Functional heavy-chain antibodies in camelidae
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Abergel, 1999, Structural significance of sequence variability in antibody complemenarity-determining regions, Res. Immunol., 55, 49
Al-Lazikani, 1997, Standard conformations for the canonical structures of immunoglobulins, J. Mol. Biol., 273, 927, 10.1006/jmbi.1997.1354
Almagro, 1997, The differences between the structural repertoires of VH germ-line gene segments of mice and humans: impli-cation for the molecular mechanism of the immune response, Mol. Immunol., 34, 1199, 10.1016/S0161-5890(97)00118-1
Atarhouch, 1997, cDNA sequence coding for the constant region of the dromedary γ3 heavy chain antibody, J. Camel Practice Res., 4, 177
Azwai, 1996, Immunoglobulins of camel (Camelus dromedarius) colostrum, J. Comp. Pathol., 114, 273, 10.1016/S0021-9975(96)80049-1
Berry, 1992, Use of antibody fragments in immunoaffinity chromatography, J. Chromatogr., 597, 239, 10.1016/0021-9673(92)80116-C
Bianchi, 1986, Kariological conservatism in South American camelids, Experientia, 42, 622, 10.1007/BF01955563
Blond-Elguindi, 1993, Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP, Cell, 75, 717, 10.1016/0092-8674(93)90492-9
Borrebaeck, 2000, Antibodies in diagnostics-from immunoassays to protein chips, Immunol. Today, 21, 379, 10.1016/S0167-5699(00)01683-2
Chothia, 1987, Canonical structures for the hypervariable regions of im-munoglobulins, J. Mol. Biol., 196, 901, 10.1016/0022-2836(87)90412-8
Chothia, 1985, Domain association in immuno-globulin molecules, 186, 651
Chothia, 1989, Conformations of immunoglobulin variable regions, Nature, 342, 877, 10.1038/342877a0
Chothia, 1992, Structural repertoire of human VH segments, J. Mol. Biol., 227, 799, 10.1016/0022-2836(92)90224-8
Cogne, 1989, Immunoglobulin gene alterations in human heavy chain disease, Res. Immunol., 140, 487, 10.1016/0923-2494(89)90115-6
Conrath, 2001, Camel single-domain an-tibodies as modular building units in bispecific and bivalent antibody constructs, J. Biol. Chem., 276
Cook, 1995, The human immunoglobulin VH repertoire, Immunol. Today, 16, 237, 10.1016/0167-5699(95)80166-9
Davies, 1994, Camelising human antibody fragments: NMR studies on VH domains, FEBS Lett., 339, 285, 10.1016/0014-5793(94)80432-X
Davies, 1995, Antibody VH domains as small recognition units, Bio/Technology, 13, 475, 10.1038/nbt0595-475
Davies, 1996, Single antibody domains as small recognition units: design and in vitro antigen selection of camelised, human VH domains with improved protein stability, Prot. Eng., 9, 531, 10.1093/protein/9.6.531
Davies, 1996, Affinity improvement of single antibody VH domains, 2, 169
de Bruin, 1999, Selection of high affinity phage antibodies from phage display libraries, Nat. Biotechnol., 17, 397, 10.1038/7959
de Wildt, 1999, Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire, J. Mol. Biol., 285, 895, 10.1006/jmbi.1998.2396
de Wildt, 2000, Antibody arrays for high-throughput screening of antibody-antigen interactions, Nat. Biotechnol., 18, 989, 10.1038/79494
Decanniere, 1999, A single-domain antibody fragment in complex with RNase A: non-canonical loop struc-tures and nanomolar affinity using two CDR loops, Structure, 7, 361, 10.1016/S0969-2126(99)80049-5
Decanniere, 2000, Canonical antigen binding loop structures: more structures, more canonical classes?, J. Mol. Biol., 300, 83, 10.1006/jmbi.2000.3839
Desmyter, 1996, Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme, Nat. Struct. Biol., 3, 803, 10.1038/nsb0996-803
Diaz, 1998, Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in the antigen-driven reactions in the absence of germinal centers, 95, 14343
Evans, 1986, Sequence imposed structural constraints in the Ton B protein of E. coli, FEBS Lett., 208, 211, 10.1016/0014-5793(86)81020-1
Fan, 1992, Three dimensional structure of an Fv from a human IgM immunoglobulin, J. Mol. Biol., 228, 188, 10.1016/0022-2836(92)90500-J
Foote, 1991, Kinetic maturation of an immune response, Nature, 352, 530, 10.1038/352530a0
