Functional neurogenesis in the adult hippocampus

Nature - Tập 415 Số 6875 - Trang 1030-1034 - 2002
Henriette van Praag1, Alejandro F. Schinder, Brian R. Christie, Nicolas Toni, Theo D. Palmer, Fred H. Gage
1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. [email protected]

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Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal neurogenesis in rats. J. Comp. Neurol. 124, 319–335 (1965).

Kaplan, M. S. & Hinds, J. W. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197, 1092–1094 (1977).

Kuhn, H. G., Dickinson-Anson, H. & Gage, F. H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027–2033 (1996).

Kornack, D. R. & Rakic, P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc. Natl Acad. Sci. USA 96, 5768–5773 (1999).

Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nature Med. 4, 1313–1317 (1998).

Barnea, A. & Nottebohm, F. Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees. Proc. Natl Acad. Sci. USA 91, 11217–11221 (1994).

Kempermann, G., Kuhn, H. G. & Gage, F. H. More hippocampal neurons in adult mice living in an enriched environment. Nature 386, 493–495 (1997).

van Praag, H., Kempermann, G. & Gage, F. H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neurosci. 2, 266–270 (1999).

van Praag, H., Christie, B. R., Sejnowski, T. J. & Gage, F. H. Running enhances neurogenesis, learning and long-term potentiation in mice. Proc. Natl Acad. Sci. USA 96, 13427–13431 (1999).

Liu, J., Solway, K., Messing, R. O. & Sharp, F. R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18, 7768–7778 (1998).

Parent, J. M. et al. Dentate granule neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult hippocampus. J. Neurosci. 17, 3727–3738 (1997).

Magavi, S. S., Leavitt, B. R. & Macklis, J. D. Induction of neurogenesis in the neocortex of adult mice. Nature 405, 951–955 (2000).

Gould, E., Cameron, H. A., Daniels, D. C., Wooley, C. S. & McEwen, B. S. Adrenal hormones suppress cell division in the adult rat dentate gyrus. J. Neurosci 12, 3642–3650 (1992).

Lemaire, V., Koehl, M., Le Moal, M. & Abrous, D. N. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc. Natl Acad. Sci. USA 97, 11032–11037 (2000).

Vicario-Abejon, C., Collin, C., Tsoulfas, P. & McKay, R. D. Hippocampal stem cells differentiate into excitatory and inhibitory neurons. Eur. J. Neurosci. 12, 677–688 (2000).

Sah, D. W., Ray, J. & Gage, F. H. Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cells in vitro. J. Neurobiol. 32, 95–110 (1997).

Roy, N. S. et al. In vitro neurogenesis by progenitor cells isolated from the adult hippocampus. Nature Med. 6, 271–277 (2000).

Lewis, P. F. & Emerman, M. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J. Virol. 68, 510–516 (1994).

Palmer, T. D., Willhoite, A. R. & Gage, F. H. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479–494 (2000).

Xu, L., Yee, J. K., Wolff, J. A. & Friedmann, T. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology 171, 331–341 (1989).

Markakis, E. A. & Gage, F. H. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J. Comp. Neurol. 406, 449–460 (1999).

Edwards, F. A. Anatomy and electrophysiology of fast central synapses lead to a structural model for long-term potentiation. Physiol. Rev. 75, 759–787 (1995).

Crain, B., Cotman, C., Taylor, D. & Lynch, G. A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat. Brain Res. 63, 195–204 (1973).

Suzuki, F., Makiura, Y., Guilhem, D., Sorensen, J. C. & Onteniente, B. Correlated axonal sprouting and dendritic spine formation during kainate-induced neuronal morphogenesis in the dentate gyrus of adult mice. Exp. Neurol. 145, 203–213 (1997).

Staley, K. J., Otis, T. S. & Mody, I. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. J. Neurophysiol. 67, 1346–1358 (1992).

Lübke, J., Frotscher, M. & Spruston, N. Specialized electrophysiological properties of anatomically identified neurons in the hilar region of the rat fascia dentate. J. Neurophysiol. 79, 1518–1534 (1998).

Coleman, P. A. & Miller, R. F. Measurement of passive membrane parameters with whole-cell recording from neurons in the intact amphibian retina. J. Neurophysiol. 61, 218–230 (1989).

Biebl, M., Cooper, C. M., Winkler, J. & Kuhn, H. G. Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain. Neurosci. Lett. 291, 17–20 (2000).

Coleman, L. A. & Friedlander, M. J. Intracellular injections of permanent tracers in the fixed slice: a comparison of HRP and biocytin. J. Neurosci. Methods 44, 167–177 (1992).

Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F. & Gage, F. H. Fibroblast growth factor-2 activates a latent neurogenic progam in neural stem cells from diverse regions of the adult CNS. J. Neurosci. 19, 8487–8497 (1999).