Functional Indicators for Assessing Zinc Deficiency

Food and Nutrition Bulletin - Tập 28 Số 3_suppl3 - Trang S454-S479 - 2007
Christa L. Fischer Walker1, Robert E. Black2
1Johns Hopkins University Bloomberg School of Public Health, Department of International Health, Baltimore, Maryland 21205, USA.
2Bloomberg School of Public Health

Tóm tắt

Zinc is an essential micronutrient for growth and proper immune function. There is currently no simple recommendation for the assessment of population-level zinc deficiency. Trials of zinc supplementation have shown positive effects of supplementation on clinical outcomes and growth. We reviewed the results of randomized trials of zinc supplementation and correlation studies that assessed infectious diseases, growth, and development outcomes among children under 5 years of age. The results indicate that zinc supplementation decreases the incidence and prevalence of diarrhea and pneumonia, but the use of trial data to make population-level estimates of zinc deficiency is not practical and is difficult to quantify. The data also indicate that zinc supplementation increases growth, especially among children who are stunted. Stunting rates are commonly estimated and can be used to estimate zinc deficiency. Previous recommendations suggest that stunting rates at or above 20% should be indicative of zinc deficiency among children under 5 years of age. This review provides additional data and analysis to support the current recommendation.

Từ khóa


Tài liệu tham khảo

10.1001/archinte.1963.03620280007003

10.1093/ajcn/79.3.451

10.1093/jn/134.9.2178

10.1177/15648265040251S205

10.1093/ajcn/72.6.1516

10.1016/S0140-6736(04)16252-1

10.1093/ajcn/75.6.1062

10.1016/S0022-3476(99)70086-7

10.1179/000349803125002797

10.1067/mpd.2002.128543

10.1136/bmj.325.7372.1059

10.1097/00005176-200401000-00010

10.1093/ajcn/82.3.605

10.1093/tropej/46.5.259

10.1111/j.1651-2227.1999.tb01074.x

10.13181/mji.v7i4.750

10.1093/ajcn.81.2.495

10.1136/adc.77.3.196

10.1097/00005176-198811000-00015

10.1056/NEJM199509283331304

10.1542/peds.109.5.898

Food and Nutrition Board/Institute of Medicine, 2001, Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc

10.1080/080352501750126159

10.1016/S0022-3476(99)70024-7

10.1542/peds.103.4.e42

10.1111/j.1651-2227.1998.tb00943.x

10.1080/02724936.1990.11747411

10.1093/ajcn/79.3.430

10.1093/ajcn/76.3.604

10.1093/ajcn/76.4.805

10.1136/bmj.323.7308.314

10.1038/sj.ejcn.1600734

10.4269/ajtmh.2006.75.1.0750126

10.1093/ajcn/82.2.399

10.1093/ajcn/79.3.457

10.1093/ajcn/80.3.729

10.1542/peds.112.6.1327

10.1111/j.1651-2227.2003.tb02501.x

10.1136/bmj.324.7350.1358

10.1542/peds.109.6.e86

10.1093/ajcn/76.6.1401

10.1542/peds.108.6.1280

10.1016/S0140-6736(00)02348-5

10.4269/ajtmh.2000.62.663

10.1093/ajcn/68.6.1261

10.1542/peds.102.1.1

10.1093/ajcn/68.2.418S

10.1038/sj.ejcn.1600509

10.1542/peds.99.6.808

10.1093/ajcn/65.1.13

10.1093/ajcn/66.2.413

Sempértegui F, 1996, Eur J Clin Nutr, 50, 42

10.1093/ajcn/63.4.514

10.1093/ajcn/45.3.602

10.1079/BJN19930026

10.1016/S0140-6736(05)67109-7

10.1093/jn/133.12.4150

10.1080/07315724.1999.10718854

10.1515/JPEM.2000.13.8.1121

10.1093/jn/131.11.2860

10.1067/mpd.2001.110530

10.1093/jn/128.3.556

10.1093/ajcn/66.6.1406

10.1038/sj.ejcn.1600358

10.1016/S0022-3476(95)70296-2

10.1007/978-1-4899-2575-6_18

10.1093/ajcn/57.3.344

Shrivastava SP, 1993, Indian Pediatr, 30, 779

Hong ZY, 1992, Chin Med J (Engl), 105, 844

10.1093/ajcn/28.7.721

10.1111/j.1651-2227.1994.tb13154.x

Samman S, 2002, Essentials of human nutrition

10.1093/ajcn/49.6.1266

10.1093/ajcn/32.12.2532

Hambidge KM, 1978, Proceedings of the 3rd International Symposium of Trace Element Metabolism in Man and Animals, 296

Heinig MJ, 1998, FASEB J, 12, A970

Hong ZY, 1987, Chung Hua I Hsueh Tsa Chih, 67, 16

10.1016/S0022-3476(05)81538-0

10.1093/ajcn/56.1.50

10.1016/0140-6736(92)92229-9

10.1093/ajcn/29.10.1114

Walravens PA, 1989, Pediatrics, 83, 532, 10.1542/peds.83.4.532

10.1093/ajcn/38.2.195

Hong ZY, 1982, Chung Hua I Hsueh Tsa Chih, 62, 415

10.1542/peds.113.5.1297

10.1093/ajcn/80.4.903

10.1093/jn/127.7.1333

Ashworth A, 1998, Eur J Clin Nutr, 52, S34, 10.1038/sj.ejcn.1600553

10.1093/ajcn/74.3.381

10.1038/sj.ejcn.1600660

10.1093/ajcn/71.2.550

10.1093/ajcn/68.2.414S

10.1093/ajcn/53.3.782

10.1093/ajcn/58.4.549

Shakur MS, 2004, Indian Pediatr, 41, 478

Demirci M, 2003, J Health Popul Nutr, 21, 72

10.1016/S0022-3476(88)80627-9

Chaudhary S, 1996, J Diarrhoeal Dis Res, 14, 190

World Health Organization, 1996, Trace elements in human nutrition and health

World Health Organization, 1995, World Health Organ Tech Rep Ser, 854, 1