Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI

NeuroImage - Tập 16 Số 2 - Trang 331-348 - 2002
K. Luan Phan1, Tor D. Wager2, Stephan F. Taylor1, Israel Liberzon1,3
1Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109
2Department of Psychology, University of Michigan, Ann Arbor, Michigan, 48109
3Psychiatry Service, Ann Arbor VAMC, Ann Arbor, Michigan, 48105

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Abercrombie, 1996, Medial prefrontal and amygdalar glucose metabolism in depressed and control subjects: an FDG-PET study, Psychophysiology, 33, S17

Adolphs, 1995, Fear and the human amygdala, J. Neurosci., 15, 5879, 10.1523/JNEUROSCI.15-09-05879.1995

Adolphs, 1996, Cortical systems for the recognition of emotion in facial expressions, J. Neurosci., 16, 7678, 10.1523/JNEUROSCI.16-23-07678.1996

Aggleton, 1990, Visual impairments in macaques following inferior temporal lesions are exacerbated selectively by additional damage to superior temporal sulcus, Behav. Brain Res., 39, 262, 10.1016/0166-4328(90)90032-A

Amaral, 1984, Amygdalo-cortical projections in the monkey (Macaca fascicularis), J. Comp. Neurol., 230, 465, 10.1002/cne.902300402

Anderson, 1999, Impairment of social and moral behavior related to early damage in human prefrontal cortex, Nat. Neurosci., 2, 1032, 10.1038/12194

Augustine, 1996, Circuitry and functional aspects of the insular lobe in primates including humans, Brain Res. Brain Res. Rev., 229, 10.1016/S0165-0173(96)00011-2

Baker, 1997, The interaction between mood and cognitive function studied with PET, Psychol. Med., 27, 565, 10.1017/S0033291797004856

Baxter, 1985, Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18, Arch. Gen. Psychiatry., 42, 441, 10.1001/archpsyc.1985.01790280019002

Beauregard, 1997, The neural substrate for concrete, abstract, and emotional word lexica: A positron emission tomography study, J. Cognit. Neurosci., 9, 441, 10.1162/jocn.1997.9.4.441

Beauregard, 1998, The functional neuroanatomy of major depression: An fMRI study using an emotional activation paradigm, NeuroReport, 9, 3253, 10.1097/00001756-199810050-00022

Bechara, 1995, Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans, Science, 269, 1115, 10.1126/science.7652558

Blair, 1999, Dissociable neural responses to facial expressions of sadness and anger, Brain, 122, 883, 10.1093/brain/122.5.883

Blood, 1999, Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions, Nat. Neurosci., 2, 382, 10.1038/7299

Breiter, 1996, Response and habituation of the human amygdala during visual processing of facial expression, Neuron, 17, 875, 10.1016/S0896-6273(00)80219-6

Breiter, 1997, Acute effects of cocaine on human brain activity and emotion, Neuron, 19, 591, 10.1016/S0896-6273(00)80374-8

Bremner, 1999, Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study, Biol. Psychiatry, 45, 806, 10.1016/S0006-3223(98)00297-2

Brody, 1999, Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine, Psychiatry Res., 91, 127, 10.1016/S0925-4927(99)00034-7

Büchel, 1998, Brain systems mediating aversive conditioning: an event-related fMRI study, Neuron, 20, 947, 10.1016/S0896-6273(00)80476-6

Büchel, 1999, Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging, J. Neurosci., 19, 10869, 10.1523/JNEUROSCI.19-24-10869.1999

Büchel, 2000, Classical fear conditioning in functional neuroimaging, Curr. Opin. Neurobiol., 10, 219, 10.1016/S0959-4388(00)00078-7

Bush, 2000, Cognitive and emotional influences in anterior cingulate cortex, Trends Cogn. Sci., 4, 215, 10.1016/S1364-6613(00)01483-2

Cabeza, 2000, Imaging cognition II: An empirical review of 275 PET and fMRI studies, J. Cogn. Neurosci., 12, 1, 10.1162/08989290051137585

Calder, 1996, Facial emotion recognition after bilateral amygdala damage: Differentially severe impairment of fear, Cogn. Neuropsychol., 13, 699, 10.1080/026432996381890