Fowler, 1997, Evolutionary history and differences between camelids and ruminants, J. Camel Practice Res., 4, 99
Franklin, 1964, Heavy chain disease, 37, 332
Frenken, 2000, Isolation of antigen specific llama VHH antibody fragments and their high level secretion by Saccharomyces cerevisiae, J. Biotechnol., 78, 11, 10.1016/S0168-1656(99)00228-X
Ghahroudi, 1997, Selection and identification of single domain antibody fragments from camel heavy-chain antibodies, FEBS Lett., 414, 521, 10.1016/S0014-5793(97)01062-4
Glennie, 2000, Clinical trials of antibody therapy, Immunol. Today, 21, 403, 10.1016/S0167-5699(00)01669-8
Glockshuber, 1990, A comparison of strategies to stabilize immunoglobulin Fv fragments, Biochemistry, 29, 1362, 10.1021/bi00458a002
Greenberg, 1995, A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversifi-cation in sharks, Nature, 374, 168, 10.1038/374168a0
Hamers, 1998, Immunology of the camels and llamas, 421
Hamers-Casterman, 1993, Naturally occurring antibodies devoid of light chains, Nature, 363, 446, 10.1038/363446a0
Harris, 2000, Comparison of intact antibody structures and the implications for effector function, Adv. Immunol., 72, 191, 10.1016/S0065-2776(08)60021-8
Harrison, 1985, Giant camels from the Cenozoic of North America, Smithson. Contr. PaleoBiol., 57, 1, 10.5479/si.00810266.57.1
Henderschot, 1987, Assembly and secretion of heavy chains that do not associate posttransla-tionally with immunoglobulin heavy chain-binding protein, J. Cell Biol., 104, 761, 10.1083/jcb.104.3.761
Hoogenboom, 1997, Mix and match: building manifold binding sites, Nat. Biotechnol., 15, 125, 10.1038/nbt0297-125
Hoogenboom, 2000, Natural and designer binding sites made by phage display technology, Immunol. Today, 21, 371, 10.1016/S0167-5699(00)01667-4
Hoogenboom, 1998, Antibody phage display technology and its applications, Immunotechnology, 4, 309, 10.1016/S1380-2933(98)00007-4
Horne, 1982, Noncovalent association of heavy and light chains of human immunoglobulins, J. Immunol., 129, 660
Hsu, 1992, Primary structure of immunoglobulins through evolution, Curr. Opin. Struct. Biol., 2, 422, 10.1016/0959-440X(92)90234-X
Huck, 1986, Sequence of a human immunoglobulin γ3 heavy chain constant region gene: comparison with the other human C γgenes, Nucl. Acids Res., 14, 1779, 10.1093/nar/14.4.1779
Hufton, 2000, Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands, FEBS Lett., 475, 225, 10.1016/S0014-5793(00)01701-4
Huse, 1989, Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda, Science, 246, 1275, 10.1126/science.2531466
Jackson, 1992, Nucleotide sequences and expression of cDNAs for a bovine antitestosterone monoclonal IgG1 antibody, Mol. Immunol., 29, 667, 10.1016/0161-5890(92)90204-B
Kabat, 1991, Sequence of Proteins of Immunological Interest
Kirkham, 1992, Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding, EMBO J., 11, 603, 10.1002/j.1460-2075.1992.tb05092.x
Knarr, 1995, BiP Binding sequences in antibodies, J. Biol. Chem., 270, 27589, 10.1074/jbc.270.46.27589
Knight, 1992, Restricted VH gene usage and generation of antibody diversity in rabbit, Annu. Rev. Immunol., 10, 593, 10.1146/annurev.iy.10.040192.003113
Koide, 1998, The fibronectin type III domain as scaffold for novel binding proteins, J. Mol. Biol., 284, 1141, 10.1006/jmbi.1998.2238
Koulisher, 1971, Mammalian cytogenetics. IV. The chromo-somes of two male Camelidae: Camelus bactrianus and Lama vicugna, Acta Zool. Pathol. Antwerp, 52, 89
Laskowski, 1996, Protein clefts in molecular recognition and function, Protein Sci., 5, 2438
Lauwereys, 1998, Potent enzyme inhibitors derived from dromedary heavy-chain antibodies, EMBO J., 17, 3512, 10.1093/emboj/17.13.3512
Legssyer, 1995, Characterization of light chains in camel immunoglobulins, Arch. Physiol. Biochem., 103, B47
Lesk, 1988, Elbow motion in immunoglobulins involves a molecular ball-and- socket joint, Nature, 335, 188, 10.1038/335188a0
Litman, 1999, Evolution of antigen binding receptors, Annu. Rev. Biochem., 17, 109
Lo Conte, 1999, The atomic structure of protein-protein recognition sites, J. Mol. Biol., 285, 2177, 10.1006/jmbi.1998.2439
