Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors
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Berg, 1998, Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus, Mol. Pharmacol., 541, 94, 10.1124/mol.54.1.94
Bridges, 2008, G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms, ACS Chem. Biol., 39, 530, 10.1021/cb800116f
Celanire, 2011, Discovery and characterization of novel metabotropic glutamate receptor 4 (mGluR4) allosteric potentiators, Curr. Neuropharmacology, 9, 9
Conn, 2009, Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders, Nat. Rev. Drug Discov., 81, 41, 10.1038/nrd2760
De Deurwaerdere, 2004, Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens, J. Neurosci., 2413, 3235, 10.1523/JNEUROSCI.0112-04.2004
Drolet, 2011
Engers, 2010, Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS), Bioorg. Med. Chem. Lett., 2017, 5175, 10.1016/j.bmcl.2010.07.007
Fallarino, 2010, Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation, Nat. Med., 168, 897, 10.1038/nm.2183
Jones, 2011, The mGlu4 positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine A2A antagonist in preclinical rodent models of Parkinson's disease, J. Pharmacol. Exp. Ther
Kenakin, 2005, New concepts in drug discovery: collateral efficacy and permissive antagonism, Nat. Rev. Drug Discov., 411, 919, 10.1038/nrd1875
Keov, 2011, Allosteric modulation of G protein-coupled receptors: a pharmacological perspective, Neuropharmacology, 601, 24, 10.1016/j.neuropharm.2010.07.010
Lee, 1993, Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits, J. Biol. Chem., 26834, 25952, 10.1016/S0021-9258(19)74479-2
Marlo, 2009, Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity, Mol. Pharmacol., 753, 577, 10.1124/mol.108.052886
Mathiesen, 2005, Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2, Mol. Pharmacol., 682, 393, 10.1124/mol.104.010520
Neki, 1996, Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody, Neurosci. Lett., 2023, 197, 10.1016/0304-3940(95)12248-6
Niswender, 2008, Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4, Mol. Pharmacol., 745, 1345, 10.1124/mol.108.049551
Niswender, 2010, Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7, Mol. Pharmacol., 773, 459, 10.1124/mol.109.058768
Nordstedt, 1990, A modification of a protein-binding method for rapid quantification of cAMP in cell-culture supernatants and body fluid, Anal. Biochem., 1892, 231, 10.1016/0003-2697(90)90113-N
O'Brien, 2004, A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain, J. Pharmacol. Exp. Ther., 3092, 568, 10.1124/jpet.103.061747
Petralia, 1996, The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations, Neuroscience, 714, 949, 10.1016/0306-4522(95)00533-1
Pin, 2009, G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors, J. Physiol., 587, 5337, 10.1113/jphysiol.2009.179978
Reynolds, 2008
Rives, 2009, Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration, EMBO J., 2815, 2195, 10.1038/emboj.2009.177
Sheffler, 2008, Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells, Neuropharmacology, 554, 419, 10.1016/j.neuropharm.2008.06.047
Thakkar, 2011, Histamine in the regulation of wakefulness, Sleep Med. Rev., 151, 65, 10.1016/j.smrv.2010.06.004
Urban, 2007, Functional selectivity and classical concepts of quantitative pharmacology, J. Pharmacol. Exp. Ther., 3201, 1, 10.1124/jpet.106.104463
Vanbervliet, 2011, Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T-cell mediated skin inflammation, J. Allergy Clin. Immunol., 1244
Watts, 1996, Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors, Mol. Pharmacol., 504, 966
Wisler, 2007, A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling, Proc. Natl. Acad. Sci. U S A, 10442, 16657, 10.1073/pnas.0707936104
Zhang, 2005, Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes, J. Pharmacol. Exp. Ther., 3153, 1212, 10.1124/jpet.105.090308