Canli, 1998, Hemispheric asymmetry for emotional stimuli detected with fMRI, NeuroReport, 9, 3233, 10.1097/00001756-199810050-00019

Casey, 1994, Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli, J. Neurophysiol., 71, 802, 10.1152/jn.1994.71.2.802

Cechetto, 1990, Role of the cerebral cortex in autonomic function

Corbetta, 1993, A PET study of visuospatial attention, J. Neurosci., 13, 1202, 10.1523/JNEUROSCI.13-03-01202.1993

Crosson., 1999, Left-hemisphere processing of emotional connotation during word generation, NeuroReport, 10, 2449, 10.1097/00001756-199908200-00003

Damasio, 1994

Damasio, 2000, Subcortical and cortical brain activity during the feeling of self-generated emotions, Nat. Neurosci., 3, 1049, 10.1038/79871

Davidson, 1990, Approach/withdrawal and cerebral asymmetry: Emotional expression and brain physiology, I. J. Pers. Soc. Psychol., 58, 330, 10.1037/0022-3514.58.2.330

Davidson, 1999, The functional neuroanatomy of emotion and affective style, Trends Cogn. Sci., 3, 11, 10.1016/S1364-6613(98)01265-0

Davis, 2001, The amygdala: Vigilance and emotion, Mol. Psychiatry, 6, 13, 10.1038/sj.mp.4000812

Devinsky, 1995, Contributions of anterior cingulate cortex to behaviour, Brain, 118, 279, 10.1093/brain/118.1.279

Dolan, 1998, A cognitive affective role for the cerebellum, Brain, 121, 545, 10.1093/brain/121.4.545

Dolan, 2000, Dissociable temporal lobe activations during emotional episodic memory retrieval, NeuroImage, 11, 203, 10.1006/nimg.2000.0538

Dougherty, 1999, Anger in healthy men: A PET study using script-driven imagery, Biol. Psychiatry, 46, 466, 10.1016/S0006-3223(99)00063-3

Drevets, 1997, Subgenual prefrontal cortex abnormalities in mood disorders, Nature, 386, 824, 10.1038/386824a0

Drevets, 1998, Reciprocal Suppression of Regional Cerebral Blood Flow during Emotional versus Higher Cognitive Processes: Implications for interaction between Emotion and Cognition, Cogn. Emotion, 12, 353, 10.1080/026999398379646

Duncan, 2000, Common regions of the human frontal lobe recruited by diverse cognitive demands, Trends Neurosci., 23, 475, 10.1016/S0166-2236(00)01633-7

Everitt, 1991, The basolateral amygdala-ventral striatal system and conditioned place preference: Further evidence of limbic-striatal interactions underlying reward-related processes, Neuroscience, 42, 1, 10.1016/0306-4522(91)90145-E

Fox, 1998, Beyond the single study: Function/location metanalysis in cognitive neuroimaging, Curr. Opin. Neurobiol., 8, 178, 10.1016/S0959-4388(98)80138-4

Frey, 2000, Orbitofrontal involvement in the processing of unpleasant auditory information, Eur. J. Neurosci., 12, 3709, 10.1046/j.1460-9568.2000.00227.x

Gemar, 1996, Effects of self-generated sad mood on regional cerebral activity: A PET study in normal subjects, Depression, 4, 81, 10.1002/(SICI)1522-7162(1996)4:2<81::AID-DEPR8>3.0.CO;2-I

George, 1993, Brain regions involved in recognizing facial emotion or identity: An oxygen-15 PET study, J. Neuropsychiatry Clin. Neurosci., 5, 384, 10.1176/jnp.5.4.384

George, 1995, Brain activity during transient sadness and happiness in healthy women, Am. J. Psychiatry, 152, 341, 10.1176/ajp.152.3.341

George, 1996, Understanding emotional prosody activates right hemisphere regions, Arch. Neurol., 53, 665, 10.1001/archneur.1996.00550070103017

George, 1996, Gender differences in regional cerebral blood flow during transient self-induced sadness or happiness, Biol. Psychiatry, 40, 859, 10.1016/0006-3223(95)00572-2

