Functional analysis of LHβ knockout mice

Bousfield, 1994, Gonadotropins: chemistry and biosynthesis, 1749 Holdcraft, 2004, Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids, Development, 131, 459, 10.1242/dev.00957 Holdcraft, 2004, Hormonal regulation of spermatogenesis, Int. J. Androl., 27, 335, 10.1111/j.1365-2605.2004.00502.x Huhtaniemi, 1999, Mutations and polymorphisms in gonadotropin genes, Mol. Cell. Endocrinol., 151, 89, 10.1016/S0303-7207(99)00015-5 Huhtaniemi, 2002, The role of mutations affecting gonadotrophin secretion and action in disorders of pubertal development, Best Pract. Res. Clin. Endocrinol. Metab., 16, 123, 10.1053/beem.2002.0185 Kumar, 1995, Cloning of the mouse gonadotropin beta-subunit-encoding genes. II. Structure of the luteinizing hormone beta-subunit-encoding genes, Gene, 166, 335, 10.1016/0378-1119(96)81753-7 Kumar, 2000, Gene knockout models to study the hypothalamus-pituitary-gonadal axis Kumar, 1999, Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis, Mol. Endocrinol., 13, 851, 10.1210/me.13.6.851 Kumar, 1997, Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility, Nat. Genet., 15, 201, 10.1038/ng0297-201 Kumar, 1996, Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice, Endocrinology, 137, 4210, 10.1210/en.137.10.4210 Lei, 2001, Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene, Mol. Endocrinol., 15, 184, 10.1210/me.15.1.184 Ma, 2004, Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility, Proc. Natl. Acad. Sci. U.S.A., 101, 17294, 10.1073/pnas.0404743101 Matzuk, 2003, Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice, Biol. Reprod., 69, 338, 10.1095/biolreprod.102.013953 Nagy, 2005, Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers, Biol. Reprod., 73, 851, 10.1095/biolreprod.105.043489 Pierce, 1981, Glycoprotein hormones: structure and function, Annu. Rev. Biochem., 50, 465, 10.1146/annurev.bi.50.070181.002341 Themmen, 1998, Activating and inactivating mutations in LH receptors, Mol. Cell. Endocrinol., 145, 137, 10.1016/S0303-7207(98)00180-4 Themmen, 2000, Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function, Endocr. Rev., 21, 551, 10.1210/er.21.5.551 Valdes-Socin, 2004, Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene, N. Engl. J. Med., 351, 2619, 10.1056/NEJMoa040326 Weiss, 1992, Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone, N. Engl. J. Med., 326, 179, 10.1056/NEJM199201163260306 Weiss, 2002, Gonadotropin-releasing hormone antagonists: pharmacology and clinical use in women, Treat. Endocrinol., 1, 281, 10.2165/00024677-200201050-00002 Zhang, 2001, Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice, Mol. Endocrinol., 15, 172, 10.1210/me.15.1.172