev, A. Ciarlone, G. Giannoni, A. Kenthao, P. Galvin, Design, fabrication and skin-electrode contact analysis of polymer microneedle-based ecg electrodes. J. Micromech. Microeng. 26(8), 084005 (2016) K. Chen, L. Ren, Z. Chen, C. Pan, W. Zhou, L. Jiang, Fabrication of micro-needle electrodes for bio-signal recording by a magnetization-induced self-assembly method. Sensors 16(9), 1533 (2016) G. Stavrinidis, K. Michelakis, V. Kontomitrou, G. Giannakakis, M. Sevrisarianos, G. Sevrisarianos, N. Chaniotakis, Y. Alifragis, G. Konstantinidis, Su-8 microneedles based dry electrodes for electroencephalogram. Microelectr. Eng. 159, 114–120 (2016) S. Sharma, Z. Huang, M. Rogers, M. Boutelle, A.E.G. Cass, Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring. Anal. Bioanal. Chem. 408(29), 8427–8435 (2016) S. Sharma, A. El-Laboudi, M. Reddy, N. Jugnee, S. Sivasubramaniyam, M. El Sharkawy, P. Georgiou, D. Johnston, N. Oliver, E.G. Anthony, A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring. Anal. Methods 10, 2088–2095 (2018) A.E.G. Cass, S. Sharma, Chapter fifteen—microneedle enzyme sensor arrays for continuous in vivo monitoring, in Enzymes as sensors of methods in enzymology, vol. 589, ed. by R.B. Thompson, C.A. Fierke (Academic Press, New York, 2017), pp. 413–427 A. McConville, J. Davis, Transdermal microneedle sensor arrays based on palladium: polymer composites. Electrochem. Commun. 72, 162–165 (2016) P. Dardano, A. Calio, J. Politi, V. Di Palma, M.F. Bevilacqua, I. Rea, M. Casalino, A. Di Matteo, I. Rendina, L. De Stefano, Hybrid microneedles devices for diagnostic and therapeutic applications: fabrication and preliminary results. Int. Soc. Optics Phot. 9518, 95180 (2015) P. Dardano, A. Calio, J. Politi, I. Rea, L. De Stefano, V. Di Palma, M. F. Bevilacqua, A. Di Matteo, Diagnostic and therapeutic devices based on polymeric microneedles: fabrication and preliminary results, in 2015 XVIII AISEM annual conference, pp. 1–4 (2015) C. Barrett, K. Dawson, C. O’Mahony, A. O’Riordan, Development of low cost rapid fabrication of sharp polymer microneedles for in vivo glucose biosensing applications. ECS J. Solid State Sci. Technol. 4(10), S3–S8 (2015) S. Sharma, E. Takagi, T. Cass, W. Tsugawa, K. Sode, Minimally invasive microneedle array electrodes employing direct electron transfer type glucose dehydrogenase for the development of continuous glucose monitoring sensors. Procedia Technol. 27, 208–209 (2017) K.D. Hee, J.H. Sang, W. Taejun, S.M. Hwan, K. Young-Eun, K.K. Hean, A. One, H.S. Kwang, Microneedle biosensor for real-time electrical detection of nitric oxide for in situ cancer diagnosis during endomicroscopy. Adv. Healthcare Mater. 4(8), 1153–1158 (2015) S. Sharma, A. Saeed, C. Johnson, N. Gadegaard, A.E.G. Cass, Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring. Sens. Bio-Sens. Res. 13, 104–108 (2017) J.R. Windmiller, G. Valdes-Ramirez, N. Zhou, M. Zhou, P.R. Miller, C. Jin, S.M. Brozik, R. Polsky, E. Katz, R. Narayan, J. Wang, Bicomponent microneedle array biosensor for minimally-invasive glutamate monitoring. Electroanalysis 23(10), 2 (2011) G. Valdes-Ramfrez, Y.-C. Li, J. Kim, W. Jia, A.J. Bandodkar, R. Nunez-Flores, P.R. Miller, W. Shu-Yii, R. Narayan, J.R. Windmiller, R. Polsky, J. Wang, Microneedle-based self-powered glucose sensor. Electrochem. Commun. 