Gray, 1982

Halgren, 1978, Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala, Brain, 101, 83, 10.1093/brain/101.1.83

Hamann, 1999, Amygdala activity related to enhanced memory for pleasant and aversive stimuli, Nat. Neurosci., 2, 289, 10.1038/6404

Hariri, 2000, Modulating emotional responses: Effects of a neocortical network on the limbic system, NeuroReport, 11, 43, 10.1097/00001756-200001170-00009

Hutchinson, M., Schiffer, W., Joseffer, S., Liu, A., Schlosser, R., Dikshit, S., Goldberg, E., and Brodie, J. D.Task-specific deactivation patterns in functional magnetic resonance imaging. Magn. Reson. Imag.17: 1427–1436.

Irwin, 1996, Human amygdala activation detected with echo-planar functional magnetic resonance imaging, NeuroReport, 7, 1765, 10.1097/00001756-199607290-00014

Isenberg, 1999, Linguistic threat activates the human amygdala, Proc. Natl. Acad. Sci. USA, 96, 10456, 10.1073/pnas.96.18.10456

Iwai, 1987, Amygdalar connections with middle and inferior temporal gyri of the monkey, Neurosci. Lett., 83, 25, 10.1016/0304-3940(87)90210-2

Jennings, 1997, Cognitive subtractions may not add up: The interaction between semantic processing and response mode, NeuroImage, 5, 229, 10.1006/nimg.1997.0257

Kalin, 1997, Functional magnetic resonance imaging studies of emotional processing in normal and depressed patients: Effects of venlafaxine, J. Clin. Psychiatry, 58, 32

Ketter, 1996, Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences, Arch. Gen. Psychiatry, 53, 59, 10.1001/archpsyc.1996.01830010061009

Kimbrell, 1999, Regional brain activity during transient self-induced anxiety and anger in healthy adults, Biol. Psychiatry, 46, 454, 10.1016/S0006-3223(99)00103-1

King, 1992, 355

Kluver, 1939, Preliminary analysis of functions of the temporal lobes in monkeys, Arch. Neurol. Psychiatry, 42, 979, 10.1001/archneurpsyc.1939.02270240017001

Koch, 1996, Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens, NeuroReport, 7, 1442, 10.1097/00001756-199605310-00024

Koepp, 1998, Evidence for striatal dopamine release during a video game, Nature, 393, 266, 10.1038/30498

Koob, 1992, Neurobiological mechanisms of cocaine and opiate dependence

Kosslyn, 1996, Neural effects of visualizing and perceiving aversive stimuli: A PET investigation, NeuroReport, 7, 1569, 10.1097/00001756-199607080-00007

LaBar, 1995, Impaired fear condition following unilateral temporal lobectomy in humans, J. Neurosci., 15, 6846, 10.1523/JNEUROSCI.15-10-06846.1995

LaBar, 1998, Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study, Neuron, 20, 937, 10.1016/S0896-6273(00)80475-4

Lane, 1997, Neuroanatomical correlates of happiness, sadness, and disgust, Am. J. Psychiatry, 154, 926, 10.1176/ajp.154.7.926

Lane, 1997, Neuroanatomical correlates of pleasant and unpleasant emotion, Neuropsychologia, 35, 1437, 10.1016/S0028-3932(97)00070-5

Lane, 1997, Neural activation during selective attention to subjective emotional responses, NeuroReport, 8, 3969, 10.1097/00001756-199712220-00024

Lane, 1998, Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex, J. Cogn. Neurosci., 10, 525, 10.1162/089892998562924

Lane, 1999, Common effects of emotional valence, arousal and attention on neural activation during visual processing of pictures, Neuropsychologia, 37, 989, 10.1016/S0028-3932(99)00017-2

Lane, 2000

Lang, 1993, Looking at pictures: Affective, facial, visceral, and behavioral reactions, Psychophysiology, 30, 261, 10.1111/j.1469-8986.1993.tb03352.x

Lang, 1998, Emotional arousal and activation of the visual cortex: An fMRI analysis, Psychophysiology, 35, 199, 10.1111/1469-8986.3520199

