Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

Ale, 2011, Important determinants for fucoidan bioactivity: A critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds, Marine Drugs, 9, 2106, 10.3390/md9102106

Anastasiou, 2017, Tumour microenvironment factors shaping the cancer metabolism landscape, British Journal of Cancer, 116, 277, 10.1038/bjc.2016.412

Atashrazm, 2015, Fucoidan and cancer: A multifunctional molecule with anti-tumor potential, Marine Drugs, 13, 2327, 10.3390/md13042327

Azam, 2010, Mechanisms of resistance to antiangiogenesis therapy, European Journal of Cancer, 46, 1323, 10.1016/j.ejca.2010.02.020

Boisson-Vidal, 2007, Neoangiogenesis induced by progenitor endothelial cells: Effect of fucoidan from marine algae, Cardiovascular & Hematological Agents in Medicinal Chemistry, 5, 67, 10.2174/187152507779315778

Carmeliet, 2005, Angiogenesis in life, disease and medicine, Nature, 438, 932, 10.1038/nature04478

Carmeliet, 2011, Molecular mechanisms and clinical applications of angiogenesis, Nature, 473, 298, 10.1038/nature10144

Chen, 2016, Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling, Cancer Letters, 382, 44, 10.1016/j.canlet.2016.08.020

Chen, 2015, Low molecular weight fucoidan inhibits tumor angiogenesis through downregulation of HIF-1/VEGF signaling under hypoxia, Marine Drugs, 13, 4436, 10.3390/md13074436

Chen, 2007, Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation, Pharmaceutical Research, 24, 258, 10.1007/s11095-006-9173-4

DeCicco-Skinner, 2014, Endothelial cell tube formation assay for the in vitro study of angiogenesis, Journal of Visualized Experiments : JoVE, 91

di Tomaso, 2009, PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment, PloS One, 4, e5123, 10.1371/journal.pone.0005123

Dithmer, 2014, Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro, PloS One, 9, e89150, 10.1371/journal.pone.0089150

Dithmer, 2017, Fucoidan does not exert anti-tumorigenic effects on uveal melanoma cell lines, Marine Drugs, 15, 10.3390/md15070193

Ferrara, 2003, The biology of VEGF and its receptors, Nature Medicine, 9, 669, 10.1038/nm0603-669

Fitton, 2015, Therapies from fucoidan: An update, Marine Drugs, 13, 5920, 10.3390/md13095920

Folkman, 1974, Proceedings: Tumor angiogenesis factor, Cancer Research, 34, 2109

Folkman, 1974, Tumor angiogensis: Role in regulation of tumor growth, The Symposium Society for Developmental Biology, 30, 43

Gabrielli, 2003, Developmental expression of glycocomponents in the chick chorioallantoic membrane, Anat Embryol (Berl), 207, 63, 10.1007/s00429-003-0316-7

Henry, 1995, Differential lectin binding to microvascular endothelial glycoconjugates during normal angiogenesis in the chick chorioallantoic membrane, Microvascular Research, 49, 201, 10.1006/mvre.1995.1016

Jilani, 2003, Selective binding of lectins to embryonic chicken vasculature, The Journal of Histochemistry and Cytochemistry, 51, 597, 10.1177/002215540305100505

Kim, 2018, Fucoidan-induced osteogenic differentiation promotes angiogenesis by inducing vascular endothelial growth factor secretion and accelerates bone repair, Journal of Tissue Engineering and Regenerative Medicine, 12, e1311, 10.1002/term.2509

Klagsbrun, 1991, Regulators of angiogenesis, Annual Review of Physiology, 53, 217, 10.1146/annurev.ph.53.030191.001245

Kubota, 2012, Tumor angiogenesis and anti-angiogenic therapy, The Keio Journal of Medicine, 61, 47, 10.2302/kjm.61.47

Liu, 2016, Fucoidan inhibits angiogenesis induced by multiple myeloma cells, Oncology Reports, 36, 1963, 10.3892/or.2016.4987

Martinho, 2012, Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas, PloS One, 7, 10.1371/journal.pone.0030769

Nelson, 1998, Inhibitors of angiogenesis enter phase III testing, Journal of the National Cancer Institute, 90, 960, 10.1093/jnci/90.13.960a

Oliveira, 2017, The key role of sulfation and branching on fucoidan antitumor activity, Macromolecular Bioscience, 17, 10.1002/mabi.201600340

Petrovic, 2016, Targeting Angiogenesis in Cancer Treatments: Where do we Stand?, Journal of Pharmacy & Pharmaceutical Sciences, 19, 226, 10.18433/J30033

Ribatti, 2008, Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis, International Review of Cell and Molecular Biology, 270, 181, 10.1016/S1937-6448(08)01405-6

Ribatti, 2014, The chick embryo chorioallantoic membrane as a model for tumor biology, Experimental Cell Research, 328, 314, 10.1016/j.yexcr.2014.06.010

Ribatti, 2016, The chick embryo chorioallantoic membrane (CAM). A multifaceted experimental model, Mechanisms of Development, 141, 70, 10.1016/j.mod.2016.05.003

Rui, 2017, Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: Possible JAK-STAT3 pathway, BMC Complementary and Alternative Medicine, 17, 378, 10.1186/s12906-017-1885-y

Shahneh, 2013, Tumor angiogenesis and anti-angiogenic therapies, Human Antibodies, 22, 15, 10.3233/HAB-130267

Shanmugam, 2017, Potential role of natural compounds as anti-angiogenic agents in Cancer, Current Vascular Pharmacology, 15, 503, 10.2174/1570161115666170713094319

Shen, 2017, Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis, Molecular Medicine Reports, 15, 2620, 10.3892/mmr.2017.6338

Storgard, 2005, Angiogenesis assays in the chick CAM, Methods in Molecular Biology, 294, 123

Unger, 2002, In vitro expression of the endothelial phenotype: Comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R, Microvascular Research, 64, 384, 10.1006/mvre.2002.2434

Ustyuzhanina, 2014, Fucoidans: pro-or antiangiogenic agents?, Glycobiology, 24, 1265, 10.1093/glycob/cwu063

Wang, 2017, Crude fucoidan extracts impair angiogenesis in models relevant for bone regeneration and osteosarcoma via reduction of VEGF and SDF-1, Marine Drugs, 15, 10.3390/md15060186

Winlaw, 1997, Angiogenesis in the pathobiology and treatment of vascular and malignant diseases, The Annals of Thoracic Surgery, 64, 1204, 10.1016/S0003-4975(97)00716-9

Xue, 2012, Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo, PloS One, 7, 10.1371/journal.pone.0043483

Yang, 2017, Revision of the concept of anti-angiogenesis and its applications in tumor treatment, Chronic Dis Transl Med, 3, 33, 10.1016/j.cdtm.2017.01.002

Zhu, 2013, Fucoidan inhibits the growth of hepatocellular carcinoma independent of angiogenesis, Evidence-based Complementary and Alternative Medicine: ECAM, 2013, 10.1155/2013/692549