47, 58–62 (2014) K. Rupesh, A.M. Mishra, M. Vinu, S. Fernando, C. Robert, W. Joseph, A microneedle biosensor for minimally-invasive transdermal detection of nerve agents. Analyst 142, 918–924 (2017) A.M. Vinu, Mohan, Joshua Ray Windmiller, Rupesh K. Mishra, and Joseph Wang. Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays. Biosens. Bioelectron. 91, 574–579 (2017) C. Bianca, M. Aida, M. Rupesh, B. Barbara, N. Tatsuo, D. Thomas, L. Mengjia, C. Cecilia, S. Robert, W. Joseph, Wearable wireless tyrosinase bandage and microneedle sensors: toward melanoma screening. Adv. Healthcare Mater. 7(7), 1701264 (2018) F. Ribet, G. Stemme, N Roxhed, Microneedle-based system for minimally invasive continuous monitoring of glucose in the dermal interstitial fluid, in 2018 IEEE micro electro mechanical systems (MEMS), pp. 408–411 (2018) N. Vasylieva, S. Marinesco, D. Barbier, A. Sabac, Silicon/su8 multi-electrode micro-needle for in vivo neurochemical monitoring. Biosens. Bioelectron. 72, 148–155 (2015) F. Barz, P. Ruther, S. Takeuchi, O. Paul, Flexible silicon-polymer neural probe rigidified by dissolvable insertion vehicle for high-resolution neural recording with improved duration, in 2015 28th IEEE international conference on micro electro mechanical systems (MEMS), pp. 636–639 (2015) K. Seidl, S. Herwik, T. Torfs, H.P. Neves, O. Paul, P. Ruther, Cmos-based high-density silicon microprobe arrays for electronic depth control in intracortical neural recording. J. Microelectromech. Syst. 20(6), 1439–1448 (2011) P. R, Stanislav Herwik, S. Kisban, K. Seidl, O. Paul, Recent progress in neural probes using silicon mems technology. IEEJ Trans. Elect. Electr. Eng. 5(5), 505–515 (2010) S. Herwik, S. Kisban, A.A.A. Aarts, K. Seidl, G. Girardeau, K. Benchenane, M.B. Zugaro, S.I. Wiener, O. Paul, H.P. Neves, P. Ruther, Fabrication technology for silicon-based microprobe arrays used in acute and sub-chronic neural recording. J. Micromech. Microeng. 19(7), 074008 (2009) P. Parikh, H. Mochari, L. Mosca, Clinical utility of a fingerstick technology to identify individuals with abnormal blood lipids and high-sensitivity c-reactive protein levels. Am. J. Health Promot. 23(4), 279–282 (2009) S.K. Garg, R.O. Potts, N.R. Ackerman, S.J. Fermi, J.A. Tamada, H.P. Chase, Correlation of fingerstick blood glucose measurements with glucowatch biographer glucose results in young subjects with type 1 diabetes. Diabetes Care 22(10), 1708–1714 (1999) D. Loewenstein, C. Stake, M. Cichon, Assessment of using fingerstick blood sample with i-stat point-of-care device for cardiac troponin i assay. Am. J. Emerg. Med. 31(8), 1236–1239 (2013) S.D. Gittard, A. Ovsianikov, B.N. Chichkov, A. Doraiswamy, R.J. Narayan, Two-photon polymerization of microneedles for transdermal drug delivery. Expert Opin. Drug Delivery 7(4), 513–533 (2010) R. Liu, X. Wang, Y. Feng, G. Wang, J. Liu, H. Ding, Theoretical analytical flow model in hollow microneedles for non-forced fluid extraction, in 2006 1st IEEE international conference on nano/micro engineered and molecular systems, pp. 1039–1042 (2006) C.G. Li, C.Y. Lee, K. Lee, H. Jung, An optimized hollow microneedle for minimally invasive blood extraction. Biomed. Microdevices 15(1), 