LeDoux, 1993, Emotional memory systems in the brain, Behavi. Brain Res., 58, 69, 10.1016/0166-4328(93)90091-4

LeDoux, 1996

LeDoux, 2000, Emotion circuits in the brain, Annu. Rev. Neurosci., 23, 155, 10.1146/annurev.neuro.23.1.155

Liberzon, 2000, Limbic activation and psychophysiologic responses to aversive visual stimuli. Interaction with cognitive task, Neuropsychopharmacology, 23, 508, 10.1016/S0893-133X(00)00157-3

Liotti, 2000, Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: Implications for affective disorders, Biol. Psychiatry, 48, 30, 10.1016/S0006-3223(00)00874-X

MacLean, 1952, Some psychiatric implications of physiological studies on the frontotemporal portion of limbic system (visceral brain), Electroencephalogr. Clin. Neurophysiol., 4, 407, 10.1016/0013-4694(52)90073-4

Maddock, 1997, Activation of left posterior cingulate gyrus by the auditory presentation of threat-related words: An fMRI study, Psychiatry Res., 75, 1, 10.1016/S0925-4927(97)00018-8

Maddock, 1999, The retrosplenial cortex and emotion: New insights from functional neuroimaging of the human brain, Trends Neurosci., 22, 310, 10.1016/S0166-2236(98)01374-5

Mayberg, 1994, Paralimbic hypoperfusion in unipolar depression, J. Nucl. Med., 35, 929

Mayberg, 1999, Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness, Am. J. Psychiatry, 156, 675, 10.1176/ajp.156.5.675

Mayberg, 2000, Regional metabolic effects of fluoxetine in major depression: Serial changes and relationship to clinical response, Biol. Psychiatry., 48, 830, 10.1016/S0006-3223(00)01036-2

Morgan, 1993, Extinction of emotional learning: Contribution of medial prefrontal cortex, Neurosci. Lett., 163, 109, 10.1016/0304-3940(93)90241-C

Morris, 1996, A differential neural response in the human amygdala to fearful and happy facial expressions, Nature, 383, 812, 10.1038/383812a0

Morris, 1998, A neuromodulatory role for the human amygdala in processing emotional facial expressions, Brain, 121, 47, 10.1093/brain/121.1.47

Morris, 1998, Conscious and unconscious emotional learning in the human amygdala, Nature, 393, 467, 10.1038/30976

Morris, 1999, Saying it with feeling: Neural responses to emotional vocalizations, Neuropsychologia, 37, 1155, 10.1016/S0028-3932(99)00015-9

Nakamura, 1999, Activation of the right inferior frontal cortex during assesment of facial emotion, J. Neurophysiol., 82, 1610, 10.1152/jn.1999.82.3.1610

O'Doherty, 2001, Abstract reward and punishment representations in the human orbitofrontal cortex, Nat. Neurosci., 4, 95, 10.1038/82959

Panksepp, 1998

Papez, 1937, A proposed mechanism of emotion, Arch. Neurol. Psychiatry, 38, 725, 10.1001/archneurpsyc.1937.02260220069003

Paradiso, 1997, Emotional activation of limbic circuitry in elderly normal subjects in a PET study, Am. J. Psychiatry., 154, 384, 10.1176/ajp.154.3.384

Paradiso, 1999, Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects, Am. J. Psychiatry, 156, 1618, 10.1176/ajp.156.10.1618

Pardo, 1993, Neural correlates of self-induced dysphoria, Am. J. Psychiatry, 150, 713, 10.1176/ajp.150.5.713

Partiot, 1995, Brain activation during the generation of non-emotional and emotional plans, NeuroReport, 6, 1397, 10.1097/00001756-199507100-00009

Petrides, 1999, Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns, Eur. J. Neurosci., 11, 1011, 10.1046/j.1460-9568.1999.00518.x

Pietrini, 2000, Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects, Am. J. Psychiatry, 157, 1772, 10.1176/appi.ajp.157.11.1772

Phillips, 1997, A specific neural substrate for perceiving facial expressions of disgust, Nature, 389, 495, 10.1038/39051