Lopez, 1998, A single VH family and long CDR3s are the targets for hypermutation in bovine immunoglobulin heavy chains, Immunol. Rev., 162, 55, 10.1111/j.1600-065X.1998.tb01429.x
Mage, 1987, Molecular biology of rabbit immunoglobulin and T cell receptor genes, 106
Magor, 1994, One gene encodes the heavy chains for the three different forms of IgY in the duck, J. Immunol., 153, 5549
Martin, 1997, Affinity selection of a camelised VH domain antibody inhibitor of hepatitis C virus NS3 protease, Prot. Eng., 10, 607, 10.1093/protein/10.5.607
McConnell, 1995, Tendamistat as a scaffold for conformationally constrained phage peptide libraries, J. Mol. Biol., 250, 460, 10.1006/jmbi.1995.0390
Melchers, 1994, Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage, Annu. Rev. Immunol., 12, 209, 10.1146/annurev.iy.12.040194.001233
Milstein, 1998, Both DNA strands of antibody genes are hypermutation targets, 95, 8791
Murphy, 1989, Immune response of the llama (Lama glama) to tetanus toxoid vaccination, Am. J. Vet. Res., 50, 1279
Muyldermans, 1994, Se-quence and structure of VHdomain from naturally occurring camel heavy chain immunoglobulins lacking light chains, Prot. Eng., 7, 1129, 10.1093/protein/7.9.1129
Nei, 1997, Evolution by the birth-and-death process in multigene families of the vertebrate immune system, 94, 7799
Nemazee, 2000, Receptor editing in B cells, Adv. Immunol., 74, 89, 10.1016/S0065-2776(08)60909-8
Nguyen, 1998, The specific variable domain of camel heavy-chain antibodies is encoded in the germline, J. Mol. Biol., 257, 413, 10.1006/jmbi.1997.1477
Nguyen, 1999, Loss of splice consensus signal is responsible for the removal of the entire CH1 domain of the functional camel IgG2A heavy chain antibodies, Mol. Immunol., 36, 515, 10.1016/S0161-5890(99)00067-X
Nguyen, 2000, Camel heavy-chain antibodies: diverse germline VHH and specific mechanisms enlarge the antigen-binding repertoire, EMBO J., 19, 921, 10.1093/emboj/19.5.921
Nieba, 1997, Disruption of the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment, Prot. Eng., 10, 435, 10.1093/protein/10.4.435
Nisonoff, 1975
Nutall, 2000, Immunoglobulin VH domains and beyond: design and selection of single domain binding and targeting reagents, Curr. Pharmaceut. Biotechnol., 1, 253, 10.2174/1389201003378906
Ota, 1995, Evolution of immunoglobulin VH pseudogenes in chickens, Mol. Biol. Evol., 12, 94, 10.1093/oxfordjournals.molbev.a040194
Padlan, 1994, Anatomy of the antibody molecule, Mol. Immunol., 31, 169, 10.1016/0161-5890(94)90001-9
Padlan, 1996, X-ray crystallography of antibodies, Adv. Prot. Chem., 49, 57, 10.1016/S0065-3233(08)60488-X
Padlan, 1995, Identification of specificity-determining residues in antibodies, FASEB J., 9, 133, 10.1096/fasebj.9.1.7821752
Parslow, 1984, Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence, 81, 2650
Porter, 1959, The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain, Biochem. J., 73, 119, 10.1042/bj0730119
Potter, 1996, Staphylococcal protein A simultaneously interacts with framework region 1, complementarity determining region 2 and framework region 3 on human VH3 encoded Igs, J. Immunol., 157, 2982
Rajewsky, 1996, Clonal selection and learning in the antibody system, Nature, 381, 751, 10.1038/381751a0
Ramsden, 1994, Conservation of sequence in recombination signal sequence spacers, Nucl. Acids Res., 22, 1785, 10.1093/nar/22.10.1785
Rast, 1998, Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes, Immunogenetics, 47, 234, 10.1007/s002510050353
Reiter, 1999, An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface, J. Mol. Biol., 290, 685, 10.1006/jmbi.1999.2923
Reynaud, 1989, Somatic hyperconversion diversifies the single VH gen of the chicken with a high incidence in the D region, Cell, 59, 171, 10.1016/0092-8674(89)90879-9
Reynaud, 1995, Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process, Cell, 80, 115, 10.1016/0092-8674(95)90456-5
Riechmann, 1996, Rearrangement of the former VL interface in the solution structure of a camelised, single domain VH antibody, J. Mol. Biol., 259, 957, 10.1006/jmbi.1996.0373