17–25 (2013) H.L. Thanh, B.Q. Ta, H.L. The, V. Nguyen, K. Wang, F. Karlsen, Low-cost fabrication of hollow microneedle arrays using cnc machining and uv lithography. J. Microelectromech. Syst. 24(5), 1583–1593 (2015) C.G. Li, M. Dangol, C.Y. Lee, M. Jang, H. Jung, A self-powered one-touch blood extraction system: a novel polymer-capped hollow microneedle integrated with a pre-vacuum actuator. Lab Chip 518, 15 (2015) B.Q. Tran, P.R. Miller, R.M. Taylor, G. Boyd, P.M. Mach, C.N. Rosenzweig, J.T. Baca, R. Polsky, T. Glaros, Proteomic characterization of dermal interstitial fluid extracted using a novel microneedle-assisted technique. J. Proteome Res. 17(1), 479–485 (2018) D.S. Lee, C.G. Li, C. Ihm, H. Jung, A three-dimensional and bevel-angled ultrahigh aspect ratio microneedle for minimally invasive and painless blood sampling. Sens. Actuators B 255, 384 (2018) M. Philip, M. Matthew, M. Ron, A. Carlee, B. Igal, W. David, N. Roger, P. Ronen, Towards an integrated microneedle total analysis chip for protein detection. Electroanalysis 28(6), 1 (2016) P.R. Miller, X. Xiao, I. Brener, D.B. Burckel, R. Narayan, R. Polsky, Microneedle-based transdermal sensor for on- chip potentiometric determination of k+. Adv Healthcare Mater. 3(6), 876–881 (2013) S. Zimmermann, D. Fienbork, B. Stoeber, A.W. Flounders, D. Liepmann, A microneedle-based glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization, in 12th international conference on TRANSDUCERS, Solid-State sensors, actuators and microsystems, 2003, vol 1, pp. 99–102 (2003) E.V. Mukerjee, S.D. Collins, R.R. Isseroff, R.L. Smith, Microneedle array for transdermal biological fluid extraction and in situ analysis. Sens. Actuators A: Phys. 114(2), 267–275 (2004) P.M. Wang, M. Cornwell, M.R. Prausnitz, Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles. Diabetes Technol. Ther. 7(1), 131–141 (2005) B. Chua, S.P. Desai, M.J. Tierney, J.A. Tamada, A.N. Jina, Effect of microneedles shape on skin penetration and minimally invasive continuous glucose monitoring in vivo. Sens. Actuators A 203, 373 (2013) L.M. Strambini, A. Longo, S. Scarano, T. Prescimone, I. Palchetti, M. Minunni, D. Giannessi, G. Barillaro, Self-powered microneedle-based biosensors for pain-free high-accuracy measurement of glycaemia in interstitial fluid. Biosens. Bioelectron. 66, 162–168 (2015) C.G. Li, H.-A. Joung, H. Noh, M.-B. Song, M.-G. Kim, H. Jung, One-touch-activated blood multidiagnostic system using a minimally invasive hollow microneedle integrated with a paper-based sensor. Lab Chip 15, 6 (2015) D. Nicholas, K.A. Logan, Y. Sheng, J. Gao, S. Farrell, D. Dixon, B. Callan, A.P. McHale, J.F. Callan, Rapid paper based colorimetric detection of glucose using a hollow microneedle device. Int. J. Pharm. 547(1), 244–249 (2018) L.M. Yu, F.E.H. Tay, D.G. Guo, L. Xu, K.L. Yap, A microfabricated electrode with hollow microneedles for ECG measurement. Sens. Actuators, A 151(1), 17–22 (2009) S.A. Ranamukhaarachchi, C. Padeste, M. Diibner, U.O. Hafeli, B. Stoeber, V.J. Cadarso, Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes. Sci. Rep. 6, 29075 (2016) S.A. Ranamukhaarachchi, C. Padeste, U.O. Hafeli, B. Stoeber, V.J. Cadarso, Design considerations of a hollow microneedle-optofluidic biosensing platform incorporating enzyme-linked assays. J. Micromech. Microeng. 