Phillips, 1998, Neural responses to facial and vocal expressions of fear and disgust, Proc. R. Soc. Lond. B. Biol. Sci., 265, 1809, 10.1098/rspb.1998.0506

Phillips, 1998, Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study, Psychiatry Res. Neuroimag., 83, 127, 10.1016/S0925-4927(98)00036-5

Raichle, 2001, Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function, Pro. Natl. Acad. Sci. USA, 98, 676, 10.1073/pnas.98.2.676

Rauch, 1999, Neural activation during sexual and competitive arousal in healthy men, Psychiatry Res. Neuroimag. Section, 91, 1, 10.1016/S0925-4927(99)00020-7

Redoute, 2000, Brain processing of visual sexual stimuli in human males, Hum. Brain Mapp., 11, 162, 10.1002/1097-0193(200011)11:3<162::AID-HBM30>3.0.CO;2-A

Reiman, 1989, Neuroanatomical correlates of anticipatory anxiety, Science, 243, 1071, 10.1126/science.2784226

Reiman, 1989, Involvement of the temporal poles in pathologial and normal forms of anxiety, J. Cereb Blood Flow Metab., 9, S589

Reiman, 1997, Neuroanatomical correlates of externally and internally generated human emotion, Am. J. Psychiatry, 154, 918, 10.1176/ajp.154.7.918

Rolls, 1999

Rolls, 2000, The orbitofrontal cortex and reward, Cereb. Cortex, 10, 284, 10.1093/cercor/10.3.284

Royet, 2000, Emotional responses to pleasant and unpleasant olfactory, visual, and auditory stimuli: A positron emission tomography study, J. Neurosci., 20, 7752, 10.1523/JNEUROSCI.20-20-07752.2000

Rozin, 1987, A perspective on disgust, Psychol. Rev., 94, 23, 10.1037/0033-295X.94.1.23

Scott, 1997, Impaired auditory recognition of fear and anger following bilateral amygdalar lesions, Nature, 385, 254, 10.1038/385254a0

Shin, 2000, Activation of anterior paralimbic structures during guilt-related script-driven imagery, Biol. Psychiatry, 48, 43, 10.1016/S0006-3223(00)00251-1

Simpson, 2000, The emotional modulation of cognitive processing: An fMRI study, J. Cogn. Neurosci., 12, 157, 10.1162/089892900564019

Small, 1999, Human cortical gustatory areas: A review of functional neuroimaging data, NeuroReport, 10, 7, 10.1097/00001756-199901180-00002

Sprengelmeyer, 1996, Loss of disgust: Perception of faces and emotions in Huntington's disease, Brain, 119, 1647, 10.1093/brain/119.5.1647

Sprengelmeyer, 1997, Recognition of facial expressions: Selective impairment of specific emotions in Huntington's disease, Cogn. Neuropsychol., 14, 839, 10.1080/026432997381376

Sprengelmeyer, 1998, Neural structures associated with recognition of facial expressions of basic emotions, Proc. R. Soc. Lond. B. Biol. Sci., 265, 1927, 10.1098/rspb.1998.0522

Stein, 1998, Nicotine-induced limbic cortical activation in the human brain: A functional MRI study, Am. J. Psychiatry, 155, 1009, 10.1176/ajp.155.8.1009

Talairach, 1988

Taylor, 1998, The effect of emotional content on visual recognition memory: A PET activation study, NeuroImage, 8, 188, 10.1006/nimg.1998.0356

Taylor, 2000, The effect of graded aversive stimuli on limbic and visual activation, Neuropsychologia, 38, 1415, 10.1016/S0028-3932(00)00032-4

Teasdale, 1999, Functional MRI study of the cognitive generation of affect, Am. J. Psychiatry, 156, 209, 10.1176/ajp.156.2.209

Weiskrantz, 1956, Behavioral changes associated with ablation of the amygdaloid complex in monkeys, J. Comp. Physiol. Psychol., 49, 381, 10.1037/h0088009

Whalen, 1998, The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division, Biol. Psychiatry, 44, 1219, 10.1016/S0006-3223(98)00251-0

Whalen, 1998, Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge, J. Neurosci., 18, 411, 10.1523/JNEUROSCI.18-01-00411.1998