Riechmann, 1999, Single domain antibodies: comparison of camel VH and camelised human VH domains, J. Immunol. Meth., 231, 25, 10.1016/S0022-1759(99)00138-6
Roditi, 1989, Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of trypanosoma brucei, J. Cell Biol., 108, 737, 10.1083/jcb.108.2.737
Rondon, 1997, Intracellular antibodies (intrabodies) for gene therapy of infectious diseases, Annu. Rev. Microbiol., 51, 257, 10.1146/annurev.micro.51.1.257
Roux, 1998, Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins, 95, 11804
Saini, 1997, A single predominantly expressed polymorphic VH gene family, related to mammalian group I, class II, is identified in cattle, Mol. Immunol., 34, 641, 10.1016/S0161-5890(97)00055-2
Saini, 1999, Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies, Eur. J. Immunol., 29, 2420, 10.1002/(SICI)1521-4141(199908)29:08<2420::AID-IMMU2420>3.0.CO;2-A
Schroeder, 1989, Structure and evolution of mammalian VH families, Int. Immunol., 2, 41, 10.1093/intimm/2.1.41
Seligmann, 1979, Heavy chain diseases: current findings and concepts, Immunol. Rev., 48, 145, 10.1111/j.1600-065X.1979.tb00302.x
Sheriff, 1996, Redefining the minimal antigen-binding fragment, Nat. Struct. Bio., 3, 733, 10.1038/nsb0996-733
Spinelli, 2000, Camelid heavy-chain variable domains provide efficient combining sites to haptens, Biochemistry, 39, 1217, 10.1021/bi991830w
Taylor, 1968, Uniformity of karyotypes in the Camelidae, Cytogenetics, 7, 8, 10.1159/000129967
Tomlinson, 1992, The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops, J. Mol. Biol., 227, 776, 10.1016/0022-2836(92)90223-7
Tomlinson, 1994, Human immunoglobulin VH and D segments on chromosome 15q 11.2 and 16p 11.2, Hum. Mol. Genet., 3, 853, 10.1093/hmg/3.6.853
Tonegawa, 1983, Somatic generation of antibody diversity, Nature, 302, 575, 10.1038/302575a0
Transue, 1998, Camel single domain antibody inhibits enzyme by mimicking carbohydrate substrate, Proteins: Structure, Function, and Genetics, 32, 515, 10.1002/(SICI)1097-0134(19980901)32:4<515::AID-PROT9>3.0.CO;2-E
van der Linden, 1999, Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies, Biochim. Biophys. Acta, 1431, 37, 10.1016/S0167-4838(99)00030-8
van der Linden, 2000, Induction of immune responses and molecular cloning of the heavy chain antibody repertoire of Lama glama, J. Immunol. Meth., 240, 185, 10.1016/S0022-1759(00)00188-5
Vargas-Madrazo, 1995, Canonical structure repertoire of the antigen binding site of immunoglobulins suggests strong geometrical restrictions associated to the mechanism of immune recognition, J. Mol. Biol., 254, 497, 10.1006/jmbi.1995.0633
Vaughan, 1996, Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library, Nat. Biotechnol., 14, 309, 10.1038/nbt0396-309
Visintin, 1999, Selection of antibod-ies for intracellular function using a two-hybrid in vivo system, 96, 11723
Vu, 1997, Comparison of llama VH sequences from conventional and heavy chain antibodies, Mol. Immunol., 34, 1121, 10.1016/S0161-5890(97)00146-6
Wagner, 1996, Somatic hypermutation of immunoglobulin genes, Annu. Rev. Immunol., 14, 441, 10.1146/annurev.immunol.14.1.441
Ward, 1989, Binding activities of a repertoire of single immunoglobulin variable domains secreted from E. coli, Nature, 341, 544, 10.1038/341544a0
Webb, 1972, Locomotor evolution in camels, Forma Functio, 5, 99
Webster, 1994, Antibody-antigen interactions, Curr. Opin. Struc. Biol., 4, 123, 10.1016/S0959-440X(94)90070-1
Wernery, 1997, Camel pox in the United Arab Emirates and its prevention, J. Camel Practice Res., 4, 135
Whitlow, 1993, An improved linker for scFv with reduced aggregation and enhanced proteolytic stability, Prot. Eng., 6, 989, 10.1093/protein/6.8.989
Winter, 1994, Making antibodies by phage display technology, Annu. Rev. Immunol., 12, 433, 10.1146/annurev.iy.12.040194.002245
Woolven, 1999, The structure of the llama heavy chain constant genes reveals a mechanism for heavy-chain antibody formation, Immuno-genetics, 50, 98, 10.1007/s002510050694
Wu, 1993, Length distribution of CDR H3 in antibodies, Proteins: Structure, Function, and Genetics, 16, 1, 10.1002/prot.340160102