28(2), 024002 (2018) Andrey V. Romanyuk, Vasiliy N. Zvezdin, Pradnya Samant, Mark I. Grenader, Marina Zemlyanova, Mark R. Prausnitz, Collection of analytes from microneedle patches. Anal. Chem. 86(21), 10520–10523 (2014) R.F. Donnelly, M.T.C. McCrudden, A.Z. Alkilani, E. Larraneta, E. McAlister, A.J. Courtenay, M.-C. Kearney, T.R.R. Singh, H.O. McCarthy, V.L. Kett, E. CafFarel-Salvador, S. Al-Zahrani, A.D. Woolfson, Hydrogel-forming microneedles prepared from “super swelling” polymers combined with lyophilised wafers for transdermal drug delivery. PLoS ONE. 9(10), 1–12 (2014) E. CafFarel-Salvador, A.J. Brady, E. Eltayib, T. Meng, A. Alonso-Vicente, P. Gonzalez-Vazquez, B.M. Torrisi, E.M. Vicente-Perez, K. Mooney, D.S. Jones, S.E.J. Bell, C.P. McCoy, H.O. McCarthy, J.C. McElnay, R.F. Donnelly, Hydrogel-forming microneedle arrays allow detection of drugs and glucose in vivo: potential for use in diagnosis and therapeutic drug monitoring. PLoS ONE. 10(12), 1–21 (2016) H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni, R. Kang, J. Tian, D.P. Khanh, L. Liu, P. Chen, C. Xu, A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis. Adv. Mater. 29(37), 1702243 (2017) MinYoung Kim, Bokyung Jung, Jung-Hwan Park, Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials 33(2), 668–678 (2012) R.F. Donnelly, T. Raghu, R. Singh, A.Z. Alkilani, M.T.C. McCrudden, S. O’Neill, C. O’Mahony, K. Armstrong, N. McLoone, P. Kole, A.D. Woolfson, Hydrogel-forming microneedle arrays exhibit antimicrobial properties: potential for enhanced patient safety. Int. J. Pharm. 451(1), 76–91 (2013) R.F. Donnelly, K. Mooney, M.T.C. Mccrudden, E.M. Vicente-Perez, L. Belaid, P. Gonzalez-Vazquez, J.C. Mcelnay, A.D. Woolfson, Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected. J. Pharm. Sci. 103(5), 1478–1486 (2014) J.G. Hardy, E. Larraneta, R.F. Donnelly, N. McGoldrick, K. Migalska, M.T.C. McCrudden, N.J. Irwin, L. Donnelly, C.P. McCoy, Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery. Mol. Pharm. 13(3), 907–914 (2016) J. Ji, F.E.H. Tay, J. Miao, C. lliescu, Microfabricated microneedle with porous tip for drug delivery. J. Micromech. Microeng. 16(5), 958 (2006) M. Shirkhanzadeh, Microneedles coated with porous calcium phosphate ceramics: effective vehicles for transdermal delivery of solid trehalose. J. Mater. Sci. 16(1), 37–45 (2005) J.-H. Park, S.-O. Choi, R. Kamath, Y.-K. Yoon, M.G. Allen, M.R. Prausnitz, Polymer particle-based micromolding to fabricate novel microstructures. Biomed. Microdev. 9(2), 223–234 (2007) K. van der Maaden, R. Luttge, P. Jan Vos, J. Bouwstra, G. Kersten, I Ploemen. Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays. Drug Deliv. Transl. Res. 5(4), 406 (2015) J. Li, B. Liu, Y. Zhou, Z. Chen, L. Jiang, W. Yuan, L. Liang, Fabrication of a ti porous microneedle array by metal injection molding for transdermal drug delivery. PLoS ONE 12(2), 1–15 (2017) Laith Humrez, Maximiano Ramos, Ahmed Al-Jumaily, Mira Petchu, John Ingram, Synthesis and characterisation of porous polymer microneedles. J. Polym. Res. 18(5), 1043–1052 (2011) M. Verhoeven, S. Bystrova, L. Winnubst, H. Qureshi, T.D. de Gruijl, R.J. Scheper, R. Luttge, Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex vivo human skin model. Microelect. Eng. 98, 659–662 (2012) Liming Liu, Hiroyuki Kai, Kuniaki Nagamine, Yudai Ogawa, Matsuhiko Nishizawa, Porous polymer microneedles with interconnecting microchannels for rapid fluid transport. RSC Adv. 6, 48630–48635 (2016) Kuniaki Nagamine, Jun Kubota, Hiroyuki Kai, Yoshinobu Ono, Matsuhiko Nishizawa, An array of porous microneedles for transdermal monitoring of intercellular swelling. Biomed. Microdev. 