Các thuộc tính chức năng của tế bào T phản ứng trong nhiễm virus viêm gan C: Những tiến bộ gần đây trong việc kỹ thuật hóa các tế bào T kháng virus có chức năng

Abdel-Hakeem MS, Bedard N, Badr G et al (2010) Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus. J Virol 84:10429–10435 Alanio C, Lemaitre F, Law HK et al (2010) Enumeration of human antigen-specific naive CD8 + T cells reveals conserved precursor frequencies. Blood 115:3718–3725 Antia R, Ganusov VV, Ahmed R (2005) The role of models in understanding CD8 + T-cell memory. Nat Rev Immunol 5:101–111 Appay V, Douek DC, Price DA (2008) CD8 + T cell efficacy in vaccination and disease. Nat Med 14:623–628 Badr G, Bedard N, Abdel-Hakeem MS et al (2008) Early interferon therapy for hepatitis C virus infection rescues poly-functional, long-lived CD8 + memory T cells. J Virol 82:10017–10031 Bettini ML, Bettini M, Vignali DA (2012) T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology 136:265–272 Bowen DG, Walker CM (2005) Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436:946–952 Callender GG, Rosen HR, Roszkowski JJ et al (2006) Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition. Hepatology 43:973–981 Chen M, Sallberg M, Sonnerborg A et al (1999) Limited humoral immunity in hepatitis C virus infection. Gastroenterology 116:135–143 Chen M, Sallberg M, Thung SN et al (2000) Non-deletional T-cell receptor transgenic mice: model for the CD4(+) T-cell repertoire in chronic hepatitis B virus infection. J Virol 74:7587–7599 Chen MT, Billaud JN, Sallberg M et al (2004) A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci USA 101:14913–14918 Chen M, Sallberg M, Hughes J et al (2005) Immune tolerance split between hepatitis B virus precore and core proteins. J Virol 79:3016–3027 Ciuffreda D, Comte D, Cavassini M et al (2008) Poly-functional HCV-specific T-cell responses are associated with effective control of HCV replication. Eur J Immunol 38:2665–2677 Dorner M, Horwitz JA, Robbins JB et al (2011) A genetically humanized mouse model for hepatitis C virus infection. Nature 474:208–211 Farci P, Alter HJ, Wong DC et al (1994) Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci USA 91:7792–7796 Farci P, Shimoda A, Wong D et al (1996) Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 93:15394–15399 Garrone P, Fluckiger AC, Mangeot PE et al (2011) A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques. Sci Transl Med 3: 94ra71 Ghany MG, Nelson DR, Strader DB et al (2011) An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American association for the study of liver diseases. Hepatology 54:1433–1444 Giang E, Dorner M, Prentoe JC et al (2012) Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci USA 109:6205–6210 Gilead Sciences (2013) Results from Gilead phase 3 trials with Sofosbuvir. Available at http://wwwhepctrustorguk/News_Resources/news/2013/January/Results+from+Gilead+phase+3+trials+with+sofosbuvir Grakoui A, Shoukry NH, Woollard DJ et al (2003) HCV persistence and immune evasion in the absence of memory T cell help. Science 302:659–662 Guidotti LG, Chisari FV (2001) Non cytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 19:65–91 Guidotti LG, Rochford R, Chung J et al (1999) Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825–829 Jacobson IM, McHutchison JG, Dusheiko G (2011) Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 364:2405–2416 Kim PS, Ahmed R (2010) Features of responding T cells in cancer and chronic infection. Curr Opin Immunol 22:223–230 Klebanoff CA, Gattinoni L, Restifo NP (2006) CD8 + T-cell memory in tumor immunology and immunotherapy. Immunol Rev 211:214–224 Klebanoff CA, Gattinoni L, Palmer DC et al (2011) Determinants of successful CD8 + T-cell adoptive immunotherapy for large established tumors in mice. Clin Can Res 17:5343–5352 Klenerman P, Thimme R (2012) T cell responses in hepatitis C: the good, the bad and the unconventional. Gut 61:1226–1234 Lamana ML, Bueren JA, Vicario JL et al (2004) Functional and phenotypic variations in human T cells subjected to retroviral-mediated gene transfer. Gen Ther 11:474–482 Law M, Maruyama T, Lewis J et al (2008) Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 14:25–27 Lechner F, Wong DK, Dunbar PR et al (2000) Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 191:1499–1512 Logvinoff C, Major ME, Oldach D et al (2004) Neutralizing antibody response during acute and chronic hepatitis C virus infection. Proc Natl Acad Sci USA 101:10149–10154 Nakamoto N, Kaplan DE, Coleclough J et al (2008) Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134:1927–1937 Netski DM, Mosbruger T, Depla E et al (2005) Humoral immune response in acute hepatitis C virus infection. Clin Inf Dis 41:667–675 Neumann-Haefelin C, Timm J, Spangenberg HC et al (2008) Virological and immunological determinants of intrahepatic virus-specific CD8 + T-cell failure in chronic hepatitis C virus infection. Hepatology 47:1824–1836 Nishimura T, Kaneko S, Kawana-Tachikawa A et al (2013) Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell 12:114–126 Pasetto A, Frelin L, Aleman S et al (2012a) TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity. J Immunol 189:4510–4519 Pasetto A, Frelin L, Brass A et al (2012b) Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3. J Gen Virol 93(Pt 2):247–258 Radziewicz H, Ibegbu CC, Fernandez ML et al (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81:2545–2553 Radziewicz H, Ibegbu CC, Hon H et al (2008) Impaired hepatitis C virus (HCV)-specific effector CD8 + T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection. J Virol 82:9808–9822 Rehermann B (2009) Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Inv 119:1745–1754 Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5:215–229 Restifo NP, Dudley ME, Rosenberg SA (2012) Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12:269–281 Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22:745–763 Sarrazin C, Hezode C, Zeuzem S et al (2012) Antiviral strategies in hepatitis C virus infection. J Hepatol 56(Suppl 1):S88–S100 Schmidt J, Neumann-Haefelin C, Altay T et al (2011) Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8 + T cell responses is linked to naive-precursor frequency. J Virol 85:5232–5236 Spangenberg HC, Viazov S, Kersting N et al (2005) Intrahepatic CD8 + T-cell failure during chronic hepatitis C virus infection. Hepatology 42:828–837 Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676 Thimme R, Oldach D, Chang KM et al (2001) Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194:1395–1406 Vizcardo R, Masuda K, Yamada D et al (2013) Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell 12:31–36 Wang A, Chandran S, Shah SA et al (2012) The stoichiometric production of IL-2 and IFN-gamma mRNA defines memory T cells that can self-renew after adoptive transfer in humans. Sci Transl Med 4: 149ra120 Wherry EJ (2011) T cell exhaustion. Nat Immunol 12:492–499 Yang S, Dudley ME, Rosenberg SA et al (2010) A simplified method for the clinical-scale generation of central memory-like CD8 + T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors. J Immunother 33:648–658 Yang S, Ji Y, Gattinoni L et al (2012) Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails. Cancer Immunol Immunother 62:727–736 Zhang Y, Liu Y, Moxley KM et al (2010) Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog 6:e1001018 Zimmerli SC, Harari A, Cellerai C et al (2005) HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc Natl Acad Sci USA 102:7239–7244