From discovery to production: Scale-out of continuous flow meso reactors

Beilstein Journal of Organic Chemistry - Tập 5
Peter Styring1, A. Parracho2
1Department of Chemical and Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom
2Department of Chemical & Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom

Tóm tắt

A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.

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Beilstein Journal of Organic Chemistry

Tập 5

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