19(3), 68 (2017) Pradnya P. Samant, Mark R. Prausnitz, Mechanisms of sampling interstitial fluid from skin using a microneedle patch. Proc. Natl. Acad. Sci. 115(18), 4583–4588 (2018) K. Takeuchi, B. Kim, K. Sharma, P. Ruther, O. Paul, Microfluidic chip for glucose monitoring with biodegradable microneedles, in 5th international conference on microneedles. 2018, pp. 101 W.K. Ward, J.E. Troupe, Assessment of chronically implanted subcutaneous glucose sensors in dogs: the effect of surrounding fluid masses. ASAIO J. 45(6), 555–561 (1999) R.M. Rhemrev-Boom, R.G. Tiessen, A.A. Jonker, K. Venema, P. Vadgama, J. Korf, A lightweight measuring device for the continuous in vivo monitoring of glucose by means of ultraslow microdialysis in combination with a miniaturised flow-through biosensor. Clin. Chim. Acta. 1, 1–10 (2002) M. Gerritsen, J.A. Jansen, A. Kros, D.M. Vriezema, N.A.J.M. Sommerdijk, R.J.M. Nolte, J.A. Lutterman, S.W.F.M. Van Hovell, A. Van der Gaag, Influence of inflammatory cells and serum on the performance of implantable glucose sensors. J. Biomed. Mater. Res. 54(1), 69–75 (2000) Taira Kajisa, Toshiya Sakata, Glucose-responsive hydrogel electrode for biocompatible glucose transistor. Sci. Technol. Adv. Mater. 18(1), 26–33 (2017) Akira Matsumoto, Naoko Sato, Toshiya Sakata, Kazunori Kataoka, Yuji Miyahara, Glucose-sensitive field effect transistor using totally synthetic compounds. J. Solid State Electrochem. 13(1), 165–170 (2009) J. Liu, M. Agarwal, K. Varahramyan, Glucose sensor based on organic thin film transistor using glucose oxidase and conducting polymer. Sensors Actuators B 135(1), 195–199 (2008) B.U. Moon, M.G. de Vries, B.H.C. Westerink, E. Verpoorte, Development and characterization of a microfluidic glucose sensing system based on an enzymatic microreactor and chemiluminescence detection. Sci. China Chem. 55(4), 515–523 (2012) Yongjun Zhao, Siqi Li, Arthur Davidson, Bozhi Yang, Qian Wang, Qiao Lin, A mems viscometric sensor for continuous glucose monitoring. J. Micromech. Microeng. 17(12), 2528 (2007) Xian Huang, Siqi Li, Jerome S. Schultz, Qian Wang, Qiao Lin, A mems affinity glucose sensor using a biocompatible glucose-responsive polymer. Sensors Actuators B 140(2), 603–609 (2009) G. Piechotta, J. Albers, R. Hintsche, Novel micromachined silicon sensor for continuous glucose monitoring. Biosens. Bioelectron. 21(5), 802–808 (2005) C.-J. Huang, Y.-H. Chen, C.-H. Wang, T.-C. Chou, G.-B. Lee, Integrated microfluidic systems for automatic glucose sensing and insulin injection. Sensors Actuators B. 122(2), 461–468 (2007) Pu Zhihua, Chongwei Zou, Ridong Wang, Xiaochen Lai, Yu. Haixia, Xu Kexin, Dachao Li, A continuous glucose monitoring device by graphene modified electrochemical sensor in microfluidic system. Biomicrofluidics 10(1), 011910 (2016)